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Clinical controversies in abdominal sepsis. Insights for critical care settings.

Martin-Loeches I, Timsit JF, Leone M, de Waele J, Sartelli M, Kerrigan S, Azevedo LCP, Einav S.

J Crit Care. 2019 Jun 3;53:53-58. doi: 10.1016/j.jcrc.2019.05.023. [Epub ahead of print] Review.


Advances in heart regeneration based on cardiomyocyte proliferation and regenerative potential of binucleated cardiomyocytes and polyploidization.

Leone M, Engel FB.

Clin Sci (Lond). 2019 Jun 7;133(11):1229-1253. doi: 10.1042/CS20180560. Print 2019 Jun 14. Review.


Association between high Gal-3 serum levels and worsening of renal function in chronic heart failure outpatients.

Iacoviello M, Di Serio F, Rizzo C, Leone M, Grande D, Guida P, Gioia MI, Parisi G, Leopizzi T, Caldarola P, Ciccone MM, Gesualdo L.

Biomark Med. 2019 Jun 3. doi: 10.2217/bmm-2018-0349. [Epub ahead of print]


Differential modulatory effects of Propofol and Sevoflurane anesthesia on blood monocyte HLA-DR and CD163 expression during and after cardiac surgery with cardiopulmonary bypass: a preliminary randomized flow cytometry study.

Sbrana S, Nunziata A, Storti S, Haxhiademi D, Mazzone A, Leone M, Solinas M, Del Sarto P.

Perfusion. 2019 May 31:267659119848295. doi: 10.1177/0267659119848295. [Epub ahead of print]


Effects of the discontinuation sequence of norepinephrine and vasopressin on hypotension incidence in patients with septic shock: A meta-analysis.

Duclos G, Baumstarck K, Dünser M, Zieleskiewicz L, Leone M.

Heart Lung. 2019 May 21. pii: S0147-9563(19)30115-3. doi: 10.1016/j.hrtlng.2019.05.007. [Epub ahead of print]


Candida Prophylaxis and Treatment in Critically Ill Patients after Abdominal Surgery: A Survey of Practice.

Einav S, Raveh D, Lachish T, Baumstarck K, Martin C, Martin-Loeches I, Leone M.

Surg Infect (Larchmt). 2019 May 17. doi: 10.1089/sur.2018.267. [Epub ahead of print]


Strategy focused on clinical parameters of microcirculation to resuscitate patients in septic shock: Do not forget any tools.

Barbar SD, Muller L, Bruckert V, Leone M, Singer M.

Anaesth Crit Care Pain Med. 2019 Jun;38(3):209-210. doi: 10.1016/j.accpm.2019.04.011. No abstract available.


Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France.

Atramont A, Lindecker-Cournil V, Rudant J, Tajahmady A, Drewniak N, Fouard A, Singer M, Leone M, Legrand M.

JAMA Netw Open. 2019 May 3;2(5):e193215. doi: 10.1001/jamanetworkopen.2019.3215.


What headache services in sub-Saharan Africa? The DREAM program as possible model.

Leone M, Palombi L, Guidotti G, Ciccacci F, Lunghi R, Orlando S, Nurja MA, Sangare MH, Marazzi CM.

Cephalalgia. 2019 May 9:333102419849014. doi: 10.1177/0333102419849014. [Epub ahead of print] No abstract available.


First demonstration of antimatter wave interferometry.

Sala S, Ariga A, Ereditato A, Ferragut R, Giammarchi M, Leone M, Pistillo C, Scampoli P.

Sci Adv. 2019 May 3;5(5):eaav7610. doi: 10.1126/sciadv.aav7610. eCollection 2019 May.


Social network analysis to characterize women victims of violence.

Leone M, Lapucci E, De Sario M, Davoli M, Farchi S, Michelozzi P.

BMC Public Health. 2019 May 2;19(1):494. doi: 10.1186/s12889-019-6797-y.


Value of early repeated abdominal CT in selective non-operative management for blunt bowel and mesenteric injury.

Lannes F, Scemama U, Maignan A, Boyer L, Beyer-Berjot L, Berdah SV, Chaumoître K, Leone M, Bège T.

Eur Radiol. 2019 Apr 25. doi: 10.1007/s00330-019-06212-w. [Epub ahead of print]


WITHDRAWN: Strategy focused on clinical parameters of microcirculation to resuscitate patients in septic shock: do not forget any tools.

Barbar SD, Muller L, Brucker V, Leone M, Singer M.

Anaesth Crit Care Pain Med. 2019 Apr 21. pii: S2352-5568(19)30168-7. doi: 10.1016/j.accpm.2019.04.009. [Epub ahead of print] No abstract available.


Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care.

Oddo M, Bracard S, Cariou A, Chanques G, Citerio G, Clerckx B, Godeau B, Godier A, Horn J, Jaber S, Jung B, Kuteifan K, Leone M, Mailles A, Mazighi M, Mégarbane B, Outin H, Puybasset L, Sharshar T, Sandroni C, Sonneville R, Weiss N, Taccone FS.

Ann Intensive Care. 2019 Apr 16;9(1):47. doi: 10.1186/s13613-019-0523-x. Review.


Multidrug-resistant Pseudomonas aeruginosa and mortality inmechanically ventilated ICU patients.

Denis JB, Lehingue S, Pauly V, Cassir N, Gainnier M, Léone M, Daviet F, Coiffard B, Baron S, Guervilly C, Forel JM, Roch A, Papazian L.

Am J Infect Control. 2019 Apr 6. pii: S0196-6553(19)30144-0. doi: 10.1016/j.ajic.2019.02.030. [Epub ahead of print]


Cluster headache: insights from resting-state functional magnetic resonance imaging.

Ferraro S, Nigri A, Bruzzone MG, Demichelis G, Pinardi C, Brivio L, Giani L, Proietti A, Leone M, Chiapparini L.

Neurol Sci. 2019 May;40(Suppl 1):45-47. doi: 10.1007/s10072-019-03874-8. Review.


Implementation of antibiotic stewardship programmes in French ICUs in 2018: a nationwide cross-sectional survey.

Delannoy M, Agrinier N, Charmillon A, Degand N, Dellamonica J, Leone M, Pulcini C, Novy E.

J Antimicrob Chemother. 2019 Apr 1. pii: dkz113. doi: 10.1093/jac/dkz113. [Epub ahead of print]


Novel autoantibodies in rheumatoid arthritis.

Bonifacio AF, Alunno A, La Paglia GMC, Valentini E, Leone MC, Bartoloni E, Gerli R.

Reumatismo. 2019 Apr 1;71(1):1-12. doi: 10.4081/reumatismo.2019.1102.


Gender and survival of critically ill patients: results from the FROG-ICU study.

Hollinger A, Gayat E, Féliot E, Paugam-Burtz C, Fournier MC, Duranteau J, Lefrant JY, Leone M, Jaber S, Mebazaa A, Arrigo M; FROG ICU study investigators.

Ann Intensive Care. 2019 Mar 29;9(1):43. doi: 10.1186/s13613-019-0514-y.


Impact of renin-angiotensin system inhibitors continuation versus discontinuation on outcome after major surgery: protocol of a multicenter randomized, controlled trial (STOP-or-NOT trial).

Legrand M, Futier E, Leone M, Deniau B, Mebazaa A, Plaud B, Coriat P, Rossignol P, Vicaut E, Gayat E; STOP-OR-NOT study investigators.

Trials. 2019 Mar 5;20(1):160. doi: 10.1186/s13063-019-3247-1.


Antibioprophylaxis in surgery and interventional medicine. (adult patients) Update 2017.

Martin C, Auboyer C, Boisson M, Dupont H, Gauzit R, Kitzis M, Leone M, Lepape A, Mimoz O, Montravers P, Pourriat JL.

Anaesth Crit Care Pain Med. 2019 Mar 2. pii: S2352-5568(19)30085-2. doi: 10.1016/j.accpm.2019.02.017. [Epub ahead of print]


Cost-conscious high-quality care and guideline development education: a strange contradiction or simple solution?

Majoie HJM, van Gaalen J, Verstegen DML, van Mastrigt GAPG, Kleijnen J, Alonso-Coello P, Gartlehner G, Ritchie K, Service D, Leone M, Evers SMAA.

Eur J Neurol. 2019 Apr;26(4):e48-e49. doi: 10.1111/ene.13855. No abstract available.


Anti-CGRP in cluster headache therapy.

Giani L, Proietti Cecchini A, Leone M.

Neurol Sci. 2019 May;40(Suppl 1):129-135. doi: 10.1007/s10072-019-03786-7. Review.


Epidemiology of trauma in France: mortality and risk factors based on a national medico-administrative database.

Bège T, Pauly V, Orleans V, Boyer L, Leone M.

Anaesth Crit Care Pain Med. 2019 Feb 23. pii: S2352-5568(18)30537-X. doi: 10.1016/j.accpm.2019.02.007. [Epub ahead of print]


A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit.

Kotfis K, Wittebole X, Jaschinski U, Solé-Violán J, Kashyap R, Leone M, Nanchal R, Fontes LE, Sakr Y, Vincent JL; ICON Investigators.

J Crit Care. 2019 Jun;51:122-132. doi: 10.1016/j.jcrc.2019.02.015. Epub 2019 Feb 13.


Paired acute-baseline serum tryptase levels in perioperative anaphylaxis: An observational study.

Vitte J, Amadei L, Gouitaa M, Mezouar S, Zieleskiewicz L, Albanese J, Bruder N, Lagier D, Mertès PM, Mège JL, Schwartz LB, Leone M.

Allergy. 2019 Jun;74(6):1157-1165. doi: 10.1111/all.13752. Epub 2019 Mar 21.


Reply to the Letter to the Editor.

Coiffard B, Leone M, Mege JL.

Shock. 2019 Feb 14. doi: 10.1097/SHK.0000000000001331. [Epub ahead of print] No abstract available.


About TFE: Old and New Findings.

Vincenzi M, Mercurio FA, Leone M.

Curr Protein Pept Sci. 2019;20(5):425-451. doi: 10.2174/1389203720666190214152439.


Direct observation of alpha-lactalbumin, adsorption and incorporation into lipid membrane and formation of lipid/protein hybrid structures.

Rao E, Foderà V, Leone M, Vetri V.

Biochim Biophys Acta Gen Subj. 2019 May;1863(5):784-794. doi: 10.1016/j.bbagen.2019.02.005. Epub 2019 Feb 8.


Preliminary results of synergy between norepinephrine and terlipressin during septic shock.

Duclos G, Cantaloube M, Medam S, Resseguier N, Leone M.

Intensive Care Med. 2019 May;45(5):730-732. doi: 10.1007/s00134-018-05514-9. Epub 2019 Feb 6. No abstract available.


Attributable deaths caused by infections with antibiotic-resistant bacteria in France.

Raoult D, Leone M, Roussel Y, Rolain JM.

Lancet Infect Dis. 2019 Feb;19(2):128-129. doi: 10.1016/S1473-3099(18)30800-4. Epub 2019 Jan 30. No abstract available.


Sudden death in mild hypertrophic cardiomyopathy with compound DSG2/DSC2/MYH6 mutations: Revisiting phenotype after genetic assessment in a master runner athlete.

Castellana S, Mastroianno S, Palumbo P, Palumbo O, Biagini T, Leone MP, De Luca G, Potenza DR, Amico CM, Mazza T, Russo A, Di Stolfo G, Carella M.

J Electrocardiol. 2019 Mar - Apr;53:95-99. doi: 10.1016/j.jelectrocard.2019.01.002. Epub 2019 Jan 2.


Current use of vasopressors in septic shock.

Scheeren TWL, Bakker J, De Backer D, Annane D, Asfar P, Boerma EC, Cecconi M, Dubin A, Dünser MW, Duranteau J, Gordon AC, Hamzaoui O, Hernández G, Leone M, Levy B, Martin C, Mebazaa A, Monnet X, Morelli A, Payen D, Pearse R, Pinsky MR, Radermacher P, Reuter D, Saugel B, Sakr Y, Singer M, Squara P, Vieillard-Baron A, Vignon P, Vistisen ST, van der Horst ICC, Vincent JL, Teboul JL.

Ann Intensive Care. 2019 Jan 30;9(1):20. doi: 10.1186/s13613-019-0498-7.


Post-lumbar puncture headache: an adverse effect in multiple sclerosis work-up.

Vecchio D, Naldi P, Ferro V, Comi C, Leone MA, Cantello R.

Neurol Sci. 2019 Apr;40(4):759-762. doi: 10.1007/s10072-019-3724-z. Epub 2019 Jan 21.


The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures.

Tito A, Barbulova A, Zappelli C, Leone M, Ruvo M, Mercurio FA, Chambery A, Russo R, Colucci MG, Apone F.

Mol Biotechnol. 2019 Mar;61(3):209-220. doi: 10.1007/s12033-019-00154-w.


Targeting Inflammation to Prevent Cardiovascular Disease in Chronic Rheumatic Diseases: Myth or Reality?

Bartoloni E, Alunno A, Valentini V, Luccioli F, Valentini E, La Paglia GMC, Leone MC, Cafaro G, Marcucci E, Gerli R.

Front Cardiovasc Med. 2018 Dec 11;5:177. doi: 10.3389/fcvm.2018.00177. eCollection 2018.


French intensive care unit organisation.

Leone M, Constantin JM, Dahyot-Fizelier C, Duracher-Gout C, Joannes-Boyau O, Langeron O, Legrand M, Mahjoub Y, Mirek S, Mrozek S, Muller L, Orban JC, Quesnel C, Roquilly A, Virat A, Capdevila X.

Anaesth Crit Care Pain Med. 2018 Dec;37(6):625-627. doi: 10.1016/j.accpm.2018.10.011. Epub 2018 Oct 25.


Choice of fluids in critically ill patients.

Martin C, Cortegiani A, Gregoretti C, Martin-Loeches I, Ichai C, Leone M, Marx G, Einav S.

BMC Anesthesiol. 2018 Dec 22;18(1):200. doi: 10.1186/s12871-018-0669-3. Review.


The LNK Gene Family: At the Crossroad between Light Signaling and the Circadian Clock.

de Leone MJ, Hernando CE, Romanowski A, García-Hourquet M, Careno D, Casal J, Rugnone M, Mora-García S, Yanovsky MJ.

Genes (Basel). 2018 Dec 20;10(1). pii: E2. doi: 10.3390/genes10010002.


Design and analysis of EphA2-SAM peptide ligands: A multi-disciplinary screening approach.

Mercurio FA, Di Natale C, Pirone L, Marasco D, Calce E, Vincenzi M, Pedone EM, De Luca S, Leone M.

Bioorg Chem. 2019 Mar;84:434-443. doi: 10.1016/j.bioorg.2018.12.009. Epub 2018 Dec 8.


Efficacy and safety of antimicrobial de-escalation as a clinical strategy.

Mathieu C, Pastene B, Cassir N, Martin-Loeches I, Leone M.

Expert Rev Anti Infect Ther. 2019 Feb;17(2):79-88. doi: 10.1080/14787210.2019.1561275. Epub 2018 Dec 28. Review.


Extra-articular rheumatoid arthritis.

Marcucci E, Bartoloni E, Alunno A, Leone MC, Cafaro G, Luccioli F, Valentini V, Valentini E, La Paglia GMC, Bonifacio AF, Gerli R.

Reumatismo. 2018 Dec 20;70(4):212-224. doi: 10.4081/reumatismo.2018.1106.


Sepsis in Intensive Care Unit Patients: Worldwide Data From the Intensive Care over Nations Audit.

Sakr Y, Jaschinski U, Wittebole X, Szakmany T, Lipman J, Ñamendys-Silva SA, Martin-Loeches I, Leone M, Lupu MN, Vincent JL; ICON Investigators.

Open Forum Infect Dis. 2018 Nov 19;5(12):ofy313. doi: 10.1093/ofid/ofy313. eCollection 2018 Dec.


Beyond Transcription: Fine-Tuning of Circadian Timekeeping by Post-Transcriptional Regulation.

Mateos JL, de Leone MJ, Torchio J, Reichel M, Staiger D.

Genes (Basel). 2018 Dec 10;9(12). pii: E616. doi: 10.3390/genes9120616. Review.


Complemental analysis about postoperative opioid consumption between video-assisted thoracic surgery (VATS) and robotic-assisted thoracic surgery (RATS) for early-stage lung cancer.

Duclos G, Resseguier N, Ronfle R, Thomas PA, Leone M.

J Thorac Dis. 2018 Oct;10(10):E764-E765. doi: 10.21037/jtd.2018.09.95. No abstract available.


Surgical antimicrobial prophylaxis in intensive care unit (ICU) patients: a preliminary, observational, retrospective study.

Duclos G, Pastene B, Depeyre F, Meresse Z, Cassir N, Martin-Loeches I, Einav S, Zieleskiewicz L, Leone M.

Ann Transl Med. 2018 Oct;6(20):402. doi: 10.21037/atm.2018.09.56.


Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment.

Leone M, Priester MI, Romeijn S, Nejadnik MR, Mönkäre J, O'Mahony C, Jiskoot W, Kersten G, Bouwstra JA.

Eur J Pharm Biopharm. 2019 Jan;134:49-59. doi: 10.1016/j.ejpb.2018.11.013. Epub 2018 Nov 16.


GEMO, a National Resource to Study Genetic Modifiers of Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Pathogenic Variant Carriers.

Lesueur F, Mebirouk N, Jiao Y, Barjhoux L, Belotti M, Laurent M, Léone M, Houdayer C, Bressac-de Paillerets B, Vaur D, Sobol H, Noguès C, Longy M, Mortemousque I, Fert-Ferrer S, Mouret-Fourme E, Pujol P, Venat-Bouvet L, Bignon YJ, Leroux D, Coupier I, Berthet P, Mari V, Delnatte C, Gesta P, Collonge-Rame MA, Giraud S, Bonadona V, Baurand A, Faivre L, Buecher B, Lasset C, Gauthier-Villars M, Damiola F, Mazoyer S, Caputo SM, Andrieu N, Stoppa-Lyonnet D; GEMO Study Collaborators.

Front Oncol. 2018 Oct 31;8:490. doi: 10.3389/fonc.2018.00490. eCollection 2018. No abstract available.


Sex and bacterial infectious diseases.

Mege JL, Bretelle F, Leone M.

New Microbes New Infect. 2018 Jun 6;26:S100-S103. doi: 10.1016/j.nmni.2018.05.010. eCollection 2018 Nov. Review.


Renal Venous Pattern: A New Parameter for Predicting Prognosis in Heart Failure Outpatients.

Puzzovivo A, Monitillo F, Guida P, Leone M, Rizzo C, Grande D, Ciccone MM, Iacoviello M.

J Cardiovasc Dev Dis. 2018 Nov 3;5(4). pii: E52. doi: 10.3390/jcdd5040052.

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