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Items: 1 to 50 of 314

1.

Biology and regulation of IL-2: from molecular mechanisms to human therapy.

Spolski R, Li P, Leonard WJ.

Nat Rev Immunol. 2018 Aug 8. doi: 10.1038/s41577-018-0046-y. [Epub ahead of print] Review.

PMID:
30089912
2.

Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity.

Cho H, Jaime H, de Oliveira RP, Kang B, Spolski R, Vaziri T, Myers TG, Thovarai V, Shen Z, Fox JG, Leonard WJ, Kelsall BL.

Mucosal Immunol. 2018 Aug 7. doi: 10.1038/s41385-018-0056-x. [Epub ahead of print]

PMID:
30087442
3.

Act1 is a negative regulator in T and B cells via direct inhibition of STAT3.

Zhang CJ, Wang C, Jiang M, Gu C, Xiao J, Chen X, Martin BN, Tang F, Yamamoto E, Xian Y, Wang H, Li F, Sartor RB, Smith H, Husni ME, Shi FD, Gao J, Carman J, Dongre A, McKarns SC, Coppieters K, Jørgensen TN, Leonard WJ, Li X.

Nat Commun. 2018 Jul 16;9(1):2745. doi: 10.1038/s41467-018-04974-3.

4.

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity.

Béziat V, Li J, Lin JX, Ma CS, Li P, Bousfiha A, Pellier I, Zoghi S, Baris S, Keles S, Gray P, Du N, Wang Y, Zerbib Y, Lévy R, Leclercq T, About F, Lim AI, Rao G, Payne K, Pelham SJ, Avery DT, Deenick EK, Pillay B, Chou J, Guery R, Belkadi A, Guérin A, Migaud M, Rattina V, Ailal F, Benhsaien I, Bouaziz M, Habib T, Chaussabel D, Marr N, El-Benna J, Grimbacher B, Wargon O, Bustamante J, Boisson B, Müller-Fleckenstein I, Fleckenstein B, Chandesris MO, Titeux M, Fraitag S, Alyanakian MA, Leruez-Ville M, Picard C, Meyts I, Di Santo JP, Hovnanian A, Somer A, Ozen A, Rezaei N, Chatila TA, Abel L, Leonard WJ, Tangye SG, Puel A, Casanova JL.

Sci Immunol. 2018 Jun 15;3(24). pii: eaat4956. doi: 10.1126/sciimmunol.aat4956.

PMID:
29907691
5.

TSLP signaling in CD4+ T cells programs a pathogenic T helper 2 cell state.

Rochman Y, Dienger-Stambaugh K, Richgels PK, Lewkowich IP, Kartashov AV, Barski A, Khurana Hershey GK, Leonard WJ, Singh H.

Sci Signal. 2018 Mar 13;11(521). pii: eaam8858. doi: 10.1126/scisignal.aam8858.

PMID:
29535264
6.

Biology of IL-2 and its therapeutic modulation: Mechanisms and strategies.

Mitra S, Leonard WJ.

J Leukoc Biol. 2018 Apr;103(4):643-655. doi: 10.1002/JLB.2RI0717-278R. Epub 2018 Mar 9. Review.

PMID:
29522246
7.

All-Trans Retinoic Acid Enhances Antibody Production by Inducing the Expression of Thymic Stromal Lymphopoietin Protein.

Hatayama T, Segawa R, Mizuno N, Eguchi S, Akamatsu H, Fukuda M, Nakata F, Leonard WJ, Hiratsuka M, Hirasawa N.

J Immunol. 2018 Apr 15;200(8):2670-2676. doi: 10.4049/jimmunol.1701276. Epub 2018 Mar 2.

PMID:
29500243
8.

The γ c family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response.

Spolski R, Gromer D, Leonard WJ.

F1000Res. 2017 Oct 23;6:1872. doi: 10.12688/f1000research.12202.1. eCollection 2017. Review.

9.

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells.

Lin JX, Du N, Li P, Kazemian M, Gebregiorgis T, Spolski R, Leonard WJ.

Nat Commun. 2017 Nov 6;8(1):1320. doi: 10.1038/s41467-017-01477-5.

10.

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus.

Li P, Mitra S, Spolski R, Oh J, Liao W, Tang Z, Mo F, Li X, West EE, Gromer D, Lin JX, Liu C, Ruan Y, Leonard WJ.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12111-12119. doi: 10.1073/pnas.1714019114. Epub 2017 Oct 24.

11.

The Common Cytokine Receptor γ Chain Family of Cytokines.

Lin JX, Leonard WJ.

Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9). pii: a028449. doi: 10.1101/cshperspect.a028449. Review.

PMID:
29038115
12.

Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.

Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ.

PLoS Pathog. 2017 Aug 21;13(8):e1006544. doi: 10.1371/journal.ppat.1006544. eCollection 2017 Aug.

13.

A TSLP-complement axis mediates neutrophil killing of methicillin-resistant Staphylococcus aureus.

West EE, Spolski R, Kazemian M, Yu ZX, Kemper C, Leonard WJ.

Sci Immunol. 2016 Nov 18;1(5). pii: eaaf8471. doi: 10.1126/sciimmunol.aaf8471.

PMID:
28783679
14.

Genetic background-dependent role of Egr1 for eyelid development.

Oh J, Wang Y, Chen S, Li P, Du N, Yu ZX, Butcher D, Gebregiorgis T, Strachan E, Lehmann OJ, Brooks BP, Chan CC, Leonard WJ.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7131-E7139. doi: 10.1073/pnas.1705848114. Epub 2017 Aug 4.

15.

Skin-derived TSLP systemically expands regulatory T cells.

Leichner TM, Satake A, Harrison VS, Tanaka Y, Archambault AS, Kim BS, Siracusa MC, Leonard WJ, Naji A, Wu GF, Artis D, Kambayashi T.

J Autoimmun. 2017 May;79:39-52. doi: 10.1016/j.jaut.2017.01.003. Epub 2017 Jan 23.

16.

Immunology: JAK3 inhibition—is it sufficient?

Leonard WJ, Mitra S, Lin JX.

Nat Chem Biol. 2016 May;12(5):308-10. No abstract available.

PMID:
27556128
17.

Molecular Models of STAT5A Tetramers Complexed to DNA Predict Relative Genome-Wide Frequencies of the Spacing between the Two Dimer Binding Motifs of the Tetramer Binding Sites.

Sathyanarayana BK, Li P, Lin JX, Leonard WJ, Lee B.

PLoS One. 2016 Aug 18;11(8):e0160339. doi: 10.1371/journal.pone.0160339. eCollection 2016.

18.

Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice.

Sakuraba K, Oyamada A, Fujimura K, Spolski R, Iwamoto Y, Leonard WJ, Yoshikai Y, Yamada H.

Arthritis Res Ther. 2016 Aug 17;18:188. doi: 10.1186/s13075-016-1086-y.

19.

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells.

Naradikian MS, Myles A, Beiting DP, Roberts KJ, Dawson L, Herati RS, Bengsch B, Linderman SL, Stelekati E, Spolski R, Wherry EJ, Hunter C, Hensley SE, Leonard WJ, Cancro MP.

J Immunol. 2016 Aug 15;197(4):1023-8. doi: 10.4049/jimmunol.1600522. Epub 2016 Jul 18.

20.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.

Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126/science.aad1210.

21.

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.

Roychoudhuri R, Clever D, Li P, Wakabayashi Y, Quinn KM, Klebanoff CA, Ji Y, Sukumar M, Eil RL, Yu Z, Spolski R, Palmer DC, Pan JH, Patel SJ, Macallan DC, Fabozzi G, Shih HY, Kanno Y, Muto A, Zhu J, Gattinoni L, O'Shea JJ, Okkenhaug K, Igarashi K, Leonard WJ, Restifo NP.

Nat Immunol. 2016 Jul;17(7):851-860. doi: 10.1038/ni.3441. Epub 2016 May 9.

22.

William E. Paul, MD (1936-2015).

Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ.

Trends Immunol. 2015 Dec;36(12):751-3. No abstract available.

PMID:
27064162
23.

IL-21 Signaling in Immunity.

Leonard WJ, Wan CK.

F1000Res. 2016 Feb 26;5. pii: F1000 Faculty Rev-224. doi: 10.12688/f1000research.7634.1. eCollection 2016. Review.

24.

A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.

Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, Olshansky M, Lin JX, Li P, Speed TP, Smyth GK, Ernst M, Leonard WJ, Pellegrini M, Kaech SM, Nutt SL, Shi W, Belz GT, Kallies A.

Nat Immunol. 2016 Apr;17(4):422-32. doi: 10.1038/ni.3410. Epub 2016 Mar 7.

25.

Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection.

Yan M, Wang H, Sun J, Liao W, Li P, Zhu Y, Xu C, Joo J, Sun Y, Abbasi S, Kovalchuk A, Lv N, Leonard WJ, Morse HC 3rd.

J Immunol. 2016 Mar 1;196(5):1999-2003. doi: 10.4049/jimmunol.1500766. Epub 2016 Feb 3.

26.

T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite.

Ballesteros-Tato A, Randall TD, Lund FE, Spolski R, Leonard WJ, León B.

Immunity. 2016 Feb 16;44(2):259-73. doi: 10.1016/j.immuni.2015.11.017. Epub 2016 Jan 26.

27.

William E. Paul, M.D. (1936–2015).

Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ.

Immunity. 2015 Oct 20;43(4):617-9. No abstract available.

28.

Endothelial interleukin-21 receptor up-regulation in peripheral artery disease.

Wang T, Cunningham A, Houston K, Sharma AM, Chen L, Dokun AO, Lye RJ, Spolski R, Leonard WJ, Annex BH.

Vasc Med. 2016 Apr;21(2):99-104. doi: 10.1177/1358863X15621798. Epub 2015 Dec 24.

29.

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

Sukumar M, Liu J, Mehta GU, Patel SJ, Roychoudhuri R, Crompton JG, Klebanoff CA, Ji Y, Li P, Yu Z, Whitehill GD, Clever D, Eil RL, Palmer DC, Mitra S, Rao M, Keyvanfar K, Schrump DS, Wang E, Marincola FM, Gattinoni L, Leonard WJ, Muranski P, Finkel T, Restifo NP.

Cell Metab. 2016 Jan 12;23(1):63-76. doi: 10.1016/j.cmet.2015.11.002. Epub 2015 Dec 8.

30.

Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis.

Wan CK, He C, Sun L, Egwuagu CE, Leonard WJ.

J Immunol. 2016 Jan 15;196(2):543-6. doi: 10.4049/jimmunol.1502080. Epub 2015 Dec 7.

31.

IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells.

Wan CK, Li P, Spolski R, Oh J, Andraski AB, Du N, Yu ZX, Dillon CP, Green DR, Leonard WJ.

Nat Commun. 2015 Aug 13;6:7988. doi: 10.1038/ncomms8988.

32.

Comprehensive assembly of novel transcripts from unmapped human RNA-Seq data and their association with cancer.

Kazemian M, Ren M, Lin JX, Liao W, Spolski R, Leonard WJ.

Mol Syst Biol. 2015 Aug 7;11(8):826. doi: 10.15252/msb.156172.

33.

Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells.

Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA 2nd, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9394-9. doi: 10.1073/pnas.1511711112. Epub 2015 Jul 13.

34.

Possible Human Papillomavirus 38 Contamination of Endometrial Cancer RNA Sequencing Samples in The Cancer Genome Atlas Database.

Kazemian M, Ren M, Lin JX, Liao W, Spolski R, Leonard WJ.

J Virol. 2015 Sep;89(17):8967-73. doi: 10.1128/JVI.00822-15. Epub 2015 Jun 17.

35.

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ.

Immunity. 2015 May 19;42(5):826-38. doi: 10.1016/j.immuni.2015.04.018.

36.

New insights into heterogeneity of peritoneal B-1a cells.

Wang H, Lin JX, Li P, Skinner J, Leonard WJ, Morse HC 3rd.

Ann N Y Acad Sci. 2015 Dec;1362:68-76. doi: 10.1111/nyas.12791. Epub 2015 May 18. Review.

37.

Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.

Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A.

Nat Immunol. 2015 May;16(5):544. doi: 10.1038/ni0515-544d. No abstract available.

PMID:
25898200
38.

Loss of interleukin-21 receptor activation in hypoxic endothelial cells impairs perfusion recovery after hindlimb ischemia.

Wang T, Cunningham A, Dokun AO, Hazarika S, Houston K, Chen L, Lye RJ, Spolski R, Leonard WJ, Annex BH.

Arterioscler Thromb Vasc Biol. 2015 May;35(5):1218-25. doi: 10.1161/ATVBAHA.115.305476. Epub 2015 Apr 2.

39.

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.

Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A.

Nat Immunol. 2015 Mar;16(3):276-85. doi: 10.1038/ni.3085. Epub 2015 Jan 19. Erratum in: Nat Immunol. 2015 May;16(5):544.

PMID:
25599561
40.

EGR2 is critical for peripheral naïve T-cell differentiation and the T-cell response to influenza.

Du N, Kwon H, Li P, West EE, Oh J, Liao W, Yu Z, Ren M, Leonard WJ.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16484-9. doi: 10.1073/pnas.1417215111. Epub 2014 Nov 3.

41.

Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock.

Shimura E, Shibui A, Narushima S, Nambu A, Yamaguchi S, Akitsu A, Leonard WJ, Iwakura Y, Matsumoto K, Suto H, Okumura K, Sudo K, Nakae S.

Biochem Biophys Res Commun. 2014 Oct 10;453(1):1-6. doi: 10.1016/j.bbrc.2014.09.004. Epub 2014 Sep 6.

42.

Complex interactions of transcription factors in mediating cytokine biology in T cells.

Li P, Spolski R, Liao W, Leonard WJ.

Immunol Rev. 2014 Sep;261(1):141-56. doi: 10.1111/imr.12199. Review.

43.

Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators.

Tedder TF, Leonard WJ.

Nat Rev Rheumatol. 2014 Aug;10(8):452-3. doi: 10.1038/nrrheum.2014.95. Epub 2014 Jun 17. Erratum in: Nat Rev Rheumatol. 2014 Nov;10(11):636.

PMID:
24934192
44.

Interleukin-21: a double-edged sword with therapeutic potential.

Spolski R, Leonard WJ.

Nat Rev Drug Discov. 2014 May;13(5):379-95. doi: 10.1038/nrd4296. Epub 2014 Apr 22. Review.

PMID:
24751819
45.

Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.

Proctor WR, Chakraborty M, Fullerton AM, Korrapati MC, Ryan PM, Semple K, Morrison JC, Berkson JD, Chea LS, Yang Q, Li AP, Spolski R, West EE, Rochman Y, Leonard WJ, Bourdi M, Pohl LR.

Hepatology. 2014 Nov;60(5):1741-52. doi: 10.1002/hep.27169. Epub 2014 May 20.

46.

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression.

Liao W, Spolski R, Li P, Du N, West EE, Ren M, Mitra S, Leonard WJ.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3508-13. doi: 10.1073/pnas.1301138111. Epub 2014 Feb 18.

47.

Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation.

Goenka R, Matthews AH, Zhang B, O'Neill PJ, Scholz JL, Migone TS, Leonard WJ, Stohl W, Hershberg U, Cancro MP.

J Exp Med. 2014 Jan 13;211(1):45-56. doi: 10.1084/jem.20130505. Epub 2013 Dec 23.

48.

TSLP: A Key Regulator of Asthma Pathogenesis.

West EE, Kashyap M, Leonard WJ.

Drug Discov Today Dis Mech. 2012 Dec 1;9(3-4). doi: 10.1016/j.ddmec.2012.09.003.

49.

Induction of thymic stromal lymphopoietin production by nonanoic acid and exacerbation of allergic inflammation in mice.

Yamashita S, Segawa R, Satou N, Hiratsuka M, Leonard WJ, Hirasawa N.

Allergol Int. 2013 Dec;62(4):463-71. doi: 10.2332/allergolint.13-OA-0552. Epub 2013 Sep 25.

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