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Items: 1 to 50 of 514

1.
2.

Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade.

Jadhav RR, Im SJ, Hu B, Hashimoto M, Li P, Lin JX, Leonard WJ, Greenleaf WJ, Ahmed R, Goronzy JJ.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14113-14118. doi: 10.1073/pnas.1903520116. Epub 2019 Jun 21.

3.

Longitudinal Changes in Measures of Body Fat and Diet Among Adult Tsimane' Forager-Horticulturalists of Bolivia, 2002-2010.

Bethancourt HJ, Leonard WR, Tanner S, Schultz AF, Rosinger AY.

Obesity (Silver Spring). 2019 Jun 20. doi: 10.1002/oby.22556. [Epub ahead of print]

PMID:
31219239
4.

Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses.

Wang H, Jain S, Li P, Lin JX, Oh J, Qi C, Gao Y, Sun J, Sakai T, Naghashfar Z, Abbasi S, Kovalchuk AL, Bolland S, Nutt SL, Leonard WJ, Morse HC 3rd.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9511-9520. doi: 10.1073/pnas.1901258116. Epub 2019 Apr 18.

PMID:
31000603
5.

The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications.

Leonard WJ, Lin JX, O'Shea JJ.

Immunity. 2019 Apr 16;50(4):832-850. doi: 10.1016/j.immuni.2019.03.028. Review.

PMID:
30995502
6.

IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus.

Spolski R, West EE, Li P, Veenbergen S, Yung S, Kazemian M, Oh J, Yu ZX, Freeman AF, Holland SM, Murphy PM, Leonard WJ.

Elife. 2019 Apr 16;8. pii: e45501. doi: 10.7554/eLife.45501.

7.

Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium.

Kobayashi T, Voisin B, Kim DY, Kennedy EA, Jo JH, Shih HY, Truong A, Doebel T, Sakamoto K, Cui CY, Schlessinger D, Moro K, Nakae S, Horiuchi K, Zhu J, Leonard WJ, Kong HH, Nagao K.

Cell. 2019 Feb 21;176(5):982-997.e16. doi: 10.1016/j.cell.2018.12.031. Epub 2019 Jan 31.

PMID:
30712873
8.

Fine-Tuning Cytokine Signals.

Lin JX, Leonard WJ.

Annu Rev Immunol. 2019 Apr 26;37:295-324. doi: 10.1146/annurev-immunol-042718-041447. Epub 2019 Jan 16.

PMID:
30649989
9.

Chromatin Accessibility and Interactions in the Transcriptional Regulation of T Cells.

Li P, Leonard WJ.

Front Immunol. 2018 Nov 22;9:2738. doi: 10.3389/fimmu.2018.02738. eCollection 2018. Review.

10.

Brown adipose tissue, energy expenditure, and biomarkers of cardio-metabolic health among the Yakut (Sakha) of northeastern Siberia.

Levy SB, Klimova TM, Zakharova RN, Federov AI, Fedorova VI, Baltakhinova ME, Leonard WR.

Am J Hum Biol. 2018 Nov;30(6):e23175. doi: 10.1002/ajhb.23175. Epub 2018 Oct 4.

PMID:
30368978
11.

Birth seasons and heights among girls and boys below 12 years of age: lasting effects and catch-up growth among native Amazonians in Bolivia.

Brabec M, Behrman JR, Emmett SD, Gibson E, Kidd C, Leonard W, Penny ME, Piantadosi ST, Sharma A, Tanner S, Undurraga EA, Godoy RA.

Ann Hum Biol. 2018 Jun;45(4):299-313. doi: 10.1080/03014460.2018.1490453.

12.

Influence of nutritional status on basal metabolic rates among rural agriculturalists of Ngilo-Ilo, East Java.

Miller AA, Indriati E, Leonard WR.

Am J Hum Biol. 2018 Sep;30(5):e23169. doi: 10.1002/ajhb.23169. Epub 2018 Sep 11.

PMID:
30203432
13.

Biology and regulation of IL-2: from molecular mechanisms to human therapy.

Spolski R, Li P, Leonard WJ.

Nat Rev Immunol. 2018 Oct;18(10):648-659. doi: 10.1038/s41577-018-0046-y. Review.

PMID:
30089912
14.

Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity.

Cho H, Jaime H, de Oliveira RP, Kang B, Spolski R, Vaziri T, Myers TG, Thovarai V, Shen Z, Fox JG, Leonard WJ, Kelsall BL.

Mucosal Immunol. 2019 Jan;12(1):85-96. doi: 10.1038/s41385-018-0056-x. Epub 2018 Aug 7.

15.

Act1 is a negative regulator in T and B cells via direct inhibition of STAT3.

Zhang CJ, Wang C, Jiang M, Gu C, Xiao J, Chen X, Martin BN, Tang F, Yamamoto E, Xian Y, Wang H, Li F, Sartor RB, Smith H, Husni ME, Shi FD, Gao J, Carman J, Dongre A, McKarns SC, Coppieters K, Jørgensen TN, Leonard WJ, Li X.

Nat Commun. 2018 Jul 16;9(1):2745. doi: 10.1038/s41467-018-04974-3.

16.

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity.

Béziat V, Li J, Lin JX, Ma CS, Li P, Bousfiha A, Pellier I, Zoghi S, Baris S, Keles S, Gray P, Du N, Wang Y, Zerbib Y, Lévy R, Leclercq T, About F, Lim AI, Rao G, Payne K, Pelham SJ, Avery DT, Deenick EK, Pillay B, Chou J, Guery R, Belkadi A, Guérin A, Migaud M, Rattina V, Ailal F, Benhsaien I, Bouaziz M, Habib T, Chaussabel D, Marr N, El-Benna J, Grimbacher B, Wargon O, Bustamante J, Boisson B, Müller-Fleckenstein I, Fleckenstein B, Chandesris MO, Titeux M, Fraitag S, Alyanakian MA, Leruez-Ville M, Picard C, Meyts I, Di Santo JP, Hovnanian A, Somer A, Ozen A, Rezaei N, Chatila TA, Abel L, Leonard WJ, Tangye SG, Puel A, Casanova JL.

Sci Immunol. 2018 Jun 15;3(24). pii: eaat4956. doi: 10.1126/sciimmunol.aat4956.

17.

Centennial perspective on human adaptability.

Leonard WR.

Am J Phys Anthropol. 2018 Apr;165(4):813-833. doi: 10.1002/ajpa.23401. No abstract available.

PMID:
29574834
18.

Sex, drugs and social connectedness: wellbeing among HIV-positive gay and bisexual men who use party-and-play drugs.

Power J, Mikołajczak G, Bourne A, Brown G, Leonard W, Lyons A, Dowsett GW, Lucke J.

Sex Health. 2018 Apr;15(2):135-143. doi: 10.1071/SH17151.

PMID:
29544599
19.

TSLP signaling in CD4+ T cells programs a pathogenic T helper 2 cell state.

Rochman Y, Dienger-Stambaugh K, Richgels PK, Lewkowich IP, Kartashov AV, Barski A, Khurana Hershey GK, Leonard WJ, Singh H.

Sci Signal. 2018 Mar 13;11(521). pii: eaam8858. doi: 10.1126/scisignal.aam8858.

20.

Biology of IL-2 and its therapeutic modulation: Mechanisms and strategies.

Mitra S, Leonard WJ.

J Leukoc Biol. 2018 Apr;103(4):643-655. doi: 10.1002/JLB.2RI0717-278R. Epub 2018 Mar 9. Review.

PMID:
29522246
21.

All-Trans Retinoic Acid Enhances Antibody Production by Inducing the Expression of Thymic Stromal Lymphopoietin Protein.

Hatayama T, Segawa R, Mizuno N, Eguchi S, Akamatsu H, Fukuda M, Nakata F, Leonard WJ, Hiratsuka M, Hirasawa N.

J Immunol. 2018 Apr 15;200(8):2670-2676. doi: 10.4049/jimmunol.1701276. Epub 2018 Mar 2.

22.

Improving alcohol and mental health treatment for lesbian, bisexual and queer women: Identity matters.

Pennay A, McNair R, Hughes TL, Leonard W, Brown R, Lubman DI.

Aust N Z J Public Health. 2018 Feb;42(1):35-42. doi: 10.1111/1753-6405.12739. Epub 2017 Dec 13.

PMID:
29235690
23.

The γ c family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response.

Spolski R, Gromer D, Leonard WJ.

F1000Res. 2017 Oct 23;6:1872. doi: 10.12688/f1000research.12202.1. eCollection 2017. Review.

24.

Diet, atherosclerosis, and helmintic infection in Tsimane.

Masterson EE, Leonard WR, Hujoel PP.

Lancet. 2017 Nov 4;390(10107):2034-2035. doi: 10.1016/S0140-6736(17)31945-1. No abstract available.

PMID:
29115238
25.

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells.

Lin JX, Du N, Li P, Kazemian M, Gebregiorgis T, Spolski R, Leonard WJ.

Nat Commun. 2017 Nov 6;8(1):1320. doi: 10.1038/s41467-017-01477-5.

26.

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus.

Li P, Mitra S, Spolski R, Oh J, Liao W, Tang Z, Mo F, Li X, West EE, Gromer D, Lin JX, Liu C, Ruan Y, Leonard WJ.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12111-12119. doi: 10.1073/pnas.1714019114. Epub 2017 Oct 24.

27.

The Common Cytokine Receptor γ Chain Family of Cytokines.

Lin JX, Leonard WJ.

Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9). pii: a028449. doi: 10.1101/cshperspect.a028449. Review.

PMID:
29038115
28.

Child stunting is associated with weaker human capital among native Amazonians.

Undurraga EA, Behrman JR, Emmett SD, Kidd C, Leonard WR, Piantadosi ST, Reyes-García V, Sharma A, Zhang R, Godoy RA.

Am J Hum Biol. 2018 Jan;30(1). doi: 10.1002/ajhb.23059. Epub 2017 Sep 13.

PMID:
28901592
29.

Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.

Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ.

PLoS Pathog. 2017 Aug 21;13(8):e1006544. doi: 10.1371/journal.ppat.1006544. eCollection 2017 Aug.

30.

A TSLP-complement axis mediates neutrophil killing of methicillin-resistant Staphylococcus aureus.

West EE, Spolski R, Kazemian M, Yu ZX, Kemper C, Leonard WJ.

Sci Immunol. 2016 Nov 18;1(5). pii: eaaf8471. doi: 10.1126/sciimmunol.aaf8471.

PMID:
28783679
31.

Genetic background-dependent role of Egr1 for eyelid development.

Oh J, Wang Y, Chen S, Li P, Du N, Yu ZX, Butcher D, Gebregiorgis T, Strachan E, Lehmann OJ, Brooks BP, Chan CC, Leonard WJ.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7131-E7139. doi: 10.1073/pnas.1705848114. Epub 2017 Aug 4.

32.

Skin-derived TSLP systemically expands regulatory T cells.

Leichner TM, Satake A, Harrison VS, Tanaka Y, Archambault AS, Kim BS, Siracusa MC, Leonard WJ, Naji A, Wu GF, Artis D, Kambayashi T.

J Autoimmun. 2017 May;79:39-52. doi: 10.1016/j.jaut.2017.01.003. Epub 2017 Jan 23.

33.

Stigma, gay men and biomedical prevention: the challenges and opportunities of a rapidly changing HIV prevention landscape.

Brown G, Leonard W, Lyons A, Power J, Sander D, McColl W, Johnson R, James C, Hodson M, Carman M.

Sex Health. 2017 Feb;14(1):111-118. doi: 10.1071/SH16052. Review.

PMID:
27977386
34.

Response to commentary regarding the article: "Lifestyle mediates seasonal changes in metabolic health among the Yakut (Sakha) of Northeastern Siberia".

Levy SB, Leonard WR.

Am J Hum Biol. 2016 Nov;28(6):956. doi: 10.1002/ajhb.22926. Epub 2016 Nov 3. No abstract available.

PMID:
27807904
35.

Sympathetic Innervation of Cold-Activated Brown and White Fat in Lean Young Adults.

Muzik O, Mangner TJ, Leonard WR, Kumar A, Granneman JG.

J Nucl Med. 2017 May;58(5):799-806. doi: 10.2967/jnumed.116.180992. Epub 2016 Oct 27.

36.

Immunology: JAK3 inhibition—is it sufficient?

Leonard WJ, Mitra S, Lin JX.

Nat Chem Biol. 2016 May;12(5):308-10. No abstract available.

PMID:
27556128
37.

Molecular Models of STAT5A Tetramers Complexed to DNA Predict Relative Genome-Wide Frequencies of the Spacing between the Two Dimer Binding Motifs of the Tetramer Binding Sites.

Sathyanarayana BK, Li P, Lin JX, Leonard WJ, Lee B.

PLoS One. 2016 Aug 18;11(8):e0160339. doi: 10.1371/journal.pone.0160339. eCollection 2016.

38.

Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice.

Sakuraba K, Oyamada A, Fujimura K, Spolski R, Iwamoto Y, Leonard WJ, Yoshikai Y, Yamada H.

Arthritis Res Ther. 2016 Aug 17;18:188. doi: 10.1186/s13075-016-1086-y.

39.

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells.

Naradikian MS, Myles A, Beiting DP, Roberts KJ, Dawson L, Herati RS, Bengsch B, Linderman SL, Stelekati E, Spolski R, Wherry EJ, Hunter C, Hensley SE, Leonard WJ, Cancro MP.

J Immunol. 2016 Aug 15;197(4):1023-8. doi: 10.4049/jimmunol.1600522. Epub 2016 Jul 18.

40.

Gender-specific health implications of minority stress among lesbians and gay men.

Bariola E, Lyons A, Leonard W.

Aust N Z J Public Health. 2016 Dec;40(6):506-512. doi: 10.1111/1753-6405.12539. Epub 2016 Jul 3.

PMID:
27372452
41.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.

Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126/science.aad1210.

42.

Lifestyle mediates seasonal changes in metabolic health among the yakut (sakha) of northeastern siberia.

Levy SB, Leonard WR, Tarskaia LA, Klimova TM, Fedorova VI, Baltakhinova ME, Josh Snodgrass J.

Am J Hum Biol. 2016 Nov;28(6):868-878. doi: 10.1002/ajhb.22879. Epub 2016 Jun 13.

PMID:
27292232
43.

Catch-up growth and growth deficits: Nine-year annual panel child growth for native Amazonians in Bolivia.

Zhang R, Undurraga EA, Zeng W, Reyes-García V, Tanner S, Leonard WR, Behrman JR, Godoy RA.

Ann Hum Biol. 2016 Jul;43(4):304-15. doi: 10.1080/03014460.2016.1197312. Epub 2016 Jun 29.

44.

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.

Roychoudhuri R, Clever D, Li P, Wakabayashi Y, Quinn KM, Klebanoff CA, Ji Y, Sukumar M, Eil RL, Yu Z, Spolski R, Palmer DC, Pan JH, Patel SJ, Macallan DC, Fabozzi G, Shih HY, Kanno Y, Muto A, Zhu J, Gattinoni L, O'Shea JJ, Okkenhaug K, Igarashi K, Leonard WJ, Restifo NP.

Nat Immunol. 2016 Jul;17(7):851-860. doi: 10.1038/ni.3441. Epub 2016 May 9.

45.

William E. Paul, MD (1936-2015).

Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ.

Trends Immunol. 2015 Dec;36(12):751-3. No abstract available.

PMID:
27064162
46.

IL-21 Signaling in Immunity.

Leonard WJ, Wan CK.

F1000Res. 2016 Feb 26;5. pii: F1000 Faculty Rev-224. doi: 10.12688/f1000research.7634.1. eCollection 2016. Review.

47.

A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.

Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, Olshansky M, Lin JX, Li P, Speed TP, Smyth GK, Ernst M, Leonard WJ, Pellegrini M, Kaech SM, Nutt SL, Shi W, Belz GT, Kallies A.

Nat Immunol. 2016 Apr;17(4):422-32. doi: 10.1038/ni.3410. Epub 2016 Mar 7.

48.

Myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion.

Leonard W, Dufait I, Schwarze JK, Law K, Engels B, Jiang H, Van den Berge D, Gevaert T, Storme G, Verovski V, Breckpot K, De Ridder M.

Radiother Oncol. 2016 May;119(2):291-9. doi: 10.1016/j.radonc.2016.01.014. Epub 2016 Feb 10.

PMID:
26874542
49.

Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection.

Yan M, Wang H, Sun J, Liao W, Li P, Zhu Y, Xu C, Joo J, Sun Y, Abbasi S, Kovalchuk A, Lv N, Leonard WJ, Morse HC 3rd.

J Immunol. 2016 Mar 1;196(5):1999-2003. doi: 10.4049/jimmunol.1500766. Epub 2016 Feb 3.

50.

T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite.

Ballesteros-Tato A, Randall TD, Lund FE, Spolski R, Leonard WJ, León B.

Immunity. 2016 Feb 16;44(2):259-73. doi: 10.1016/j.immuni.2015.11.017. Epub 2016 Jan 26.

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