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Items: 1 to 50 of 523

1.
2.

The Second Conversation project: -Improving training in end of life care communication among junior doctors.

Mathew R, Weil A, Sleeman KE, Bristowe K, Shukla P, Schiff R, Flanders L, Leonard P, Minton O, Wakefield D, St John K, Carey I.

Future Healthc J. 2019 Jun;6(2):129-136. doi: 10.7861/futurehosp.6-2-129.

3.

The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues.

Pisaneschi F, Lin YH, Leonard PG, Satani N, Yan VC, Hammoudi N, Raghavan S, Link TM, K Georgiou D, Czako B, Muller FL.

Molecules. 2019 Jul 9;24(13). pii: E2510. doi: 10.3390/molecules24132510.

4.

Anomeric 5-Aza-7-deaza-2'-deoxyguanosines in Silver-Ion-Mediated Homo and Hybrid Base Pairs: Impact of Mismatch Structure, Helical Environment, and Nucleobase Substituents on DNA Stability.

Zhou X, Kondhare D, Leonard P, Seela F.

Chemistry. 2019 Aug 6;25(44):10408-10419. doi: 10.1002/chem.201901276. Epub 2019 Jul 9.

PMID:
31062885
5.

Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.

Toledo-Sherman L, Breccia P, Cachope R, Bate JR, Angulo-Herrera I, Wishart G, Matthews KL, Martin SL, Cox HC, McAllister G, Penrose SD, Vater H, Esmieu W, Van de Poël A, Van de Bospoort R, Strijbosch A, Lamers M, Leonard P, Jarvis RE, Blackaby W, Barnes K, Eznarriaga M, Dowler S, Smith GD, Fischer DF, Lazari O, Yates D, Rose M, Jang SW, Muñoz-Sanjuan I, Dominguez C.

J Med Chem. 2019 Mar 28;62(6):2988-3008. doi: 10.1021/acs.jmedchem.8b01819. Epub 2019 Mar 19.

PMID:
30840447
6.

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.

Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, Miao L, Ma X, Feng N, Giuliani V, Geck Do M, Czako B, Palmer WS, Mseeh F, Asara JM, Jiang Y, Morlacchi P, Zhao S, Peoples M, Tieu TN, Warmoes MO, Lorenzi PL, Muller FL, DePinho RA, Draetta GF, Toniatti C, Jones P, Heffernan TP, Marszalek JR.

Cell Rep. 2019 Jan 8;26(2):469-482.e5. doi: 10.1016/j.celrep.2018.12.043.

7.

Functionalized Silver-Ion-Mediated α-dC/β-dC Hybrid Base Pairs with Exceptional Stability: α-d-5-Iodo-2'-Deoxycytidine and Its Octadiynyl Derivative in Metal DNA.

Müller SL, Zhou X, Leonard P, Korzhenko O, Daniliuc C, Seela F.

Chemistry. 2019 Feb 26;25(12):3077-3090. doi: 10.1002/chem.201805299. Epub 2019 Feb 4.

PMID:
30520165
8.

Prediction of the intestinal resistome by a three-dimensional structure-based method.

Ruppé E, Ghozlane A, Tap J, Pons N, Alvarez AS, Maziers N, Cuesta T, Hernando-Amado S, Clares I, Martínez JL, Coque TM, Baquero F, Lanza VF, Máiz L, Goulenok T, de Lastours V, Amor N, Fantin B, Wieder I, Andremont A, van Schaik W, Rogers M, Zhang X, Willems RJL, de Brevern AG, Batto JM, Blottière HM, Léonard P, Léjard V, Letur A, Levenez F, Weiszer K, Haimet F, Doré J, Kennedy SP, Ehrlich SD.

Nat Microbiol. 2019 Jan;4(1):112-123. doi: 10.1038/s41564-018-0292-6. Epub 2018 Nov 26.

PMID:
30478291
9.

Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.

Luckhurst CA, Aziz O, Beaumont V, Bürli RW, Breccia P, Maillard MC, Haughan AF, Lamers M, Leonard P, Matthews KL, Raphy G, Stott AJ, Munoz-Sanjuan I, Thomas B, Wall M, Wishart G, Yates D, Dominguez C.

Bioorg Med Chem Lett. 2019 Jan 1;29(1):83-88. doi: 10.1016/j.bmcl.2018.11.009. Epub 2018 Nov 13.

PMID:
30463802
10.

Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies.

Ip CKM, Ng PKS, Jeong KJ, Shao SH, Ju Z, Leonard PG, Hua X, Vellano CP, Woessner R, Sahni N, Scott KL, Mills GB.

Nat Commun. 2018 Nov 2;9(1):4583. doi: 10.1038/s41467-018-06949-w.

11.

Circuit-theory applications to connectivity science and conservation.

Dickson BG, Albano CM, Anantharaman R, Beier P, Fargione J, Graves TA, Gray ME, Hall KR, Lawler JJ, Leonard PB, Littlefield CE, McClure ML, Novembre J, Schloss CA, Schumaker NH, Shah VB, Theobald DM.

Conserv Biol. 2019 Apr;33(2):239-249. doi: 10.1111/cobi.13230. Epub 2018 Nov 27. Review.

PMID:
30311266
12.

Nucleoside macrocycles formed by intramolecular click reaction: efficient cyclization of pyrimidine nucleosides decorated with 5'-azido residues and 5-octadiynyl side chains.

Liu J, Leonard P, Müller SL, Daniliuc C, Seela F.

Beilstein J Org Chem. 2018 Sep 13;14:2404-2410. doi: 10.3762/bjoc.14.217. eCollection 2018.

13.

Measuring Antibody-Antigen Binding Kinetics Using Surface Plasmon Resonance.

Hearty S, Leonard P, Ma H, O'Kennedy R.

Methods Mol Biol. 2018;1827:421-455. doi: 10.1007/978-1-4939-8648-4_22.

PMID:
30196510
14.

Can paediatric emergency clinicians identify and manage clavicle fractures without radiographs in the emergency department? A prospective study.

Lirette MP, Bailey B, Grant S, Jackson M, Leonard P.

BMJ Paediatr Open. 2018 Aug 10;2(1):e000304. doi: 10.1136/bmjpo-2018-000304. eCollection 2018.

15.

Efficient treatment of dairy processing wastewater in a pilot scale Intermittently Aerated Sequencing Batch Reactor (IASBR).

Leonard P, Finnegan W, Barrett M, Zhan X.

J Dairy Res. 2018 Aug;85(3):384-387. doi: 10.1017/S0022029918000596. Epub 2018 Aug 8.

PMID:
30088469
16.

DairyWater: striving for sustainability within the dairy processing industry in the Republic of Ireland.

Finnegan W, Clifford E, Goggins J, O'Leary N, Dobson A, Rowan N, Xiao L, Miao S, Fitzhenry K, Leonard P, Tarpey E, Gil-Pulido B, Gao F, Zhan X.

J Dairy Res. 2018 Aug;85(3):366-374. doi: 10.1017/S0022029918000614. Epub 2018 Aug 8. Review.

PMID:
30088465
17.

Efficient treatment of dairy processing wastewater in a laboratory scale Intermittently Aerated Sequencing Batch Reactor (IASBR).

Leonard P, Tarpey E, Finnegan W, Zhan X.

J Dairy Res. 2018 Aug;85(3):379-383. doi: 10.1017/S0022029918000584. Epub 2018 Aug 8.

PMID:
30088457
18.
19.

Factors associated with late presentation for HIV care in a single Belgian reference center: 2006-2017.

Darcis G, Lambert I, Sauvage AS, Frippiat F, Meuris C, Uurlings F, Lecomte M, Léonard P, Giot JB, Fombellida K, Vaira D, Moutschen M.

Sci Rep. 2018 Jun 5;8(1):8594. doi: 10.1038/s41598-018-26852-0.

20.

Hepatic alveolar echinococcosis.

Detry O, Meurisse N, Delwaide J, Giot JB, Leonard P, Losson B, Hayette MP, Bletard N, Meunier P, Honoré P.

Acta Chir Belg. 2018 Dec;118(6):402-403. doi: 10.1080/00015458.2018.1427838. Epub 2018 Apr 13. No abstract available.

21.

The Future of Landscape Conservation.

Baldwin RF, Trombulak SC, Leonard PB, Noss RF, Hilty JA, Possingham HP, Scarlett L, Anderson MG.

Bioscience. 2018 Feb 1;68(2):60-63. doi: 10.1093/biosci/bix142. Epub 2018 Jan 6. No abstract available.

22.

[Multidisciplinary management of alveolar echinococcosis : Echino-Liege Working Group].

Cambier A, Giot JB, Leonard P, Bletard N, Meunier P, Hustinx R, Delwaide J, Meurisse N, Honore P, Losson B, Hayette MP, Detry O.

Rev Med Liege. 2018 Mar;73(3):135-142. French.

24.

5-Aza-7-deaza-2'-deoxyguanosine and 2'-Deoxycytidine Form Programmable Silver-Mediated Base Pairs with Metal Ions in the Core of the DNA Double Helix.

Guo X, Leonard P, Ingale SA, Liu J, Mei H, Sieg M, Seela F.

Chemistry. 2018 Jun 21;24(35):8883-8892. doi: 10.1002/chem.201801273. Epub 2018 May 29.

PMID:
29573347
25.

Alveolar echinococcosis in southern Belgium: retrospective experience of a tertiary center.

Cambier A, Leonard P, Losson B, Giot JB, Bletard N, Meunier P, Hustinx R, Meurisse N, Delwaide J, Honore P, Hayette MP, Detry O.

Eur J Clin Microbiol Infect Dis. 2018 Jun;37(6):1195-1196. doi: 10.1007/s10096-018-3233-7. Epub 2018 Mar 21. No abstract available.

26.

[Multidisciplinary management of a giant hepatic hydatidosis].

Halleux D, Juriens I, Delwaide J, Frippiat F, Léonard P, Bletard N, Detry O.

Rev Med Liege. 2018 Feb;73(2):65-71. French.

27.

Campylobacter coli meningitis in a 57-year-old patient.

Cambier A, Martiny D, Hallin M, Wautier M, Giot JB, Khaldi MZ, Cambier J, Léonard P.

Acta Clin Belg. 2018 Dec;73(6):427-430. doi: 10.1080/17843286.2018.1431015. Epub 2018 Jan 31.

PMID:
29384014
28.

Associations between provider and hospital volumes and postoperative mortality following total hip arthroplasty in New Brunswick: results from a provincial-level cohort study.

Crouse DL, Leonard PSJ, Boudreau J, McDonald JT.

Can J Surg. 2018 Jan 24;61(2):6917. doi: 10.1503/cjs.006917. [Epub ahead of print]

29.

[Endocarditis of mitral and aortic prosthetic heart valves caused by Aggregatibacter aphrophilus].

Deleixhe B, Frippiat F, Léonard P, Withofs N, Meex C, Piérard L, Moutschen M.

Rev Med Liege. 2017 Dec;72(12):522-528. French.

30.

Human case of bubonic plague resulting from the bite of a wild Gunnison's prairie dog during translocation from a plague-endemic area.

Melman SD, Ettestad PE, VinHatton ES, Ragsdale JM, Takacs N, Onischuk LM, Leonard PM, Master SS, Lucero VS, Kingry LC, Petersen JM.

Zoonoses Public Health. 2018 Feb;65(1):e254-e258. doi: 10.1111/zph.12419. Epub 2017 Nov 6.

31.

Landscape-scale conservation design across biotic realms: sequential integration of aquatic and terrestrial landscapes.

Leonard PB, Baldwin RF, Hanks RD.

Sci Rep. 2017 Nov 6;7(1):14556. doi: 10.1038/s41598-017-15304-w.

32.

Simple and Efficient Synthesis of Explosive Cocrystals containing 3,5-Dimethylpyrazol-1-yl-substituted-1,2,4,5-tetrazines.

Snyder CJ, Chavez DE, Imler GH, Byrd EFC, Leonard PW, Parrish DA.

Chemistry. 2017 Nov 21;23(65):16466-16471. doi: 10.1002/chem.201704394. Epub 2017 Oct 30.

PMID:
28968487
33.

Gemcitabine, Pyrrologemcitabine, and 2'-Fluoro-2'-Deoxycytidines: Synthesis, Physical Properties, and Impact of Sugar Fluorination on Silver Ion Mediated Base Pairing.

Guo X, Leonard P, Ingale SA, Seela F.

Chemistry. 2017 Dec 14;23(70):17740-17754. doi: 10.1002/chem.201703427. Epub 2017 Nov 22.

PMID:
28906062
34.

The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding.

Tsoi PS, Choi KJ, Leonard PG, Sizovs A, Moosa MM, MacKenzie KR, Ferreon JC, Ferreon ACM.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12590-12593. doi: 10.1002/anie.201706769. Epub 2017 Sep 5.

PMID:
28833982
35.

Carboplatin versus two doses of cisplatin in combination with gemcitabine in the treatment of advanced non-small-cell lung cancer: Results from a British Thoracic Oncology Group randomised phase III trial.

Ferry D, Billingham L, Jarrett H, Dunlop D, Woll PJ, Nicolson M, Shah R, Thompson J, Spicer J, Muthukumar D, Skailes G, Leonard P, Chetiyawardana AD, Wells P, Lewanski C, Crosse B, Hill M, Gaunt P, O'Byrne K.

Eur J Cancer. 2017 Sep;83:302-312. doi: 10.1016/j.ejca.2017.05.037. Epub 2017 Aug 4.

36.

Crystal structures of the three closely related compounds: bis-[(1H-tetra-zol-5-yl)meth-yl]nitramide, tri-amino-guanidinium 5-({[(1H-tetra-zol-5-yl)meth-yl](nitro)-amino}-meth-yl)tetra-zol-1-ide, and di-ammonium bis-[(tetra-zol-1-id-5-yl)meth-yl]nitramide monohydrate.

Mitchell LA, Imler GH, Parrish DA, Deschamps JR, Leonard PW, Chavez DE.

Acta Crystallogr E Crystallogr Commun. 2017 Jun 20;73(Pt 7):1056-1061. doi: 10.1107/S2056989017008817. eCollection 2017 Jul 1.

37.

Reply letter to: Economic evaluations of clinician training - make your research meaningful to decision makers.

Theilen U, Fraser L, Jones P, Leonard P, Simpson D.

Resuscitation. 2017 Oct;119:e3-e4. doi: 10.1016/j.resuscitation.2017.07.008. Epub 2017 Jul 13. No abstract available.

PMID:
28713044
38.

Recurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy.

Darcis G, Van der Auwera G, Giot JB, Hayette MP, Tassin F, Arrese Estrada J, Cnops L, Moutschen M, de Leval L, Leonard P.

BMC Infect Dis. 2017 Jul 7;17(1):478. doi: 10.1186/s12879-017-2571-x.

39.

[Neuropsychiatric syndroms in seropositive population].

Iweins A, Léonard P, Piette C.

Rev Med Liege. 2017 Jun;72(6):312-317. Review. French.

40.

Quantitative Neuromuscular Blockade Monitoring: Two Pictures of Unexpected Rocuronium Effect: A Case Report.

Leonard PA, Todd MM.

A A Case Rep. 2017 Oct 1;9(7):190-192. doi: 10.1213/XAA.0000000000000568.

PMID:
28542054
41.

Regular in-situ simulation training of paediatric Medical Emergency Team leads to sustained improvements in hospital response to deteriorating patients, improved outcomes in intensive care and financial savings.

Theilen U, Fraser L, Jones P, Leonard P, Simpson D.

Resuscitation. 2017 Jun;115:61-67. doi: 10.1016/j.resuscitation.2017.03.031. Epub 2017 Mar 28.

PMID:
28359769
42.

Exploring ways to manage healthcare professional-patient communication issues.

Leonard P.

Support Care Cancer. 2017 Apr;25(Suppl 1):7-9. doi: 10.1007/s00520-017-3635-6. Epub 2017 Feb 21.

43.

Silver-Mediated Base Pairs in DNA Incorporating Purines, 7-Deazapurines, and 8-Aza-7-deazapurines: Impact of Reduced Nucleobase Binding Sites and an Altered Glycosylation Position.

Zhao H, Leonard P, Guo X, Yang H, Seela F.

Chemistry. 2017 Apr 24;23(23):5529-5540. doi: 10.1002/chem.201605982. Epub 2017 Mar 31.

PMID:
28195414
44.

Off-site Emergency Planning at UK Nuclear Licensed Sites.

Leonard P, Thomas G.

Radiat Prot Dosimetry. 2017 Apr 1;173(1-3):157-162. doi: 10.1093/rpd/ncw315.

PMID:
27909158
45.

A national survey of offending behaviour amongst intellectually disabled users of mental health services in Ireland.

Leonard P, Morrison A, Delany-Warner M, Calvert GJ.

Ir J Psychol Med. 2016 Dec;33(4):207-215. doi: 10.1017/ipm.2015.21.

PMID:
30115152
46.

Single cell screening approaches for antibody discovery.

Fitzgerald V, Leonard P.

Methods. 2017 Mar 1;116:34-42. doi: 10.1016/j.ymeth.2016.11.006. Epub 2016 Nov 15. Review.

PMID:
27864085
47.

An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State.

Davlieva M, Tovar-Yanez A, DeBruler K, Leonard PG, Zianni MR, Arias CA, Shamoo Y.

J Mol Biol. 2016 Nov 6;428(22):4503-4519. doi: 10.1016/j.jmb.2016.09.016. Epub 2016 Sep 23.

48.

SF2312 is a natural phosphonate inhibitor of enolase.

Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR 4th, Sun D, Prasad BAB, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL.

Nat Chem Biol. 2016 Dec;12(12):1053-1058. doi: 10.1038/nchembio.2195. Epub 2016 Oct 10.

49.

Measuring Protein-Protein Interactions Using Biacore.

Leonard P, Hearty S, Ma H, O'Kennedy R.

Methods Mol Biol. 2017;1485:339-354.

PMID:
27730561
50.

Purification of Antibodies Using Affinity Chromatography.

Darcy E, Leonard P, Fitzgerald J, Danaher M, Ma H, O'Kennedy R.

Methods Mol Biol. 2017;1485:305-318.

PMID:
27730559

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