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Items: 45

1.

Safety/tolerability of the anti-semaphorin 4D Antibody VX15/2503 in a randomized phase 1 trial.

LaGanke C, Samkoff L, Edwards K, Jung Henson L, Repovic P, Lynch S, Stone L, Mattson D, Galluzzi A, Fisher TL, Reilly C, Winter LA, Leonard JE, Zauderer M.

Neurol Neuroimmunol Neuroinflamm. 2017 Jun 16;4(4):e367. doi: 10.1212/NXI.0000000000000367. eCollection 2017 Jul.

2.

Saturation monitoring of VX15/2503, a novel semaphorin 4D-specific antibody, in clinical trials.

Fisher TL, Seils J, Reilly C, Litwin V, Green L, Salkowitz-Bokal J, Walsh R, Harville S, Leonard JE, Smith E, Zauderer M.

Cytometry B Clin Cytom. 2016 Mar;90(2):199-208. doi: 10.1002/cyto.b.21338. Epub 2015 Dec 24.

3.

Safety, Pharmacokinetics, and Pharmacodynamics of a Humanized Anti-Semaphorin 4D Antibody, in a First-In-Human Study of Patients with Advanced Solid Tumors.

Patnaik A, Weiss GJ, Leonard JE, Rasco DW, Sachdev JC, Fisher TL, Winter LA, Reilly C, Parker RB, Mutz D, Blaydorn L, Tolcher AW, Zauderer M, Ramanathan RK.

Clin Cancer Res. 2016 Feb 15;22(4):827-36. doi: 10.1158/1078-0432.CCR-15-0431. Epub 2015 Oct 7.

4.

Generation and preclinical characterization of an antibody specific for SEMA4D.

Fisher TL, Reilly CA, Winter LA, Pandina T, Jonason A, Scrivens M, Balch L, Bussler H, Torno S, Seils J, Mueller L, Huang H, Klimatcheva E, Howell A, Kirk R, Evans E, Paris M, Leonard JE, Smith ES, Zauderer M.

MAbs. 2016;8(1):150-62. doi: 10.1080/19420862.2015.1102813. Epub 2015 Oct 2.

5.

Nonclinical Safety Evaluation of VX15/2503, a Humanized IgG4 Anti-SEMA4D Antibody.

Leonard JE, Fisher TL, Winter LA, Cornelius CA, Reilly C, Smith ES, Zauderer M.

Mol Cancer Ther. 2015 Apr;14(4):964-72. doi: 10.1158/1535-7163.MCT-14-0924. Epub 2015 Feb 5.

6.

SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease.

Smith ES, Jonason A, Reilly C, Veeraraghavan J, Fisher T, Doherty M, Klimatcheva E, Mallow C, Cornelius C, Leonard JE, Marchi N, Janigro D, Argaw AT, Pham T, Seils J, Bussler H, Torno S, Kirk R, Howell A, Evans EE, Paris M, Bowers WJ, John G, Zauderer M.

Neurobiol Dis. 2015 Jan;73:254-68. doi: 10.1016/j.nbd.2014.10.008. Epub 2014 Oct 18.

7.

Data gaps in toxicity testing of chemicals allowed in food in the United States.

Neltner TG, Alger HM, Leonard JE, Maffini MV.

Reprod Toxicol. 2013 Dec;42:85-94. doi: 10.1016/j.reprotox.2013.07.023. Epub 2013 Aug 13.

8.

Finding relevant references to genes and proteins in Medline using a Bayesian approach.

Leonard JE, Colombe JB, Levy JL.

Bioinformatics. 2002 Nov;18(11):1515-22.

PMID:
12424124
9.

Disruption of estrogen receptor beta gene impairs spatial learning in female mice.

Rissman EF, Heck AL, Leonard JE, Shupnik MA, Gustafsson JA.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3996-4001. Epub 2002 Mar 12.

10.

Rituximab: the first monoclonal antibody approved for the treatment of lymphoma.

Grillo-López AJ, White CA, Dallaire BK, Varns CL, Shen CD, Wei A, Leonard JE, McClure A, Weaver R, Cairelli S, Rosenberg J.

Curr Pharm Biotechnol. 2000 Jul;1(1):1-9. Review.

PMID:
11467356
11.

Preclinical evaluation of 90Y-labeled anti-CD20 monoclonal antibody for treatment of non-Hodgkin's lymphoma.

Chinn PC, Leonard JE, Rosenberg J, Hanna N, Anderson DR.

Int J Oncol. 1999 Nov;15(5):1017-25.

PMID:
10536187
12.

Apical and coronal seal of roots obturated with a dentine bonding agent and resin.

Leonard JE, Gutmann JL, Guo IY.

Int Endod J. 1996 Mar;29(2):76-83.

PMID:
9206428
13.

Multidisciplinary aspects of root resection failure: a case report.

Leonard JE, Gutmann JL.

Int Endod J. 1995 May;28(3):137-40.

PMID:
8626197
14.

Problem solving in endodontic working-length determination.

Gutmann JL, Leonard JE.

Compend Contin Educ Dent. 1995 Mar;16(3):288, 290, 293-4 passim; quiz 304. Review.

PMID:
8935000
15.

Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20.

Reff ME, Carner K, Chambers KS, Chinn PC, Leonard JE, Raab R, Newman RA, Hanna N, Anderson DR.

Blood. 1994 Jan 15;83(2):435-45.

PMID:
7506951
16.

Music therapy: fertile ground for application of research in practice.

Leonard JE.

Neonatal Netw. 1993 Mar;12(2):47-8.

PMID:
8446081
17.

Assessment of ligand effects in intracellular trafficking of ricin A chain using anti-ricin hybridomas.

Kornfeld SB, Leonard JE, Mullen MD, Taetle R.

Cancer Res. 1991 Mar 15;51(6):1689-93.

18.

Ricin binding and protein synthesis inhibition in human hematopoietic cell lines.

Leonard JE, Grothaus CD, Taetle R.

Blood. 1988 Oct;72(4):1357-63.

PMID:
3167211
19.

Inhibition of human T-cell tumor growth by T101-ricin A-chain in an athymic mouse model.

Leonard JE, Johnson DE, Shawler DL, Dillman RO.

Cancer Res. 1988 Sep 1;48(17):4862-7.

20.

Establishment of a human B-cell tumor in athymic mice.

Leonard JE, Johnson DE, Felsen RB, Tanney LE, Royston I, Dillman RO.

Cancer Res. 1987 Jun 1;47(11):2899-902.

21.

Monoclonal antibodies to purified ricin A-chain: production and properties.

Leonard JE, Tanney LE, Collins ML, Royston I, Taetle R.

Hybridoma. 1987 Apr;6(2):135-49.

PMID:
3570304
22.

Immunogenicity and viability of alpha-class II immunotoxin-treated pig islet cells.

Mullen Y, Shiogama T, Ozawa A, Leonard JE, Papoian T, Tsunoda T, Terada M, Motojima K, Brown J.

Transplant Proc. 1987 Feb;19(1 Pt 2):934-6. No abstract available.

PMID:
2978886
23.

Athymic mouse model of a human T-cell tumor.

Dillman RO, Johnson DE, Shawler DL, Halpern SE, Leonard JE, Hagan PL.

Cancer Res. 1985 Nov;45(11 Pt 2):5632-6.

24.

Kinetics of protein synthesis inactivation in human T-lymphocytes by selective monoclonal antibody-ricin conjugates.

Leonard JE, Wang QC, Kaplan NO, Royston I.

Cancer Res. 1985 Nov;45(11 Pt 1):5263-9.

25.
26.
27.

Carbon dioxide laser blepharoplasty.

Baker SS, Muenzler WS, Small RG, Leonard JE.

Ophthalmology. 1984 Mar;91(3):238-44.

PMID:
6425760
29.

Mannitol-specific enzyme II of the bacterial phosphotransferase system. I. Properties of the purified permease.

Jacobson GR, Lee CA, Leonard JE, Saier MH Jr.

J Biol Chem. 1983 Sep 10;258(17):10748-56.

30.

Does the rare male advantage result from faulty experimental design?

Leonard JE, Ehrman L.

Genetics. 1983 Aug;104(4):713-6. No abstract available.

31.

Substances derived from 4-de-N-methylfortimicin B.

Kurath P, Tadanier J, Johnson P, Grampovnik D, Egan RS, Stanaszek RS, Cirovic M, Washburn WH, Leonard JE.

J Antibiot (Tokyo). 1981 Jun;34(6):691-700.

32.
33.

Otorhinolaryngologic screening of children with vocal quality disturbances.

Leeper HA Jr, Leonard JE, Iverson RL.

Int J Pediatr Otorhinolaryngol. 1980 Jun;2(2):123-31.

PMID:
7188057
34.

4-N-Aminoacylfortimicins E.

Kurath P, Grampovnik D, Tadanier J, Martin JR, Egan RS, Stanaszek RS, Cirovic M, Washburn WH, Hill P, Dunnigan DA, Leonard JE, Johnson P, Goldstein AW.

J Antibiot (Tokyo). 1979 Sep;32(9):884-90.

35.
36.

Bioassay of a Drosophila pheromone influencing sexual selection.

Leonard JE, Ehrman L, Schorsch M.

Nature. 1974 Jul 19;250(463):261-2. No abstract available.

PMID:
4850763
37.

Pheromones as a means of genetic control of behavior.

Leonard JE, Ehrman L.

Annu Rev Genet. 1974;8:179-93. Review. No abstract available.

PMID:
4374116
38.

Effect of anoxia on the cations and direct current potential in the endolymph. An experiment on the kanamycin sulfate-poisoned guinea pig.

Nakashima T, Leonard JE, Snow JB Jr.

Arch Otolaryngol. 1973 Jun;97(6):452-6. No abstract available.

PMID:
4704440
39.

The effects of damage to the organ of Corti and the stria vascularis on end olymphatic cationic changes.

Leonard JE, Nakashima T, Snow JE Jr.

Arch Otolaryngol. 1971 Dec;94(6):541-7. No abstract available.

PMID:
5129225
40.

Pathophysiologic responses of the inner ear to intense sound.

Snow JB Jr, Suga F, Sullivan MJ, Nakashima T, Leonard JE, Meiring NL.

Ann Otol Rhinol Laryngol. 1971 Dec;80(6):871-80. No abstract available.

PMID:
5127757
41.

Urinary iron excretion studies in paroxysmal nocturnal hemoglobinuria.

Halpern SE, Leonard JE, Whitcomb WH, Bottomley SS.

Arch Intern Med. 1971 Jun;127(6):1028-32. No abstract available.

PMID:
5578558
42.

Effect of anoxia on sodium and potassium changes in the endolymph.

Leonard JE, Nakashima T, Snow JB Jr.

Surg Forum. 1971;22:461-3. No abstract available.

PMID:
5121442
43.

A new electrode system for continuous measurement of PH, PCO2, PO2, and temperature on flowing blood.

Buzza EE, Leonard JE, Watanabe H, Carlsen EN.

J Assoc Adv Med Instrum. 1970 Jul-Aug;4(4):136-44. No abstract available.

PMID:
5520703
44.

Pharmacologically active acetylene compounds. II. Propynyl-substituted indole derivatives.

Neumeyer JL, Moyer UV, Leonard JE.

J Med Chem. 1969 May;12(3):450-2. No abstract available.

PMID:
5788161
45.

Junction potential variations in blood pH measurements.

Kater JA, Leonard JE, Matsuyama G.

Ann N Y Acad Sci. 1968 Feb 1;148(1):54-66. No abstract available.

PMID:
5237648

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