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Atopic dermatitis endotypes based on allergen sensitization, reactivity to Staphylococcus aureus antigens, and underlying systemic inflammation.

Leonard A, Wang J, Yu L, Liu H, Estrada Y, Greenlees L, McPhee R, Ruzin A, Guttman-Yassky E, Howell MD.

J Allergy Clin Immunol Pract. 2019 Aug 17. pii: S2213-2198(19)30719-6. doi: 10.1016/j.jaip.2019.08.013. [Epub ahead of print]


Racial disparities and factors associated with pregnancy in kidney transplant recipients in the United States.

Shah S, Christianson AL, Verma P, Meganathan K, Leonard AC, Schauer DP, Thakar CV.

PLoS One. 2019 Aug 9;14(8):e0220916. doi: 10.1371/journal.pone.0220916. eCollection 2019.


Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy.

Bertero A, Fields PA, Smith AST, Leonard A, Beussman K, Sniadecki NJ, Kim DH, Tse HF, Pabon L, Shendure J, Noble WS, Murry CE.

J Cell Biol. 2019 Aug 8. pii: jcb.201902117. doi: 10.1083/jcb.201902117. [Epub ahead of print]


Blocking the Trigger: Inhibition of the Initiation of Bacterial Chromosome Replication as an Antimicrobial Strategy.

Grimwade JE, Leonard AC.

Antibiotics (Basel). 2019 Aug 6;8(3). pii: E111. doi: 10.3390/antibiotics8030111. Review.


Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration.

Bargehr J, Ong LP, Colzani M, Davaapil H, Hofsteen P, Bhandari S, Gambardella L, Le Novère N, Iyer D, Sampaziotis F, Weinberger F, Bertero A, Leonard A, Bernard WG, Martinson A, Figg N, Regnier M, Bennett MR, Murry CE, Sinha S.

Nat Biotechnol. 2019 Aug;37(8):895-906. doi: 10.1038/s41587-019-0197-9. Epub 2019 Aug 2.


Bacterial Anti-adhesives: Inhibition of Staphylococcus aureus Nasal Colonization.

Leonard AC, Petrie LE, Cox G.

ACS Infect Dis. 2019 Aug 15. doi: 10.1021/acsinfecdis.9b00193. [Epub ahead of print]


Modality-specific impairment of learning by a neonicotinoid pesticide.

Muth F, Francis JS, Leonard AS.

Biol Lett. 2019 Jul 26;15(7):20190359. doi: 10.1098/rsbl.2019.0359. Epub 2019 Jul 31.


Determining the Temporal Profile of Intracranial Pressure Changes Following Transient Stroke in an Ovine Model.

Sorby-Adams AJ, Leonard AV, Elms LE, Marian OC, Hoving JW, Yassi N, Vink R, Thornton E, Turner RJ.

Front Neurosci. 2019 Jul 9;13:587. doi: 10.3389/fnins.2019.00587. eCollection 2019.


Nectar quality changes the ecological costs of chemically defended pollen.

Francis JS, Acevedo CR, Muth F, Leonard AS.

Curr Biol. 2019 Jul 22;29(14):R679-R680. doi: 10.1016/j.cub.2019.05.046.


NK1-r Antagonist Treatment Comparable to Decompressive Craniectomy in Reducing Intracranial Pressure Following Stroke.

Sorby-Adams AJ, Leonard AV, Hoving JW, Yassi N, Vink R, Wells AJ, Turner RJ.

Front Neurosci. 2019 Jul 5;13:681. doi: 10.3389/fnins.2019.00681. eCollection 2019.


Evolution of interface binding strengths in simplified model of protein quaternary structure.

Leonard AS, Ahnert SE.

PLoS Comput Biol. 2019 Jun 3;15(6):e1006886. doi: 10.1371/journal.pcbi.1006886. eCollection 2019 Jun.


Changes in Heart Rate Variability During Heartfulness Meditation: A Power Spectral Analysis Including the Residual Spectrum.

Léonard A, Clément S, Kuo CD, Manto M.

Front Cardiovasc Med. 2019 May 14;6:62. doi: 10.3389/fcvm.2019.00062. eCollection 2019.


Critical role of autophagy regulator Beclin1 in endothelial cell inflammation and barrier disruption.

Leonard A, Millar MW, Slavin SA, Bijli KM, Dionisio Santos DA, Dean DA, Fazal F, Rahman A.

Cell Signal. 2019 Sep;61:120-129. doi: 10.1016/j.cellsig.2019.04.013. Epub 2019 May 1.


Bariatric Surgery is Associated With Reduced Risk of Breast Cancer in Both Premenopausal and Postmenopausal Women.

Feigelson HS, Caan B, Weinmann S, Leonard AC, Powers JD, Yenumula PR, Arterburn DE, Koebnick C, Altaye M, Schauer DP.

Ann Surg. 2019 Apr 13. doi: 10.1097/SLA.0000000000003331. [Epub ahead of print]


Bone marrow characterization in sickle cell disease: inflammation and stress erythropoiesis lead to suboptimal CD34 recovery.

Leonard A, Bonifacino A, Dominical VM, Luo M, Haro-Mora JJ, Demirci S, Uchida N, Pierciey FJ Jr, Tisdale JF.

Br J Haematol. 2019 Jul;186(2):286-299. doi: 10.1111/bjh.15902. Epub 2019 Apr 10.


A neonicotinoid pesticide impairs foraging, but not learning, in free-flying bumblebees.

Muth F, Leonard AS.

Sci Rep. 2019 Mar 18;9(1):4764. doi: 10.1038/s41598-019-39701-5.


Virulence Factors Produced by Staphylococcus aureus Biofilms Have a Moonlighting Function Contributing to Biofilm Integrity.

Graf AC, Leonard A, Schäuble M, Rieckmann LM, Hoyer J, Maass S, Lalk M, Becher D, Pané-Farré J, Riedel K.

Mol Cell Proteomics. 2019 Jun;18(6):1036-1053. doi: 10.1074/mcp.RA118.001120. Epub 2019 Mar 8.


Association of age-related macular degeneration with complement activation products, smoking, and single nucleotide polymorphisms in South Carolinians of European and African descent.

Rohrer B, Frazer-Abel A, Leonard A, Ratnapriya R, Ward T, Pietraszkiewicz A, O'Quinn E, Adams K, Swaroop A, Wolf BJ.

Mol Vis. 2019 Feb 8;25:79-92. eCollection 2019.


Temporal Trends in Incident Mortality in Dialysis Patients: Focus on Sex and Racial Disparities.

Shah S, Leonard AC, Meganathan K, Christianson AL, Thakar CV.

Am J Nephrol. 2019;49(3):241-253. doi: 10.1159/000497446. Epub 2019 Feb 28.


Loss of Stromal Galectin-1 Enhances Multiple Myeloma Development: Emphasis on a Role in Osteoclasts.

Muller J, Duray E, Lejeune M, Dubois S, Plougonven E, Léonard A, Storti P, Giuliani N, Cohen-Solal M, Hempel U, Thijssen VL, Beguin Y, Heusschen R, Caers J.

Cancers (Basel). 2019 Feb 23;11(2). pii: E261. doi: 10.3390/cancers11020261.


High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Culture with Poloxamer and Prostaglandin E2.

Uchida N, Nassehi T, Drysdale CM, Gamer J, Yapundich M, Demirci S, Haro-Mora JJ, Leonard A, Hsieh MM, Tisdale JF.

Mol Ther Methods Clin Dev. 2019 Jan 25;13:187-196. doi: 10.1016/j.omtm.2019.01.005. eCollection 2019 Jun 14.


Developing and Testing of Lipid Force Fields with Applications to Modeling Cellular Membranes.

Leonard AN, Wang E, Monje-Galvan V, Klauda JB.

Chem Rev. 2019 May 8;119(9):6227-6269. doi: 10.1021/acs.chemrev.8b00384. Epub 2019 Feb 20.


Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury.

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F.

Sci Rep. 2019 Feb 14;9(1):2096. doi: 10.1038/s41598-018-38312-w.


Identification of red blood cell antibodies in maternal breast milk implicated in prolonged hemolytic disease of the fetus and newborn.

Leonard A, Hittson Boal L, Pary P, Mo YD, Jacquot C, Luban NL, Darbari DS, Webb J.

Transfusion. 2019 Apr;59(4):1183-1189. doi: 10.1111/trf.15154. Epub 2019 Feb 5.


CRISPR/Cas9 for Sickle Cell Disease: Applications, Future Possibilities, and Challenges.

Demirci S, Leonard A, Haro-Mora JJ, Uchida N, Tisdale JF.

Adv Exp Med Biol. 2019;1144:37-52. doi: 10.1007/5584_2018_331. Review.


Photoinduced, reversible phase transitions in all-inorganic perovskite nanocrystals.

Kirschner MS, Diroll BT, Guo P, Harvey SM, Helweh W, Flanders NC, Brumberg A, Watkins NE, Leonard AA, Evans AM, Wasielewski MR, Dichtel WR, Zhang X, Chen LX, Schaller RD.

Nat Commun. 2019 Jan 30;10(1):504. doi: 10.1038/s41467-019-08362-3.


Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis.

Zhou L, Leonard A, Pavel AB, Malik K, Raja A, Glickman J, Estrada YD, Peng X, Del Duca E, Sanz-Cabanillas J, Ruano J, Xu H, Zhang N, Wen HC, Gonzalez J, Garcet S, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2019 Jul;144(1):144-156. doi: 10.1016/j.jaci.2019.01.015. Epub 2019 Jan 24.


Isothermal Titration Calorimetry of Be2+ with Phosphatidylserine Models Guides All-Atom Force-Field Development for Lipid-Ion Interactions.

Leonard AN, Klauda JB, Sukharev S.

J Phys Chem B. 2019 Feb 21;123(7):1554-1565. doi: 10.1021/acs.jpcb.8b11884. Epub 2019 Feb 8.


A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity.

Kim JD, Chun AY, Mangan RJ, Brown G, Mourao Pacheco B, Doyle H, Leonard A, El Bejjani R.

J Cell Sci. 2019 Feb 15;132(5). pii: jcs223586. doi: 10.1242/jcs.223586.


Pre-dialysis acute care hospitalizations and clinical outcomes in dialysis patients.

Shah S, Meganathan K, Christianson AL, Leonard AC, Thakar CV.

PLoS One. 2019 Jan 16;14(1):e0209578. doi: 10.1371/journal.pone.0209578. eCollection 2019.


LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion.

Chi C, Leonard A, Knight WE, Beussman KM, Zhao Y, Cao Y, Londono P, Aune E, Trembley MA, Small EM, Jeong MY, Walker LA, Xu H, Sniadecki NJ, Taylor MR, Buttrick PM, Song K.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):556-565. doi: 10.1073/pnas.1808618116. Epub 2018 Dec 24.


Blood endotyping distinguishes the profile of vitiligo from that of other inflammatory and autoimmune skin diseases.

Czarnowicki T, He H, Leonard A, Kim HJ, Kameyama N, Pavel AB, Li R, Estrada Y, Wen HC, Kimmel GW, Kim HJ, Chima M, Lebwohl M, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2019 Jun;143(6):2095-2107. doi: 10.1016/j.jaci.2018.11.031. Epub 2018 Dec 18.


Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients.

Brunner PM, Israel A, Leonard A, Pavel AB, Kim HJ, Zhang N, Czarnowicki T, Patel K, Murphrey M, Ramsey K, Rangel S, Zebda R, Soundararajan V, Zheng X, Estrada YD, Xu H, Krueger JG, Paller AS, Guttman-Yassky E.

Ann Allergy Asthma Immunol. 2019 Mar;122(3):318-330.e3. doi: 10.1016/j.anai.2018.11.025. Epub 2018 Dec 1.


Infected abdominal aortic aneurysm graft complicated by lumbar discitis.

Sumrein HB, Parry SD, Ayer RV, Leonard AP.

BJR Case Rep. 2018 Feb 9;4(2):20170101. doi: 10.1259/bjrcr.20170101. eCollection 2018.


Determinism and boundedness of self-assembling structures.

Tesoro S, Ahnert SE, Leonard AS.

Phys Rev E. 2018 Aug;98(2-1):022113. doi: 10.1103/PhysRevE.98.022113.


Optical Signatures of Transiently Disordered Semiconductor Nanocrystals.

Kirschner MS, Diroll BT, Brumberg A, Leonard AA, Hannah DC, Chen LX, Schaller RD.

ACS Nano. 2018 Oct 23;12(10):10008-10015. doi: 10.1021/acsnano.8b04435. Epub 2018 Sep 26.


E×B Flux Driven Detachment Bifurcation in the DIII-D Tokamak.

Jaervinen AE, Allen SL, Eldon D, Fenstermacher ME, Groth M, Hill DN, Leonard AW, McLean AG, Porter GD, Rognlien TD, Samuell CM, Wang HQ.

Phys Rev Lett. 2018 Aug 17;121(7):075001. doi: 10.1103/PhysRevLett.121.075001.


Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab.

Brunner PM, Pavel AB, Khattri S, Leonard A, Malik K, Rose S, Jim On S, Vekaria AS, Traidl-Hoffmann C, Singer GK, Baum D, Gilleaudeau P, Sullivan-Whalen M, Fuentes-Duculan J, Li X, Zheng X, Estrada Y, Garcet S, Wen HC, Gonzalez J, Coats I, Cueto I, Neumann AU, Lebwohl MG, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2019 Jan;143(1):142-154. doi: 10.1016/j.jaci.2018.07.028. Epub 2018 Aug 17.


High prevalence of hypertension in an agricultural village in Madagascar.

Manus MB, Bloomfield GS, Leonard AS, Guidera LN, Samson DR, Nunn CL.

PLoS One. 2018 Aug 16;13(8):e0201616. doi: 10.1371/journal.pone.0201616. eCollection 2018.


Low Affinity DnaA-ATP Recognition Sites in E. coli oriC Make Non-equivalent and Growth Rate-Dependent Contributions to the Regulated Timing of Chromosome Replication.

Rao P, Rozgaja TA, Alqahtani A, Grimwade JE, Leonard AC.

Front Microbiol. 2018 Jul 26;9:1673. doi: 10.3389/fmicb.2018.01673. eCollection 2018.


Infection and metabolism - Streptococcus pneumoniae metabolism facing the host environment.

Leonard A, Lalk M.

Cytokine. 2018 Dec;112:75-86. doi: 10.1016/j.cyto.2018.07.021. Epub 2018 Aug 1.


Severe group A streptococcal infections in mothers and their newborns in London and the South East, 2010-2016: assessment of risk and audit of public health management.

Leonard A, Wright A, Saavedra-Campos M, Lamagni T, Cordery R, Nicholls M, Domoney C, Sriskandan S, Balasegaram S.

BJOG. 2019 Jan;126(1):44-53. doi: 10.1111/1471-0528.15415. Epub 2018 Sep 9.


Examining HIV-Related stigma in relation to pain interference and psychological inflexibility among persons living with HIV/AIDS: The role of anxiety sensitivity.

Wong CCY, Paulus DJ, Lemaire C, Leonard A, Sharp C, Neighbors C, Brandt CP, Lu Q, Zvolensky MJ.

J HIV AIDS Soc Serv. 2018;17(1):1-15. doi: 10.1080/15381501.2017.1370680. Epub 2017 Nov 30.


Gender and Racial Disparities in Initial Hemodialysis Access and Outcomes in Incident End-Stage Renal Disease Patients.

Shah S, Leonard AC, Meganathan K, Christianson AL, Thakar CV.

Am J Nephrol. 2018;48(1):4-14. doi: 10.1159/000490624. Epub 2018 Jul 10.


The relationship of discrimination related to sexual orientation and HIV-relevant risk behaviors among men who have sex with men.

Rogers AH, Jardin C, Mayorga NA, Bakhshaie J, Leonard A, Lemaire C, Zvolensky MJ.

Psychiatry Res. 2018 Sep;267:102-107. doi: 10.1016/j.psychres.2018.05.081. Epub 2018 May 30.


Stem cell transplantation in sickle cell disease: therapeutic potential and challenges faced.

Leonard A, Tisdale JF.

Expert Rev Hematol. 2018 Jul;11(7):547-565. doi: 10.1080/17474086.2018.1486703. Epub 2018 Jun 20. Review.


Acute Kidney Injury before Dialysis Initiation Predicts Adverse Outcomes in Hemodialysis Patients.

Lee T, Shah S, Leonard AC, Parikh P, Thakar CV.

Am J Nephrol. 2018;47(6):427-434. doi: 10.1159/000489949. Epub 2018 Jun 7.


Parameterization of the CHARMM All-Atom Force Field for Ether Lipids and Model Linear Ethers.

Leonard AN, Pastor RW, Klauda JB.

J Phys Chem B. 2018 Jul 5;122(26):6744-6754. doi: 10.1021/acs.jpcb.8b02743. Epub 2018 Jun 21.


Origin recognition is the predominant role for DnaA-ATP in initiation of chromosome replication.

Grimwade JE, Rozgaja TA, Gupta R, Dyson K, Rao P, Leonard AC.

Nucleic Acids Res. 2018 Jul 6;46(12):6140-6151. doi: 10.1093/nar/gky457.


Shared decision-making tool for thromboprophylaxis in atrial fibrillation - A feasibility study.

Eckman MH, Costea A, Attari M, Munjal J, Wise RE, Knochelmann C, Flaherty ML, Baker P, Ireton R, Harnett BM, Leonard AC, Steen D, Rose A, Kues J.

Am Heart J. 2018 May;199:13-21. doi: 10.1016/j.ahj.2018.01.003. Epub 2018 Jan 12.


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