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Items: 1 to 50 of 118

1.

Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats.

Siques P, Brito J, Flores K, Ordenes S, Arriaza K, Pena E, León-Velarde F, López de Pablo ÁL, Gonzalez MC, Arribas S.

Front Physiol. 2018 Jun 28;9:799. doi: 10.3389/fphys.2018.00799. eCollection 2018.

2.

Rapid growth of biomedical research in Peru.

Glass RI, Garcia PJ, Belter CW, Livinski AA, Leon-Velarde F.

Lancet Glob Health. 2018 Jul;6(7):e728-e729. doi: 10.1016/S2214-109X(18)30234-1. No abstract available.

3.

Excessive Erythrocytosis and Cardiovascular Risk in Andean Highlanders.

Corante N, Anza-Ramírez C, Figueroa-Mujíca R, Macarlupú JL, Vizcardo-Galindo G, Bilo G, Parati G, Gamboa JL, León-Velarde F, Villafuerte FC.

High Alt Med Biol. 2018 Sep;19(3):221-231. doi: 10.1089/ham.2017.0123. Epub 2018 May 21.

4.

Long-Term Intermittent Work at High Altitude: Right Heart Functional and Morphological Status and Associated Cardiometabolic Factors.

Brito J, Siques P, López R, Romero R, León-Velarde F, Flores K, Lüneburg N, Hannemann J, Böger RH.

Front Physiol. 2018 Mar 22;9:248. doi: 10.3389/fphys.2018.00248. eCollection 2018.

5.

Obesity as a Conditioning Factor for High-Altitude Diseases.

San Martin R, Brito J, Siques P, León-Velarde F.

Obes Facts. 2017;10(4):363-372. doi: 10.1159/000477461. Epub 2017 Aug 16. Review.

6.

Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults.

Lüneburg N, Siques P, Brito J, De La Cruz JJ, León-Velarde F, Hannemann J, Ibanez C, Böger RH.

High Alt Med Biol. 2017 Sep;18(3):226-233. doi: 10.1089/ham.2016.0123. Epub 2017 Apr 28.

7.

Dark Adaptation at High Altitude: An Unexpected Pupillary Response to Chronic Hypoxia in Andean Highlanders.

Healy K, Labrique AB, Miranda JJ, Gilman RH, Danz D, Davila-Roman VG, Huicho L, León-Velarde F, Checkley W.

High Alt Med Biol. 2016 Sep;17(3):208-213. Epub 2016 Jul 25.

PMID:
27454014
8.

Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?

Lüneburg N, Siques P, Brito J, Arriaza K, Pena E, Klose H, Leon-Velarde F, Böger RH.

Pulm Med. 2016;2016:6578578. doi: 10.1155/2016/6578578. Epub 2016 May 30.

9.

Increased Cardiometabolic Risk and Worsening Hypoxemia at High Altitude.

Miele CH, Schwartz AR, Gilman RH, Pham L, Wise RA, Davila-Roman VG, Jun JC, Polotsky VY, Miranda JJ, Leon-Velarde F, Checkley W.

High Alt Med Biol. 2016 Jun;17(2):93-100. doi: 10.1089/ham.2015.0084.

10.

Towards sustainable partnerships in global health: the case of the CRONICAS Centre of Excellence in Chronic Diseases in Peru.

Miranda JJ, Bernabé-Ortiz A, Diez-Canseco F, Málaga G, Cárdenas MK, Carrillo-Larco RM, Lazo-Porras M, Moscoso-Porras M, Pesantes MA, Ponce V, Araya R, Beran D, Busse P, Boggio O, Checkley W, García PJ, Huicho L, León-Velarde F, Lescano AG, Mohr DC, Pan W, Peiris D, Perel P, Rabadán-Diehl C, Rivera-Chira M, Sacksteder K, Smeeth L, Trujillo AJ, Wells JC, Yan LL, García HH, Gilman RH.

Global Health. 2016 Jun 2;12(1):29. doi: 10.1186/s12992-016-0170-z. Review.

11.

Plasma soluble erythropoietin receptor is decreased during sleep in Andean highlanders with Chronic Mountain Sickness.

Villafuerte FC, Corante N, Anza-Ramírez C, Figueroa-Mujíca R, Vizcardo-Galindo G, Mercado A, Macarlupú JL, León-Velarde F.

J Appl Physiol (1985). 2016 Jul 1;121(1):53-8. doi: 10.1152/japplphysiol.00107.2016. Epub 2016 Apr 28.

12.

SENP1, but not fetal hemoglobin, differentiates Andean highlanders with chronic mountain sickness from healthy individuals among Andean highlanders.

Hsieh MM, Callacondo D, Rojas-Camayo J, Quesada-Olarte J, Wang X, Uchida N, Maric I, Remaley AT, Leon-Velarde F, Villafuerte FC, Tisdale JF.

Exp Hematol. 2016 Jun;44(6):483-490.e2. doi: 10.1016/j.exphem.2016.02.010. Epub 2016 Mar 4.

PMID:
26952840
13.

Developmental Effects Determine Submaximal Arterial Oxygen Saturation in Peruvian Quechua.

Kiyamu M, León-Velarde F, Rivera-Chira M, Elías G, Brutsaert TD.

High Alt Med Biol. 2015 Jun;16(2):138-46. doi: 10.1089/ham.2014.1126. Epub 2015 May 15.

14.

Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude.

Vyas KJ, Danz D, Gilman RH, Wise RA, León-Velarde F, Miranda JJ, Checkley W.

High Alt Med Biol. 2015 Jun;16(2):162-8. doi: 10.1089/ham.2015.0026. Epub 2015 May 14.

15.

Association between serum concentrations of hypoxia inducible factor responsive proteins and excessive erythrocytosis in high altitude Peru.

Painschab MS, Malpartida GE, Dávila-Roman VG, Gilman RH, Kolb TM, León-Velarde F, Miranda JJ, Checkley W.

High Alt Med Biol. 2015 Mar;16(1):26-33. doi: 10.1089/ham.2014.1086. Epub 2015 Mar 11.

16.

Building a platform for translational research in chronic noncommunicable diseases to address population health: lessons from NHLBI supported CRONICAS in Peru.

Miranda JJ, Bernabé-Ortiz A, Diez-Canseco F, Málaga G, Cardenas MK, Carrillo-Larco RM, Pesantes MA, Araya R, Boggio O, Checkley W, García PJ, León-Velarde F, Lescano AG, Montori V, Pan W, Rivera-Chira M, Sacksteder K, Smeeth L, García HH, Gilman RH.

Glob Heart. 2015 Mar;10(1):13-9. doi: 10.1016/j.gheart.2014.12.012. Review.

17.

Adventitial alterations are the main features in pulmonary artery remodeling due to long-term chronic intermittent hypobaric hypoxia in rats.

Brito J, Siques P, Arribas SM, López de Pablo AL, González MC, Naveas N, Arriaza K, Flores K, León-Velarde F, Pulido R, Ordenes S, López MR.

Biomed Res Int. 2015;2015:169841. doi: 10.1155/2015/169841. Epub 2015 Feb 8.

18.

Decreased plasma soluble erythropoietin receptor in high-altitude excessive erythrocytosis and Chronic Mountain Sickness.

Villafuerte FC, Macarlupú JL, Anza-Ramírez C, Corrales-Melgar D, Vizcardo-Galindo G, Corante N, León-Velarde F.

J Appl Physiol (1985). 2014 Dec 1;117(11):1356-62. doi: 10.1152/japplphysiol.00619.2014. Epub 2014 Oct 16.

19.

Plasma and liver lipid profiles in rats exposed to chronic hypobaric hypoxia: changes in metabolic pathways.

Siques P, Brito J, Naveas N, Pulido R, De la Cruz JJ, Mamani M, León-Velarde F.

High Alt Med Biol. 2014 Sep;15(3):388-95. doi: 10.1089/ham.2013.1134. Epub 2014 Sep 3.

20.

Vascular endothelial growth factor-A is associated with chronic mountain sickness in the Andean population.

Espinoza JR, Alvarez G, León-Velarde F, Preciado HF, Macarlupu JL, Rivera-Ch M, Rodriguez J, Favier J, Gimenez-Roqueplo AP, Richalet JP.

High Alt Med Biol. 2014 Jun;15(2):146-54. doi: 10.1089/ham.2013.1121.

21.

Prevalence, clinical profile, iron status, and subject-specific traits for excessive erythrocytosis in andean adults living permanently at 3,825 meters above sea level.

De Ferrari A, Miranda JJ, Gilman RH, Dávila-Román VG, León-Velarde F, Rivera-Ch M, Huicho L, Bernabé-Ortiz A, Wise RA, Checkley W.

Chest. 2014 Nov;146(5):1327-1336. doi: 10.1378/chest.14-0298.

22.

Nitric oxide and superoxide anion balance in rats exposed to chronic and long term intermittent hypoxia.

Siques P, López de Pablo AL, Brito J, Arribas SM, Flores K, Arriaza K, Naveas N, González MC, Hoorntje A, León-Velarde F, López MR.

Biomed Res Int. 2014;2014:610474. doi: 10.1155/2014/610474. Epub 2014 Feb 26.

23.

A cross-sectional study of differences in 6-min walk distance in healthy adults residing at high altitude versus sea level.

Caffrey D, Miranda JJ, Gilman RH, Davila-Roman VG, Cabrera L, Dowling R, Stewart T, Bernabe-Ortiz A, Wise R, Leon-Velarde F, Checkley W; CRONICAS Cohort Study Group.

Extrem Physiol Med. 2014 Feb 1;3(1):3. doi: 10.1186/2046-7648-3-3.

24.

Rebuttal to pro statements.

León-Velarde F, Villafuerte FC.

High Alt Med Biol. 2013 Sep;14(3):218. doi: 10.1089/ham.2013.1064. No abstract available.

PMID:
24067181
25.

Con: All dwellers at high altitude are persons of impaired physical and mental powers: the view from the Andes.

León-Velarde F, Villafuerte FC.

High Alt Med Biol. 2013 Sep;14(3):212-3. doi: 10.1089/ham.2013.1039. No abstract available.

PMID:
24067177
26.

Andean and Tibetan patterns of adaptation to high altitude.

Bigham AW, Wilson MJ, Julian CG, Kiyamu M, Vargas E, Leon-Velarde F, Rivera-Chira M, Rodriquez C, Browne VA, Parra E, Brutsaert TD, Moore LG, Shriver MD.

Am J Hum Biol. 2013 Mar-Apr;25(2):190-7. doi: 10.1002/ajhb.22358. Epub 2013 Jan 24.

27.

Developmental and genetic components explain enhanced pulmonary volumes of female Peruvian Quechua.

Kiyamu M, Bigham A, Parra E, León-Velarde F, Rivera-Chira M, Brutsaert TD.

Am J Phys Anthropol. 2012 Aug;148(4):534-42. doi: 10.1002/ajpa.22069. Epub 2012 May 3.

28.

Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas.

Galanter JM, Fernandez-Lopez JC, Gignoux CR, Barnholtz-Sloan J, Fernandez-Rozadilla C, Via M, Hidalgo-Miranda A, Contreras AV, Figueroa LU, Raska P, Jimenez-Sanchez G, Zolezzi IS, Torres M, Ponte CR, Ruiz Y, Salas A, Nguyen E, Eng C, Borjas L, Zabala W, Barreto G, González FR, Ibarra A, Taboada P, Porras L, Moreno F, Bigham A, Gutierrez G, Brutsaert T, León-Velarde F, Moore LG, Vargas E, Cruz M, Escobedo J, Rodriguez-Santana J, Rodriguez-Cintrón W, Chapela R, Ford JG, Bustamante C, Seminara D, Shriver M, Ziv E, Burchard EG, Haile R, Parra E, Carracedo A; LACE Consortium.

PLoS Genet. 2012;8(3):e1002554. doi: 10.1371/journal.pgen.1002554. Epub 2012 Mar 8.

29.

Regulation of hepcidin expression at high altitude.

Talbot NP, Lakhal S, Smith TG, Privat C, Nickol AH, Rivera-Ch M, León-Velarde F, Dorrington KL, Mole DR, Robbins PA.

Blood. 2012 Jan 19;119(3):857-60. doi: 10.1182/blood-2011-03-341776. Epub 2011 Nov 30.

30.

Intravenous iron supplementation may protect against acute mountain sickness: a randomized, double-blinded, placebo-controlled trial.

Talbot NP, Smith TG, Privat C, Nickol AH, Rivera-Ch M, León-Velarde F, Dorrington KL, Robbins PA.

High Alt Med Biol. 2011 Fall;12(3):265-9. doi: 10.1089/ham.2011.1005.

PMID:
21962070
31.

Chronic mountain sickness and the heart.

León-Velarde F, Villafuerte FC, Richalet JP.

Prog Cardiovasc Dis. 2010 May-Jun;52(6):540-9. doi: 10.1016/j.pcad.2010.02.012. Review.

PMID:
20417348
32.

Upregulation of arginase expression and activity in hypertensive rats exposed to chronic intermittent hypobaric hypoxia.

Lopez V, Siques P, Brito J, Vallejos C, Naveas N, Carvallo C, León-Velarde F, Carvajal N.

High Alt Med Biol. 2009 Winter;10(4):373-81. doi: 10.1089/ham.2008.1072.

PMID:
20039818
33.

Blood pressure responses in young adults first exposed to high altitude for 12 months at 3550 m.

Siqués P, Brito J, Banegas JR, León-Velarde F, de la Cruz-Troca JJ, López V, Naveas N, Herruzo R.

High Alt Med Biol. 2009 Winter;10(4):329-35. doi: 10.1089/ham.2008.1103.

PMID:
20039813
34.

Developing capacity in health informatics in a resource poor setting: lessons from Peru.

Kimball AM, Curioso WH, Arima Y, Fuller S, Garcia PJ, Segovia-Juarez J, Castagnetto JM, Leon-Velarde F, Holmes KK.

Hum Resour Health. 2009 Oct 27;7:80. doi: 10.1186/1478-4491-7-80.

35.

Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials.

Smith TG, Talbot NP, Privat C, Rivera-Ch M, Nickol AH, Ratcliffe PJ, Dorrington KL, León-Velarde F, Robbins PA.

JAMA. 2009 Oct 7;302(13):1444-50. doi: 10.1001/jama.2009.1404.

PMID:
19809026
36.

Pulmonary pressure and cardiac function in chronic mountain sickness patients.

Maignan M, Rivera-Ch M, Privat C, Leòn-Velarde F, Richalet JP, Pham I.

Chest. 2009 Feb;135(2):499-504. doi: 10.1378/chest.08-1094. Epub 2008 Aug 21.

PMID:
18719057
37.

Effect of acetazolamide on ventilatory response in subjects with chronic mountain sickness.

Rivera-Ch M, Huicho L, Bouchet P, Richalet JP, León-Velarde F.

Respir Physiol Neurobiol. 2008 Aug 31;162(3):184-9. doi: 10.1016/j.resp.2008.06.010. Epub 2008 Jun 17.

PMID:
18603026
38.

Angiotensin-converting enzyme genotype and arterial oxygen saturation at high altitude in Peruvian Quechua.

Bigham AW, Kiyamu M, León-Velarde F, Parra EJ, Rivera-Ch M, Shriver MD, Brutsaert TD.

High Alt Med Biol. 2008 Summer;9(2):167-78. doi: 10.1089/ham.2007.1066.

39.

Gene expression in chronic high altitude diseases.

León-Velarde F, Mejía O.

High Alt Med Biol. 2008 Summer;9(2):130-9. doi: 10.1089/ham.2007.1077. Review.

PMID:
18578644
40.

Acetazolamide for Monge's disease: efficiency and tolerance of 6-month treatment.

Richalet JP, Rivera-Ch M, Maignan M, Privat C, Pham I, Macarlupu JL, Petitjean O, León-Velarde F.

Am J Respir Crit Care Med. 2008 Jun 15;177(12):1370-6. doi: 10.1164/rccm.200802-196OC. Epub 2008 Apr 3.

PMID:
18388356
41.

Carlos Monge Cassinelli: a portrait.

León-Velarde F, Richalet JP.

Adv Exp Med Biol. 2007;618:291-7.

PMID:
18269206
42.

Hematological and lipid profile changes in sea-level natives after exposure to 3550-m altitude for 8 months.

Siqués P, Brito J, León-Velarde F, Barrios L, De La Cruz JJ, López V, Herruzo R.

High Alt Med Biol. 2007 Winter;8(4):286-95.

PMID:
18081504
43.

Oxygen transport at high altitude--an integrated perspective. Introduction.

Frappell PB, León-Velarde F, Rivera-Ch M.

Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):115-20. Epub 2007 Aug 17. No abstract available.

PMID:
17889816
44.

Chronic intermittent hypoxia at high altitude exposure for over 12 years: assessment of hematological, cardiovascular, and renal effects.

Brito J, Siqués P, León-Velarde F, De La Cruz JJ, López V, Herruzo R.

High Alt Med Biol. 2007 Fall;8(3):236-44.

PMID:
17824824
45.

Ventilatory response to acute hypoxia in transgenic mice over-expressing erythropoietin: effect of acclimation to 3-week hypobaric hypoxia.

Villafuerte FC, Cárdenas-Alayza R, Macarlupú JL, Monge-C C, León-Velarde F.

Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):243-50. Epub 2007 Jun 29.

PMID:
17693141
46.

Brain stem NO modulates ventilatory acclimatization to hypoxia in mice.

El Hasnaoui-Saadani R, Alayza RC, Launay T, Pichon A, Quidu P, Beaudry M, Léon-Velarde F, Richalet JP, Duvallet A, Favret F.

J Appl Physiol (1985). 2007 Nov;103(5):1506-12. Epub 2007 Aug 9.

47.

Treatment of chronic mountain sickness: critical reappraisal of an old problem.

Rivera-Ch M, León-Velarde F, Huicho L.

Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):251-65. Epub 2007 May 10. Review.

PMID:
17580125
48.

A genomewide admixture mapping panel for Hispanic/Latino populations.

Mao X, Bigham AW, Mei R, Gutierrez G, Weiss KM, Brutsaert TD, Leon-Velarde F, Moore LG, Vargas E, McKeigue PM, Shriver MD, Parra EJ.

Am J Hum Genet. 2007 Jun;80(6):1171-8. Epub 2007 Apr 20.

49.

Respiratory control in residents at high altitude: physiology and pathophysiology.

León-Velarde F, Richalet JP.

High Alt Med Biol. 2006 Summer;7(2):125-37. Review.

PMID:
16764526
50.

Carotid baroreflex regulation of vascular resistance in high-altitude Andean natives with and without chronic mountain sickness.

Moore JP, Claydon VE, Norcliffe LJ, Rivera-Ch MC, Lèon-Velarde F, Appenzeller O, Hainsworth R.

Exp Physiol. 2006 Sep;91(5):907-13. Epub 2006 Jun 8.

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