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Fatty acid synthase is required for profibrotic TGF-β signaling.

Jung MY, Kang JH, Hernandez DM, Yin X, Andrianifahanana M, Wang Y, Gonzalez-Guerrico A, Limper AH, Lupu R, Leof EB.

FASEB J. 2018 Jul;32(7):3803-3815. doi: 10.1096/fj.201701187R. Epub 2018 Feb 16.


CorMatrix Wrapped Around the Adventitia of the Arteriovenous Fistula Outflow Vein Attenuates Venous Neointimal Hyperplasia.

Yang B, Kilari S, Brahmbhatt A, McCall DL, Torres EN, Leof EB, Mukhopadhyay D, Misra S.

Sci Rep. 2017 Oct 30;7(1):14298. doi: 10.1038/s41598-017-14696-z.


Basolateral delivery of the type I transforming growth factor beta receptor is mediated by a dominant-acting cytoplasmic motif.

Yin X, Kang JH, Andrianifahanana M, Wang Y, Jung MY, Hernandez DM, Leof EB.

Mol Biol Cell. 2017 Oct 1;28(20):2701-2711. doi: 10.1091/mbc.E17-05-0334. Epub 2017 Aug 2.


Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling.

Kang JH, Jung MY, Yin X, Andrianifahanana M, Hernandez DM, Leof EB.

J Clin Invest. 2017 Jun 30;127(7):2541-2554. doi: 10.1172/JCI88696. Epub 2017 May 22.


Profibrotic up-regulation of glucose transporter 1 by TGF-β involves activation of MEK and mammalian target of rapamycin complex 2 pathways.

Andrianifahanana M, Hernandez DM, Yin X, Kang JH, Jung MY, Wang Y, Yi ES, Roden AC, Limper AH, Leof EB.

FASEB J. 2016 Nov;30(11):3733-3744. Epub 2016 Aug 1.


The Role of Repeat Administration of Adventitial Delivery of Lentivirus-shRNA-Vegf-A in Arteriovenous Fistula to Prevent Venous Stenosis Formation.

Janardhanan R, Yang B, Kilari S, Leof EB, Mukhopadhyay D, Misra S.

J Vasc Interv Radiol. 2016 Apr;27(4):576-83. doi: 10.1016/j.jvir.2015.12.751. Epub 2016 Mar 2.


Tracking and Therapeutic Value of Human Adipose Tissue-derived Mesenchymal Stem Cell Transplantation in Reducing Venous Neointimal Hyperplasia Associated with Arteriovenous Fistula.

Yang B, Brahmbhatt A, Nieves Torres E, Thielen B, McCall DL, Engel S, Bansal A, Pandey MK, Dietz AB, Leof EB, DeGrado TR, Mukhopadhyay D, Misra S.

Radiology. 2016 May;279(2):513-22. doi: 10.1148/radiol.2015150947. Epub 2015 Nov 19.


Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor β signaling.

Wilkes MC, Repellin CE, Kang JH, Andrianifahanana M, Yin X, Leof EB.

Mol Biol Cell. 2015 Nov 1;26(21):3879-91. doi: 10.1091/mbc.E15-07-0545. Epub 2015 Sep 2.


Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis.

Wang Y, Cao Y, Yamada S, Thirunavukkarasu M, Nin V, Joshi M, Rishi MT, Bhattacharya S, Camacho-Pereira J, Sharma AK, Shameer K, Kocher JP, Sanchez JA, Wang E, Hoeppner LH, Dutta SK, Leof EB, Shah V, Claffey KP, Chini EN, Simons M, Terzic A, Maulik N, Mukhopadhyay D.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1401-12. doi: 10.1161/ATVBAHA.115.305566. Epub 2015 Apr 16.


Cell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activation.

Nallet-Staub F, Yin X, Gilbert C, Marsaud V, Ben Mimoun S, Javelaud D, Leof EB, Mauviel A.

Dev Cell. 2015 Mar 9;32(5):640-51. doi: 10.1016/j.devcel.2015.01.011.


Adventitial transduction of lentivirus-shRNA-VEGF-A in arteriovenous fistula reduces venous stenosis formation.

Yang B, Janardhanan R, Vohra P, Greene EL, Bhattacharya S, Withers S, Roy B, Nieves Torres EC, Mandrekar J, Leof EB, Mukhopadhyay D, Misra S.

Kidney Int. 2014 Feb;85(2):289-306. doi: 10.1038/ki.2013.290. Epub 2013 Aug 7.


Profibrotic TGFβ responses require the cooperative action of PDGF and ErbB receptor tyrosine kinases.

Andrianifahanana M, Wilkes MC, Gupta SK, Rahimi RA, Repellin CE, Edens M, Wittenberger J, Yin X, Maidl E, Becker J, Leof EB.

FASEB J. 2013 Nov;27(11):4444-54. doi: 10.1096/fj.12-224907. Epub 2013 Aug 2.


Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosome.

Yin X, Murphy SJ, Wilkes MC, Ji Y, Leof EB.

Mol Biol Cell. 2013 Jul;24(14):2285-98. doi: 10.1091/mbc.E13-02-0093. Epub 2013 May 29.


Simvastatin reduces venous stenosis formation in a murine hemodialysis vascular access model.

Janardhanan R, Yang B, Vohra P, Roy B, Withers S, Bhattacharya S, Mandrekar J, Kong H, Leof EB, Mukhopadhyay D, Misra S.

Kidney Int. 2013 Aug;84(2):338-52. doi: 10.1038/ki.2013.112. Epub 2013 May 1.


Fibrosis, regeneration, and aging: playing chess with evolution.

Torres VE, Leof EB.

J Am Soc Nephrol. 2011 Aug;22(8):1393-6. doi: 10.1681/ASN.2011060603. Epub 2011 Jul 14. No abstract available.


Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase.

Hong M, Wilkes MC, Penheiter SG, Gupta SK, Edens M, Leof EB.

J Biol Chem. 2011 May 20;286(20):17841-50. doi: 10.1074/jbc.M111.233676. Epub 2011 Mar 28.


Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2.

Penheiter SG, Singh RD, Repellin CE, Wilkes MC, Edens M, Howe PH, Pagano RE, Leof EB.

Mol Biol Cell. 2010 Nov 15;21(22):4009-19. doi: 10.1091/mbc.E09-12-1019. Epub 2010 Sep 29.


ERBB receptor activation is required for profibrotic responses to transforming growth factor beta.

Andrianifahanana M, Wilkes MC, Repellin CE, Edens M, Kottom TJ, Rahimi RA, Leof EB.

Cancer Res. 2010 Oct 1;70(19):7421-30. doi: 10.1158/0008-5472.CAN-10-0232. Epub 2010 Sep 14.


Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype.

Cao Y, Szabolcs A, Dutta SK, Yaqoob U, Jagavelu K, Wang L, Leof EB, Urrutia RA, Shah VH, Mukhopadhyay D.

J Biol Chem. 2010 Oct 8;285(41):31840-8. doi: 10.1074/jbc.M110.151696. Epub 2010 Jul 30.


Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis.

Wang S, Wilkes MC, Leof EB, Hirschberg R.

Am J Physiol Renal Physiol. 2010 Jan;298(1):F142-9. doi: 10.1152/ajprenal.00320.2009. Epub 2009 Oct 21.


TGFbeta versatility: PI3K as a critical mediator of distinct cell type and context specific responses.

Rahimi RA, Leof EB.

Cell Cycle. 2009 Jun 15;8(12):1813-4. Epub 2009 Jun 6. No abstract available.


Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta.

Wilkes MC, Repellin CE, Hong M, Bracamonte M, Penheiter SG, Borg JP, Leof EB.

Dev Cell. 2009 Mar;16(3):433-44. doi: 10.1016/j.devcel.2009.01.009.


Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta.

Rahimi RA, Andrianifahanana M, Wilkes MC, Edens M, Kottom TJ, Blenis J, Leof EB.

Cancer Res. 2009 Jan 1;69(1):84-93. doi: 10.1158/0008-5472.CAN-08-2146.


Histologic studies of the intraocular toxicity of imatinib mesylate in rabbits.

Kitzmann AS, Baratz KH, Mohney BG, Pulido JS, Cameron JD, Lee ES, Leof EB.

Eye (Lond). 2008 May;22(5):712-4. doi: 10.1038/sj.eye.6703092. Epub 2008 Feb 1.


Phase I trial of sirolimus combined with radiation and cisplatin in non-small cell lung cancer.

Sarkaria JN, Schwingler P, Schild SE, Grogan PT, Mladek AC, Mandrekar SJ, Tan AD, Kobayashi T, Marks RS, Kita H, Miller RC, Limper AH, Leof EB.

J Thorac Oncol. 2007 Aug;2(8):751-7.


TGF-beta signaling: a tale of two responses.

Rahimi RA, Leof EB.

J Cell Biochem. 2007 Oct 15;102(3):593-608. Review.


A unique element in the cytoplasmic tail of the type II transforming growth factor-beta receptor controls basolateral delivery.

Murphy SJ, Shapira KE, Henis YI, Leof EB.

Mol Biol Cell. 2007 Oct;18(10):3788-99. Epub 2007 Jul 18.


Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2.

Wilkes MC, Mitchell H, Penheiter SG, Doré JJ, Suzuki K, Edens M, Sharma DK, Pagano RE, Leof EB.

Cancer Res. 2005 Nov 15;65(22):10431-40.


Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo.

Wang S, Wilkes MC, Leof EB, Hirschberg R.

FASEB J. 2005 Jan;19(1):1-11.


Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis.

Daniels CE, Wilkes MC, Edens M, Kottom TJ, Murphy SJ, Limper AH, Leof EB.

J Clin Invest. 2004 Nov;114(9):1308-16.


Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11.

Mitchell H, Choudhury A, Pagano RE, Leof EB.

Mol Biol Cell. 2004 Sep;15(9):4166-78. Epub 2004 Jun 30.


Differential trafficking of transforming growth factor-beta receptors and ligand in polarized epithelial cells.

Murphy SJ, Doré JJ, Edens M, Coffey RJ, Barnard JA, Mitchell H, Wilkes M, Leof EB.

Mol Biol Cell. 2004 Jun;15(6):2853-62. Epub 2004 Apr 9.


Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3.

Wilkes MC, Murphy SJ, Garamszegi N, Leof EB.

Mol Cell Biol. 2003 Dec;23(23):8878-89.


Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit.

Yao D, Ehrlich M, Henis YI, Leof EB.

Mol Biol Cell. 2002 Nov;13(11):4001-12.


Internalization-dependent and -independent requirements for transforming growth factor beta receptor signaling via the Smad pathway.

Penheiter SG, Mitchell H, Garamszegi N, Edens M, Doré JJ Jr, Leof EB.

Mol Cell Biol. 2002 Jul;22(13):4750-9.


Transforming growth factor beta receptor signaling and endocytosis are linked through a COOH terminal activation motif in the type I receptor.

Garamszegi N, Doré JJ Jr, Penheiter SG, Edens M, Yao D, Leof EB.

Mol Biol Cell. 2001 Sep;12(9):2881-93.


Differential regulation of growth and checkpoint control mediated by a Cdc25 mitotic phosphatase from Pneumocystis carinii.

Gustafson MP, Thomas CF Jr, Rusnak F, Limper AH, Leof EB.

J Biol Chem. 2001 Jan 5;276(1):835-43.


Growth factor receptor signalling: location, location, location.

Leof EB.

Trends Cell Biol. 2000 Aug;10(8):343-8. Review.


Pneumocystis carinii uses a functional cdc13 B-type cyclin complex during its life cycle.

Kottom TJ, Thomas CF Jr, Mubarak KK, Leof EB, Limper AH.

Am J Respir Cell Mol Biol. 2000 Jun;22(6):722-31.


In vitro assays for measuring TGF-beta growth stimulation and inhibition.

Edens M, Leof EB.

Methods Mol Biol. 2000;142:1-11. Review. No abstract available.


FKBP12 is a negative regulator of transforming growth factor-beta receptor internalization.

Yao D, Doré JJ Jr, Leof EB.

J Biol Chem. 2000 Apr 28;275(17):13149-54.


Analysis of Pneumocystis carinii introns.

Thomas CF Jr, Leof EB, Limper AH.

Infect Immun. 1999 Nov;67(11):6157-60.


Characterization of the Cdc25 phosphatase in Pneumocystis carinii.

Gustafson MP, Limper AH, Leof EB.

J Eukaryot Microbiol. 1999 Sep-Oct;46(5):129S. No abstract available.


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