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Items: 1 to 50 of 265

1.

NK cells are activated and primed for skin-homing during acute dengue virus infection in humans.

Zimmer CL, Cornillet M, Solà-Riera C, Cheung KW, Ivarsson MA, Lim MQ, Marquardt N, Leo YS, Lye DC, Klingström J, MacAry PA, Ljunggren HG, Rivino L, Björkström NK.

Nat Commun. 2019 Aug 29;10(1):3897. doi: 10.1038/s41467-019-11878-3.

2.

Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5.

Solà-Riera C, Gupta S, Maleki KT, González-Rodriguez P, Saidi D, Zimmer CL, Vangeti S, Rivino L, Leo YS, Lye DC, MacAry PA, Ahlm C, Smed-Sörensen A, Joseph B, Björkström NK, Ljunggren HG, Klingström J.

Cell Rep. 2019 Aug 20;28(8):2124-2139.e6. doi: 10.1016/j.celrep.2019.07.066.

3.

Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients.

Amrun SN, Yee WX, Abu Bakar F, Lee B, Kam YW, Lum FM, Tan JJ, Lim VW, Watthanaworawit W, Ling C, Nosten F, Renia L, Leo YS, Ng LF.

Clin Transl Immunology. 2019 Jul 26;8(7):e1066. doi: 10.1002/cti2.1066. eCollection 2019.

4.

Incidence of syphilis among HIV-infected men in Singapore, 2006-2017: temporal trends and associated risk factors.

Ang LW, Wong CS, Ng OT, Leo YS.

Sex Transm Infect. 2019 Aug 1. pii: sextrans-2019-054163. doi: 10.1136/sextrans-2019-054163. [Epub ahead of print]

5.

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection.

Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azziz-Baumgartner E, Bajjou T, Bassetti M, Beovic B, Bertisch B, Bonmarin I, Booy R, Borja-Aburto VH, Burgmann H, Cao B, Carratala J, Chinbayar T, Cilloniz C, Denholm JT, Dominguez SR, Duarte PAD, Dubnov-Raz G, Fanella S, Gao Z, Gérardin P, Giannella M, Gubbels S, Herberg J, Higuera Iglesias AL, Hoeger PH, Hu XY, Islam QT, Jiménez MF, Keijzers G, Khalili H, Kusznierz G, Kuzman I, Langenegger E, Lankarani KB, Leo YS, Libster RP, Linko R, Madanat F, Maltezos E, Mamun A, Manabe T, Metan G, Mickiene A, Mikić D, Mohn KGI, Oliva ME, Ozkan M, Parekh D, Paul M, Rath BA, Refaey S, Rodríguez AH, Sertogullarindan B, Skręt-Magierło J, Somer A, Talarek E, Tang JW, To K, Tran D, Uyeki TM, Vaudry W, Vidmar T, Zarogoulidis P; PRIDE Consortium Investigators , Nguyen-Van-Tam JS.

J Infect Dis. 2019 Jul 17. pii: jiz152. doi: 10.1093/infdis/jiz152. [Epub ahead of print]

PMID:
31314899
6.

Factors Associated with Hepatitis B and C Co-Infection among HIV-Infected Patients in Singapore, 2006-2017.

Choy CY, Ang LW, Ng OT, Leo YS, Wong CS.

Trop Med Infect Dis. 2019 May 27;4(2). pii: E87. doi: 10.3390/tropicalmed4020087.

7.

A 15-year review of dengue hospitalizations in Singapore: Reducing admissions without adverse consequences, 2003 to 2017.

Ang LW, Thein TL, Ng Y, Boudville IC, Chia PY, Lee VJM, Leo YS.

PLoS Negl Trop Dis. 2019 May 15;13(5):e0007389. doi: 10.1371/journal.pntd.0007389. eCollection 2019 May.

8.

Differential age-specific distribution of influenza virus types and subtypes in tropical Singapore, 2011 to 2017.

Ang LW, Cui L, Mak TM, Ng Y, Leo YS, Lee VJM, Lin RT.

J Med Virol. 2019 Aug;91(8):1415-1422. doi: 10.1002/jmv.25473. Epub 2019 Apr 9.

PMID:
30927452
9.

ZIKV-Specific NS1 Epitopes as Serological Markers of Acute Zika Virus Infection.

Kam YW, Leite JA, Amrun SN, Lum FM, Yee WX, Bakar FA, Eng KE, Lye DC, Leo YS, Chong CY, Freitas ARR, Milanez GP, Proença-Modena JL, Rénia L, Costa FTM, Ng LFP; Zika-Unicamp Network .

J Infect Dis. 2019 Jun 19;220(2):203-212. doi: 10.1093/infdis/jiz092.

PMID:
30901054
10.

Multiplex targeted mass spectrometry assay for one-shot flavivirus diagnosis.

Wee S, Alli-Shaik A, Kek R, Swa HLF, Tien WP, Lim VW, Leo YS, Ng LC, Hapuarachchi HC, Gunaratne J.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6754-6759. doi: 10.1073/pnas.1817867116. Epub 2019 Mar 18.

11.

Hyperlipidemia, statin use and dengue severity.

Chia PY, Htun HL, Ling WP, Leo YS, Yeo TW, Lye DCB.

Sci Rep. 2018 Nov 21;8(1):17147. doi: 10.1038/s41598-018-35334-2.

12.

Development of standard clinical endpoints for use in dengue interventional trials: introduction and methodology.

Jaenisch T, Hendrickx K, Erpicum M, Agulto L, Tomashek KM, Dempsey W, Siqueira JB, Marks MA, Fay MP, Laughlin C, L'Azou M, Leo YS, Narvaez F, Teyssou R, Thomas SJ, Tissera H, Wallace D, Wilder-Smith A, Gubler DJ, Cassetti MC.

BMC Med Res Methodol. 2018 Nov 15;18(1):134. doi: 10.1186/s12874-018-0601-z.

13.

Serological evidence of human infection by bat orthoreovirus in Singapore.

Uehara A, Tan CW, Mani S, Chua KB, Leo YS, Anderson DE, Wang LF.

J Med Virol. 2019 Apr;91(4):707-710. doi: 10.1002/jmv.25355. Epub 2018 Nov 28.

PMID:
30411364
14.

Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus.

Lim MQ, Kumaran EAP, Tan HC, Lye DC, Leo YS, Ooi EE, MacAry PA, Bertoletti A, Rivino L.

Front Immunol. 2018 Oct 1;9:2225. doi: 10.3389/fimmu.2018.02225. eCollection 2018.

15.

Factors influencing seasonal influenza vaccination uptake among health care workers in an adult tertiary care hospital in Singapore: A cross-sectional survey.

Kyaw WM, Chow A, Hein AA, Lee LT, Leo YS, Ho HJ.

Am J Infect Control. 2019 Feb;47(2):133-138. doi: 10.1016/j.ajic.2018.08.011. Epub 2018 Oct 4.

PMID:
30293741
16.

Development of standard clinical endpoints for use in dengue interventional trials.

Tomashek KM, Wills B, See Lum LC, Thomas L, Durbin A, Leo YS, de Bosch N, Rojas E, Hendrickx K, Erpicum M, Agulto L, Jaenisch T, Tissera H, Suntarattiwong P, Collers BA, Wallace D, Schmidt AC, Precioso A, Narvaez F, Thomas SJ, Edelman R, Siqueira JB, Cassetti MC, Dempsey W, Gubler DJ.

PLoS Negl Trop Dis. 2018 Oct 4;12(10):e0006497. doi: 10.1371/journal.pntd.0006497. eCollection 2018 Oct.

17.

High Yield of HIV Testing in Dengue-Like Febrile Illness in Singapore.

Verrall AJ, Lye DC, Pada S, Smitasin N, Lee CK, Khoo MJ, Koay ES, Leo YS, Fisher DA, Archuleta S.

Open Forum Infect Dis. 2018 Jul 13;5(8):ofy171. doi: 10.1093/ofid/ofy171. eCollection 2018 Aug.

18.

Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore.

Xu C, Pang J, Hsu JP, Leo YS, Lye DCB.

PLoS One. 2018 Aug 15;13(8):e0201441. doi: 10.1371/journal.pone.0201441. eCollection 2018.

19.

The 2016 Singapore Zika virus outbreak did not cause a surge in Guillain-Barré syndrome.

Umapathi T, Kam YW, Ohnmar O, Ng BCJ, Ng Y, Premikha M, Leo YS, Ng LFP.

J Peripher Nerv Syst. 2018 Sep;23(3):197-201. doi: 10.1111/jns.12284. Epub 2018 Aug 21.

PMID:
30070025
20.

Methicillin-resistant Staphylococcus aureus colonisation: epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore.

Htun HL, Kyaw WM, de Sessions PF, Low L, Hibberd ML, Chow A, Leo YS.

Epidemiol Infect. 2018 Oct;146(14):1785-1792. doi: 10.1017/S0950268818001966. Epub 2018 Jul 18.

PMID:
30019657
21.

Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore.

Yan G, Pang L, Cook AR, Ho HJ, Win MS, Khoo AL, Wong JGX, Lee CK, Yan B, Jureen R, Ho SS, Lye DC, Tambyah PA, Leo YS, Fisher D, Oon J, Bagdasarian N, Chow A, Smitasin N, Chai LYA.

Emerg Infect Dis. 2018 Aug;24(8):1565-1568. doi: 10.3201/eid2408.171883.

22.

Correlation of clinical illness with viremia in Zika virus disease during an outbreak in Singapore.

Ng DHL, Ho HJ, Chow A, Wong J, Kyaw WM, Tan A, Chia PY, Choy CY, Tan G, Yeo TW, Leo YS.

BMC Infect Dis. 2018 Jul 4;18(1):301. doi: 10.1186/s12879-018-3211-9.

23.

An unusual outbreak of rotavirus G8P[8] gastroenteritis in adults in an urban community, Singapore, 2016.

Chia G, Ho HJ, Ng CG, Neo FJ, Win MK, Cui L, Leo YS, Chow A.

J Clin Virol. 2018 Aug;105:57-63. doi: 10.1016/j.jcv.2018.06.004. Epub 2018 Jun 6.

PMID:
29902679
24.

An Outbreak of Streptococcus pyogenes in a Mental Health Facility: Advantage of Well-Timed Whole-Genome Sequencing Over emm Typing.

Bergin SM, Periaswamy B, Barkham T, Chua HC, Mok YM, Fung DSS, Su AHC, Lee YL, Chua MLI, Ng PY, Soon WJW, Chu CW, Tan SL, Meehan M, Ang BSP, Leo YS, Holden MTG, De P, Hsu LY, Chen SL, de Sessions PF, Marimuthu K.

Infect Control Hosp Epidemiol. 2018 Jul;39(7):852-860. doi: 10.1017/ice.2018.101. Epub 2018 May 9.

PMID:
29739475
25.

Longitudinal Study of Cellular and Systemic Cytokine Signatures to Define the Dynamics of a Balanced Immune Environment During Disease Manifestation in Zika Virus-Infected Patients.

Lum FM, Lye DCB, Tan JJL, Lee B, Chia PY, Chua TK, Amrun SN, Kam YW, Yee WX, Ling WP, Lim VWX, Pang VJX, Lee LK, Mok EWH, Chong CY, Leo YS, Ng LFP.

J Infect Dis. 2018 Jul 24;218(5):814-824. doi: 10.1093/infdis/jiy225.

26.

Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity.

Lum FM, Lee D, Chua TK, Tan JJL, Lee CYP, Liu X, Fang Y, Lee B, Yee WX, Rickett NY, Chia PY, Lim V, Leo YS, Matthews DA, Hiscox JA, Ng LFP.

mSphere. 2018 Mar 28;3(2). pii: e00120-18. doi: 10.1128/mSphereDirect.00120-18. eCollection 2018 Mar-Apr.

27.

Metformin Use and Severe Dengue in Diabetic Adults.

Htun HL, Yeo TW, Tam CC, Pang J, Leo YS, Lye DC.

Sci Rep. 2018 Feb 20;8(1):3344. doi: 10.1038/s41598-018-21612-6.

28.

Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity.

Lum FM, Couderc T, Chia BS, Ong RY, Her Z, Chow A, Leo YS, Kam YW, Rénia L, Lecuit M, Ng LFP.

Sci Rep. 2018 Jan 30;8(1):1860. doi: 10.1038/s41598-018-20305-4.

29.

Serum metabolome changes in adult patients with severe dengue in the critical and recovery phases of dengue infection.

Cui L, Pang J, Lee YH, Ooi EE, Ong CN, Leo YS, Tannenbaum SR.

PLoS Negl Trop Dis. 2018 Jan 24;12(1):e0006217. doi: 10.1371/journal.pntd.0006217. eCollection 2018 Jan.

30.

Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore.

Tan CH, Tan LK, Hapuarachchi HC, Lai YL, Wong PSJ, Yap G, Mak KW, Wong WY, Leo YS, Wong MC, Ng LC.

Viruses. 2018 Jan 18;10(1). pii: E44. doi: 10.3390/v10010044.

31.

Diagnostic Accuracy of Parameters for Zika and Dengue Virus Infections, Singapore.

Ho HJ, Wong JGX, Mar Kyaw W, Lye DC, Leo YS, Chow A.

Emerg Infect Dis. 2017 Dec;23(12):2085-2088. doi: 10.3201/eid2312.171224.

32.

Epidemiology and Relative Severity of Influenza Subtypes in Singapore in the Post-Pandemic Period from 2009 to 2010.

Goh EH, Jiang L, Hsu JP, Tan LWL, Lim WY, Phoon MC, Leo YS, Barr IG, Chow VTK, Lee VJ, Lin C, Lin R, Sadarangani SP, Young B, Chen MI.

Clin Infect Dis. 2017 Nov 13;65(11):1905-1913. doi: 10.1093/cid/cix694.

33.

Progress and Challenges towards Point-of-Care Diagnostic Development for Dengue.

Pang J, Chia PY, Lye DC, Leo YS.

J Clin Microbiol. 2017 Dec;55(12):3339-3349. doi: 10.1128/JCM.00707-17. Epub 2017 Sep 13. Review.

34.

Persistence of Zika virus in conjunctival fluid of convalescence patients.

Tan JJL, Balne PK, Leo YS, Tong L, Ng LFP, Agrawal R.

Sci Rep. 2017 Sep 11;7(1):11194. doi: 10.1038/s41598-017-09479-5.

35.

Contacts of healthcare workers, patients and visitors in general wards in Singapore.

Jiang L, Ng HL, Ho HJ, Leo YS, Prem K, Cook AR, Chen MI.

Epidemiol Infect. 2017 Oct;145(14):3085-3095. doi: 10.1017/S0950268817002035. Epub 2017 Sep 8.

PMID:
28885136
36.

Mapping infectious disease hospital surge threats to lessons learnt in Singapore: a systems analysis and development of a framework to inform how to DECIDE on planning and response strategies.

Singh SR, Coker R, Vrijhoef HJ, Leo YS, Chow A, Lim PL, Tan Q, Chen MI, Hildon ZJ.

BMC Health Serv Res. 2017 Sep 4;17(1):622. doi: 10.1186/s12913-017-2552-1.

37.

Dengue in the elderly: a review.

Lin RJ, Lee TH, Leo YS.

Expert Rev Anti Infect Ther. 2017 Aug;15(8):729-735. doi: 10.1080/14787210.2017.1358610. Epub 2017 Jul 28. Review.

PMID:
28730853
38.

Comparing patient and healthcare worker experiences during a dengue outbreak in Singapore: understanding the patient journey and the introduction of a point-of-care test (POCT) toward better care delivery.

Tan Q, Hildon ZJ, Singh S, Jing J, Thein TL, Coker R, Vrijhoef HJM, Leo YS.

BMC Infect Dis. 2017 Jul 19;17(1):503. doi: 10.1186/s12879-017-2580-9.

39.
40.

A Sensitive Method for Detecting Zika Virus Antigen in Patients' Whole-Blood Specimens as an Alternative Diagnostic Approach.

Lum FM, Lin C, Susova OY, Teo TH, Fong SW, Mak TM, Lee LK, Chong CY, Lye DCB, Lin RTP, Merits A, Leo YS, Ng LFP.

J Infect Dis. 2017 Jul 15;216(2):182-190. doi: 10.1093/infdis/jix276.

41.

Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity.

Tang TH, Alonso S, Ng LF, Thein TL, Pang VJ, Leo YS, Lye DC, Yeo TW.

Sci Rep. 2017 Apr 10;7:46191. doi: 10.1038/srep46191.

42.

Serodiagnosis of dengue virus infection using commercially available antibody and NS1 antigen ELISAs.

Granger D, Leo YS, Lee LK, Theel ES.

Diagn Microbiol Infect Dis. 2017 Jun;88(2):120-124. doi: 10.1016/j.diagmicrobio.2017.03.015. Epub 2017 Mar 30.

PMID:
28389145
43.

Clinical features of patients with Zika and dengue virus co-infection in Singapore.

Chia PY, Yew HS, Ho H, Chow A, Sadarangani SP, Chan M, Kam YW, Chong CY, Thoon KC, Yung CF, Li JH, Lye DC, De PP, Ng LFP, Yeo TW, Leo YS.

J Infect. 2017 Jun;74(6):611-615. doi: 10.1016/j.jinf.2017.03.007. Epub 2017 Mar 23. No abstract available.

PMID:
28344113
44.

Zika Virus and the Eye.

Agrawal R, Oo HH, Balne PK, Ng L, Tong L, Leo YS.

Ocul Immunol Inflamm. 2018;26(5):654-659. doi: 10.1080/09273948.2017.1294184. Epub 2017 Mar 20. Review.

PMID:
28318359
45.

Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial.

Lye DC, Archuleta S, Syed-Omar SF, Low JG, Oh HM, Wei Y, Fisher D, Ponnampalavanar SSL, Wijaya L, Lee LK, Ooi EE, Kamarulzaman A, Lum LC, Tambyah PA, Leo YS.

Lancet. 2017 Apr 22;389(10079):1611-1618. doi: 10.1016/S0140-6736(17)30269-6. Epub 2017 Mar 8.

PMID:
28283286
46.

Serological response to trivalent inactivated influenza vaccine in HIV-infected adults in Singapore.

Lau YF, Tang LH, Chien Lye D, Ooi EE, Leo YS.

Hum Vaccin Immunother. 2017 Mar 4;13(3):551-560. doi: 10.1080/21645515.2016.1246636. Epub 2017 Feb 17.

47.

Detection of viral respiratory pathogens in mild and severe acute respiratory infections in Singapore.

Jiang L, Lee VJ, Cui L, Lin R, Tan CL, Tan LW, Lim WY, Leo YS, Low L, Hibberd M, Chen MI.

Sci Rep. 2017 Feb 20;7:42963. doi: 10.1038/srep42963.

48.

Results from a Patient-Based Health Education Intervention in Reducing Antibiotic Use for Acute Upper Respiratory Tract Infections in the Private Sector Primary Care Setting in Singapore.

Lee MHM, Pan DST, Huang JH, Chen MI, Chong JWC, Goh EH, Jiang L, Leo YS, Lee TH, Wong CS, Loh VWK, Lim FS, Poh AZ, Tham TY, Wong WM, Yu Y.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02257-16. doi: 10.1128/AAC.02257-16. Print 2017 May.

49.

The immune response to 6-monthly versus annual standard dose inactivated trivalent influenza vaccination in older people: study protocol for a randomised clinical trial.

Young B, Sadarangani S, Yew HS, Yung CF, Leo YS, Chen MI, Wilder-Smith A.

Trials. 2017 Feb 10;18(1):67. doi: 10.1186/s13063-017-1808-8.

50.

Assessing Sensitivity and Specificity of Surveillance Case Definitions for Zika Virus Disease.

Chow A, Ho H, Win MK, Leo YS.

Emerg Infect Dis. 2017 Apr;23(4):677-679. doi: 10.3201/eid2304.161716. Epub 2017 Apr 15.

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