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COVID-19 in Singapore-Current Experience: Critical Global Issues That Require Attention and Action.

Wong JEL, Leo YS, Tan CC.

JAMA. 2020 Feb 20. doi: 10.1001/jama.2020.2467. [Epub ahead of print] No abstract available.


Of migration, macaques, mice and men.

Tay JY, Vasoo S, Leo YS.

Singapore Med J. 2020 Jan 28. doi: 10.11622/smedj.2020010. [Epub ahead of print] No abstract available.


Severe dengue and liver involvement: an overview and review of the literature.

Chia PY, Thein TL, Ong SWX, Lye DC, Leo YS.

Expert Rev Anti Infect Ther. 2020 Mar;18(3):181-189. doi: 10.1080/14787210.2020.1720652. Epub 2020 Feb 3.


Dynamic dengue haemorrhagic fever calculators as clinical decision support tools in adult dengue.

Tan KW, Tan B, Thein TL, Leo YS, Lye DC, Dickens BL, Wong JGX, Cook AR.

Trans R Soc Trop Med Hyg. 2020 Jan 6;114(1):7-15. doi: 10.1093/trstmh/trz099.


Safety and immunogenicity of a single dose of a tetravalent dengue vaccine with two different serotype-2 potencies in adults in Singapore: A phase 2, double-blind, randomised, controlled trial.

Tricou V, Low JG, Oh HM, Leo YS, Kalimuddin S, Wijaya L, Pang J, Ling LM, Lee TH, Brose M, Hutagalung Y, Rauscher M, Borkowski A, Wallace D.

Vaccine. 2020 Feb 5;38(6):1513-1519. doi: 10.1016/j.vaccine.2019.11.061. Epub 2019 Dec 13.


Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates.

Chng MHY, Lim MQ, Rouers A, Becht E, Lee B, MacAry PA, Lye DC, Leo YS, Chen J, Fink K, Rivino L, Newell EW.

Immunity. 2019 Dec 17;51(6):1119-1135.e5. doi: 10.1016/j.immuni.2019.10.007. Epub 2019 Nov 19.


Passive immune therapy and other immunomodulatory agents for the treatment of severe influenza: Systematic review and meta-analysis.

Lim VW, Tudor Car L, Leo YS, Chen MI, Young B.

Influenza Other Respir Viruses. 2019 Nov 16. doi: 10.1111/irv.12699. [Epub ahead of print]


Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women.

Lum FM, Narang V, Hue S, Chen J, McGovern N, Rajarethinam R, Tan JJ, Amrun SN, Chan YH, Lee CY, Chua TK, Yee WX, Yeo NK, Tan TC, Liu X, Haldenby S, Leo YS, Ginhoux F, Chan JK, Hiscox J, Chong CY, Ng LF.

Clin Transl Immunology. 2019 Nov 5;8(11):e01082. doi: 10.1002/cti2.1082. eCollection 2019.


Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore.

Ivan FX, Zhou X, Lau SH, Rashid S, Teo JSM, Lee HK, Koay ES, Chan KP, Leo YS, Chen MIC, Kwoh CK, Chow VT.

Int J Infect Dis. 2020 Jan;90:84-96. doi: 10.1016/j.ijid.2019.10.024. Epub 2019 Oct 25.


A case of imported Monkeypox in Singapore.

Ng OT, Lee V, Marimuthu K, Vasoo S, Chan G, Lin RTP, Leo YS.

Lancet Infect Dis. 2019 Nov;19(11):1166. doi: 10.1016/S1473-3099(19)30537-7. No abstract available.


Predictors and Clinical Outcomes of Poor Platelet Recovery in Adult Dengue With Thrombocytopenia: A Multicenter, Prospective Study.

Archuleta S, Chia PY, Wei Y, Syed-Omar SF, Low JG, Oh HM, Fisher D, Ponnampalavanar SSL, Wijaya L, Kamarulzaman A, Lum LCS, Tambyah PA, Leo YS, Lye DC.

Clin Infect Dis. 2019 Oct 18. pii: ciz850. doi: 10.1093/cid/ciz850. [Epub ahead of print]


NK cells are activated and primed for skin-homing during acute dengue virus infection in humans.

Zimmer CL, Cornillet M, Solà-Riera C, Cheung KW, Ivarsson MA, Lim MQ, Marquardt N, Leo YS, Lye DC, Klingström J, MacAry PA, Ljunggren HG, Rivino L, Björkström NK.

Nat Commun. 2019 Aug 29;10(1):3897. doi: 10.1038/s41467-019-11878-3.


Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5.

Solà-Riera C, Gupta S, Maleki KT, González-Rodriguez P, Saidi D, Zimmer CL, Vangeti S, Rivino L, Leo YS, Lye DC, MacAry PA, Ahlm C, Smed-Sörensen A, Joseph B, Björkström NK, Ljunggren HG, Klingström J.

Cell Rep. 2019 Aug 20;28(8):2124-2139.e6. doi: 10.1016/j.celrep.2019.07.066.


Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients.

Amrun SN, Yee WX, Abu Bakar F, Lee B, Kam YW, Lum FM, Tan JJ, Lim VW, Watthanaworawit W, Ling C, Nosten F, Renia L, Leo YS, Ng LF.

Clin Transl Immunology. 2019 Jul 26;8(7):e1066. doi: 10.1002/cti2.1066. eCollection 2019.


Incidence of syphilis among HIV-infected men in Singapore, 2006-2017: temporal trends and associated risk factors.

Ang LW, Wong CS, Ng OT, Leo YS.

Sex Transm Infect. 2019 Aug 1. pii: sextrans-2019-054163. doi: 10.1136/sextrans-2019-054163. [Epub ahead of print]


Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection.

Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azziz-Baumgartner E, Bajjou T, Bassetti M, Beovic B, Bertisch B, Bonmarin I, Booy R, Borja-Aburto VH, Burgmann H, Cao B, Carratala J, Chinbayar T, Cilloniz C, Denholm JT, Dominguez SR, Duarte PAD, Dubnov-Raz G, Fanella S, Gao Z, Gérardin P, Giannella M, Gubbels S, Herberg J, Higuera Iglesias AL, Hoeger PH, Hu XY, Islam QT, Jiménez MF, Keijzers G, Khalili H, Kusznierz G, Kuzman I, Langenegger E, Lankarani KB, Leo YS, Libster RP, Linko R, Madanat F, Maltezos E, Mamun A, Manabe T, Metan G, Mickiene A, Mikić D, Mohn KGI, Oliva ME, Ozkan M, Parekh D, Paul M, Rath BA, Refaey S, Rodríguez AH, Sertogullarindan B, Skręt-Magierło J, Somer A, Talarek E, Tang JW, To K, Tran D, Uyeki TM, Vaudry W, Vidmar T, Zarogoulidis P; PRIDE Consortium Investigators , Nguyen-Van-Tam JS.

J Infect Dis. 2020 Jan 14;221(3):356-366. doi: 10.1093/infdis/jiz152.


Factors Associated with Hepatitis B and C Co-Infection among HIV-Infected Patients in Singapore, 2006-2017.

Choy CY, Ang LW, Ng OT, Leo YS, Wong CS.

Trop Med Infect Dis. 2019 May 27;4(2). pii: E87. doi: 10.3390/tropicalmed4020087.


A 15-year review of dengue hospitalizations in Singapore: Reducing admissions without adverse consequences, 2003 to 2017.

Ang LW, Thein TL, Ng Y, Boudville IC, Chia PY, Lee VJM, Leo YS.

PLoS Negl Trop Dis. 2019 May 15;13(5):e0007389. doi: 10.1371/journal.pntd.0007389. eCollection 2019 May.


Differential age-specific distribution of influenza virus types and subtypes in tropical Singapore, 2011 to 2017.

Ang LW, Cui L, Mak TM, Ng Y, Leo YS, Lee VJM, Lin RT.

J Med Virol. 2019 Aug;91(8):1415-1422. doi: 10.1002/jmv.25473. Epub 2019 Apr 9.


ZIKV-Specific NS1 Epitopes as Serological Markers of Acute Zika Virus Infection.

Kam YW, Leite JA, Amrun SN, Lum FM, Yee WX, Bakar FA, Eng KE, Lye DC, Leo YS, Chong CY, Freitas ARR, Milanez GP, Proença-Modena JL, Rénia L, Costa FTM, Ng LFP; Zika-Unicamp Network.

J Infect Dis. 2019 Jun 19;220(2):203-212. doi: 10.1093/infdis/jiz092.


Multiplex targeted mass spectrometry assay for one-shot flavivirus diagnosis.

Wee S, Alli-Shaik A, Kek R, Swa HLF, Tien WP, Lim VW, Leo YS, Ng LC, Hapuarachchi HC, Gunaratne J.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6754-6759. doi: 10.1073/pnas.1817867116. Epub 2019 Mar 18.


Hyperlipidemia, statin use and dengue severity.

Chia PY, Htun HL, Ling WP, Leo YS, Yeo TW, Lye DCB.

Sci Rep. 2018 Nov 21;8(1):17147. doi: 10.1038/s41598-018-35334-2.


Development of standard clinical endpoints for use in dengue interventional trials: introduction and methodology.

Jaenisch T, Hendrickx K, Erpicum M, Agulto L, Tomashek KM, Dempsey W, Siqueira JB, Marks MA, Fay MP, Laughlin C, L'Azou M, Leo YS, Narvaez F, Teyssou R, Thomas SJ, Tissera H, Wallace D, Wilder-Smith A, Gubler DJ, Cassetti MC.

BMC Med Res Methodol. 2018 Nov 15;18(1):134. doi: 10.1186/s12874-018-0601-z.


Serological evidence of human infection by bat orthoreovirus in Singapore.

Uehara A, Tan CW, Mani S, Chua KB, Leo YS, Anderson DE, Wang LF.

J Med Virol. 2019 Apr;91(4):707-710. doi: 10.1002/jmv.25355. Epub 2018 Nov 28.


Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus.

Lim MQ, Kumaran EAP, Tan HC, Lye DC, Leo YS, Ooi EE, MacAry PA, Bertoletti A, Rivino L.

Front Immunol. 2018 Oct 1;9:2225. doi: 10.3389/fimmu.2018.02225. eCollection 2018.


Factors influencing seasonal influenza vaccination uptake among health care workers in an adult tertiary care hospital in Singapore: A cross-sectional survey.

Kyaw WM, Chow A, Hein AA, Lee LT, Leo YS, Ho HJ.

Am J Infect Control. 2019 Feb;47(2):133-138. doi: 10.1016/j.ajic.2018.08.011. Epub 2018 Oct 4.


Development of standard clinical endpoints for use in dengue interventional trials.

Tomashek KM, Wills B, See Lum LC, Thomas L, Durbin A, Leo YS, de Bosch N, Rojas E, Hendrickx K, Erpicum M, Agulto L, Jaenisch T, Tissera H, Suntarattiwong P, Collers BA, Wallace D, Schmidt AC, Precioso A, Narvaez F, Thomas SJ, Edelman R, Siqueira JB, Cassetti MC, Dempsey W, Gubler DJ.

PLoS Negl Trop Dis. 2018 Oct 4;12(10):e0006497. doi: 10.1371/journal.pntd.0006497. eCollection 2018 Oct.


High Yield of HIV Testing in Dengue-Like Febrile Illness in Singapore.

Verrall AJ, Lye DC, Pada S, Smitasin N, Lee CK, Khoo MJ, Koay ES, Leo YS, Fisher DA, Archuleta S.

Open Forum Infect Dis. 2018 Jul 13;5(8):ofy171. doi: 10.1093/ofid/ofy171. eCollection 2018 Aug.


Differences in clinical features and dengue severity between local and migrant Chinese with dengue infection in Singapore.

Xu C, Pang J, Hsu JP, Leo YS, Lye DCB.

PLoS One. 2018 Aug 15;13(8):e0201441. doi: 10.1371/journal.pone.0201441. eCollection 2018.


The 2016 Singapore Zika virus outbreak did not cause a surge in Guillain-Barré syndrome.

Umapathi T, Kam YW, Ohnmar O, Ng BCJ, Ng Y, Premikha M, Leo YS, Ng LFP.

J Peripher Nerv Syst. 2018 Sep;23(3):197-201. doi: 10.1111/jns.12284. Epub 2018 Aug 21.


Methicillin-resistant Staphylococcus aureus colonisation: epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore.

Htun HL, Kyaw WM, de Sessions PF, Low L, Hibberd ML, Chow A, Leo YS.

Epidemiol Infect. 2018 Oct;146(14):1785-1792. doi: 10.1017/S0950268818001966. Epub 2018 Jul 18.


Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore.

Yan G, Pang L, Cook AR, Ho HJ, Win MS, Khoo AL, Wong JGX, Lee CK, Yan B, Jureen R, Ho SS, Lye DC, Tambyah PA, Leo YS, Fisher D, Oon J, Bagdasarian N, Chow A, Smitasin N, Chai LYA.

Emerg Infect Dis. 2018 Aug;24(8):1565-1568. doi: 10.3201/eid2408.171883.


Correlation of clinical illness with viremia in Zika virus disease during an outbreak in Singapore.

Ng DHL, Ho HJ, Chow A, Wong J, Kyaw WM, Tan A, Chia PY, Choy CY, Tan G, Yeo TW, Leo YS.

BMC Infect Dis. 2018 Jul 4;18(1):301. doi: 10.1186/s12879-018-3211-9.


An unusual outbreak of rotavirus G8P[8] gastroenteritis in adults in an urban community, Singapore, 2016.

Chia G, Ho HJ, Ng CG, Neo FJ, Win MK, Cui L, Leo YS, Chow A.

J Clin Virol. 2018 Aug;105:57-63. doi: 10.1016/j.jcv.2018.06.004. Epub 2018 Jun 6.


An Outbreak of Streptococcus pyogenes in a Mental Health Facility: Advantage of Well-Timed Whole-Genome Sequencing Over emm Typing.

Bergin SM, Periaswamy B, Barkham T, Chua HC, Mok YM, Fung DSS, Su AHC, Lee YL, Chua MLI, Ng PY, Soon WJW, Chu CW, Tan SL, Meehan M, Ang BSP, Leo YS, Holden MTG, De P, Hsu LY, Chen SL, de Sessions PF, Marimuthu K.

Infect Control Hosp Epidemiol. 2018 Jul;39(7):852-860. doi: 10.1017/ice.2018.101. Epub 2018 May 9.


Longitudinal Study of Cellular and Systemic Cytokine Signatures to Define the Dynamics of a Balanced Immune Environment During Disease Manifestation in Zika Virus-Infected Patients.

Lum FM, Lye DCB, Tan JJL, Lee B, Chia PY, Chua TK, Amrun SN, Kam YW, Yee WX, Ling WP, Lim VWX, Pang VJX, Lee LK, Mok EWH, Chong CY, Leo YS, Ng LFP.

J Infect Dis. 2018 Jul 24;218(5):814-824. doi: 10.1093/infdis/jiy225.


Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity.

Lum FM, Lee D, Chua TK, Tan JJL, Lee CYP, Liu X, Fang Y, Lee B, Yee WX, Rickett NY, Chia PY, Lim V, Leo YS, Matthews DA, Hiscox JA, Ng LFP.

mSphere. 2018 Mar 28;3(2). pii: e00120-18. doi: 10.1128/mSphereDirect.00120-18. eCollection 2018 Mar-Apr.


Metformin Use and Severe Dengue in Diabetic Adults.

Htun HL, Yeo TW, Tam CC, Pang J, Leo YS, Lye DC.

Sci Rep. 2018 Feb 20;8(1):3344. doi: 10.1038/s41598-018-21612-6.


Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity.

Lum FM, Couderc T, Chia BS, Ong RY, Her Z, Chow A, Leo YS, Kam YW, Rénia L, Lecuit M, Ng LFP.

Sci Rep. 2018 Jan 30;8(1):1860. doi: 10.1038/s41598-018-20305-4.


Serum metabolome changes in adult patients with severe dengue in the critical and recovery phases of dengue infection.

Cui L, Pang J, Lee YH, Ooi EE, Ong CN, Leo YS, Tannenbaum SR.

PLoS Negl Trop Dis. 2018 Jan 24;12(1):e0006217. doi: 10.1371/journal.pntd.0006217. eCollection 2018 Jan.


Viral and Antibody Kinetics, and Mosquito Infectivity of an Imported Case of Zika Fever Due to Asian Genotype (American Strain) in Singapore.

Tan CH, Tan LK, Hapuarachchi HC, Lai YL, Wong PSJ, Yap G, Mak KW, Wong WY, Leo YS, Wong MC, Ng LC.

Viruses. 2018 Jan 18;10(1). pii: E44. doi: 10.3390/v10010044.


Diagnostic Accuracy of Parameters for Zika and Dengue Virus Infections, Singapore.

Ho HJ, Wong JGX, Mar Kyaw W, Lye DC, Leo YS, Chow A.

Emerg Infect Dis. 2017 Dec;23(12):2085-2088. doi: 10.3201/eid2312.171224.


Epidemiology and Relative Severity of Influenza Subtypes in Singapore in the Post-Pandemic Period from 2009 to 2010.

Goh EH, Jiang L, Hsu JP, Tan LWL, Lim WY, Phoon MC, Leo YS, Barr IG, Chow VTK, Lee VJ, Lin C, Lin R, Sadarangani SP, Young B, Chen MI.

Clin Infect Dis. 2017 Nov 13;65(11):1905-1913. doi: 10.1093/cid/cix694.


Progress and Challenges towards Point-of-Care Diagnostic Development for Dengue.

Pang J, Chia PY, Lye DC, Leo YS.

J Clin Microbiol. 2017 Dec;55(12):3339-3349. doi: 10.1128/JCM.00707-17. Epub 2017 Sep 13. Review.


Persistence of Zika virus in conjunctival fluid of convalescence patients.

Tan JJL, Balne PK, Leo YS, Tong L, Ng LFP, Agrawal R.

Sci Rep. 2017 Sep 11;7(1):11194. doi: 10.1038/s41598-017-09479-5.


Contacts of healthcare workers, patients and visitors in general wards in Singapore.

Jiang L, Ng HL, Ho HJ, Leo YS, Prem K, Cook AR, Chen MI.

Epidemiol Infect. 2017 Oct;145(14):3085-3095. doi: 10.1017/S0950268817002035. Epub 2017 Sep 8.


Mapping infectious disease hospital surge threats to lessons learnt in Singapore: a systems analysis and development of a framework to inform how to DECIDE on planning and response strategies.

Singh SR, Coker R, Vrijhoef HJ, Leo YS, Chow A, Lim PL, Tan Q, Chen MI, Hildon ZJ.

BMC Health Serv Res. 2017 Sep 4;17(1):622. doi: 10.1186/s12913-017-2552-1.


Dengue in the elderly: a review.

Lin RJ, Lee TH, Leo YS.

Expert Rev Anti Infect Ther. 2017 Aug;15(8):729-735. doi: 10.1080/14787210.2017.1358610. Epub 2017 Jul 28. Review.


Comparing patient and healthcare worker experiences during a dengue outbreak in Singapore: understanding the patient journey and the introduction of a point-of-care test (POCT) toward better care delivery.

Tan Q, Hildon ZJ, Singh S, Jing J, Thein TL, Coker R, Vrijhoef HJM, Leo YS.

BMC Infect Dis. 2017 Jul 19;17(1):503. doi: 10.1186/s12879-017-2580-9.


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