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Mitochondrial dysfunction, AMPK activation and peroxisomal metabolism: A coherent scenario for non-canonical 3-methylglutaconic acidurias.

Vamecq J, Papegay B, Nuyens V, Boogaerts J, Leo O, Kruys V.

Biochimie. 2019 Oct 15;168:53-82. doi: 10.1016/j.biochi.2019.10.004. [Epub ahead of print] Review.


HO-1 mitigates acute kidney injury and subsequent kidney-lung cross-talk.

Rossi M, Delbauve S, Roumeguère T, Wespes E, Leo O, Flamand V, Le Moine A, Hougardy JM.

Free Radic Res. 2019 Oct;53(9-10):1035-1043. doi: 10.1080/10715762.2019.1668936. Epub 2019 Sep 29.


Protection in a model of liver injury is parallel to energy mobilization capacity under distinct nutritional status.

Papegay B, Nuyens V, Albert A, Cherkaoui-Malki M, Leo O, Kruys V, Boogaerts JG, Vamecq J.

Nutrition. 2019 Jun 12;67-68:110517. doi: 10.1016/j.nut.2019.05.009. [Epub ahead of print]


ASAP: A new global early warning system to detect anomaly hot spots of agricultural production for food security analysis.

Rembold F, Meroni M, Urbano F, Csak G, Kerdiles H, Perez-Hoyos A, Lemoine G, Leo O, Negre T.

Agric Syst. 2019 Jan;168:247-257. doi: 10.1016/j.agsy.2018.07.002.


Dual effect of hemin on renal ischemia-reperfusion injury.

Rossi M, Delbauve S, Wespes E, Roumeguère T, Leo O, Flamand V, Le Moine A, Hougardy JM.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):2820-2825. doi: 10.1016/j.bbrc.2018.08.046. Epub 2018 Aug 9.


Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties.

Givord C, Welsby I, Detienne S, Thomas S, Assabban A, Lima Silva V, Molle C, Gineste R, Vermeersch M, Perez-Morga D, Leo O, Collignon C, Didierlaurent AM, Goriely S.

NPJ Vaccines. 2018 Jun 28;3:20. doi: 10.1038/s41541-018-0058-4. eCollection 2018.


A Flow Cytometry-Based Protocol to Measure Lymphocyte Viability Upon Metabolic Stress.

Denanglaire S, Pirnay T, Leo O, Andris F.

Methods Mol Biol. 2018;1732:465-476. doi: 10.1007/978-1-4939-7598-3_29.


Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells.

Fontaine M, Vogel I, Van Eycke YR, Galuppo A, Ajouaou Y, Decaestecker C, Kassiotis G, Moser M, Leo O.

EMBO J. 2018 Feb 1;37(3):398-412. doi: 10.15252/embj.201796881. Epub 2017 Dec 20.


Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells.

Hanoteau A, Henin C, Svec D, Bisilliat Donnet C, Denanglaire S, Colau D, Romero P, Leo O, Van den Eynde B, Moser M.

Oncoimmunology. 2017 May 11;6(8):e1318234. doi: 10.1080/2162402X.2017.1318234. eCollection 2017.


The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells.

Andris F, Denanglaire S, Anciaux M, Hercor M, Hussein H, Leo O.

Front Immunol. 2017 Apr 27;8:480. doi: 10.3389/fimmu.2017.00480. eCollection 2017.


Nicotinamide Phosphoribosyltransferase in Smooth Muscle Cells Maintains Genome Integrity, Resists Aortic Medial Degeneration, and Is Suppressed in Human Thoracic Aortic Aneurysm Disease.

Watson A, Nong Z, Yin H, O'Neil C, Fox S, Balint B, Guo L, Leo O, Chu MWA, Gros R, Pickering JG.

Circ Res. 2017 Jun 9;120(12):1889-1902. doi: 10.1161/CIRCRESAHA.116.310022. Epub 2017 Mar 29.


Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury.

Rossi M, Thierry A, Delbauve S, Preyat N, Soares MP, Roumeguère T, Leo O, Flamand V, Le Moine A, Hougardy JM.

Sci Rep. 2017 Mar 15;7(1):197. doi: 10.1038/s41598-017-00220-w.


Vaccine development: From concept to early clinical testing.

Cunningham AL, Garçon N, Leo O, Friedland LR, Strugnell R, Laupèze B, Doherty M, Stern P.

Vaccine. 2016 Dec 20;34(52):6655-6664. doi: 10.1016/j.vaccine.2016.10.016. Epub 2016 Oct 18. Review.


Antigen-presenting cell-derived IL-6 restricts the expression of GATA3 and IL-4 by follicular helper T cells.

Hercor M, Anciaux M, Denanglaire S, Debuisson D, Leo O, Andris F.

J Leukoc Biol. 2017 Jan;101(1):5-14. doi: 10.1189/jlb.1HI1115-511R. Epub 2016 Jul 29.


Reassessing the role of NAD as a prosurvival factor.

Preyat N, Leo O.

Mol Cell Oncol. 2015 Jul 6;3(1):e1062591. doi: 10.1080/23723556.2015.1062591. eCollection 2016 Jan.


Complex role of nicotinamide adenine dinucleotide in the regulation of programmed cell death pathways.

Preyat N, Leo O.

Biochem Pharmacol. 2016 Feb 1;101:13-26. doi: 10.1016/j.bcp.2015.08.110. Epub 2015 Sep 3.


Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner.

Preyat N, Rossi M, Kers J, Chen L, Bertin J, Gough PJ, Le Moine A, Rongvaux A, Van Gool F, Leo O.

Cell Death Differ. 2016 Jan;23(1):29-40. doi: 10.1038/cdd.2015.60. Epub 2015 May 22.


Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells.

Martinet V, Tonon S, Torres D, Azouz A, Nguyen M, Kohler A, Flamand V, Mao CA, Klein WH, Leo O, Goriely S.

Nat Commun. 2015 May 8;6:7089. doi: 10.1038/ncomms8089.


Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire.

Dimova T, Brouwer M, Gosselin F, Tassignon J, Leo O, Donner C, Marchant A, Vermijlen D.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E556-65. doi: 10.1073/pnas.1412058112. Epub 2015 Jan 23.


TH1/TH2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism?

Muraille E, Leo O, Moser M.

Front Immunol. 2014 Nov 26;5:603. doi: 10.3389/fimmu.2014.00603. eCollection 2014. Review.


AMPK in lymphocyte metabolism and function.

Andris F, Leo O.

Int Rev Immunol. 2015 Jan;34(1):67-81. doi: 10.3109/08830185.2014.969422. Epub 2014 Oct 31. Review.


Antigen presenting cell-derived IL-6 restricts Th2-cell differentiation.

Mayer A, Debuisson D, Denanglaire S, Eddahri F, Fievez L, Hercor M, Triffaux E, Moser M, Bureau F, Leo O, Andris F.

Eur J Immunol. 2014 Nov;44(11):3252-62. doi: 10.1002/eji.201444646. Epub 2014 Sep 5.


A microRNA profile of human CD8(+) regulatory T cells and characterization of the effects of microRNAs on Treg cell-associated genes.

Jebbawi F, Fayyad-Kazan H, Merimi M, Lewalle P, Verougstraete JC, Leo O, Romero P, Burny A, Badran B, Martiat P, Rouas R.

J Transl Med. 2014 Aug 6;12:218. doi: 10.1186/s12967-014-0218-x.


PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation.

Welsby I, Hutin D, Gueydan C, Kruys V, Rongvaux A, Leo O.

J Biol Chem. 2014 Sep 19;289(38):26642-57. doi: 10.1074/jbc.M114.589515. Epub 2014 Aug 1.


Myor/ABF-1 mRNA [corrected] Expression Marks Follicular Helper T Cells but Is Dispensable for Tfh Cell Differentiation and Function In Vivo.

Debuisson D, Mari N, Denanglaire S, Leo O, Andris F.

PLoS One. 2013 Dec 26;8(12):e84415. doi: 10.1371/journal.pone.0084415. eCollection 2013. Erratum in: PLoS One. 2014;9(1); doi:10.1371/annotation/b0c3d5f5-5778-48af-85ed-abf1b9113a48.


Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease.

Molle C, Zhang T, Ysebrant de Lendonck L, Gueydan C, Andrianne M, Sherer F, Van Simaeys G, Blackshear PJ, Leo O, Goriely S.

J Exp Med. 2013 Aug 26;210(9):1675-84. doi: 10.1084/jem.20120707. Epub 2013 Aug 12.


IL-17A mediates early post-transplant lesions after heterotopic trachea allotransplantation in Mice.

Lemaître PH, Vokaer B, Charbonnier LM, Iwakura Y, Estenne M, Goldman M, Leo O, Remmelink M, Le Moine A.

PLoS One. 2013 Jul 30;8(7):e70236. doi: 10.1371/journal.pone.0070236. Print 2013.


STAT3 signaling induces the differentiation of human ICOS(+) CD4 T cells helping B lymphocytes.

Ysebrant de Lendonck L, Eddahri F, Delmarcelle Y, Nguyen M, Leo O, Goriely S, Marchant A.

PLoS One. 2013 Jul 26;8(7):e71029. doi: 10.1371/journal.pone.0071029. Print 2013.


Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes.

Ysebrant de Lendonck L, Tonon S, Nguyen M, Vandevenne P, Welsby I, Martinet V, Molle C, Charbonnier LM, Leo O, Goriely S.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3189-97. doi: 10.1073/pnas.1219221110. Epub 2013 Aug 5.


Neonatal follicular Th cell responses are impaired and modulated by IL-4.

Debock I, Jaworski K, Chadlaoui H, Delbauve S, Passon N, Twyffels L, Leo O, Flamand V.

J Immunol. 2013 Aug 1;191(3):1231-9. doi: 10.4049/jimmunol.1203288. Epub 2013 Jun 26.


The capacity of Th2 lymphocytes to deliver B-cell help requires expression of the transcription factor STAT3.

Mari N, Hercor M, Denanglaire S, Leo O, Andris F.

Eur J Immunol. 2013 Jun;43(6):1489-98. doi: 10.1002/eji.201242938. Epub 2013 Apr 19.


Cyclosporine A drives a Th17- and Th2-mediated posttransplant obliterative airway disease.

Lemaître PH, Vokaer B, Charbonnier LM, Iwakura Y, Field KA, Estenne M, Goldman M, Leo O, Remmelink M, Le Moine A.

Am J Transplant. 2013 Mar;13(3):611-20. doi: 10.1111/ajt.12067. Epub 2013 Jan 17.


Sirtuin deacylases: a molecular link between metabolism and immunity.

Preyat N, Leo O.

J Leukoc Biol. 2013 May;93(5):669-80. doi: 10.1189/jlb.1112557. Epub 2013 Jan 16. Review.


CTLA4-Ig restores rejection of MHC class-II mismatched allografts by disabling IL-2-expanded regulatory T cells.

Charbonnier LM, Vokaer B, Lemaître PH, Field KA, Leo O, Le Moine A.

Am J Transplant. 2012 Sep;12(9):2313-21. doi: 10.1111/j.1600-6143.2012.04184.x. Epub 2012 Jul 3.


Complex roles of members of the ADP-ribosyl transferase super family in immune defences: looking beyond PARP1.

Welsby I, Hutin D, Leo O.

Biochem Pharmacol. 2012 Jul 1;84(1):11-20. doi: 10.1016/j.bcp.2012.02.016. Epub 2012 Mar 1. Review.


The cationic lipid, diC14 amidine, extends the adjuvant properties of aluminum salts through a TLR-4- and caspase-1-independent mechanism.

Wilmar A, Lonez C, Vermeersch M, Andrianne M, Pérez-Morga D, Ruysschaert JM, Vandenbranden M, Leo O, Temmerman ST.

Vaccine. 2012 Jan 5;30(2):414-24. doi: 10.1016/j.vaccine.2011.10.071. Epub 2011 Nov 7.


Th17 alloimmunity prevents neonatal establishment of lymphoid chimerism in IL-4-deprived mice.

Debock I, Delbauve S, Dubois A, Pétein M, Leo O, Goldman M, Flamand V.

Am J Transplant. 2012 Jan;12(1):81-9. doi: 10.1111/j.1600-6143.2011.03778.x. Epub 2011 Oct 12.


Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-γ activity in dendritic cells.

Legutko A, Marichal T, Fiévez L, Bedoret D, Mayer A, de Vries H, Klotz L, Drion PV, Heirman C, Cataldo D, Louis R, Thielemans K, Andris F, Leo O, Lekeux P, Desmet CJ, Bureau F.

J Immunol. 2011 Nov 1;187(9):4517-29. doi: 10.4049/jimmunol.1101493. Epub 2011 Sep 23.


Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction.

Andris F, Denanglaire S, Baus E, Rongvaux A, Steuve J, Flavell RA, Leo O.

J Immunol. 2011 Feb 15;186(4):2245-53. doi: 10.4049/jimmunol.1002333. Epub 2011 Jan 19.


Sirtuins and inflammation: Friends or foes?

Gallí M, Van Gool F, Leo O.

Biochem Pharmacol. 2011 Mar 1;81(5):569-76. doi: 10.1016/j.bcp.2010.12.010. Epub 2010 Dec 22. Review.


Key concepts in immunology.

Moser M, Leo O.

Vaccine. 2010 Aug 31;28 Suppl 3:C2-13. doi: 10.1016/j.vaccine.2010.07.022. Review.


The nicotinamide phosphoribosyltransferase: a molecular link between metabolism, inflammation, and cancer.

Gallí M, Van Gool F, Rongvaux A, Andris F, Leo O.

Cancer Res. 2010 Jan 1;70(1):8-11. doi: 10.1158/0008-5472.CAN-09-2465. Epub 2009 Dec 22. Review.


Developmental regulation of the composite CAG promoter activity in the murine T lymphocyte cell lineage.

Baup D, Moser M, Schurmans S, Leo O.

Genesis. 2009 Dec;47(12):799-804. doi: 10.1002/dvg.20569.


Variegation and silencing in a lentiviral-based murine transgenic model.

Baup D, Fraga L, Pernot E, Van Acker A, Vanherck AS, Breckpot K, Thielemans K, Schurmans S, Moser M, Leo O.

Transgenic Res. 2010 Jun;19(3):399-414. doi: 10.1007/s11248-009-9318-4. Epub 2009 Aug 23.


[A new inflammatory pathway linked to NAD].

Van Gool F, Galli M, Rongvaux A, Andris F, Leo O.

Med Sci (Paris). 2009 Jun-Jul;25(6-7):551-3. doi: 10.1051/medsci/2009256-7551. French. No abstract available.


Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.

Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O.

Nat Med. 2009 Feb;15(2):206-10. doi: 10.1038/nm.1906. Epub 2009 Jan 18.


Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities.

Eddahri F, Denanglaire S, Bureau F, Spolski R, Leonard WJ, Leo O, Andris F.

Blood. 2009 Mar 12;113(11):2426-33. doi: 10.1182/blood-2008-04-154682. Epub 2008 Nov 19.


Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress.

Rongvaux A, Galli M, Denanglaire S, Van Gool F, Drèze PL, Szpirer C, Bureau F, Andris F, Leo O.

J Immunol. 2008 Oct 1;181(7):4685-95.


Immune response to human papillomavirus after prophylactic vaccination with AS04-adjuvanted HPV-16/18 vaccine: improving upon nature.

Schwarz TF, Leo O.

Gynecol Oncol. 2008 Sep;110(3 Suppl 1):S1-10. doi: 10.1016/j.ygyno.2008.05.036. Epub 2008 Jul 24.


Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD.

Busso N, Karababa M, Nobile M, Rolaz A, Van Gool F, Galli M, Leo O, So A, De Smedt T.

PLoS One. 2008 May 21;3(5):e2267. doi: 10.1371/journal.pone.0002267.

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