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Items: 1 to 50 of 232

1.

MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity.

Tyka K, Jörns A, Turatsinze JV, Eizirik DL, Lenzen S, Gurgul-Convey E.

Cell Death Dis. 2019 Jan 10;10(1):29. doi: 10.1038/s41419-018-1268-4.

2.

Development of a conversation approach for practice nurses aimed at making shared decisions on goals and action plans with primary care patients.

Lenzen SA, Daniëls R, van Bokhoven MA, van der Weijden T, Beurskens A.

BMC Health Serv Res. 2018 Nov 26;18(1):891. doi: 10.1186/s12913-018-3734-1.

3.

Light-induced intracellular hydrogen peroxide generation through genetically encoded photosensitizer KillerRed-SOD1.

Laporte A, Nordenbrock A, Lenzen S, Elsner M.

Free Radic Res. 2018 Oct;52(10):1170-1181. doi: 10.1080/10715762.2018.1540042.

PMID:
30350732
4.

β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes.

Horwitz E, Krogvold L, Zhitomirsky S, Swisa A, Fischman M, Lax T, Dahan T, Hurvitz N, Weinberg-Corem N, Klochendler A, Powers AC, Brissova M, Jörns A, Lenzen S, Glaser B, Dahl-Jørgensen K, Dor Y.

Diabetes. 2018 Nov;67(11):2305-2318. doi: 10.2337/db17-1006. Epub 2018 Aug 27.

5.

Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings.

Tsikas D, Hanff E, Bollenbach A, Kruger R, Pham VV, Chobanyan-Jürgens K, Wedekind D, Arndt T, Jörns A, Berbée JFP, Princen HMG, Lücke T, Mariotti F, Huneau JF, Ückert S, Frölich JC, Lenzen S.

Amino Acids. 2018 Jul;50(7):799-821. doi: 10.1007/s00726-018-2573-z. Epub 2018 May 4.

PMID:
29728915
6.

Immune cell and cytokine patterns in children with type 1 diabetes mellitus undergoing a remission phase: A longitudinal study.

Fitas AL, Martins C, Borrego LM, Lopes L, Jörns A, Lenzen S, Limbert C.

Pediatr Diabetes. 2018 Aug;19(5):963-971. doi: 10.1111/pedi.12671. Epub 2018 Mar 27.

PMID:
29527790
7.

An editorial on the article 'Patents in the Diabetes Area in the Years 2008-2016'.

Lenzen S.

Expert Opin Ther Pat. 2018 Mar;28(3):173-174. doi: 10.1080/13543776.2018.1427734. Epub 2018 Jan 15. No abstract available.

PMID:
29334286
8.

What makes it so difficult for nurses to coach patients in shared decision making? A process evaluation.

Lenzen SA, Daniëls R, van Bokhoven MA, van der Weijden T, Beurskens A.

Int J Nurs Stud. 2018 Apr;80:1-11. doi: 10.1016/j.ijnurstu.2017.12.005. Epub 2017 Dec 16.

PMID:
29331655
9.

The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells.

Plötz T, Krümmel B, Laporte A, Pingitore A, Persaud SJ, Jörns A, Elsner M, Mehmeti I, Lenzen S.

Nutr Diabetes. 2017 Dec 21;7(12):305. doi: 10.1038/s41387-017-0005-x.

10.

Dynamics of Insulin Secretion from EndoC-βH1 β-Cell Pseudoislets in Response to Glucose and Other Nutrient and Nonnutrient Secretagogues.

Teraoku H, Lenzen S.

J Diabetes Res. 2017;2017:2309630. doi: 10.1155/2017/2309630. Epub 2017 Oct 19.

11.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P.

Diabetologia. 2018 Mar;61(3):641-657. doi: 10.1007/s00125-017-4500-3. Epub 2017 Nov 28.

12.

Disentangling self-management goal setting and action planning: A scoping review.

Lenzen SA, Daniëls R, van Bokhoven MA, van der Weijden T, Beurskens A.

PLoS One. 2017 Nov 27;12(11):e0188822. doi: 10.1371/journal.pone.0188822. eCollection 2017. Review.

13.

miRNome Profiling of Purified Endoderm and Mesoderm Differentiated from hESCs Reveals Functions of miR-483-3p and miR-1263 for Cell-Fate Decisions.

Ishikawa D, Diekmann U, Fiedler J, Just A, Thum T, Lenzen S, Naujok O.

Stem Cell Reports. 2017 Nov 14;9(5):1588-1603. doi: 10.1016/j.stemcr.2017.10.011.

14.

Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity.

Hahn C, Tyka K, Saba JD, Lenzen S, Gurgul-Convey E.

J Biol Chem. 2017 Dec 8;292(49):20292-20304. doi: 10.1074/jbc.M117.814491. Epub 2017 Oct 25.

15.

ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity.

Mehmeti I, Lortz S, Avezov E, Jörns A, Lenzen S.

Free Radic Biol Med. 2017 Nov;112:121-130. doi: 10.1016/j.freeradbiomed.2017.07.021. Epub 2017 Jul 24.

PMID:
28751022
16.

Animal models of human type 1 diabetes for evaluating combination therapies and successful translation to the patient with type 1 diabetes.

Lenzen S.

Diabetes Metab Res Rev. 2017 Oct;33(7). doi: 10.1002/dmrr.2915. Epub 2017 Aug 2. Review.

PMID:
28692149
17.

Chemistry and biology of reactive species with special reference to the antioxidative defence status in pancreatic β-cells.

Lenzen S.

Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):1929-1942. doi: 10.1016/j.bbagen.2017.05.013. Epub 2017 May 17. Review.

PMID:
28527893
18.

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

Melo EP, Lopes C, Gollwitzer P, Lortz S, Lenzen S, Mehmeti I, Kaminski CF, Ron D, Avezov E.

BMC Biol. 2017 Mar 27;15(1):24. doi: 10.1186/s12915-017-0367-5.

19.

Influence of age and cognitive performance on resting-state brain networks of older adults in a population-based cohort.

Jockwitz C, Caspers S, Lux S, Eickhoff SB, Jütten K, Lenzen S, Moebus S, Pundt N, Reid A, Hoffstaedter F, Jöckel KH, Erbel R, Cichon S, Nöthen MM, Shah NJ, Zilles K, Amunts K.

Cortex. 2017 Apr;89:28-44. doi: 10.1016/j.cortex.2017.01.008. Epub 2017 Jan 23.

PMID:
28192723
20.

Interprofessional primary care team meetings: a qualitative approach comparing observations with personal opinions.

van Dongen JJ, van Bokhoven MA, Daniëls R, Lenzen SA, van der Weijden T, Beurskens A.

Fam Pract. 2017 Feb;34(1):98-106. doi: 10.1093/fampra/cmw106. Epub 2016 Oct 18.

21.

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines.

Gurgul-Convey E, Mehmeti I, Plötz T, Jörns A, Lenzen S.

Diabetologia. 2016 Oct;59(10):2125-33. doi: 10.1007/s00125-016-4060-y. Epub 2016 Jul 27.

PMID:
27460666
22.

What does it take to set goals for self-management in primary care? A qualitative study.

Lenzen SA, van Dongen JJ, Daniëls R, van Bokhoven MA, van der Weijden T, Beurskens A.

Fam Pract. 2016 Dec;33(6):698-703. Epub 2016 Jul 13.

23.

Improved antioxidative defence protects insulin-producing cells against homocysteine toxicity.

Scullion SM, Hahn C, Tyka K, Flatt PR, McClenaghan NH, Lenzen S, Gurgul-Convey E.

Chem Biol Interact. 2016 Aug 25;256:37-46. doi: 10.1016/j.cbi.2016.06.019. Epub 2016 Jun 16.

PMID:
27317948
24.

Interprofessional collaboration regarding patients' care plans in primary care: a focus group study into influential factors.

van Dongen JJ, Lenzen SA, van Bokhoven MA, Daniëls R, van der Weijden T, Beurskens A.

BMC Fam Pract. 2016 May 28;17:58. doi: 10.1186/s12875-016-0456-5.

25.

The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells.

Plötz T, Hartmann M, Lenzen S, Elsner M.

Nutr Metab (Lond). 2016 Feb 25;13:16. doi: 10.1186/s12986-016-0076-z. eCollection 2016.

26.

Susceptibility of brown adipocytes to pro-inflammatory cytokine toxicity and reactive oxygen species.

Rebiger L, Lenzen S, Mehmeti I.

Biosci Rep. 2016 Jan 21;36(2). pii: e00306. doi: 10.1042/BSR20150193.

27.

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

Konno T, Pinho Melo E, Lopes C, Mehmeti I, Lenzen S, Ron D, Avezov E.

J Cell Biol. 2015 Oct 26;211(2):253-9. doi: 10.1083/jcb.201506123.

28.

A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes.

Arndt T, Wedekind D, Jörns A, Tsiavaliaris G, Cuppen E, Hedrich HJ, Lenzen S.

Diabetologia. 2015 Dec;58(12):2800-9. doi: 10.1007/s00125-015-3757-7. Epub 2015 Sep 12.

PMID:
26363782
29.

Impact of scavenging hydrogen peroxide in the endoplasmic reticulum for β cell function.

Lortz S, Lenzen S, Mehmeti I.

J Mol Endocrinol. 2015 Aug;55(1):21-9. doi: 10.1530/JME-15-0132. Epub 2015 Jun 24.

PMID:
26108484
30.

Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells.

Gehrmann W, Würdemann W, Plötz T, Jörns A, Lenzen S, Elsner M.

Cell Physiol Biochem. 2015;36(3):852-65. doi: 10.1159/000430261. Epub 2015 May 27.

31.

Physiological characterization of the human EndoC-βH1 β-cell line.

Gurgul-Convey E, Kaminski MT, Lenzen S.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):13-9. doi: 10.1016/j.bbrc.2015.05.072. Epub 2015 May 28.

PMID:
26028562
32.

Is nitric oxide really the primary mediator of pancreatic β-cell death in type 1 diabetes?

Gurgul-Convey E, Lenzen S.

J Biol Chem. 2015 Apr 17;290(16):10570. doi: 10.1074/jbc.L115.648089. No abstract available.

33.

TNF-α Antibody Therapy in Combination With the T-Cell-Specific Antibody Anti-TCR Reverses the Diabetic Metabolic State in the LEW.1AR1-iddm Rat.

Jörns A, Ertekin ÜG, Arndt T, Terbish T, Wedekind D, Lenzen S.

Diabetes. 2015 Aug;64(8):2880-91. doi: 10.2337/db14-1866. Epub 2015 Mar 17.

34.

Setting goals in chronic care: Shared decision making as self-management support by the family physician.

Lenzen SA, Daniëls R, van Bokhoven MA, van der Weijden T, Beurskens A.

Eur J Gen Pract. 2015 Jun;21(2):138-44. doi: 10.3109/13814788.2014.973844. Epub 2014 Dec 26. Review.

PMID:
25541857
35.

N-glycosylation-negative catalase: a useful tool for exploring the role of hydrogen peroxide in the endoplasmic reticulum.

Lortz S, Lenzen S, Mehmeti I.

Free Radic Biol Med. 2015 Mar;80:77-83. doi: 10.1016/j.freeradbiomed.2014.11.024. Epub 2014 Dec 12.

PMID:
25499853
36.

Antidiabetic Effect of Interleukin-1β Antibody Therapy Through β-Cell Protection in the Cohen Diabetes-Sensitive Rat.

Aharon-Hananel G, Jörns A, Lenzen S, Raz I, Weksler-Zangen S.

Diabetes. 2015 May;64(5):1780-5. doi: 10.2337/db14-1018. Epub 2014 Dec 8.

37.

A reliable and efficient protocol for human pluripotent stem cell differentiation into the definitive endoderm based on dispersed single cells.

Diekmann U, Lenzen S, Naujok O.

Stem Cells Dev. 2015 Jan 15;24(2):190-204. doi: 10.1089/scd.2014.0143.

PMID:
25137387
38.

Peroxiredoxin 4 improves insulin biosynthesis and glucose-induced insulin secretion in insulin-secreting INS-1E cells.

Mehmeti I, Lortz S, Elsner M, Lenzen S.

J Biol Chem. 2014 Sep 26;289(39):26904-13. doi: 10.1074/jbc.M114.568329. Epub 2014 Aug 13.

39.

The generation of definitive endoderm from human embryonic stem cells is initially independent from activin A but requires canonical Wnt-signaling.

Naujok O, Diekmann U, Lenzen S.

Stem Cell Rev. 2014 Aug;10(4):480-93. doi: 10.1007/s12015-014-9509-0.

PMID:
24913278
40.

Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells.

Lortz S, Schröter S, Stückemann V, Mehmeti I, Lenzen S.

J Mol Endocrinol. 2014 Jun;52(3):301-10. doi: 10.1530/JME-13-0261.

PMID:
24850829
41.

Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.

Naujok O, Lentes J, Diekmann U, Davenport C, Lenzen S.

BMC Res Notes. 2014 Apr 29;7:273. doi: 10.1186/1756-0500-7-273.

42.

A fresh view of glycolysis and glucokinase regulation: history and current status.

Lenzen S.

J Biol Chem. 2014 May 2;289(18):12189-94. doi: 10.1074/jbc.R114.557314. Epub 2014 Mar 17. Review.

43.

Variable immune cell frequencies in peripheral blood of LEW.1AR1-iddm rats over time compared to other congenic LEW strains.

Arndt T, Jörns A, Hedrich HJ, Lenzen S, Wedekind D.

Clin Exp Immunol. 2014 Jul;177(1):168-78. doi: 10.1111/cei.12323.

44.

Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes.

Jörns A, Akin M, Arndt T, Terbish T, Zu Vilsendorf AM, Wedekind D, Hedrich HJ, Lenzen S.

J Mol Med (Berl). 2014 Jul;92(7):743-55. doi: 10.1007/s00109-014-1137-2. Epub 2014 Mar 7.

PMID:
24599515
45.

Progesterone induces apoptosis of insulin-secreting cells: insights into the molecular mechanism.

Nunes VA, Portioli-Sanches EP, Rosim MP, Araujo MS, Praxedes-Garcia P, Valle MM, Roma LP, Hahn C, Gurgul-Convey E, Lenzen S, Azevedo-Martins AK.

J Endocrinol. 2014 Apr 22;221(2):273-84. doi: 10.1530/JOE-13-0202. Print 2014 May.

PMID:
24594616
46.

Effect of substrate rigidity in tissue culture on the function of insulin-secreting INS-1E cells.

Naujok O, Bandou Y, Shikama Y, Funaki M, Lenzen S.

J Tissue Eng Regen Med. 2017 Jan;11(1):58-65. doi: 10.1002/term.1857. Epub 2014 Jan 8.

PMID:
24399617
47.

Glucose-induced dissociation of glucokinase from its regulatory protein in the nucleus of hepatocytes prior to nuclear export.

Kaminski MT, Schultz J, Waterstradt R, Tiedge M, Lenzen S, Baltrusch S.

Biochim Biophys Acta. 2014 Mar;1843(3):554-64.

48.

Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes.

Jörns A, Arndt T, Meyer zu Vilsendorf A, Klempnauer J, Wedekind D, Hedrich HJ, Marselli L, Marchetti P, Harada N, Nakaya Y, Wang GS, Scott FW, Gysemans C, Mathieu C, Lenzen S.

Diabetologia. 2014 Mar;57(3):512-21. doi: 10.1007/s00125-013-3125-4. Epub 2013 Dec 6.

PMID:
24310561
49.

Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner.

Hofmeister-Brix A, Kollmann K, Langer S, Schultz J, Lenzen S, Baltrusch S.

J Biol Chem. 2013 Dec 13;288(50):35824-39. doi: 10.1074/jbc.M113.526632. Epub 2013 Nov 1.

50.

Comment on Binhai Ren et al. (2013; 15: 28-41): long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy.

Elsner M, Naujok O, Jörns A, Lenzen S.

J Gene Med. 2013 Aug-Sep;15(8-9):306-8. doi: 10.1002/jgm.2725. No abstract available.

PMID:
24038931

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