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Items: 1 to 50 of 246

1.

Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.

Yuen MF, Gane EJ, Kim DJ, Weilert F, Chan HLY, Lalezari J, Hwang SG, Nguyen T, Flores O, Hartman G, Liaw S, Lenz O, Kakuda TN, Talloen W, Schwabe C, Klumpp K, Brown N.

Gastroenterology. 2019 Jan 5. pii: S0016-5085(18)35438-6. doi: 10.1053/j.gastro.2018.12.023. [Epub ahead of print]

2.

How to make the reducing power of H2 available for in vivo biosyntheses and biotransformations.

Lauterbach L, Lenz O.

Curr Opin Chem Biol. 2018 Dec 10;49:91-96. doi: 10.1016/j.cbpa.2018.11.020. [Epub ahead of print] Review.

PMID:
30544016
3.

O2-tolerant [NiFe]-hydrogenases of Ralstonia eutropha H16: Physiology, molecular biology, purification, and biochemical analysis.

Lenz O, Lauterbach L, Frielingsdorf S.

Methods Enzymol. 2018;613:117-151. doi: 10.1016/bs.mie.2018.10.008. Epub 2018 Nov 24.

PMID:
30509463
4.

Molecular diversity of "Candidatus Phytoplasma mali" strains associated with apple proliferation disease in Bulgarian germplasm collection.

Fránová J, Koloniuk I, Lenz O, Sakalieva D.

Folia Microbiol (Praha). 2018 Oct 30. doi: 10.1007/s12223-018-0660-x. [Epub ahead of print]

PMID:
30377990
5.

Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778.

Helsen N, Vervoort T, Vandenbossche J, Lenz O, Monshouwer M, Pauwels F, Snoeys J.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01497-18. doi: 10.1128/AAC.01497-18. Print 2018 Nov.

PMID:
30181376
6.

Red clover-associated luteovirus - a newly classifiable member of the genus Luteovirus with an enamo-like P5 protein.

Lenz O, Sarkisová T, Koloniuk I, Fránová J, Přibylová J, Špak J.

Arch Virol. 2018 Dec;163(12):3439-3442. doi: 10.1007/s00705-018-3997-1. Epub 2018 Aug 24.

PMID:
30143875
7.

O2-Tolerant H2 Activation by an Isolated Large Subunit of a [NiFe] Hydrogenase.

Hartmann S, Frielingsdorf S, Ciaccafava A, Lorent C, Fritsch J, Siebert E, Priebe J, Haumann M, Zebger I, Lenz O.

Biochemistry. 2018 Sep 11;57(36):5339-5349. doi: 10.1021/acs.biochem.8b00760. Epub 2018 Aug 24.

PMID:
30110155
8.

In Situ Spectroelectrochemical Studies into the Formation and Stability of Robust Diazonium-Derived Interfaces on Gold Electrodes for the Immobilization of an Oxygen-Tolerant Hydrogenase.

Harris TGAA, Heidary N, Kozuch J, Frielingsdorf S, Lenz O, Mroginski MA, Hildebrandt P, Zebger I, Fischer A.

ACS Appl Mater Interfaces. 2018 Jul 11;10(27):23380-23391. doi: 10.1021/acsami.8b02273. Epub 2018 Jun 26.

PMID:
29943966
9.

Variability Studies of Two Prunus-Infecting Fabaviruses with the Aid of High-Throughput Sequencing.

Koloniuk I, Sarkisova T, Petrzik K, Lenz O, Přibylová J, Fránová J, Špak J, Lotos L, Beta C, Katsiani A, Candresse T, Maliogka VI.

Viruses. 2018 Apr 18;10(4). pii: E204. doi: 10.3390/v10040204.

10.

Identification and molecular characterization of a novel varicosa-like virus from red clover.

Koloniuk I, Fránová J, Sarkisova T, Přibylová J, Lenz O, Petrzik K, Špak J.

Arch Virol. 2018 Aug;163(8):2213-2218. doi: 10.1007/s00705-018-3838-2. Epub 2018 Apr 4.

PMID:
29619600
11.

Improved HER Catalysis through Facile, Aqueous Electrochemical Activation of Nanoscale WSe2.

Henckel DA, Lenz OM, Krishnan KM, Cossairt BM.

Nano Lett. 2018 Apr 11;18(4):2329-2335. doi: 10.1021/acs.nanolett.7b05213. Epub 2018 Mar 7.

PMID:
29498869
12.

Tracking the route of molecular oxygen in O2-tolerant membrane-bound [NiFe] hydrogenase.

Kalms J, Schmidt A, Frielingsdorf S, Utesch T, Gotthard G, von Stetten D, van der Linden P, Royant A, Mroginski MA, Carpentier P, Lenz O, Scheerer P.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2229-E2237. doi: 10.1073/pnas.1712267115. Epub 2018 Feb 20.

13.

A 3-year follow-up study after treatment with simeprevir in combination with pegylated interferon-α and ribavirin for chronic hepatitis C virus infection.

Zoulim F, Moreno C, Lee SS, Buggisch P, Horban A, Lawitz E, Corbett C, Lenz O, Fevery B, Verbinnen T, Shukla U, Jessner W.

Virol J. 2018 Jan 30;15(1):26. doi: 10.1186/s12985-018-0936-4.

14.

Enzymatic and spectroscopic properties of a thermostable [NiFe]‑hydrogenase performing H2-driven NAD+-reduction in the presence of O2.

Preissler J, Wahlefeld S, Lorent C, Teutloff C, Horch M, Lauterbach L, Cramer SP, Zebger I, Lenz O.

Biochim Biophys Acta Bioenerg. 2018 Jan;1859(1):8-18. doi: 10.1016/j.bbabio.2017.09.006. Epub 2017 Sep 29.

15.

Antiviral profiling of the capsid assembly modulator BAY41-4109 on full-length HBV genotype A-H clinical isolates and core site-directed mutants in vitro.

Berke JM, Tan Y, Verbinnen T, Dehertogh P, Vergauwen K, Vos A, Lenz O, Pauwels F.

Antiviral Res. 2017 Aug;144:205-215. doi: 10.1016/j.antiviral.2017.06.016. Epub 2017 Jun 21.

PMID:
28647474
16.

Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography.

Oberthuer D, Knoška J, Wiedorn MO, Beyerlein KR, Bushnell DA, Kovaleva EG, Heymann M, Gumprecht L, Kirian RA, Barty A, Mariani V, Tolstikova A, Adriano L, Awel S, Barthelmess M, Dörner K, Xavier PL, Yefanov O, James DR, Nelson G, Wang D, Calvey G, Chen Y, Schmidt A, Szczepek M, Frielingsdorf S, Lenz O, Snell E, Robinson PJ, Šarler B, Belšak G, Maček M, Wilde F, Aquila A, Boutet S, Liang M, Hunter MS, Scheerer P, Lipscomb JD, Weierstall U, Kornberg RD, Spence JCH, Pollack L, Chapman HN, Bajt S.

Sci Rep. 2017 Jun 21;7:46846. doi: 10.1038/srep46846.

17.

Simeprevir with peginterferon α-2a/ribavirin for chronic hepatitis C virus genotype 1 infection in treatment-experienced patients: an open-label, rollover study.

Gane EJ, DeJesus E, Janczewska E, George J, Diago M, Da Silva MH, Reesink H, Nikitin I, Hinrichsen H, Bourgeois S, Ferenci P, Shukla U, Kalmeijer R, Lenz O, Fevery B, Corbett C, Beumont M, Jessner W.

BMC Infect Dis. 2017 Jun 2;17(1):389. doi: 10.1186/s12879-017-2444-3.

18.

Clinical Significance of Intraluminal Contrast Enhancement in Patients with Spontaneous Cervical Artery Dissection: A Black-Blood MRI Study.

Coppenrath E, Lenz O, Sommer N, Lummel N, Linn J, Treitl K, Bamberg F, Reiser M, Pfefferkorn T, Saam T.

Rofo. 2017 Jul;189(7):624-631. doi: 10.1055/s-0043-104632. Epub 2017 Apr 26.

19.

Glutamate Is a Wake-Active Neurotransmitter in Drosophila melanogaster.

Zimmerman JE, Chan MT, Lenz OT, Keenan BT, Maislin G, Pack AI.

Sleep. 2017 Feb 1;40(2). doi: 10.1093/sleep/zsw046.

20.

Double-flow focused liquid injector for efficient serial femtosecond crystallography.

Oberthuer D, Knoška J, Wiedorn MO, Beyerlein KR, Bushnell DA, Kovaleva EG, Heymann M, Gumprecht L, Kirian RA, Barty A, Mariani V, Tolstikova A, Adriano L, Awel S, Barthelmess M, Dörner K, Xavier PL, Yefanov O, James DR, Nelson G, Wang D, Calvey G, Chen Y, Schmidt A, Szczepek M, Frielingsdorf S, Lenz O, Snell E, Robinson PJ, Šarler B, Belšak G, Maček M, Wilde F, Aquila A, Boutet S, Liang M, Hunter MS, Scheerer P, Lipscomb JD, Weierstall U, Kornberg RD, Spence JC, Pollack L, Chapman HN, Bajt S.

Sci Rep. 2017 Mar 16;7:44628. doi: 10.1038/srep44628. Erratum in: Sci Rep. 2017 Jun 21;7:46846.

21.

Efficacy, safety, and pharmacokinetics of simeprevir, daclatasvir, and ribavirin in patients with recurrent hepatitis C virus genotype 1b infection after orthotopic liver transplantation: The Phase II SATURN study.

Forns X, Berenguer M, Herzer K, Sterneck M, Donato MF, Andreone P, Fagiuoli S, Cieciura T, Durlik M, Calleja JL, Mariño Z, Shukla U, Verbinnen T, Lenz O, Ouwerkerk-Mahadevan S, Peeters M, Janssen K, Kalmeijer R, Jessner W.

Transpl Infect Dis. 2017 Jun;19(3). doi: 10.1111/tid.12696. Epub 2017 May 4.

PMID:
28295849
22.

Advancing the regulatory path on hepatitis B virus treatment and curative research: a stakeholders consultation.

Liu J, Goicochea P, Block T, Brosgart CL, Donaldson EF, Lenz O, Gee Lim S, Marins EG, Mishra P, Peters MG, Miller V.

J Virus Erad. 2017 Jan 1;3(1):1-6.

23.

Characterization of Frex as an NADH sensor for in vivo applications in the presence of NAD+ and at various pH values.

Wilkening S, Schmitt FJ, Horch M, Zebger I, Lenz O, Friedrich T.

Photosynth Res. 2017 Sep;133(1-3):305-315. doi: 10.1007/s11120-017-0348-0. Epub 2017 Mar 6.

PMID:
28265794
24.

Enzymes as modular catalysts for redox half-reactions in H2-powered chemical synthesis: from biology to technology.

Reeve HA, Ash PA, Park H, Huang A, Posidias M, Tomlinson C, Lenz O, Vincent KA.

Biochem J. 2017 Jan 15;474(2):215-230. doi: 10.1042/BCJ20160513. Review.

25.

Efficacy of a 12-Week Simeprevir Plus Peginterferon/Ribavirin (PR) Regimen in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 4 (GT4) Infection and Mild-To-Moderate Fibrosis Displaying Early On-Treatment Virologic Response.

Asselah T, Moreno C, Sarrazin C, Gschwantler M, Foster GR, Craxí A, Buggisch P, Sanai F, Bicer C, Lenz O, Van Dooren G, Nalpas C, Lonjon-Domanec I, Schlag M, Buti M.

PLoS One. 2017 Jan 5;12(1):e0168713. doi: 10.1371/journal.pone.0168713. eCollection 2017.

26.

CO synthesized from the central one-carbon pool as source for the iron carbonyl in O2-tolerant [NiFe]-hydrogenase.

Bürstel I, Siebert E, Frielingsdorf S, Zebger I, Friedrich B, Lenz O.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14722-14726. doi: 10.1073/pnas.1614656113. Epub 2016 Dec 5.

27.

Investigation of the NADH/NAD+ ratio in Ralstonia eutropha using the fluorescence reporter protein Peredox.

Tejwani V, Schmitt FJ, Wilkening S, Zebger I, Horch M, Lenz O, Friedrich T.

Biochim Biophys Acta Bioenerg. 2017 Jan;1858(1):86-94. doi: 10.1016/j.bbabio.2016.11.001. Epub 2016 Nov 3.

28.

Identification and characterization of a new member of the genus Luteovirus from cherry.

Lenz O, Přibylová J, Fránová J, Koloniuk I, Špak J.

Arch Virol. 2017 Feb;162(2):587-590. doi: 10.1007/s00705-016-3125-z. Epub 2016 Oct 22.

PMID:
27771793
29.

Virology analyses of HCV genotype 4 isolates from patients treated with simeprevir and peginterferon/ribavirin in the Phase III RESTORE study.

Fevery B, Verbinnen T, Peeters M, Janssen K, Witek J, Jessner W, De Meyer S, Lenz O.

J Viral Hepat. 2017 Jan;24(1):28-36. doi: 10.1111/jvh.12614. Epub 2016 Oct 3.

PMID:
27696653
30.

An Open-Label Trial of 12-Week Simeprevir plus Peginterferon/Ribavirin (PR) in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 1 (GT1).

Asselah T, Moreno C, Sarrazin C, Gschwantler M, Foster GR, Craxí A, Buggisch P, Ryan R, Lenz O, Scott J, Van Dooren G, Lonjon-Domanec I, Schlag M, Buti M.

PLoS One. 2016 Jul 18;11(7):e0158526. doi: 10.1371/journal.pone.0158526. eCollection 2016.

31.

The Role of the Cytochrome P450 System in Vulnerable Patients: An Opportunity to Improve Outcomes.

Briones PL, Lenz O, Salman L, Zdanowicz MM.

Nephrol Nurs J. 2016 Jul-Aug;43(4):347-350.

PMID:
30550062
32.

Amyloid-β induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila.

Gerstner JR, Lenz O, Vanderheyden WM, Chan MT, Pfeiffenberger C, Pack AI.

J Neurosci Res. 2017 Aug;95(8):1548-1564. doi: 10.1002/jnr.23778. Epub 2016 Jun 19.

33.

Pre-existence and Persistence of Resistant Minority Hepatitis C Virus Variants in Genotype 1-Infected Patients Treated With Simeprevir/Peginterferon/Ribavirin.

Fevery B, Thys K, Van Eygen V, Verbinnen T, Van Rossem E, Buelens A, Aerssens J, Witek J, Picchio G, De Meyer S, Lenz O.

Open Forum Infect Dis. 2016 Mar 14;3(2):ofw052. doi: 10.1093/ofid/ofw052. eCollection 2016 Mar.

34.

Reply.

Miller V, Harrington P, Howe A, Kieffer T, Lennerstrand J, Lenz O, Lontok E, McPhee F, Mo H, Parkin N, Pilot-Matias T.

Hepatology. 2016 Aug;64(2):698-9. doi: 10.1002/hep.28615. Epub 2016 May 27. No abstract available.

PMID:
27113118
35.

Krypton Derivatization of an O2 -Tolerant Membrane-Bound [NiFe] Hydrogenase Reveals a Hydrophobic Tunnel Network for Gas Transport.

Kalms J, Schmidt A, Frielingsdorf S, van der Linden P, von Stetten D, Lenz O, Carpentier P, Scheerer P.

Angew Chem Int Ed Engl. 2016 Apr 25;55(18):5586-90. doi: 10.1002/anie.201508976. Epub 2016 Feb 23.

PMID:
26913499
36.

Simeprevir plus sofosbuvir (12 and 8 weeks) in hepatitis C virus genotype 1-infected patients without cirrhosis: OPTIMIST-1, a phase 3, randomized study.

Kwo P, Gitlin N, Nahass R, Bernstein D, Etzkorn K, Rojter S, Schiff E, Davis M, Ruane P, Younes Z, Kalmeijer R, Sinha R, Peeters M, Lenz O, Fevery B, De La Rosa G, Scott J, Witek J.

Hepatology. 2016 Aug;64(2):370-80. doi: 10.1002/hep.28467. Epub 2016 Mar 22.

37.

Simeprevir plus peginterferon/ribavirin for HCV genotype 1-infected treatment-naïve patients in China and South Korea.

Wei L, Han T, Yang D, Heo J, Shang J, Cheng J, Chen X, Xie Q, Kim JH, Kalmeijer R, Ouwerkerk-Mahadevan S, Hoeben E, Lenz O, Verbinnen T, Sinha R, Li M, Scott J, Peeters M, Witek J; TIGER team.

J Gastroenterol Hepatol. 2016 May;31(5):912-20. doi: 10.1111/jgh.13288.

PMID:
26777137
38.

Reactivation from the Ni-B state in [NiFe] hydrogenase of Ralstonia eutropha is controlled by reduction of the superoxidised proximal cluster.

Radu V, Frielingsdorf S, Lenz O, Jeuken LJ.

Chem Commun (Camb). 2016 Feb 11;52(12):2632-5. doi: 10.1039/c5cc10382g. Epub 2016 Jan 11.

39.

Structure of an Actinobacterial-Type [NiFe]-Hydrogenase Reveals Insight into O2-Tolerant H2 Oxidation.

Schäfer C, Bommer M, Hennig SE, Jeoung JH, Dobbek H, Lenz O.

Structure. 2016 Feb 2;24(2):285-92. doi: 10.1016/j.str.2015.11.010. Epub 2015 Dec 31.

40.

Simeprevir plus sofosbuvir in patients with chronic hepatitis C virus genotype 1 infection and cirrhosis: A phase 3 study (OPTIMIST-2).

Lawitz E, Matusow G, DeJesus E, Yoshida EM, Felizarta F, Ghalib R, Godofsky E, Herring RW, Poleynard G, Sheikh A, Tobias H, Kugelmas M, Kalmeijer R, Peeters M, Lenz O, Fevery B, De La Rosa G, Scott J, Sinha R, Witek J.

Hepatology. 2016 Aug;64(2):360-9. doi: 10.1002/hep.28422. Epub 2016 Feb 19.

41.

Enzyme-Modified Particles for Selective Biocatalytic Hydrogenation by Hydrogen-Driven NADH Recycling.

Reeve HA, Lauterbach L, Lenz O, Vincent KA.

ChemCatChem. 2015 Nov;7(21):3480-3487. Epub 2015 Oct 28.

42.

Orientation-Controlled Electrocatalytic Efficiency of an Adsorbed Oxygen-Tolerant Hydrogenase.

Heidary N, Utesch T, Zerball M, Horch M, Millo D, Fritsch J, Lenz O, von Klitzing R, Hildebrandt P, Fischer A, Mroginski MA, Zebger I.

PLoS One. 2015 Nov 18;10(11):e0143101. doi: 10.1371/journal.pone.0143101. eCollection 2015.

43.

The Role of Endovascular Stents in Dialysis Access Maintenance.

El Kassem M, Alghamdi I, Vazquez-Padron RI, Asif A, Lenz O, Sanjar T, Fayad F, Salman L.

Adv Chronic Kidney Dis. 2015 Nov;22(6):453-8. doi: 10.1053/j.ackd.2015.02.001. Review.

44.

Comparison of three quantitative HCV RNA assays in samples from HCV genotype 1- or 4-infected patients treated with the NS3/4A protease inhibitor simeprevir.

Fevery B, Susser S, Lenz O, Cloherty G, Perner D, Gilles L, De Locht P, Picchio G, De Meyer S, Sarrazin C.

J Clin Virol. 2015 Nov;72:133-40. doi: 10.1016/j.jcv.2015.09.015. Epub 2015 Oct 8.

PMID:
26513763
45.

H2-driven biotransformation of n-octane to 1-octanol by a recombinant Pseudomonas putida strain co-synthesizing an O2-tolerant hydrogenase and a P450 monooxygenase.

Lonsdale TH, Lauterbach L, Honda Malca S, Nestl BM, Hauer B, Lenz O.

Chem Commun (Camb). 2015 Nov 21;51(90):16173-5. doi: 10.1039/c5cc06078h.

PMID:
26394141
46.

In Vitro Activity of Simeprevir against Hepatitis C Virus Genotype 1 Clinical Isolates and Its Correlation with NS3 Sequence and Site-Directed Mutants.

Verbinnen T, Fevery B, Vijgen L, Jacobs T, De Meyer S, Lenz O.

Antimicrob Agents Chemother. 2015 Dec;59(12):7548-57. doi: 10.1128/AAC.01444-15. Epub 2015 Sep 21.

47.

Cofactor composition and function of a H2-sensing regulatory hydrogenase as revealed by Mössbauer and EPR spectroscopy.

Roncaroli F, Bill E, Friedrich B, Lenz O, Lubitz W, Pandelia ME.

Chem Sci. 2015 Aug 1;6(8):4495-4507. doi: 10.1039/c5sc01560j. Epub 2015 May 26.

48.

Active Site of the NAD(+)-Reducing Hydrogenase from Ralstonia eutropha Studied by EPR Spectroscopy.

Löwenstein J, Lauterbach L, Teutloff C, Lenz O, Bittl R.

J Phys Chem B. 2015 Oct 29;119(43):13834-41. doi: 10.1021/acs.jpcb.5b04144. Epub 2015 Aug 10.

PMID:
26214595
49.

Resonance Raman Spectroscopic Analysis of the [NiFe] Active Site and the Proximal [4Fe-3S] Cluster of an O2-Tolerant Membrane-Bound Hydrogenase in the Crystalline State.

Siebert E, Rippers Y, Frielingsdorf S, Fritsch J, Schmidt A, Kalms J, Katz S, Lenz O, Scheerer P, Paasche L, Pelmenschikov V, Kuhlmann U, Mroginski MA, Zebger I, Hildebrandt P.

J Phys Chem B. 2015 Oct 29;119(43):13785-96. doi: 10.1021/acs.jpcb.5b04119. Epub 2015 Aug 7.

PMID:
26201814
50.

Electrochemical and Infrared Spectroscopic Studies Provide Insight into Reactions of the NiFe Regulatory Hydrogenase from Ralstonia eutropha with O2 and CO.

Ash PA, Liu J, Coutard N, Heidary N, Horch M, Gudim I, Simler T, Zebger I, Lenz O, Vincent KA.

J Phys Chem B. 2015 Oct 29;119(43):13807-15. doi: 10.1021/acs.jpcb.5b04164. Epub 2015 Jul 10.

PMID:
26115011

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