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Items: 1 to 50 of 252

1.

Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques.

Rowbotham JS, Ramirez MA, Lenz O, Reeve HA, Vincent KA.

Nat Commun. 2020 Mar 19;11(1):1454. doi: 10.1038/s41467-020-15310-z.

2.

A membrane-bound [NiFe]-hydrogenase large subunit precursor whose C-terminal extension is not essential for cofactor incorporation but guarantees optimal maturation.

Hartmann S, Frielingsdorf S, Caserta G, Lenz O.

Microbiologyopen. 2020 Mar 16:e1029. doi: 10.1002/mbo3.1029. [Epub ahead of print]

3.

Formyltetrahydrofolate Decarbonylase Synthesizes the Active Site CO Ligand of O2-Tolerant [NiFe] Hydrogenase.

Schulz AC, Frielingsdorf S, Pommerening P, Lauterbach L, Bistoni G, Neese F, Oestreich M, Lenz O.

J Am Chem Soc. 2020 Jan 22;142(3):1457-1464. doi: 10.1021/jacs.9b11506. Epub 2020 Jan 8.

PMID:
31830412
4.

Understanding the structure and dynamics of hydrogenases by ultrafast and two-dimensional infrared spectroscopy.

Horch M, Schoknecht J, Wrathall SLD, Greetham GM, Lenz O, Hunt NT.

Chem Sci. 2019 Aug 5;10(39):8981-8989. doi: 10.1039/c9sc02851j. eCollection 2019 Oct 21.

5.

Growth of the facultative chemolithoautotroph Ralstonia eutropha on organic waste materials: growth characteristics, redox regulation and hydrogenase activity.

Poladyan A, Blbulyan S, Sahakyan M, Lenz O, Trchounian A.

Microb Cell Fact. 2019 Nov 18;18(1):201. doi: 10.1186/s12934-019-1251-5.

6.

Discriminating changes in intracellular NADH/NAD+ levels due to anoxicity and H2 supply in R. eutropha cells using the Frex fluorescence sensor.

Wilkening S, Schmitt FJ, Lenz O, Zebger I, Horch M, Friedrich T.

Biochim Biophys Acta Bioenerg. 2019 Oct 1;1860(10):148062. doi: 10.1016/j.bbabio.2019.148062. Epub 2019 Aug 13.

PMID:
31419395
7.

Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.

Yuen MF, Gane EJ, Kim DJ, Weilert F, Yuen Chan HL, Lalezari J, Hwang SG, Nguyen T, Flores O, Hartman G, Liaw S, Lenz O, Kakuda TN, Talloen W, Schwabe C, Klumpp K, Brown N.

Gastroenterology. 2019 Apr;156(5):1392-1403.e7. doi: 10.1053/j.gastro.2018.12.023. Epub 2019 Jan 6.

8.

How to make the reducing power of H2 available for in vivo biosyntheses and biotransformations.

Lauterbach L, Lenz O.

Curr Opin Chem Biol. 2019 Apr;49:91-96. doi: 10.1016/j.cbpa.2018.11.020. Epub 2018 Dec 10. Review.

PMID:
30544016
9.

O2-tolerant [NiFe]-hydrogenases of Ralstonia eutropha H16: Physiology, molecular biology, purification, and biochemical analysis.

Lenz O, Lauterbach L, Frielingsdorf S.

Methods Enzymol. 2018;613:117-151. doi: 10.1016/bs.mie.2018.10.008. Epub 2018 Nov 24.

PMID:
30509463
10.

Molecular diversity of "Candidatus Phytoplasma mali" strains associated with apple proliferation disease in Bulgarian germplasm collection.

Fránová J, Koloniuk I, Lenz O, Sakalieva D.

Folia Microbiol (Praha). 2019 May;64(3):373-382. doi: 10.1007/s12223-018-0660-x. Epub 2018 Oct 30.

PMID:
30377990
11.

Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778.

Helsen N, Vervoort T, Vandenbossche J, Lenz O, Monshouwer M, Pauwels F, Snoeys J.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01497-18. doi: 10.1128/AAC.01497-18. Print 2018 Nov.

12.

Red clover-associated luteovirus - a newly classifiable member of the genus Luteovirus with an enamo-like P5 protein.

Lenz O, Sarkisová T, Koloniuk I, Fránová J, Přibylová J, Špak J.

Arch Virol. 2018 Dec;163(12):3439-3442. doi: 10.1007/s00705-018-3997-1. Epub 2018 Aug 24.

PMID:
30143875
13.

O2-Tolerant H2 Activation by an Isolated Large Subunit of a [NiFe] Hydrogenase.

Hartmann S, Frielingsdorf S, Ciaccafava A, Lorent C, Fritsch J, Siebert E, Priebe J, Haumann M, Zebger I, Lenz O.

Biochemistry. 2018 Sep 11;57(36):5339-5349. doi: 10.1021/acs.biochem.8b00760. Epub 2018 Aug 24.

PMID:
30110155
14.

In Situ Spectroelectrochemical Studies into the Formation and Stability of Robust Diazonium-Derived Interfaces on Gold Electrodes for the Immobilization of an Oxygen-Tolerant Hydrogenase.

Harris TGAA, Heidary N, Kozuch J, Frielingsdorf S, Lenz O, Mroginski MA, Hildebrandt P, Zebger I, Fischer A.

ACS Appl Mater Interfaces. 2018 Jul 11;10(27):23380-23391. doi: 10.1021/acsami.8b02273. Epub 2018 Jun 26.

PMID:
29943966
15.

Variability Studies of Two Prunus-Infecting Fabaviruses with the Aid of High-Throughput Sequencing.

Koloniuk I, Sarkisova T, Petrzik K, Lenz O, Přibylová J, Fránová J, Špak J, Lotos L, Beta C, Katsiani A, Candresse T, Maliogka VI.

Viruses. 2018 Apr 18;10(4). pii: E204. doi: 10.3390/v10040204.

16.

Identification and molecular characterization of a novel varicosa-like virus from red clover.

Koloniuk I, Fránová J, Sarkisova T, Přibylová J, Lenz O, Petrzik K, Špak J.

Arch Virol. 2018 Aug;163(8):2213-2218. doi: 10.1007/s00705-018-3838-2. Epub 2018 Apr 4.

PMID:
29619600
17.

Improved HER Catalysis through Facile, Aqueous Electrochemical Activation of Nanoscale WSe2.

Henckel DA, Lenz OM, Krishnan KM, Cossairt BM.

Nano Lett. 2018 Apr 11;18(4):2329-2335. doi: 10.1021/acs.nanolett.7b05213. Epub 2018 Mar 7.

PMID:
29498869
18.

Tracking the route of molecular oxygen in O2-tolerant membrane-bound [NiFe] hydrogenase.

Kalms J, Schmidt A, Frielingsdorf S, Utesch T, Gotthard G, von Stetten D, van der Linden P, Royant A, Mroginski MA, Carpentier P, Lenz O, Scheerer P.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2229-E2237. doi: 10.1073/pnas.1712267115. Epub 2018 Feb 20.

19.

A 3-year follow-up study after treatment with simeprevir in combination with pegylated interferon-α and ribavirin for chronic hepatitis C virus infection.

Zoulim F, Moreno C, Lee SS, Buggisch P, Horban A, Lawitz E, Corbett C, Lenz O, Fevery B, Verbinnen T, Shukla U, Jessner W.

Virol J. 2018 Jan 30;15(1):26. doi: 10.1186/s12985-018-0936-4.

20.

Enzymatic and spectroscopic properties of a thermostable [NiFe]‑hydrogenase performing H2-driven NAD+-reduction in the presence of O2.

Preissler J, Wahlefeld S, Lorent C, Teutloff C, Horch M, Lauterbach L, Cramer SP, Zebger I, Lenz O.

Biochim Biophys Acta Bioenerg. 2018 Jan;1859(1):8-18. doi: 10.1016/j.bbabio.2017.09.006. Epub 2017 Sep 29.

21.

Antiviral profiling of the capsid assembly modulator BAY41-4109 on full-length HBV genotype A-H clinical isolates and core site-directed mutants in vitro.

Berke JM, Tan Y, Verbinnen T, Dehertogh P, Vergauwen K, Vos A, Lenz O, Pauwels F.

Antiviral Res. 2017 Aug;144:205-215. doi: 10.1016/j.antiviral.2017.06.016. Epub 2017 Jun 21.

PMID:
28647474
22.

Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography.

Oberthuer D, Knoška J, Wiedorn MO, Beyerlein KR, Bushnell DA, Kovaleva EG, Heymann M, Gumprecht L, Kirian RA, Barty A, Mariani V, Tolstikova A, Adriano L, Awel S, Barthelmess M, Dörner K, Xavier PL, Yefanov O, James DR, Nelson G, Wang D, Calvey G, Chen Y, Schmidt A, Szczepek M, Frielingsdorf S, Lenz O, Snell E, Robinson PJ, Šarler B, Belšak G, Maček M, Wilde F, Aquila A, Boutet S, Liang M, Hunter MS, Scheerer P, Lipscomb JD, Weierstall U, Kornberg RD, Spence JCH, Pollack L, Chapman HN, Bajt S.

Sci Rep. 2017 Jun 21;7:46846. doi: 10.1038/srep46846.

23.

Simeprevir with peginterferon α-2a/ribavirin for chronic hepatitis C virus genotype 1 infection in treatment-experienced patients: an open-label, rollover study.

Gane EJ, DeJesus E, Janczewska E, George J, Diago M, Da Silva MH, Reesink H, Nikitin I, Hinrichsen H, Bourgeois S, Ferenci P, Shukla U, Kalmeijer R, Lenz O, Fevery B, Corbett C, Beumont M, Jessner W.

BMC Infect Dis. 2017 Jun 2;17(1):389. doi: 10.1186/s12879-017-2444-3.

24.

Clinical Significance of Intraluminal Contrast Enhancement in Patients with Spontaneous Cervical Artery Dissection: A Black-Blood MRI Study.

Coppenrath E, Lenz O, Sommer N, Lummel N, Linn J, Treitl K, Bamberg F, Reiser M, Pfefferkorn T, Saam T.

Rofo. 2017 Jul;189(7):624-631. doi: 10.1055/s-0043-104632. Epub 2017 Apr 26.

25.

Glutamate Is a Wake-Active Neurotransmitter in Drosophila melanogaster.

Zimmerman JE, Chan MT, Lenz OT, Keenan BT, Maislin G, Pack AI.

Sleep. 2017 Feb 1;40(2). doi: 10.1093/sleep/zsw046.

26.

Double-flow focused liquid injector for efficient serial femtosecond crystallography.

Oberthuer D, Knoška J, Wiedorn MO, Beyerlein KR, Bushnell DA, Kovaleva EG, Heymann M, Gumprecht L, Kirian RA, Barty A, Mariani V, Tolstikova A, Adriano L, Awel S, Barthelmess M, Dörner K, Xavier PL, Yefanov O, James DR, Nelson G, Wang D, Calvey G, Chen Y, Schmidt A, Szczepek M, Frielingsdorf S, Lenz O, Snell E, Robinson PJ, Šarler B, Belšak G, Maček M, Wilde F, Aquila A, Boutet S, Liang M, Hunter MS, Scheerer P, Lipscomb JD, Weierstall U, Kornberg RD, Spence JC, Pollack L, Chapman HN, Bajt S.

Sci Rep. 2017 Mar 16;7:44628. doi: 10.1038/srep44628. Erratum in: Sci Rep. 2017 Jun 21;7:46846.

27.

Efficacy, safety, and pharmacokinetics of simeprevir, daclatasvir, and ribavirin in patients with recurrent hepatitis C virus genotype 1b infection after orthotopic liver transplantation: The Phase II SATURN study.

Forns X, Berenguer M, Herzer K, Sterneck M, Donato MF, Andreone P, Fagiuoli S, Cieciura T, Durlik M, Calleja JL, Mariño Z, Shukla U, Verbinnen T, Lenz O, Ouwerkerk-Mahadevan S, Peeters M, Janssen K, Kalmeijer R, Jessner W.

Transpl Infect Dis. 2017 Jun;19(3). doi: 10.1111/tid.12696. Epub 2017 May 4.

PMID:
28295849
28.

Advancing the regulatory path on hepatitis B virus treatment and curative research: a stakeholders consultation.

Liu J, Goicochea P, Block T, Brosgart CL, Donaldson EF, Lenz O, Gee Lim S, Marins EG, Mishra P, Peters MG, Miller V.

J Virus Erad. 2017 Jan 1;3(1):1-6.

29.

Characterization of Frex as an NADH sensor for in vivo applications in the presence of NAD+ and at various pH values.

Wilkening S, Schmitt FJ, Horch M, Zebger I, Lenz O, Friedrich T.

Photosynth Res. 2017 Sep;133(1-3):305-315. doi: 10.1007/s11120-017-0348-0. Epub 2017 Mar 6.

PMID:
28265794
30.

Enzymes as modular catalysts for redox half-reactions in H2-powered chemical synthesis: from biology to technology.

Reeve HA, Ash PA, Park H, Huang A, Posidias M, Tomlinson C, Lenz O, Vincent KA.

Biochem J. 2017 Jan 15;474(2):215-230. doi: 10.1042/BCJ20160513. Review.

31.

Efficacy of a 12-Week Simeprevir Plus Peginterferon/Ribavirin (PR) Regimen in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 4 (GT4) Infection and Mild-To-Moderate Fibrosis Displaying Early On-Treatment Virologic Response.

Asselah T, Moreno C, Sarrazin C, Gschwantler M, Foster GR, Craxí A, Buggisch P, Sanai F, Bicer C, Lenz O, Van Dooren G, Nalpas C, Lonjon-Domanec I, Schlag M, Buti M.

PLoS One. 2017 Jan 5;12(1):e0168713. doi: 10.1371/journal.pone.0168713. eCollection 2017.

32.

CO synthesized from the central one-carbon pool as source for the iron carbonyl in O2-tolerant [NiFe]-hydrogenase.

Bürstel I, Siebert E, Frielingsdorf S, Zebger I, Friedrich B, Lenz O.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14722-14726. doi: 10.1073/pnas.1614656113. Epub 2016 Dec 5.

33.

Investigation of the NADH/NAD+ ratio in Ralstonia eutropha using the fluorescence reporter protein Peredox.

Tejwani V, Schmitt FJ, Wilkening S, Zebger I, Horch M, Lenz O, Friedrich T.

Biochim Biophys Acta Bioenerg. 2017 Jan;1858(1):86-94. doi: 10.1016/j.bbabio.2016.11.001. Epub 2016 Nov 3.

34.

Identification and characterization of a new member of the genus Luteovirus from cherry.

Lenz O, Přibylová J, Fránová J, Koloniuk I, Špak J.

Arch Virol. 2017 Feb;162(2):587-590. doi: 10.1007/s00705-016-3125-z. Epub 2016 Oct 22.

PMID:
27771793
35.

Virology analyses of HCV genotype 4 isolates from patients treated with simeprevir and peginterferon/ribavirin in the Phase III RESTORE study.

Fevery B, Verbinnen T, Peeters M, Janssen K, Witek J, Jessner W, De Meyer S, Lenz O.

J Viral Hepat. 2017 Jan;24(1):28-36. doi: 10.1111/jvh.12614. Epub 2016 Oct 3.

PMID:
27696653
36.

An Open-Label Trial of 12-Week Simeprevir plus Peginterferon/Ribavirin (PR) in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 1 (GT1).

Asselah T, Moreno C, Sarrazin C, Gschwantler M, Foster GR, Craxí A, Buggisch P, Ryan R, Lenz O, Scott J, Van Dooren G, Lonjon-Domanec I, Schlag M, Buti M.

PLoS One. 2016 Jul 18;11(7):e0158526. doi: 10.1371/journal.pone.0158526. eCollection 2016.

37.

The Role of the Cytochrome P450 System in Vulnerable Patients: An Opportunity to Improve Outcomes.

Briones PL, Lenz O, Salman L, Zdanowicz MM.

Nephrol Nurs J. 2016 Jul-Aug;43(4):347-350.

PMID:
30550062
38.

Amyloid-β induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila.

Gerstner JR, Lenz O, Vanderheyden WM, Chan MT, Pfeiffenberger C, Pack AI.

J Neurosci Res. 2017 Aug;95(8):1548-1564. doi: 10.1002/jnr.23778. Epub 2016 Jun 19.

39.

Pre-existence and Persistence of Resistant Minority Hepatitis C Virus Variants in Genotype 1-Infected Patients Treated With Simeprevir/Peginterferon/Ribavirin.

Fevery B, Thys K, Van Eygen V, Verbinnen T, Van Rossem E, Buelens A, Aerssens J, Witek J, Picchio G, De Meyer S, Lenz O.

Open Forum Infect Dis. 2016 Mar 14;3(2):ofw052. doi: 10.1093/ofid/ofw052. eCollection 2016 Mar.

40.

Reply.

Miller V, Harrington P, Howe A, Kieffer T, Lennerstrand J, Lenz O, Lontok E, McPhee F, Mo H, Parkin N, Pilot-Matias T.

Hepatology. 2016 Aug;64(2):698-9. doi: 10.1002/hep.28615. Epub 2016 May 27. No abstract available.

PMID:
27113118
41.

Krypton Derivatization of an O2 -Tolerant Membrane-Bound [NiFe] Hydrogenase Reveals a Hydrophobic Tunnel Network for Gas Transport.

Kalms J, Schmidt A, Frielingsdorf S, van der Linden P, von Stetten D, Lenz O, Carpentier P, Scheerer P.

Angew Chem Int Ed Engl. 2016 Apr 25;55(18):5586-90. doi: 10.1002/anie.201508976. Epub 2016 Feb 23.

PMID:
26913499
42.

Simeprevir plus sofosbuvir (12 and 8 weeks) in hepatitis C virus genotype 1-infected patients without cirrhosis: OPTIMIST-1, a phase 3, randomized study.

Kwo P, Gitlin N, Nahass R, Bernstein D, Etzkorn K, Rojter S, Schiff E, Davis M, Ruane P, Younes Z, Kalmeijer R, Sinha R, Peeters M, Lenz O, Fevery B, De La Rosa G, Scott J, Witek J.

Hepatology. 2016 Aug;64(2):370-80. doi: 10.1002/hep.28467. Epub 2016 Mar 22.

43.

Simeprevir plus peginterferon/ribavirin for HCV genotype 1-infected treatment-naïve patients in China and South Korea.

Wei L, Han T, Yang D, Heo J, Shang J, Cheng J, Chen X, Xie Q, Kim JH, Kalmeijer R, Ouwerkerk-Mahadevan S, Hoeben E, Lenz O, Verbinnen T, Sinha R, Li M, Scott J, Peeters M, Witek J; TIGER team.

J Gastroenterol Hepatol. 2016 May;31(5):912-20. doi: 10.1111/jgh.13288.

PMID:
26777137
44.

Reactivation from the Ni-B state in [NiFe] hydrogenase of Ralstonia eutropha is controlled by reduction of the superoxidised proximal cluster.

Radu V, Frielingsdorf S, Lenz O, Jeuken LJ.

Chem Commun (Camb). 2016 Feb 11;52(12):2632-5. doi: 10.1039/c5cc10382g. Epub 2016 Jan 11.

45.

Structure of an Actinobacterial-Type [NiFe]-Hydrogenase Reveals Insight into O2-Tolerant H2 Oxidation.

Schäfer C, Bommer M, Hennig SE, Jeoung JH, Dobbek H, Lenz O.

Structure. 2016 Feb 2;24(2):285-92. doi: 10.1016/j.str.2015.11.010. Epub 2015 Dec 31.

46.

Simeprevir plus sofosbuvir in patients with chronic hepatitis C virus genotype 1 infection and cirrhosis: A phase 3 study (OPTIMIST-2).

Lawitz E, Matusow G, DeJesus E, Yoshida EM, Felizarta F, Ghalib R, Godofsky E, Herring RW, Poleynard G, Sheikh A, Tobias H, Kugelmas M, Kalmeijer R, Peeters M, Lenz O, Fevery B, De La Rosa G, Scott J, Sinha R, Witek J.

Hepatology. 2016 Aug;64(2):360-9. doi: 10.1002/hep.28422. Epub 2016 Feb 19.

47.

Enzyme-Modified Particles for Selective Biocatalytic Hydrogenation by Hydrogen-Driven NADH Recycling.

Reeve HA, Lauterbach L, Lenz O, Vincent KA.

ChemCatChem. 2015 Nov;7(21):3480-3487. Epub 2015 Oct 28.

48.

Orientation-Controlled Electrocatalytic Efficiency of an Adsorbed Oxygen-Tolerant Hydrogenase.

Heidary N, Utesch T, Zerball M, Horch M, Millo D, Fritsch J, Lenz O, von Klitzing R, Hildebrandt P, Fischer A, Mroginski MA, Zebger I.

PLoS One. 2015 Nov 18;10(11):e0143101. doi: 10.1371/journal.pone.0143101. eCollection 2015.

49.

The Role of Endovascular Stents in Dialysis Access Maintenance.

El Kassem M, Alghamdi I, Vazquez-Padron RI, Asif A, Lenz O, Sanjar T, Fayad F, Salman L.

Adv Chronic Kidney Dis. 2015 Nov;22(6):453-8. doi: 10.1053/j.ackd.2015.02.001. Review.

50.

Comparison of three quantitative HCV RNA assays in samples from HCV genotype 1- or 4-infected patients treated with the NS3/4A protease inhibitor simeprevir.

Fevery B, Susser S, Lenz O, Cloherty G, Perner D, Gilles L, De Locht P, Picchio G, De Meyer S, Sarrazin C.

J Clin Virol. 2015 Nov;72:133-40. doi: 10.1016/j.jcv.2015.09.015. Epub 2015 Oct 8.

PMID:
26513763

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