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Items: 13


Synthesis, Formulation, and Adjuvanticity of Monodesmosidic Saponins with Olenanolic Acid, Hederagenin and Gypsogenin Aglycones, and some C-28 Ester Derivatives.

Greatrex BW, Daines AM, Hook S, Lenz DH, McBurney W, Rades T, Rendle PM.

ChemistryOpen. 2015 Sep 30;4(6):740-55. doi: 10.1002/open.201500149. eCollection 2015 Dec.


Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.

Gutierrez JA, Luo M, Singh V, Li L, Brown RL, Norris GE, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Schramm VL.

ACS Chem Biol. 2007 Nov 20;2(11):725-34.


A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol.

Clinch K, Evans GB, Furneaux RH, Lenz DH, Mason JM, Mee SP, Tyler PC, Wilcox SJ.

Org Biomol Chem. 2007 Sep 7;5(17):2800-2. Epub 2007 Jul 20.


The small nucleoid protein Fis is involved in Vibrio cholerae quorum sensing.

Lenz DH, Bassler BL.

Mol Microbiol. 2007 Feb;63(3):859-71. Epub 2006 Dec 20.


Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.

Singh V, Shi W, Almo SC, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Mee S, Zheng R, Schramm VL.

Biochemistry. 2006 Oct 31;45(43):12929-41.


Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases.

Clinch K, Evans GB, Fleet GW, Furneaux RH, Johnson SW, Lenz DH, Mee SP, Rands PR, Schramm VL, Taylor Ringia EA, Tyler PC.

Org Biomol Chem. 2006 Mar 21;4(6):1131-9. Epub 2006 Jan 26.


CsrA and three redundant small RNAs regulate quorum sensing in Vibrio cholerae.

Lenz DH, Miller MB, Zhu J, Kulkarni RV, Bassler BL.

Mol Microbiol. 2005 Nov;58(4):1186-202.


Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase.

Evans GB, Furneaux RH, Lenz DH, Painter GF, Schramm VL, Singh V, Tyler PC.

J Med Chem. 2005 Jul 14;48(14):4679-89.


Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.

Lewandowicz A, Ringia EA, Ting LM, Kim K, Tyler PC, Evans GB, Zubkova OV, Mee S, Painter GF, Lenz DH, Furneaux RH, Schramm VL.

J Biol Chem. 2005 Aug 26;280(34):30320-8. Epub 2005 Jun 16.


Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli.

Singh V, Evans GB, Lenz DH, Mason JM, Clinch K, Mee S, Painter GF, Tyler PC, Furneaux RH, Lee JE, Howell PL, Schramm VL.

J Biol Chem. 2005 May 6;280(18):18265-73. Epub 2005 Mar 4.


The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae.

Lenz DH, Mok KC, Lilley BN, Kulkarni RV, Wingreen NS, Bassler BL.

Cell. 2004 Jul 9;118(1):69-82.


Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae.

Miller MB, Skorupski K, Lenz DH, Taylor RK, Bassler BL.

Cell. 2002 Aug 9;110(3):303-14.


Phagocytosed Bordetella pertussis fails to survive in human neutrophils.

Lenz DH, Weingart CL, Weiss AA.

Infect Immun. 2000 Feb;68(2):956-9.

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