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Distinct Roles of Interferon Alpha and Beta in Controlling Chikungunya Virus Replication and Modulating Neutrophil-Mediated Inflammation.

Cook LE, Locke MC, Young AR, Monte K, Hedberg ML, Shimak RM, Sheehan KCF, Veis DJ, Diamond MS, Lenschow DJ.

J Virol. 2019 Dec 12;94(1). pii: e00841-19. doi: 10.1128/JVI.00841-19. Print 2019 Dec 12.


Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA.

Young AR, Locke MC, Cook LE, Hiller BE, Zhang R, Hedberg ML, Monte KJ, Veis DJ, Diamond MS, Lenschow DJ.

PLoS Pathog. 2019 Aug 29;15(8):e1007993. doi: 10.1371/journal.ppat.1007993. eCollection 2019 Aug.


Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death.

Kulkarni HS, Elvington ML, Perng YC, Liszewski MK, Byers DE, Farkouh C, Yusen RD, Lenschow DJ, Brody SL, Atkinson JP.

Am J Respir Cell Mol Biol. 2019 Feb;60(2):144-157. doi: 10.1165/rcmb.2017-0405OC.


ISG15 in antiviral immunity and beyond.

Perng YC, Lenschow DJ.

Nat Rev Microbiol. 2018 Jul;16(7):423-439. doi: 10.1038/s41579-018-0020-5. Review.


Editorial: Lessons Learned From Chikungunya in the Americas.

Miner JJ, Lenschow DJ.

Arthritis Rheumatol. 2018 Apr;70(4):477-479. doi: 10.1002/art.40421. Epub 2018 Mar 13. No abstract available.


The microbial metabolite desaminotyrosine protects from influenza through type I interferon.

Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS.

Science. 2017 Aug 4;357(6350):498-502. doi: 10.1126/science.aam5336.


Possible connections of the opposite trends in Arctic and Antarctic sea-ice cover.

Yu L, Zhong S, Winkler JA, Zhou M, Lenschow DH, Li B, Wang X, Yang Q.

Sci Rep. 2017 Apr 5;7:45804. doi: 10.1038/srep45804.


Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.

Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S.

Lancet Infect Dis. 2017 Apr;17(4):e107-e117. doi: 10.1016/S1473-3099(16)30385-1. Epub 2017 Feb 1. Review.


Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis.

Miner JJ, Cook LE, Hong JP, Smith AM, Richner JM, Shimak RM, Young AR, Monte K, Poddar S, Crowe JE Jr, Lenschow DJ, Diamond MS.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaah3438. doi: 10.1126/scitranslmed.aah3438.


The impact of ISGylation during Mycobacterium tuberculosis infection in mice.

Kimmey JM, Campbell JA, Weiss LA, Monte KJ, Lenschow DJ, Stallings CL.

Microbes Infect. 2017 Apr - May;19(4-5):249-258. doi: 10.1016/j.micinf.2016.12.006. Epub 2017 Jan 10.


ISG15 deficiency and increased viral resistance in humans but not mice.

Speer SD, Li Z, Buta S, Payelle-Brogard B, Qian L, Vigant F, Rubino E, Gardner TJ, Wedeking T, Hermann M, Duehr J, Sanal O, Tezcan I, Mansouri N, Tabarsi P, Mansouri D, Francois-Newton V, Daussy CF, Rodriguez MR, Lenschow DJ, Freiberg AN, Tortorella D, Piehler J, Lee B, García-Sastre A, Pellegrini S, Bogunovic D.

Nat Commun. 2016 May 19;7:11496. doi: 10.1038/ncomms11496.


Estimating surface NO2 and SO2 mixing ratios from fast-response total column observations and potential application to geostationary missions.

Knepp T, Pippin M, Crawford J, Chen G, Szykman J, Long R, Cowen L, Cede A, Abuhassan N, Herman J, Delgado R, Compton J, Berkoff T, Fishman J, Martins D, Stauffer R, Thompson AM, Weinheimer A, Knapp D, Montzka D, Lenschow D, Neil D.

J Atmos Chem. 2015;72(3-4):261-286. Epub 2013 May 25.


Replication-competent fluorescent-expressing influenza B virus.

Nogales A, Rodríguez-Sánchez I, Monte K, Lenschow DJ, Perez DR, Martínez-Sobrido L.

Virus Res. 2016 Feb 2;213:69-81. doi: 10.1016/j.virusres.2015.11.014. Epub 2015 Nov 15.


Multi-year ozone concentration and its spectra in Shanghai, China.

Geng F, Mao X, Zhou M, Zhong S, Lenschow D.

Sci Total Environ. 2015 Jul 15;521-522:135-43. doi: 10.1016/j.scitotenv.2015.03.082. Epub 2015 Mar 30.


Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.

Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82. doi: 10.1073/pnas.1412881112. Epub 2015 Jan 20.


Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis.

Miner JJ, Aw-Yeang HX, Fox JM, Taffner S, Malkova ON, Oh ST, Kim AHJ, Diamond MS, Lenschow DJ, Yokoyama WM.

Arthritis Rheumatol. 2015 May;67(5):1214-1220. doi: 10.1002/art.39027.


Type I interferons link viral infection to enhanced epithelial turnover and repair.

Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS.

Cell Host Microbe. 2015 Jan 14;17(1):85-97. doi: 10.1016/j.chom.2014.11.004. Epub 2014 Dec 4.


Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice.

Morales DJ, Monte K, Sun L, Struckhoff JJ, Agapov E, Holtzman MJ, Stappenbeck TS, Lenschow DJ.

J Virol. 2015 Jan;89(1):337-49. doi: 10.1128/JVI.02110-14. Epub 2014 Oct 15.


Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.

Perng YC, Campbell JA, Lenschow DJ, Yu D.

PLoS Pathog. 2014 Aug 28;10(8):e1004350. doi: 10.1371/journal.ppat.1004350. eCollection 2014 Aug.


A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.

Deng X, Agnihothram S, Mielech AM, Nichols DB, Wilson MW, StJohn SE, Larsen SD, Mesecar AD, Lenschow DJ, Baric RS, Baker SC.

J Virol. 2014 Oct;88(20):11825-33. doi: 10.1128/JVI.01749-14. Epub 2014 Aug 6.


ISG15 functions as an interferon-mediated antiviral effector early in the murine norovirus life cycle.

Rodriguez MR, Monte K, Thackray LB, Lenschow DJ.

J Virol. 2014 Aug;88(16):9277-86. doi: 10.1128/JVI.01422-14. Epub 2014 Jun 4.


Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virus.

Rohatgi A, Corbo JC, Monte K, Higgs S, Vanlandingham DL, Kardon G, Lenschow DJ.

J Virol. 2014 Mar;88(5):2414-25. doi: 10.1128/JVI.02716-13. Epub 2013 Dec 11.


Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor.

Lubman OY, Cella M, Wang X, Monte K, Lenschow DJ, Huang YH, Fremont DH.

J Virol. 2014 Jan;88(1):538-46. doi: 10.1128/JVI.02729-13. Epub 2013 Oct 30.


The antiviral activities of ISG15.

Morales DJ, Lenschow DJ.

J Mol Biol. 2013 Dec 13;425(24):4995-5008. doi: 10.1016/j.jmb.2013.09.041. Epub 2013 Oct 3. Review.


Emerging roles for immunomodulatory functions of free ISG15.

Campbell JA, Lenschow DJ.

J Interferon Cytokine Res. 2013 Dec;33(12):728-38. doi: 10.1089/jir.2013.0064. Epub 2013 Sep 6. Review.


Identification of a candidate therapeutic autophagy-inducing peptide.

Shoji-Kawata S, Sumpter R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW, Helms JB, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV, Levine B.

Nature. 2013 Feb 14;494(7436):201-6. doi: 10.1038/nature11866. Epub 2013 Jan 30.


Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy.

Joubert PE, Werneke S, de la Calle C, Guivel-Benhassine F, Giodini A, Peduto L, Levine B, Schwartz O, Lenschow D, Albert ML.

Autophagy. 2012 Aug;8(8):1261-3. doi: 10.4161/auto.20751. Epub 2012 Jul 27.


Chikungunya virus-induced autophagy delays caspase-dependent cell death.

Joubert PE, Werneke SW, de la Calle C, Guivel-Benhassine F, Giodini A, Peduto L, Levine B, Schwartz O, Lenschow DJ, Albert ML.

J Exp Med. 2012 May 7;209(5):1029-47. doi: 10.1084/jem.20110996. Epub 2012 Apr 16.


Cutting edge: paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection.

Swiecki M, Wang Y, Gilfillan S, Lenschow DJ, Colonna M.

J Immunol. 2012 Mar 15;188(6):2488-92. doi: 10.4049/jimmunol.1103145. Epub 2012 Feb 10.


ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation.

Werneke SW, Schilte C, Rohatgi A, Monte KJ, Michault A, Arenzana-Seisdedos F, Vanlandingham DL, Higgs S, Fontanet A, Albert ML, Lenschow DJ.

PLoS Pathog. 2011 Oct;7(10):e1002322. doi: 10.1371/journal.ppat.1002322. Epub 2011 Oct 20.


Antiviral Properties of ISG15.

Lenschow DJ.

Viruses. 2010 Oct;2(10):2154-68. doi: 10.3390/v2102154. Epub 2010 Sep 28.


Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413.

Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA.

J Immunol. 2011 Oct 1;187(7):3466-74. No abstract available.


Increased cerebral protein ISGylation after focal ischemia is neuroprotective.

Nakka VP, Lang BT, Lenschow DJ, Zhang DE, Dempsey RJ, Vemuganti R.

J Cereb Blood Flow Metab. 2011 Dec;31(12):2375-84. doi: 10.1038/jcbfm.2011.103. Epub 2011 Aug 17.


Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein.

Versteeg GA, Hale BG, van Boheemen S, Wolff T, Lenschow DJ, García-Sastre A.

J Virol. 2010 May;84(10):5423-30. doi: 10.1128/JVI.02395-09. Epub 2010 Mar 10.


ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus.

Giannakopoulos NV, Arutyunova E, Lai C, Lenschow DJ, Haas AL, Virgin HW.

J Virol. 2009 Feb;83(4):1602-10. doi: 10.1128/JVI.01590-08. Epub 2008 Dec 10.


Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.

Lai C, Struckhoff JJ, Schneider J, Martinez-Sobrido L, Wolff T, García-Sastre A, Zhang DE, Lenschow DJ.

J Virol. 2009 Jan;83(2):1147-51. doi: 10.1128/JVI.00105-08. Epub 2008 Nov 12.


Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation.

Okumura F, Lenschow DJ, Zhang DE.

J Biol Chem. 2008 Sep 5;283(36):24484-8. doi: 10.1074/jbc.M803795200. Epub 2008 Jul 7.


Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses.

Frias-Staheli N, Giannakopoulos NV, Kikkert M, Taylor SL, Bridgen A, Paragas J, Richt JA, Rowland RR, Schmaljohn CS, Lenschow DJ, Snijder EJ, García-Sastre A, Virgin HW 4th.

Cell Host Microbe. 2007 Dec 13;2(6):404-16.


IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.

Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, García-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1371-6. Epub 2007 Jan 16.


Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.

Lenschow DJ, Giannakopoulos NV, Gunn LJ, Johnston C, O'Guin AK, Schmidt RE, Levine B, Virgin HW 4th.

J Virol. 2005 Nov;79(22):13974-83.


Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

Giannakopoulos NV, Luo JK, Papov V, Zou W, Lenschow DJ, Jacobs BS, Borden EC, Li J, Virgin HW, Zhang DE.

Biochem Biophys Res Commun. 2005 Oct 21;336(2):496-506.


The influence of large-scale wind power on global climate.

Keith DW, Decarolis JF, Denkenberger DC, Lenschow DH, Malyshev SL, Pacala S, Rasch PJ.

Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16115-20. Epub 2004 Nov 9.


Anti-tumor necrosis factor therapy in patients with difficult to treat Takayasu arteritis.

Hoffman GS, Merkel PA, Brasington RD, Lenschow DJ, Liang P.

Arthritis Rheum. 2004 Jul;50(7):2296-304.


Polymyalgia rheumatica/temporal arteritis: recent advances.

Barilla-LaBarca ML, Lenschow DJ, Brasington RD Jr.

Curr Rheumatol Rep. 2002 Feb;4(1):39-46. Review.


B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA.

Immunity. 2000 Apr;12(4):431-40.


Particle nucleation in the tropical boundary layer and its coupling to marine sulfur sources

Clarke AD, Davis D, Kapustin VN, Eisele F, Chen G, Paluch I I, Lenschow D, Bandy AR, Thornton D, Moore K, Mauldin L, Tanner D, Litchy M, Carroll MA, Collins J, Albercook G.

Science. 1998 Oct 2;282(5386):89-92.


Dimethyl sulfide measurement by fluorine-induced chemiluminescence.

Hills AJ, Lenschow DH, Birks JW.

Anal Chem. 1998 May 1;70(9):1735-42. doi: 10.1021/ac970963p.


Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE.

Vanderlugt CL, Karandikar NJ, Lenschow DJ, Dal Canto MC, Bluestone JA, Miller SD.

J Neuroimmunol. 1997 Nov;79(2):113-8.


CD28/B7 regulation of autoimmune diabetes.

Herold KG, Lenschow DJ, Bluestone JA.

Immunol Res. 1997 Feb;16(1):71-84. Review.


CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin.

Herold KC, Vezys V, Koons A, Lenschow D, Thompson C, Bluestone JA.

J Immunol. 1997 Jan 15;158(2):984-91.


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