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Items: 1 to 50 of 65

1.

PLK1 plays dual roles in centralspindlin regulation during cytokinesis.

Adriaans IE, Basant A, Ponsioen B, Glotzer M, Lens SMA.

J Cell Biol. 2019 Apr 1;218(4):1250-1264. doi: 10.1083/jcb.201805036. Epub 2019 Feb 6.

2.

Cytokinesis defects and cancer.

Lens SMA, Medema RH.

Nat Rev Cancer. 2019 Jan;19(1):32-45. doi: 10.1038/s41568-018-0084-6. Review.

PMID:
30523339
3.

The Ins and Outs of Aurora B Inner Centromere Localization.

Hindriksen S, Lens SMA, Hadders MA.

Front Cell Dev Biol. 2017 Dec 22;5:112. doi: 10.3389/fcell.2017.00112. eCollection 2017. Review.

4.

Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics.

DeLuca KF, Meppelink A, Broad AJ, Mick JE, Peersen OB, Pektas S, Lens SMA, DeLuca JG.

J Cell Biol. 2018 Jan 2;217(1):163-177. doi: 10.1083/jcb.201707160. Epub 2017 Nov 29.

5.

Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells.

Hindriksen S, Bramer AJ, Truong MA, Vromans MJM, Post JB, Verlaan-Klink I, Snippert HJ, Lens SMA, Hadders MA.

PLoS One. 2017 Jun 22;12(6):e0179514. doi: 10.1371/journal.pone.0179514. eCollection 2017.

6.

Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing.

Hengeveld RCC, Vromans MJM, Vleugel M, Hadders MA, Lens SMA.

Nat Commun. 2017 May 31;8:15542. doi: 10.1038/ncomms15542.

7.

Compound heterozygous NEK1 variants in two siblings with oral-facial-digital syndrome type II (Mohr syndrome).

Monroe GR, Kappen IF, Stokman MF, Terhal PA, van den Boogaard MH, Savelberg SM, van der Veken LT, van Es RJ, Lens SM, Hengeveld RC, Creton MA, Janssen NG, Mink van der Molen AB, Ebbeling MB, Giles RH, Knoers NV, van Haaften G.

Eur J Hum Genet. 2016 Dec;24(12):1752-1760. doi: 10.1038/ejhg.2016.103. Epub 2016 Aug 17.

8.

Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability.

Hengeveld RC, de Boer HR, Schoonen PM, de Vries EG, Lens SM, van Vugt MA.

Dev Cell. 2015 Aug 24;34(4):466-74. doi: 10.1016/j.devcel.2015.06.014. Epub 2015 Aug 6.

9.

Chromosome segregation regulation in human zygotes: altered mitotic histone phosphorylation dynamics underlying centromeric targeting of the chromosomal passenger complex.

van de Werken C, Avo Santos M, Laven JS, Eleveld C, Fauser BC, Lens SM, Baart EB.

Hum Reprod. 2015 Oct;30(10):2275-91. doi: 10.1093/humrep/dev186. Epub 2015 Jul 29.

PMID:
26223676
10.

Inter-domain Cooperation in INCENP Promotes Aurora B Relocation from Centromeres to Microtubules.

van der Horst A, Vromans MJ, Bouwman K, van der Waal MS, Hadders MA, Lens SM.

Cell Rep. 2015 Jul 21;12(3):380-7. doi: 10.1016/j.celrep.2015.06.038. Epub 2015 Jul 9.

11.

Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation.

Meppelink A, Kabeche L, Vromans MJ, Compton DA, Lens SM.

Cell Rep. 2015 Apr 28;11(4):508-15. doi: 10.1016/j.celrep.2015.03.052. Epub 2015 Apr 16.

12.

Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores.

Vleugel M, Omerzu M, Groenewold V, Hadders MA, Lens SMA, Kops GJPL.

Mol Cell. 2015 Mar 5;57(5):824-835. doi: 10.1016/j.molcel.2014.12.036. Epub 2015 Feb 5.

13.

Functionality of the chromosomal passenger complex in cancer.

Hindriksen S, Meppelink A, Lens SM.

Biochem Soc Trans. 2015 Feb;43(1):23-32. doi: 10.1042/BST20140275. Review.

PMID:
25619243
14.

Cell biology. Mind the midzone.

Hadders MA, Lens SM.

Science. 2014 Jul 18;345(6194):265-6. doi: 10.1126/science.1257267. No abstract available.

PMID:
25035472
15.

Cell division: control of the chromosomal passenger complex in time and space.

van der Horst A, Lens SM.

Chromosoma. 2014 Mar;123(1-2):25-42. doi: 10.1007/s00412-013-0437-6. Epub 2013 Oct 3. Review.

16.

Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation.

Lei F, Song J, Haque R, Xiong X, Fang D, Wu Y, Lens SM, Croft M, Song J.

Eur J Immunol. 2013 Jul;43(7):1914-24. doi: 10.1002/eji.201243081. Epub 2013 May 28.

17.

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW.

Chromosome Res. 2013 Apr;21(2):101-6. doi: 10.1007/s10577-013-9347-y. Epub 2013 Apr 12.

18.

Mps1 promotes rapid centromere accumulation of Aurora B.

van der Waal MS, Saurin AT, Vromans MJ, Vleugel M, Wurzenberger C, Gerlich DW, Medema RH, Kops GJ, Lens SM.

EMBO Rep. 2012 Sep;13(9):847-54. doi: 10.1038/embor.2012.93. Epub 2012 Jun 26.

19.

Cell division control by the Chromosomal Passenger Complex.

van der Waal MS, Hengeveld RC, van der Horst A, Lens SM.

Exp Cell Res. 2012 Jul 15;318(12):1407-20. doi: 10.1016/j.yexcr.2012.03.015. Epub 2012 Mar 24. Review.

PMID:
22472345
20.

Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex.

Hengeveld RC, Hertz NT, Vromans MJ, Zhang C, Burlingame AL, Shokat KM, Lens SM.

Mol Cell Proteomics. 2012 May;11(5):47-59. doi: 10.1074/mcp.M111.013912. Epub 2012 Jan 20.

21.

A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis.

Wang F, Ulyanova NP, van der Waal MS, Patnaik D, Lens SM, Higgins JM.

Curr Biol. 2011 Jun 21;21(12):1061-9. doi: 10.1016/j.cub.2011.05.016. Epub 2011 Jun 9.

22.

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.

Saurin AT, van der Waal MS, Medema RH, Lens SM, Kops GJ.

Nat Commun. 2011;2:316. doi: 10.1038/ncomms1319.

23.

A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development.

Avo Santos M, van de Werken C, de Vries M, Jahr H, Vromans MJ, Laven JS, Fauser BC, Kops GJ, Lens SM, Baart EB.

Hum Reprod. 2011 Jul;26(7):1868-81. doi: 10.1093/humrep/der111. Epub 2011 Apr 14.

PMID:
21493633
24.

Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis.

DeLuca KF, Lens SM, DeLuca JG.

J Cell Sci. 2011 Feb 15;124(Pt 4):622-34. doi: 10.1242/jcs.072629. Epub 2011 Jan 25.

25.

Shared and separate functions of polo-like kinases and aurora kinases in cancer.

Lens SM, Voest EE, Medema RH.

Nat Rev Cancer. 2010 Dec;10(12):825-41. doi: 10.1038/nrc2964. Epub 2010 Nov 24. Review.

PMID:
21102634
26.

Chromosome segregation: taking the passenger seat.

Vader G, Lens SM.

Curr Biol. 2010 Oct 26;20(20):R879-81. doi: 10.1016/j.cub.2010.09.037.

27.

Aurora B levels at the centromere key to its controversial role in the mitotic checkpoint?

van der Waal MS, Lens SM.

Cell Cycle. 2010 Apr 15;9(8):1462-3. Epub 2010 Apr 15. No abstract available.

PMID:
20421718
28.

Aurora B kinase cooperates with CENP-E to promote timely anaphase onset.

Maia AF, Feij√£o T, Vromans MJ, Sunkel CE, Lens SM.

Chromosoma. 2010 Aug;119(4):405-13. doi: 10.1007/s00412-010-0265-x. Epub 2010 Mar 31.

PMID:
20354862
29.

Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates.

Liu D, Vader G, Vromans MJ, Lampson MA, Lens SM.

Science. 2009 Mar 6;323(5919):1350-3. doi: 10.1126/science.1167000. Epub 2009 Jan 15.

30.

The Aurora kinase family in cell division and cancer.

Vader G, Lens SM.

Biochim Biophys Acta. 2008 Sep;1786(1):60-72. doi: 10.1016/j.bbcan.2008.07.003. Epub 2008 Jul 23. Review.

PMID:
18662747
31.
32.

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.

Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ.

Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046.

33.

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions.

Vader G, Cruijsen CW, van Harn T, Vromans MJ, Medema RH, Lens SM.

Mol Biol Cell. 2007 Nov;18(11):4553-64. Epub 2007 Aug 15.

34.

Phosphorylation by aurora-B negatively regulates survivin function during mitosis.

Wheatley SP, Barrett RM, Andrews PD, Medema RH, Morley SJ, Swedlow JR, Lens SM.

Cell Cycle. 2007 May 15;6(10):1220-30. Epub 2007 May 21.

PMID:
17457057
35.

The case for Survivin as mitotic regulator.

Lens SM, Vader G, Medema RH.

Curr Opin Cell Biol. 2006 Dec;18(6):616-22. Epub 2006 Sep 7. Review.

PMID:
16962308
36.

The chromosomal passenger complex: guiding Aurora-B through mitosis.

Vader G, Medema RH, Lens SM.

J Cell Biol. 2006 Jun 19;173(6):833-7. Epub 2006 Jun 12. Review.

37.

Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown.

Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G.

Oncogene. 2006 Aug 10;25(35):4867-79. Epub 2006 Mar 20.

PMID:
16547492
38.

Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.

Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH.

Mol Biol Cell. 2006 Apr;17(4):1897-909. Epub 2006 Jan 25.

39.
40.

Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase-9 activation.

Eldering E, Mackus WJ, Derks IA, Evers LM, Beuling E, Teeling P, Lens SM, van Oers MH, van Lier RA.

Eur J Immunol. 2004 Jul;34(7):1950-60.

41.

The survivin/Aurora B complex: its role in coordinating tension and attachment.

Lens SM, Medema RH.

Cell Cycle. 2003 Nov-Dec;2(6):507-10. Review.

PMID:
14504461
42.

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.

Lens SM, Wolthuis RM, Klompmaker R, Kauw J, Agami R, Brummelkamp T, Kops G, Medema RH.

EMBO J. 2003 Jun 16;22(12):2934-47.

43.

Prevention of B cell antigen receptor-induced apoptosis by ligation of CD40 occurs downstream of cell cycle regulation.

Mackus WJ, Lens SM, Medema RH, Kwakkenbos MJ, Evers LM, Oers MH, Lier RA, Eldering E.

Int Immunol. 2002 Sep;14(9):973-82.

PMID:
12202395
44.

CD20-induced B cell death can bypass mitochondria and caspase activation.

van der Kolk LE, Evers LM, Omene C, Lens SM, Lederman S, van Lier RA, van Oers MH, Eldering E.

Leukemia. 2002 Sep;16(9):1735-44.

45.

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes.

Lens SM, Kataoka T, Fortner KA, Tinel A, Ferrero I, MacDonald RH, Hahne M, Beermann F, Attinger A, Orbea HA, Budd RC, Tschopp J.

Mol Cell Biol. 2002 Aug;22(15):5419-33.

46.

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2.

Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM, Medema RH.

J Immunol. 2002 May 15;168(10):5024-31.

47.

Protein kinase A regulates expression of p27(kip1) and cyclin D3 to suppress proliferation of leukemic T cell lines.

van Oirschot BA, Stahl M, Lens SM, Medema RH.

J Biol Chem. 2001 Sep 7;276(36):33854-60. Epub 2001 Jul 16.

48.

Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27- human T cells.

Baars PA, Ribeiro Do Couto LM, Leusen JH, Hooibrink B, Kuijpers TW, Lens SM, van Lier RA.

J Immunol. 2000 Aug 15;165(4):1910-7.

49.

Aberrant expression and reverse signalling of CD70 on malignant B cells.

Lens SM, Drillenburg P, den Drijver BF, van Schijndel G, Pals ST, van Lier RA, van Oers MH.

Br J Haematol. 1999 Aug;106(2):491-503.

PMID:
10460611
50.

Control of lymphocyte function through CD27-CD70 interactions.

Lens SM, Tesselaar K, van Oers MH, van Lier RA.

Semin Immunol. 1998 Dec;10(6):491-9. Review.

PMID:
9826582

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