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Asthma: moving toward a global children's charter.

Lenney W, Adachi Y, Bush A, Fischer GB, Hong J, Ostrem A, Pedersen S, Sly PD, Szefler SJ, Tilak R, Zar HJ; GSK Global Children's Asthma Group.

Lancet Respir Med. 2019 Apr;7(4):299-300. doi: 10.1016/S2213-2600(19)30074-8. Epub 2019 Feb 22. No abstract available.


The efficacy and safety of fluticasone/salmeterol compared to fluticasone in children younger than four years of age.

Yoshihara S, Tsubaki T, Ikeda M, Lenney W, Tomiak R, Hattori T, Hashimoto K, Soutome T, Kato S.

Pediatr Allergy Immunol. 2019 Mar;30(2):195-203. doi: 10.1111/pai.13010. Epub 2019 Feb 6.


Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres.

Gilchrist FJ, Buka R, Jones M, Ho SA, Lenney W, Carroll WD.

BMJ Paediatr Open. 2018 Oct 27;2(1):e000367. doi: 10.1136/bmjpo-2018-000367. eCollection 2018.


Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children.

Hmeidi H, Motamedi-Fakhr S, Chadwick EK, Gilchrist FJ, Lenney W, Iles R, Wilson RC, Alexander J.

Physiol Rep. 2018 Jun;6(12):e13752. doi: 10.14814/phy2.13752.


Radiation dose from common radiological investigations and cumulative exposure in children with cystic fibrosis: an observational study from a single UK centre.

Ward R, Carroll WD, Cunningham P, Ho SA, Jones M, Lenney W, Thompson D, Gilchrist FJ.

BMJ Open. 2017 Aug 21;7(8):e017548. doi: 10.1136/bmjopen-2017-017548.


Investigating the variation in the incidence of new Pseudomonas aeruginosa infection between paediatric cystic fibrosis centres.

Gilchrist FJ, Jones AM, Smyth AR, Southern KW, Webb AK, Lenney W.

J Cyst Fibros. 2017 Sep;16(5):e14-e16. doi: 10.1016/j.jcf.2017.06.006. Epub 2017 Jul 6. No abstract available.


Telemedicine is the way forward for the management of cystic fibrosis- the case against.

Lenney W.

Paediatr Respir Rev. 2018 Mar;26:22-23. doi: 10.1016/j.prrv.2017.03.005. Epub 2017 Mar 14. Review.


Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator.

Hmeidi H, Motamedi-Fakhr S, Chadwick E, Gilchrist FJ, Lenney W, Iles R, Wilson RC, Alexander J.

Physiol Rep. 2017 Mar;5(5). pii: e13168. doi: 10.14814/phy2.13168.


Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis.

Gilchrist FJ, Belcher J, Jones AM, Smith D, Smyth AR, Southern KW, Španěl P, Webb AK, Lenney W.

ERJ Open Res. 2015 Nov 16;1(2). pii: 00044-2015. eCollection 2015 Oct.


A systematic review of early life factors which adversely affect subsequent lung function.

Kouzouna A, Gilchrist FJ, Ball V, Kyriacou T, Henderson J, Pandyan AD, Lenney W.

Paediatr Respir Rev. 2016 Sep;20:67-75. doi: 10.1016/j.prrv.2016.03.003. Epub 2016 Mar 14. Review.


A review of prednisolone prescribing for children with acute asthma in the UK.

Gilchrist FJ, Ahmad AN, Batchelor HK, Marriott JF, Lenney W.

J Asthma. 2016 Aug;53(6):563-6. doi: 10.3109/02770903.2015.1118498. Epub 2016 May 4. Review.


Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis.

Kitt H, Lenney W, Gilchrist FJ.

BMC Pharmacol Toxicol. 2016 Mar 28;17:14. doi: 10.1186/s40360-016-0054-0.


Lessons learnt from a primary care asthma improvement project.

Lenney W, Clayton S, Gilchrist FJ, Price D, Small I, Smith J, Sutton EJ.

NPJ Prim Care Respir Med. 2016 Jan 7;26:15075. doi: 10.1038/npjpcrm.2015.75.


A brief personal reflection on 40 years of clinical practice in paediatric respiratory medicine.

Lenney W.

Paediatr Respir Rev. 2016 Jan;17:29. doi: 10.1016/j.prrv.2015.08.005. Epub 2015 Sep 5. No abstract available.


Pseudomonas aeruginosa in cystic fibrosis is potentially serious, and more than merely a marker for disease severity.

Lenney W.

Paediatr Respir Rev. 2015 Oct;16 Suppl 1:35-6. doi: 10.1016/j.prrv.2015.07.016. Epub 2015 Sep 26. Review. No abstract available.


Developing a handheld record for patients with cystic fibrosis.

Narayan O, Davies S, Tibbins C, Rees JM, Lenney W, Gilchrist FJ.

Patient Relat Outcome Meas. 2015 Aug 13;6:225-8. doi: 10.2147/PROM.S86298. eCollection 2015.


Saline in acute bronchiolitis RCT and economic evaluation: hypertonic saline in acute bronchiolitis - randomised controlled trial and systematic review.

Everard ML, Hind D, Ugonna K, Freeman J, Bradburn M, Dixon S, Maguire C, Cantrill H, Alexander J, Lenney W, McNamara P, Elphick H, Chetcuti PA, Moya EF, Powell C, Garside JP, Chadha LK, Kurian M, Lehal RS, MacFarlane PI, Cooper CL, Cross E.

Health Technol Assess. 2015 Aug;19(66):1-130. doi: 10.3310/hta19660.


Complications of a totally implantable venous access device.

Narayan O, Ho SA, Lenney W, Wells D, Gilchrist F.

Arch Dis Child Educ Pract Ed. 2016 Apr;101(2):95, 112. doi: 10.1136/archdischild-2014-307605. Epub 2015 Apr 28. No abstract available.


How to match the optimal currently available inhaler device to an individual child with asthma or recurrent wheeze.

van Aalderen WM, Garcia-Marcos L, Gappa M, Lenney W, Pedersen S, Dekhuijzen R, Price D.

NPJ Prim Care Respir Med. 2015 Jan 8;25:14088. doi: 10.1038/npjpcrm.2014.88. Review.


Bacterial distribution in the lungs of children with protracted bacterial bronchitis.

Narang R, Bakewell K, Peach J, Clayton S, Samuels M, Alexander J, Lenney W, Gilchrist FJ.

PLoS One. 2014 Sep 26;9(9):e108523. doi: 10.1371/journal.pone.0108523. eCollection 2014.


Outcomes in children with protracted bacterial bronchitis confirmed by bronchoscopy.

Pritchard MG, Lenney W, Gilchrist FJ.

Arch Dis Child. 2015 Jan;100(1):112. doi: 10.1136/archdischild-2014-307284. Epub 2014 Sep 9. No abstract available.


A 2½-year review of bronchoalveolar lavage culture results in children with cystic fibrosis.

Jawad M, Bakewell K, Peach J, Clayton S, Alexander J, Lenney W, Gilchrist FJ.

J Bronchology Interv Pulmonol. 2014 Jul;21(3):279-80. doi: 10.1097/LBR.0000000000000085. No abstract available.


The screening and diagnosis of cystic fibrosis-related diabetes in the United Kingdom.

Wickens-Mitchell KL, Gilchrist FJ, McKenna D, Raffeeq P, Lenney W.

J Cyst Fibros. 2014 Sep;13(5):589-92. doi: 10.1016/j.jcf.2014.01.008. Epub 2014 Feb 14.


Children must be protected from the tobacco industry's marketing tactics.

Hopkinson N, Wallis C, Higgins B, Gaduzo S, Sherrington R, Keilty S, Stern M, Britton J, Bush A, Moxham J, Sylvester K, Griffiths V, Sutherland T, Crossingham I, Raju R, Spencer C, Safavi S, Deegan P, Seymour J, Hickman K, Hughes J, Wieboldt J, Shaheen F, Peedell C, Mackenzie N, Nicholl D, Jolley C, Crooks G, Crooks G, Dow C, Deveson P, Bintcliffe O, Gray B, Kumar S, Haney S, Docherty M, Thomas A, Chua F, Dwarakanath A, Summers G, Prowse K, Lytton S, Ong YE, Graves J, Banerjee T, English P, Leonard A, Brunet M, Chaudhry N, Ketchell RI, Cummings N, Lebus J, Sharp C, Meadows C, Harle A, Stewart T, Parry D, Templeton-Wright S, Moore-Gillon J, Stratford- Martin J, Saini S, Matusiewicz S, Merritt S, Dowson L, Satkunam K, Hodgson L, Suh ES, Durrington H, Browne E, Walters N, Steier J, Barry S, Griffiths M, Hart N, Nikolic M, Berry M, Thomas A, Miller J, McNicholl D, Marsden P, Warwick G, Barr L, Adeboyeku D, Mohd Noh MS, Griffiths P, Davies L, Quint J, Lyall R, Shribman J, Collins A, Goldman J, Bloch S, Gill A, Man W, Christopher A, Yasso R, Rajhan A, Shrikrishna D, Moore C, Absalom G, Booton R, Fowler RW, Mackinlay C, Sapey E, Lock S, Walker P, Jha A, Satia I, Bradley B, Mustfa N, Haqqee R, Thomas M, Patel A, Redington A, Pillai A, Keaney N, Fowler S, Lowe L, Brennan A, Morrison D, Murray C, Hankinson J, Dutta P, Maddocks M, Pengo M, Curtis K, Rafferty G, Hutchinson J, Whitfield R, Turner S, Breen R, Naveed SU, Goode C, Esterbrook G, Ahmed L, Walker W, Ford D, Connett G, Davidson P, Elston W, Stanton A, Morgan D, Myerson J, Maxwell D, Harrris A, Parmar S, Houghton C, Winter R, Puthucheary Z, Thomson F, Sturney S, Harvey J, Haslam PL, Patel I, Jennings D, Range S, Mallia-Milanes B, Collett A, Tate P, Russell R, Feary J, O'Driscoll R, Eaden J, Round J, Sharkey E, Montgomery M, Vaughan S, Scheele K, Lithgow A, Partridge S, Chavasse R, Restrick L, Agrawal S, Abdallah S, Lacy-Colson A, Adams N, Mitchell S, Haja Mydin H, Ward A, Denniston S, Steel M, Ghosh D, Connellan S, Rigge L, Williams R, Grove A, Anwar S, Dobson L, Hosker H, Stableforth D, Greening N, Howell T, Casswell G, Davies S, Tunnicliffe G, Mitchelmore P, Phitidis E, Robinson L, Prowse K, Bafadhel M, Robinson G, Boland A, Lipman M, Bourke S, Kaul S, Cowie C, Forrest I, Starren E, Burke H, Furness J, Bhowmik A, Everett C, Seaton D, Holmes S, Doe S, Parker S, Graham A, Paterson I, Maqsood U, Ohri C, Iles P, Kemp S, Iftikhar A, Carlin C, Fletcher T, Emerson P, Beasley V, Ramsay M, Buttery R, Mungall S, Crooks S, Ridyard J, Ross D, Guadagno A, Holden E, Coutts I, Cullen K, O'Connor S, Barker J, Sloper K, Watson J, Smith P, Anderson P, Brown L, Nyman C, Milburn H, Clive A, Serlin M, Bolton C, Fuld J, Powell H, Dayer M, Woolhouse I, Georgiadi A, Leonard H, Dodd J, Campbell I, Ruiz G, Zurek A, Paton JY, Malin A, Wood F, Hynes G, Connell D, Spencer D, Brown S, Smith D, Cooper D, O'Kane C, Hicks A, Creagh-Brown B, Lordan J, Nickol A, Primhak R, Fleming L, Powrie D, Brown J, Zoumot Z, Elkin S, Szram J, Scaffardi A, Marshall R, Macdonald I, Lightbody D, Farmer R, Wheatley I, Radnan P, Lane I, Booth A, Tilbrook S, Capstick T, Hewitt L, McHugh M, Nelson C, Wilson P, Padmanaban V, White J, Davison J, O'Callaghan U, Hodson M, Edwards J, Campbell C, Ward S, Wooler E, Ringrose E, Bridges D, Matthew Hodson, John Edwards, Colin Campbell, Simon Ward, Edwina Wooler, Elizabeth Ringrose, Diana Bridges, Rosalind Backham, Kim Randall, Tracey Mathieson, Long A, Parkes M, Clarke S, Allen B, Connelly C, Forster G, Hoadley J, Martin K, Barnham K, Khan K, Munday M, Edwards C, O'Hara D, Turner S, Pieri-Davies S, Ford K, Daniels T, Wright J, Towns R, Fern K, Butcher J, Burgin K, Winter B, Freeman D, Olive S, Gray L, Pye K, Roots D, Cox N, Davies CA, Wicker J, Hilton K, Lloyd J, MacBean V, Wood M, Kowal J, Downs J, Ryan H, Guyatt F, Nicoll D, Lyons E, Narasimhan D, Rodman A, Walmsley S, Newey A, Buxton M, Dewar M, Cooper A, Reilly J, Lloyd J, Macmillan AB, Roots D, Olley A, Voase N, Martin S, McCarvill I, Christensen A, Agate R, Heslop K, Timlett A, Hailes K, Davey C, Pawulska B, Lane A, Ioakim S, Hough A, Treharne J, Jones H, Winter-Burke A, Miller L, Connolly B, Bingham L, Fraser U, Bott J, Johnston C, Graham A, Curry D, Sumner H, Costello CA, Bartoszewicz C, Badman R, Williamson K, Taylor A, Purcell H, Barnett E, Molloy A, Crawfurd L, Collins N, Monaghan V, Mir M, Lord V, Stocks J, Edwards A, Greenhalgh T, Lenney W, McKee M, McAuley D, Majeed A, Cookson J, Baker E, Janes S, Wedzicha W, Lomas Dean D, Harrison B, Davison T, Calverley P, Wilson R, Stockley R, Ayres J, Gibson J, Simpson J, Burge S, Warner J, Lenney W, Thomson N, Davies P, Woodcock A, Woodhead M, Spiro S, Ormerod L, Bothamley G, Partridge M, Shields M, Montgomery H, Simonds A, Barnes P, Durham S, Malone S, Arabnia G, Olivier S, Gardiner K, Edwards S.

BMJ. 2013 Dec 9;347:f7358. doi: 10.1136/bmj.f7358. No abstract available.


Hydrogen cyanide, a volatile biomarker of Pseudomonas aeruginosa infection.

Smith D, Spaněl P, Gilchrist FJ, Lenney W.

J Breath Res. 2013 Dec;7(4):044001. doi: 10.1088/1752-7155/7/4/044001. Epub 2013 Nov 28. Review.


The development of a national children's formulary.

Lenney W.

Br J Clin Pharmacol. 2015 Mar;79(3):441-5. doi: 10.1111/bcp.12280.


Pneumomediastinum and hyponatraemic dehydration as presenting features of cystic fibrosis.

Gilchrist FJ, Samuels M, Klafkowski G, Watson NA, Lenney W.

Eur Respir J. 2013 Dec;42(6):1760-2. doi: 10.1183/09031936.00124713. Epub 2013 Sep 26. No abstract available.


Is hydrogen cyanide a marker of Burkholderia cepacia complex?

Gilchrist FJ, Sims H, Alcock A, Jones AM, Bright-Thomas RJ, Smith D, Španel P, Webb AK, Lenney W.

J Clin Microbiol. 2013 Nov;51(11):3849-51. doi: 10.1128/JCM.02157-13. Epub 2013 Aug 21.


Intestinal obstruction secondary to adhesions in an infant with cystic fibrosis.

Jawad M, Klafkowski G, Lenney W, Gilchrist FJ.

BMJ Case Rep. 2013 Jul 29;2013. pii: bcr2013010444. doi: 10.1136/bcr-2013-010444. Erratum in: BMJ Case Rep. 2013;2013. doi: 10.1136/bcr-2013-010444corr1.


Hydrogen cyanide concentrations in the breath of adult cystic fibrosis patients with and without Pseudomonas aeruginosa infection.

Gilchrist FJ, Bright-Thomas RJ, Jones AM, Smith D, Spaněl P, Webb AK, Lenney W.

J Breath Res. 2013 Jun;7(2):026010. doi: 10.1088/1752-7155/7/2/026010. Epub 2013 May 17.


Management of Asthma in School age Children On Therapy (MASCOT): a randomised, double-blind, placebo-controlled, parallel study of efficacy and safety.

Lenney W, McKay AJ, Tudur Smith C, Williamson PR, James M, Price D; MASCOT Study Group.

Health Technol Assess. 2013 Feb;17(4):1-218. doi: 10.3310/hta17040.


The trachea with an air-fluid level: a rare and bizarre radiological sign.

Marsh R, Gupta A, Gilchrist FJ, Puckey M, Padley SP, Hogg C, Lenney W, Bush A.

Pediatr Pulmonol. 2012 Aug;47(8):826-30. doi: 10.1002/ppul.21623. Epub 2012 Jan 3.


An investigation of suitable bag materials for the collection and storage of breath samples containing hydrogen cyanide.

Gilchrist FJ, Razavi C, Webb AK, Jones AM, Spaněl P, Smith D, Lenney W.

J Breath Res. 2012 Sep;6(3):036004. doi: 10.1088/1752-7155/6/3/036004. Epub 2012 Jul 4.


An algorithm for the use of intravenous salbutamol in children.

Clayton S, Gilchrist F, Alexander J, Enberby B, Lenney W.

Br J Nurs. 2012 Apr 26-May 9;21(8):S30-4. No abstract available.


How do children and their caregivers perceive the benefits of inhaled asthma therapy?

Gilchrist FJ, Brady M, Gallop K, Wild DJ, Tabberer M, Jacques L, Lenney W.

J Asthma. 2012 Jun;49(5):552-6. doi: 10.3109/02770903.2012.672610. Epub 2012 Apr 10.


Paracetamol prescription by age or by weight?

Lenney W.

Arch Dis Child. 2012 Mar;97(3):277-8. doi: 10.1136/archdischild-2011-301374. Epub 2011 Dec 7. No abstract available.


Alpha-nicotinic acetylcholine receptor and tobacco smoke exposure: effects on bronchial hyperresponsiveness in children.

Torjussen TM, Lødrup Carlsen KC, Munthe-Kaas MC, Mowinckel P, Carlsen KH, Helms PJ, Gerritsen J, Whyte MK, Lenney W, Undlien DE, Shianna KV, Zhu G, Pillai SG.

Pediatr Allergy Immunol. 2012 Feb;23(1):40-9. doi: 10.1111/j.1399-3038.2011.01222.x. Epub 2011 Oct 21.


Clinical trials and tribulations: the MASCOT study.

Lenney W, Perry S, Price D.

Thorax. 2011 Jun;66(6):457-8. doi: 10.1136/thx.2010.156885. Epub 2011 Mar 11. No abstract available.


Pseudomonas aeruginosa and cyanide production.

Lenney W, Gilchrist FJ.

Eur Respir J. 2011 Mar;37(3):482-3. doi: 10.1183/09031936.00122810. No abstract available.


Variation in hydrogen cyanide production between different strains of Pseudomonas aeruginosa.

Gilchrist FJ, Alcock A, Belcher J, Brady M, Jones A, Smith D, Spanĕl P, Webb K, Lenney W.

Eur Respir J. 2011 Aug;38(2):409-14. doi: 10.1183/09031936.00166510. Epub 2011 Jan 27.


Not NICE: a better way forward?

Bush A, Lenney W, Spencer D, Warner JO.

Arch Dis Child. 2011 Oct;96(10):907-8. doi: 10.1136/adc.2010.194647. Epub 2011 Jan 24. No abstract available.


Respiratory morbidity, healthcare utilisation and cost of care at school age related to home oxygen status.

Greenough A, Alexander J, Boorman J, Chetcuti PA, Cliff I, Lenney W, Morgan C, Shaw NJ, Sylvester KP, Turner J.

Eur J Pediatr. 2011 Aug;170(8):969-75. doi: 10.1007/s00431-010-1381-6. Epub 2011 Jan 12.


Safety of formoterol in children and adolescents: experience from asthma clinical trials.

Price JF, Radner F, Lenney W, Lindberg B.

Arch Dis Child. 2010 Dec;95(12):1047-53. doi: 10.1136/adc.2010.183814. Epub 2010 Oct 27. Review.


Bronchoalveolar lavage in children with cystic fibrosis: how many lobes should be sampled?

Gilchrist FJ, Salamat S, Clayton S, Peach J, Alexander J, Lenney W.

Arch Dis Child. 2011 Mar;96(3):215-7. doi: 10.1136/adc.2009.177618. Epub 2010 Oct 7.


Lung deposition of inhaled tobramycin with eFlow rapid/LC Plus jet nebuliser in healthy and cystic fibrosis subjects.

Lenney W, Edenborough F, Kho P, Kovarik JM.

J Cyst Fibros. 2011 Jan;10(1):9-14. doi: 10.1016/j.jcf.2010.08.019.


Controversy over generic substitution.

Ferner RE, Lenney W, Marriott JF.

BMJ. 2010 Jun 1;340:c2548. doi: 10.1136/bmj.c2548. No abstract available.


Feasibility study to inform the design of a randomised controlled trial to eradicate Pseudomonas aeruginosa infection in individuals with cystic fibrosis.

Hickey HR, Jones AP, Lenney W, Williamson PR, Smyth RL.

Trials. 2010 Feb 5;11:11. doi: 10.1186/1745-6215-11-11.


Isoprene levels in the exhaled breath of 200 healthy pupils within the age range 7-18 years studied using SIFT-MS.

Smith D, Spaněl P, Enderby B, Lenney W, Turner C, Davies SJ.

J Breath Res. 2010 Mar;4(1):017101. doi: 10.1088/1752-7155/4/1/017101. Epub 2009 Dec 18.


Childhood evaluation of salmeterol tolerance--a double-blind randomized controlled trial.

Carroll WD, Jones PW, Boit P, Clayton S, Cliff I, Lenney W.

Pediatr Allergy Immunol. 2010 Mar;21(2 Pt 1):336-44. doi: 10.1111/j.1399-3038.2009.00927.x. Epub 2009 Aug 27.


Medicines used in respiratory diseases only seen in children.

Lenney W, Boner AL, Bont L, Bush A, Carlsen KH, Eber E, Fauroux B, Götz M, Greenough A, Grigg J, Hull J, Kimpen J, Sánchez Luna M, de Benedictis FM.

Eur Respir J. 2009 Sep;34(3):531-51. doi: 10.1183/09031936.00166508. Review.

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