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Items: 1 to 50 of 111

1.

Financially Effective Test-Algorithm to Identify an Aggressive, EGFR-amplified Variant of IDH-Wildtype, Lower-Grade Diffuse Glioma.

Bale TA, Jordan JT, Rapalino O, Ramamurthy N, Jessop N, DeWitt JC, Nardi V, Martinez-Lage Alvarez M, Frosch M, Batchelor TT, Louis DN, Iafrate AJ, Cahill DP, Lennerz JK.

Neuro Oncol. 2018 Nov 28. doi: 10.1093/neuonc/noy201. [Epub ahead of print]

PMID:
30496526
2.

Management of disseminated intravascular coagulation in a patient with hepatic angiosarcoma: A case report.

Rosen EA, Vallurupalli M, Choy E, Lennerz JK, Kuter DJ.

Medicine (Baltimore). 2018 Nov;97(47):e13321. doi: 10.1097/MD.0000000000013321.

3.

Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis.

Krämer LM, Brettschneider J, Lennerz JK, Walcher D, Fang L, Rosenbohm A, Balakrishnan K, Benckendorff J, Möller P, Just S, Willem M, Ludolph AC, Thal DR.

Sci Rep. 2018 Nov 9;8(1):16594. doi: 10.1038/s41598-018-34808-7.

4.

Enrichment of HER2 Amplification in Brain Metastases from Primary Gastrointestinal Malignancies.

Mitra D, Clark JW, Shih HA, Oh KS, Brastianos PK, Wo JY, Strickland MR, Curry WT, Parikh AR, Corcoran RB, Ryan DP, Iafrate AJ, Borger DR, Lennerz JK, Hong TS.

Oncologist. 2018 Oct 29. pii: theoncologist.2018-0152. doi: 10.1634/theoncologist.2018-0152. [Epub ahead of print]

PMID:
30373904
5.

Clinical Utility of Rapid EGFR Genotyping in Advanced Lung Cancer.

Dagogo-Jack I, Azzolli CG, Fintelmann F, Mino-Kenudson M, Farago AF, Gainor JF, Jiang G, Piotrowska Z, Heist RS, Lennes IT, Temel JS, Mooradian MJ, Lin JJ, Digumarthy SR, Batten JM, Robinson H, Nose V, Rivera M, Nardi V, Dias-Santagata D, Le LP, Sequist LV, Pitman M, Shepard JO, Shaw AT, Iafrate AJ, Lennerz JK.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.17.00299. Epub 2018 Jul 24.

6.

Artificial Intelligence Approach for Variant Reporting.

Zomnir MG, Lipkin L, Pacula M, Meneses ED, MacLeay A, Duraisamy S, Nadhamuni N, Al Turki SH, Zheng Z, Rivera M, Nardi V, Dias-Santagata D, Iafrate AJ, Le LP, Lennerz JK.

JCO Clin Cancer Inform. 2018;2018. doi: 10.1200/CCI.16.00079. Epub 2018 Mar 22.

7.

Recent advances in the histological and molecular classification of endometrial stromal neoplasms.

Ferreira J, Félix A, Lennerz JK, Oliva E.

Virchows Arch. 2018 Dec;473(6):665-678. doi: 10.1007/s00428-018-2470-6. Epub 2018 Oct 15. Review.

PMID:
30324234
8.

Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion.

Piotrowska Z, Isozaki H, Lennerz JK, Gainor JF, Lennes IT, Zhu VW, Marcoux N, Banwait MK, Digumarthy SR, Su W, Yoda S, Riley AK, Nangia V, Lin JJ, Nagy RJ, Lanman RB, Dias-Santagata D, Mino-Kenudson M, Iafrate AJ, Heist RS, Shaw AT, Evans EK, Clifford C, Ou SI, Wolf B, Hata AN, Sequist LV.

Cancer Discov. 2018 Dec;8(12):1529-1539. doi: 10.1158/2159-8290.CD-18-1022. Epub 2018 Sep 26.

PMID:
30257958
9.

The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome.

Kosumi K, Hamada T, Koh H, Borowsky J, Bullman S, Twombly TS, Nevo D, Masugi Y, Liu L, da Silva A, Chen Y, Du C, Gu M, Li C, Li W, Liu H, Shi Y, Mima K, Song M, Nosho K, Nowak JA, Nishihara R, Baba H, Zhang X, Wu K, Wang M, Huttenhower C, Garrett WS, Meyerson ML, Lennerz JK, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Ogino S.

Am J Pathol. 2018 Dec;188(12):2839-2852. doi: 10.1016/j.ajpath.2018.08.015. Epub 2018 Sep 20.

PMID:
30243655
10.

Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-mutant Lung Cancer.

Dagogo-Jack I, Martinez P, Yeap BY, Ambrogio C, Ferris LA, Lydon C, Nguyen T, Jessop NA, Iafrate AJ, Johnson BE, Lennerz JK, Shaw AT, Awad MM.

Clin Cancer Res. 2018 Sep 17. doi: 10.1158/1078-0432.CCR-18-2062. [Epub ahead of print]

PMID:
30224342
11.

Clinicopathologic Features of Non-Small-Cell Lung Cancer Harboring an NTRK Gene Fusion.

Farago AF, Taylor MS, Doebele RC, Zhu VW, Kummar S, Spira AI, Boyle TA, Haura EB, Arcila ME, Benayed R, Aisner DL, Horick NK, Lennerz JK, Le LP, Iafrate AJ, Ou SI, Shaw AT, Mino-Kenudson M, Drilon A.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.18.00037. Epub 2018 Jul 23.

12.

Novel gene fusions in secretory carcinoma of the salivary glands: enlarging the ETV6 family.

Guilmette J, Dias-Santagata D, Nosé V, Lennerz JK, Sadow PM.

Hum Pathol. 2018 Aug 18. pii: S0046-8177(18)30316-2. doi: 10.1016/j.humpath.2018.08.011. [Epub ahead of print]

PMID:
30130630
13.

Genotype-targeted local therapy of glioma.

Shankar GM, Kirtane AR, Miller JJ, Mazdiyasni H, Rogner J, Tai T, Williams EA, Higuchi F, Juratli TA, Tateishi K, Koerner MVA, Tummala SS, Fink AL, Penson T, Schmidt SP, Wojtkiewicz GR, Baig A, Francis JM, Rinne ML, Batten JM, Batchelor TT, Brastianos PK, Curry WT Jr, Barker FG 2nd, Jordan JT, Iafrate AJ, Chi AS, Lennerz JK, Meyerson M, Langer R, Wakimoto H, Traverso G, Cahill DP.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8388-E8394. doi: 10.1073/pnas.1805751115. Epub 2018 Aug 6.

PMID:
30082399
14.

Brigatinib in Patients With Alectinib-Refractory ALK-Positive NSCLC.

Lin JJ, Zhu VW, Schoenfeld AJ, Yeap BY, Saxena A, Ferris LA, Dagogo-Jack I, Farago AF, Taber A, Traynor A, Menon S, Gainor JF, Lennerz JK, Plodkowski AJ, Digumarthy SR, Ou SI, Shaw AT, Riely GJ.

J Thorac Oncol. 2018 Oct;13(10):1530-1538. doi: 10.1016/j.jtho.2018.06.005. Epub 2018 Jun 20.

PMID:
29935304
15.

Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer.

Yoda S, Lin JJ, Lawrence MS, Burke BJ, Friboulet L, Langenbucher A, Dardaei L, Prutisto-Chang K, Dagogo-Jack I, Timofeevski S, Hubbeling H, Gainor JF, Ferris LA, Riley AK, Kattermann KE, Timonina D, Heist RS, Iafrate AJ, Benes CH, Lennerz JK, Mino-Kenudson M, Engelman JA, Johnson TW, Hata AN, Shaw AT.

Cancer Discov. 2018 Jun;8(6):714-729. doi: 10.1158/2159-8290.CD-17-1256. Epub 2018 Apr 12.

PMID:
29650534
16.

MET Amplification in Esophageal Squamous Carcinoma.

Michaels PD, Robinson H, Nardi V, Iafrate AJ, Le L, Lennerz JK.

Int J Surg Pathol. 2018 Dec;26(8):731-732. doi: 10.1177/1066896918764301. Epub 2018 Mar 19. No abstract available.

PMID:
29552946
17.

Implementing Keytruda/Pembrolizumab Testing in Clinical Practice.

Ratner D, Lennerz JK.

Oncologist. 2018 Jun;23(6):647-649. doi: 10.1634/theoncologist.2017-0591. Epub 2018 Mar 9. No abstract available.

18.

Tracking the Evolution of Resistance to ALK Tyrosine Kinase Inhibitors through Longitudinal Analysis of Circulating Tumor DNA.

Dagogo-Jack I, Brannon AR, Ferris LA, Campbell CD, Lin JJ, Schultz KR, Ackil J, Stevens S, Dardaei L, Yoda S, Hubbeling H, Digumarthy SR, Riester M, Hata AN, Sequist LV, Lennes IT, Iafrate AJ, Heist RS, Azzoli CG, Farago AF, Engelman JA, Lennerz JK, Benes CH, Leary RJ, Shaw AT, Gainor JF.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.17.00160. Epub 2018 Jan 23.

19.

Performance comparison of two androgen receptor splice variant 7 (AR-V7) detection methods.

Bernemann C, Steinestel J, Humberg V, Bögemann M, Schrader AJ, Lennerz JK.

BJU Int. 2018 Aug;122(2):219-226. doi: 10.1111/bju.14146. Epub 2018 Feb 14.

PMID:
29359890
20.

Food Addiction, High-Glycemic-Index Carbohydrates, and Obesity.

Lennerz B, Lennerz JK.

Clin Chem. 2018 Jan;64(1):64-71. doi: 10.1373/clinchem.2017.273532. Epub 2017 Nov 20. Review.

PMID:
29158252
21.

Fluorescent Labeling and 2-Photon Imaging of Mouse Tooth Pulp Nociceptors.

Kadala A, Sotelo-Hitschfeld P, Ahmad Z, Tripal P, Schmid B, Mueller A, Bernal L, Winter Z, Brauchi S, Lohbauer U, Messlinger K, Lennerz JK, Zimmermann K.

J Dent Res. 2018 Apr;97(4):460-466. doi: 10.1177/0022034517740577. Epub 2017 Nov 12.

PMID:
29130364
22.

Cost-effectiveness of IDH testing in diffuse gliomas according to the 2016 WHO classification of tumors of the central nervous system recommendations.

DeWitt JC, Jordan JT, Frosch MP, Samore WR, Iafrate AJ, Louis DN, Lennerz JK.

Neuro Oncol. 2017 Nov 29;19(12):1640-1650. doi: 10.1093/neuonc/nox120.

24.

Origins of lymphatic and distant metastases in human colorectal cancer.

Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK.

Science. 2017 Jul 7;357(6346):55-60. doi: 10.1126/science.aai8515.

25.

Case 10-2017 - A 6-Month-Old Boy with Gastrointestinal Bleeding and Abdominal Pain.

Allister LM, Lim R, Goldstein AM, Lennerz JK.

N Engl J Med. 2017 Mar 30;376(13):1269-1277. doi: 10.1056/NEJMcpc1616020. No abstract available.

PMID:
28355500
26.

PAX8-positive Biphasic Synovial Sarcoma Expressing Hormonal Receptors.

Lordello L, Bur ME, Oliva E, Lennerz JK.

Appl Immunohistochem Mol Morphol. 2017 Feb 28. doi: 10.1097/PAI.0000000000000497. [Epub ahead of print]

PMID:
28248726
27.

ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non-Small Cell Lung Cancer.

Lin JJ, Ritterhouse LL, Ali SM, Bailey M, Schrock AB, Gainor JF, Ferris LA, Mino-Kenudson M, Miller VA, Iafrate AJ, Lennerz JK, Shaw AT.

J Thorac Oncol. 2017 May;12(5):872-877. doi: 10.1016/j.jtho.2017.01.004. Epub 2017 Jan 11.

28.

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.

Goyal L, Saha SK, Liu LY, Siravegna G, Leshchiner I, Ahronian LG, Lennerz JK, Vu P, Deshpande V, Kambadakone A, Mussolin B, Reyes S, Henderson L, Sun JE, Van Seventer EE, Gurski JM Jr, Baltschukat S, Schacher-Engstler B, Barys L, Stamm C, Furet P, Ryan DP, Stone JR, Iafrate AJ, Getz G, Porta DG, Tiedt R, Bardelli A, Juric D, Corcoran RB, Bardeesy N, Zhu AX.

Cancer Discov. 2017 Mar;7(3):252-263. doi: 10.1158/2159-8290.CD-16-1000. Epub 2016 Dec 29.

29.

Case 35-2016. A 62-Year-Old Man with Dysphagia.

Kwak EL, Hong TS, Forcione DG, Kambadakone A, Lennerz JK.

N Engl J Med. 2016 Nov 17;375(20):1983-1991. No abstract available.

PMID:
27959609
30.

Performance Testing of RREB1, MYB, and CCND1 Fluorescence In Situ Hybridization in Spindle-Cell and Desmoplastic Melanoma Argues for a Two-Step Test Algorithm.

Weissinger SE, Frick M, Möller P, Horst BA, Lennerz JK.

Int J Surg Pathol. 2017 Apr;25(2):148-157. doi: 10.1177/1066896916680072. Epub 2016 Nov 30.

PMID:
27899693
31.

Expression of Kallikrein-Related Peptidase 6 in Primary Mucosal Malignant Melanoma of the Head and Neck.

Thierauf J, Veit JA, Lennerz JK, Weissinger SE, Affolter A, Döscher J, Bergmann C, Knopf A, Grünow J, Grünmüller L, Mauch C, Plinkert PK, Hoffmann TK, Hess J.

Head Neck Pathol. 2017 Sep;11(3):314-320. doi: 10.1007/s12105-016-0769-7. Epub 2016 Nov 14.

33.

Reply from Authors re: Emmanuel S. Antonarakis, Howard I. Scher. Do Patients With AR-V7-Positive Prostate Cancer Benefit from Novel Hormonal Therapies? It All Depends on Definitions. Eur Urol 2017;71:4-6: Unsplicing a Conflict.

Steinestel J, Bernemann C, Schrader AJ, Lennerz JK.

Eur Urol. 2017 Jan;71(1):6-7. doi: 10.1016/j.eururo.2016.08.071. Epub 2016 Sep 15. No abstract available.

PMID:
27641787
34.

Classical pathology and mutational load of breast cancer - integration of two worlds.

Budczies J, Bockmayr M, Denkert C, Klauschen F, Lennerz JK, Györffy B, Dietel M, Loibl S, Weichert W, Stenzinger A.

J Pathol Clin Res. 2015 Jul 20;1(4):225-38. doi: 10.1002/cjp2.25. eCollection 2015 Oct.

35.

Health Care Infrastructure for Financially Sustainable Clinical Genomics.

Lennerz JK, McLaughlin HM, Baron JM, Rasmussen D, Sumbada Shin M, Berners-Lee N, Miller Batten J, Swoboda KJ, Gala MK, Winter HS, Schmahmann JD, Sweetser DA, Boswell M, Pacula M, Stenzinger A, Le LP, Hynes W, Rehm HL, Klibanski A, Black-Schaffer SW, Golden JA, Louis DN, Weiss ST, Iafrate AJ.

J Mol Diagn. 2016 Sep;18(5):697-706. doi: 10.1016/j.jmoldx.2016.04.003. Epub 2016 Jul 25.

36.

Biopanel identifies expression status of targetable proteins in sinonasal melanoma.

Grünmüller L, Thierauf J, Weissinger SE, Bergmann C, Bankfalvi A, Veit J, Hoffmann TK, Möller P, Lennerz JK.

Per Med. 2016 Jul;13(4):291-301. doi: 10.2217/pme-2016-0023. Epub 2016 Apr 20.

PMID:
29749817
37.

Silencer of Cytokine Signaling 1 gene is not hypermethylated in diffuse large B-cell lymphoma.

Lennerz JK, Weissinger SE, Gerstenmaier U, Marienfeld R, Möller P; network project Molecular Mechanisms in Malignant Lymphomas.

Br J Haematol. 2017 Oct;179(1):158-160. doi: 10.1111/bjh.14188. Epub 2016 Jun 15. No abstract available.

PMID:
27301865
38.

Pan-cancer analysis of copy number changes in programmed death-ligand 1 (PD-L1, CD274) - associations with gene expression, mutational load, and survival.

Budczies J, Bockmayr M, Denkert C, Klauschen F, Gröschel S, Darb-Esfahani S, Pfarr N, Leichsenring J, Onozato ML, Lennerz JK, Dietel M, Fröhling S, Schirmacher P, Iafrate AJ, Weichert W, Stenzinger A.

Genes Chromosomes Cancer. 2016 Aug;55(8):626-39. doi: 10.1002/gcc.22365. Epub 2016 May 30.

PMID:
27106868
39.

ROS1 Rearrangement in Thyroid Cancer.

Ritterhouse LL, Wirth LJ, Randolph GW, Sadow PM, Ross DS, Liddy W, Lennerz JK.

Thyroid. 2016 Jun;26(6):794-7. doi: 10.1089/thy.2016.0101.

PMID:
27089969
40.

A protein and mRNA expression-based classification of gastric cancer.

Setia N, Agoston AT, Han HS, Mullen JT, Duda DG, Clark JW, Deshpande V, Mino-Kenudson M, Srivastava A, Lennerz JK, Hong TS, Kwak EL, Lauwers GY.

Mod Pathol. 2016 Jul;29(7):772-84. doi: 10.1038/modpathol.2016.55. Epub 2016 Apr 1.

41.

Colorectal cancer in Crohn's colitis is comparable to sporadic colorectal cancer.

Lennerz JK, van der Sloot KWJ, Le LP, Batten JM, Han JY, Fan KC, Siegel CA, Srivastava A, Park DY, Chen JH, Sands BE, Korzenik JR, Odze RD, Dias-Santagata D, Borger DR, Khalili H, Iafrate AJ, Lauwers GY.

Int J Colorectal Dis. 2016 May;31(5):973-982. doi: 10.1007/s00384-016-2574-x. Epub 2016 Mar 30.

PMID:
27026089
42.

Dramatic Response to Combination Erlotinib and Crizotinib in a Patient with Advanced, EGFR-Mutant Lung Cancer Harboring De Novo MET Amplification.

Gainor JF, Niederst MJ, Lennerz JK, Dagogo-Jack I, Stevens S, Shaw AT, Sequist LV, Engelman JA.

J Thorac Oncol. 2016 Jul;11(7):e83-5. doi: 10.1016/j.jtho.2016.02.021. Epub 2016 Mar 14. No abstract available.

43.

Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma.

Pfarr N, Sinn HP, Klauschen F, Flechtenmacher C, Bockmayr M, Ridinger K, von Winterfeld M, Warth A, Lorenz K, Budczies J, Penzel R, Lennerz JK, Endris V, Weichert W, Stenzinger A.

Genes Chromosomes Cancer. 2016 Feb;55(2):113-9. doi: 10.1002/gcc.22315. Epub 2015 Oct 23.

PMID:
26493284
44.

Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer.

Kwak EL, Ahronian LG, Siravegna G, Mussolin B, Borger DR, Godfrey JT, Jessop NA, Clark JW, Blaszkowsky LS, Ryan DP, Lennerz JK, Iafrate AJ, Bardelli A, Hong TS, Corcoran RB.

Cancer Discov. 2015 Dec;5(12):1271-81. doi: 10.1158/2159-8290.CD-15-0748. Epub 2015 Oct 2. Erratum in: Cancer Discov. 2016 Dec;6(12 ):1402.

45.

ClinGen and Genetic Testing.

Lennerz JK, Ramamurthy L.

N Engl J Med. 2015 Oct;373(14):1377-8. doi: 10.1056/NEJMc1508700. No abstract available.

PMID:
26422740
46.

Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck.

Thierauf J, Veit JA, Affolter A, Bergmann C, Grünow J, Laban S, Lennerz JK, Grünmüller L, Mauch C, Plinkert PK, Hess J, Hoffmann TK.

Melanoma Res. 2015 Dec;25(6):503-9. doi: 10.1097/CMR.0000000000000197.

PMID:
26352784
47.

Suppressor of cytokine signaling 1 gene mutation status as a prognostic biomarker in classical Hodgkin lymphoma.

Lennerz JK, Hoffmann K, Bubolz AM, Lessel D, Welke C, Rüther N, Viardot A, Möller P.

Oncotarget. 2015 Oct 6;6(30):29097-110. doi: 10.18632/oncotarget.4829.

48.

Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition.

Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld FM, Hessmann E, Gaedcke J, Güthle M, Zenke M, Hartmann D, von Figura G, Weissinger SE, Rudolph KL, Möller P, Lennerz JK, Seufferlein T, Wagner M, Kleger A.

Nat Commun. 2015 Jul 29;6:7677. doi: 10.1038/ncomms8677.

49.

Basket Trials: Just the End of the First Quarter.

Stenzinger A, Weichert W, Lennerz JK, Klauschen F.

J Clin Oncol. 2015 Sep 1;33(25):2823-4. doi: 10.1200/JCO.2015.62.1516. Epub 2015 Jul 13. No abstract available.

PMID:
26169614
50.

Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis.

Pfarr N, Kriegsmann M, Sinn P, Klauschen F, Endris V, Herpel E, Muckenhuber A, Jesinghaus M, Klosterhalfen B, Penzel R, Lennerz JK, Weichert W, Stenzinger A.

Genes Chromosomes Cancer. 2015 Jul;54(7):444-52. doi: 10.1002/gcc.22256. Epub 2015 Apr 30.

PMID:
25931199

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