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Items: 33


In Vivo Imaging of Small Molecular Weight Peptides for Targeted Renal Drug Delivery: A Study in Normal and Polycystic Kidney Diseased Mice.

Lenhard SC, McAlexander A, Virtue A, Fieles W, Skedzielewski T, Rambo M, Trinh H, Cheng SH, Hong H, Isidro-Llobet A, Nadin A, Geske R, Klein JL, Lee D, Jucker BM, Hu E.

J Pharmacol Exp Ther. 2019 Sep;370(3):786-795. doi: 10.1124/jpet.119.257022. Epub 2019 Apr 1.


A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.

Karageorgis A, Lenhard SC, Yerby B, Forsgren MF, Liachenko S, Johansson E, Pilling MA, Peterson RA, Yang X, Williams DP, Ungersma SE, Morgan RE, Brouwer KLR, Jucker BM, Hockings PD.

PLoS One. 2018 May 17;13(5):e0197213. doi: 10.1371/journal.pone.0197213. eCollection 2018.


Multimodal imaging approach to examine biodistribution kinetics of Cabotegravir (GSK1265744) long acting parenteral formulation in rat.

Jucker BM, Alsaid H, Rambo M, Lenhard SC, Hoang B, Xie F, Groseclose MR, Castellino S, Damian V, Bowers G, Gupta M.

J Control Release. 2017 Dec 28;268:102-112. doi: 10.1016/j.jconrel.2017.10.017. Epub 2017 Oct 16.


Hepatic Phospholipidosis Is Associated with Altered Hepatobiliary Function as Assessed by Gadoxetate Dynamic Contrast-enhanced Magnetic Resonance Imaging.

Lenhard SC, Lev M, Webster LO, Peterson RA, Goulbourne CN, Miller RT, Jucker BM.

Toxicol Pathol. 2016 Jan;44(1):51-60. doi: 10.1177/0192623315608509. Epub 2015 Oct 28.


Atherosclerotic plaque inflammation varies between vascular sites and correlates with response to inhibition of lipoprotein-associated phospholipase A2.

Fenning RS, Burgert ME, Hamamdzic D, Peyster EG, Mohler ER, Kangovi S, Jucker BM, Lenhard SC, Macphee CH, Wilensky RL.

J Am Heart Assoc. 2015 Feb 11;4(2). pii: e001477. doi: 10.1161/JAHA.114.001477.


A high-throughput siRNA screen identifies genes that regulate mannose 6-phosphate receptor trafficking.

Anitei M, Chenna R, Czupalla C, Esner M, Christ S, Lenhard S, Korn K, Meyenhofer F, Bickle M, Zerial M, Hoflack B.

J Cell Sci. 2014 Dec 1;127(Pt 23):5079-92. doi: 10.1242/jcs.159608. Epub 2014 Oct 2.


Cardioprotection by systemic dosing of thymosin beta four following ischemic myocardial injury.

Bao W, Ballard VL, Needle S, Hoang B, Lenhard SC, Tunstead JR, Jucker BM, Willette RN, Pipes GT.

Front Pharmacol. 2013 Nov 29;4:149. doi: 10.3389/fphar.2013.00149. eCollection 2013.


Examining the relationship between exercise tolerance and isoproterenol-based cardiac reserve in murine models of heart failure.

Richards DA, Bao W, Rambo MV, Burgert M, Jucker BM, Lenhard SC.

J Appl Physiol (1985). 2013 May;114(9):1202-10. doi: 10.1152/japplphysiol.00556.2012. Epub 2013 Feb 28.


An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.

Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN.

Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276.


Sulfur-36S stable isotope labeling of amino acids for quantification (SULAQ).

Jehmlich N, Kopinke FD, Lenhard S, Vogt C, Herbst FA, Seifert J, Lissner U, Völker U, Schmidt F, von Bergen M.

Proteomics. 2012 Jan;12(1):37-42. doi: 10.1002/pmic.201100057. Epub 2011 Dec 16.


Serial MRI characterization of the functional and morphological changes in mouse lung in response to cardiac remodeling following myocardial infarction.

Alsaid H, Bao W, Rambo MV, Logan GA, Figueroa DJ, Lenhard SC, Kotzer CJ, Burgert ME, Willette RN, Ferrari VA, Jucker BM.

Magn Reson Med. 2012 Jan;67(1):191-200. doi: 10.1002/mrm.22973. Epub 2011 Jun 10.


Regulatory allospecific T cell clones abrogate chronic allograft rejection.

Waaga-Gasser AM, Grimm MR, Lutz J, Lange V, Lenhard SM, Aviles B, Kist-van Holthe JE, Lebedeva T, Samsonov D, Meyer D, Hancock WW, Heemann U, Gasser M, Chandraker A.

J Am Soc Nephrol. 2009 Apr;20(4):820-30. doi: 10.1681/ASN.2008020164. Epub 2009 Mar 18.


Hypo-functional SLC26A4 variants associated with nonsyndromic hearing loss and enlargement of the vestibular aqueduct: genotype-phenotype correlation or coincidental polymorphisms?

Choi BY, Stewart AK, Madeo AC, Pryor SP, Lenhard S, Kittles R, Eisenman D, Kim HJ, Niparko J, Thomsen J, Arnos KS, Nance WE, King KA, Zalewski CK, Brewer CC, Shawker T, Reynolds JC, Butman JA, Karniski LP, Alper SL, Griffith AJ.

Hum Mutat. 2009 Apr;30(4):599-608. doi: 10.1002/humu.20884.


Relapse and survival in early-stage ovarian cancer.

Lenhard SM, Bufe A, Kümper C, Stieber P, Mayr D, Hertlein L, Kirschenhofer A, Friese K, Burges A.

Arch Gynecol Obstet. 2009 Jul;280(1):71-7. doi: 10.1007/s00404-008-0877-z. Epub 2008 Dec 18.


Predictive value of PET-CT imaging versus AGO-scoring in patients planned for cytoreductive surgery in recurrent ovarian cancer.

Lenhard SM, Burges A, Johnson TR, Kirschenhofer A, Bruns C, Linke R, Friese K.

Eur J Obstet Gynecol Reprod Biol. 2008 Oct;140(2):263-8. doi: 10.1016/j.ejogrb.2008.05.006. Epub 2008 Jul 9.


SB 234551 selective ET(A) receptor antagonism: perfusion/diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection.

Legos JJ, Lenhard SC, Haimbach RE, Schaeffer TR, Bentley RG, McVey MJ, Chandra S, Irving EA, Andrew A Parsons, Barone FC.

Exp Neurol. 2008 Jul;212(1):53-62. doi: 10.1016/j.expneurol.2008.03.011. Epub 2008 Mar 25.


Brain MRI and neurological deficit measurements in focal stroke: rapid throughput validated with isradipine.

Lenhard SC, Strittmatter R, Price WJ, Chandra S, White RF, Barone FC.

Pharmacology. 2008;81(1):1-10. Epub 2007 Aug 28.


Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study.

Jucker BM, Yang D, Casey WM, Olzinski AR, Williams C, Lenhard SC, Legos JJ, Hawk CT, Sarkar SK, Newsholme SJ.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1256-64. Epub 2007 Aug 28.


PPARdelta activation normalizes cardiac substrate metabolism and reduces right ventricular hypertrophy in congestive heart failure.

Jucker BM, Doe CP, Schnackenberg CG, Olzinski AR, Maniscalco K, Williams C, Hu TC, Lenhard SC, Costell M, Bernard R, Sarov-Blat L, Steplewski K, Willette RN.

J Cardiovasc Pharmacol. 2007 Jul;50(1):25-34.


Noninvasive assessment of ectopic uterine tissue development in rats using magnetic resonance imaging.

Lenhard SC, Haimbach RE, Sulpizio AC, Brooks DP, Bray JD, Jucker BM.

Fertil Steril. 2007 Oct;88(4 Suppl):1058-64. Epub 2007 Mar 23.


The high-grade endometrial sarcoma: a rare entity.

Lenhard SM, Untch M, Himsl I, Ditsch N, Bittmann I, Friese K, Bauerfeind I.

Arch Gynecol Obstet. 2006 Apr;274(1):56-9. Epub 2005 Nov 26.


Differential uptake of ferumoxtran-10 and ferumoxytol, ultrasmall superparamagnetic iron oxide contrast agents in rabbit: critical determinants of atherosclerotic plaque labeling.

Yancy AD, Olzinski AR, Hu TC, Lenhard SC, Aravindhan K, Gruver SM, Jacobs PM, Willette RN, Jucker BM.

J Magn Reson Imaging. 2005 Apr;21(4):432-42.


Chronic rejection: insights from a novel immunosuppressive-free model of kidney transplantation.

Gasser M, Waaga-Gasser AM, Kist-van Holthe JE, Yuan X, Lenhard SM, Abdallah KA, Chandraker A.

J Am Soc Nephrol. 2004 Mar;15(3):687-94.


p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 2. Improved renal function as assessed by dynamic contrast-enhanced magnetic resonance imaging.

Lenhard SC, Nerurkar SS, Schaeffer TR, Mirabile RC, Boyce RW, Adams DF, Jucker BM, Willette RN.

J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. Epub 2003 Oct 15.


Strain-dependent response to cerebral ischemic preconditioning: differences between spontaneously hypertensive and stroke prone spontaneously hypertensive rats.

Purcell JE, Lenhard SC, White RF, Schaeffer T, Barone FC, Chandra S.

Neurosci Lett. 2003 Mar 20;339(2):151-5.


Modulation of the immune response with major histocompatability class II peptides via the indirect pathway of allorecognition after kidney and small bowel transplantation.

Gasser M, Lenhard SM, Otto C, Kist-van Holthe JE, Navarro E, Timmermann W, Ulrichs K, Thiede A, Waaga AM.

Transplant Proc. 2002 Sep;34(6):2244-5. No abstract available.


Normalization of brain death-induced injury to rat renal allografts by recombinant soluble P-selectin glycoprotein ligand.

Gasser M, Waaga AM, Kist-Van Holthe JE, Lenhard SM, Laskowski I, Shaw GD, Hancock WW, Tilney NL.

J Am Soc Nephrol. 2002 Jul;13(7):1937-45.


Acute stroke therapy: translating preclinical neuroprotection to therapeutic reality.

Parsons AA, Irving EA, Legos JJ, Lenhard SC, Chandra S, Schaeffer TR, Haimbach RE, White RF, Hunter AJ, Barone FC.

Curr Opin Investig Drugs. 2000 Dec;1(4):452-63. Review. No abstract available.


SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia.

Legos JJ, Erhardt JA, White RF, Lenhard SC, Chandra S, Parsons AA, Tuma RF, Barone FC.

Brain Res. 2001 Feb 16;892(1):70-7.


Prednicarbate activity and benefit/risk ratio in relation to other topical glucocorticoids.

Schäfer-Korting M, Korting HC, Kerscher MJ, Lenhard S.

Clin Pharmacol Ther. 1993 Oct;54(4):448-56.


Adenosine regulates coronary blood flow during increased work and decreased supply.

Martin SE, Lenhard SD, Schmarkey LS, Offenbacher S, Odle BM.

Am J Physiol. 1993 May;264(5 Pt 2):H1438-46.


Defective osteoclast differentiation and function in the osteopetrotic (os) rabbit.

Lenhard S, Popoff SN, Marks SC Jr.

Am J Anat. 1990 Aug;188(4):438-44.


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