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Items: 1 to 50 of 76

1.

Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration.

Tan ACS, Pilgrim MG, Fearn S, Bertazzo S, Tsolaki E, Morrell AP, Li M, Messinger JD, Dolz-Marco R, Lei J, Nittala MG, Sadda SR, Lengyel I, Freund KB, Curcio CA.

Sci Transl Med. 2018 Nov 7;10(466). pii: eaat4544. doi: 10.1126/scitranslmed.aat4544.

PMID:
30404862
2.

The clinical relevance of visualising the peripheral retina.

Quinn N, Csincsik L, Flynn E, Curcio CA, Kiss S, Sadda SR, Hogg R, Peto T, Lengyel I.

Prog Retin Eye Res. 2018 Oct 10. pii: S1350-9462(18)30039-9. doi: 10.1016/j.preteyeres.2018.10.001. [Epub ahead of print] Review.

3.

Obesity, diabetes and zinc: A workshop promoting knowledge and collaboration between the UK and Israel, november 28-30, 2016 - Israel.

Jenkins A, Lengyel I, Rutter GA, Lowe N, Shai I, Tirosh A, Petro T, Khamaisi M, Andrews S, Zmora N, Gross A, Maret W, Lewis EC, Moran A.

J Trace Elem Med Biol. 2018 Sep;49:79-85. doi: 10.1016/j.jtemb.2018.04.021. Epub 2018 Apr 24. No abstract available.

PMID:
29895375
4.

A new perspective on lipid research in age-related macular degeneration.

van Leeuwen EM, Emri E, Merle BMJ, Colijn JM, Kersten E, Cougnard-Gregoire A, Dammeier S, Meester-Smoor M, Pool FM, de Jong EK, Delcourt C, Rodrigez-Bocanegra E, Biarnés M, Luthert PJ, Ueffing M, Klaver CCW, Nogoceke E, den Hollander AI, Lengyel I.

Prog Retin Eye Res. 2018 Nov;67:56-86. doi: 10.1016/j.preteyeres.2018.04.006. Epub 2018 May 4. Review.

5.

Peripheral Retinal Imaging Biomarkers for Alzheimer's Disease: A Pilot Study.

Csincsik L, MacGillivray TJ, Flynn E, Pellegrini E, Papanastasiou G, Barzegar-Befroei N, Csutak A, Bird AC, Ritchie CW, Peto T, Lengyel I.

Ophthalmic Res. 2018;59(4):182-192. doi: 10.1159/000487053. Epub 2018 Apr 5.

6.

Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration.

Arya S, Emri E, Synowsky SA, Shirran SL, Barzegar-Befroei N, Peto T, Botting CH, Lengyel I, Stewart AJ.

Exp Eye Res. 2018 Jul;172:21-29. doi: 10.1016/j.exer.2018.03.023. Epub 2018 Mar 24.

PMID:
29580721
7.

The effects of zinc supplementation on primary human retinal pigment epithelium.

Pao PJ, Emri E, Abdirahman SB, Soorma T, Zeng HH, Hauck SM, Thompson RB, Lengyel I.

J Trace Elem Med Biol. 2018 Sep;49:184-191. doi: 10.1016/j.jtemb.2018.02.028. Epub 2018 Mar 1.

PMID:
29523386
8.

[Pre-travel advice and patient education of Hungarian travellers].

Lengyel I, Felkai P.

Orv Hetil. 2018 Mar;159(9):357-362. doi: 10.1556/650.2018.30987. Hungarian.

PMID:
29480045
9.

Localization of the zinc binding tubulin polymerization promoting protein in the mice and human eye.

Tripon RG, Oláh J, Nasir T, Csincsik L, Li CL, Szunyogh S, Gong H, Flinn JM, Ovádi J, Lengyel I.

J Trace Elem Med Biol. 2018 Sep;49:222-230. doi: 10.1016/j.jtemb.2017.12.009. Epub 2017 Dec 27.

PMID:
29317136
10.

Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS).

Florea D, Molina-López J, Hogstrand C, Lengyel I, de la Cruz AP, Rodríguez-Elvira M, Planells E.

J Trace Elem Med Biol. 2018 Sep;49:202-209. doi: 10.1016/j.jtemb.2017.11.013. Epub 2017 Nov 26.

PMID:
29199035
11.

Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration.

Kersten E, Paun CC, Schellevis RL, Hoyng CB, Delcourt C, Lengyel I, Peto T, Ueffing M, Klaver CCW, Dammeier S, den Hollander AI, de Jong EK.

Surv Ophthalmol. 2018 Jan - Feb;63(1):9-39. doi: 10.1016/j.survophthal.2017.05.003. Epub 2017 May 15. Review.

12.

Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression.

Lengyel IM, Morelli LG.

Phys Rev E. 2017 Apr;95(4-1):042412. doi: 10.1103/PhysRevE.95.042412. Epub 2017 Apr 26.

PMID:
28505727
13.

[Epidemiological data of Hungarian skiers' and snowboarders' medical problems].

Felkai P, Lengyel I, Szokoly M, Forgó G.

Orv Hetil. 2017 Apr;158(16):618-624. doi: 10.1556/650.2017.30707. Hungarian.

PMID:
28415868
14.

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model.

Pilgrim MG, Lengyel I, Lanzirotti A, Newville M, Fearn S, Emri E, Knowles JC, Messinger JD, Read RW, Guidry C, Curcio CA.

Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):708-719. doi: 10.1167/iovs.16-21060.

15.

A novel non-opioid binding site for endomorphin-1.

Lengyel I, Toth F, Biyashev D, Szatmari I, Monory K, Tomboly C, Toth G, Benyhe S, Borsodi A.

J Physiol Pharmacol. 2016 Aug;67(4):605-616.

16.

Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study.

Giacconi R, Costarelli L, Piacenza F, Basso A, Rink L, Mariani E, Fulop T, Dedoussis G, Herbein G, Provinciali M, Jajte J, Lengyel I, Mocchegiani E, Malavolta M.

Eur J Nutr. 2017 Dec;56(8):2457-2466. doi: 10.1007/s00394-016-1281-2. Epub 2016 Jul 26.

PMID:
27459881
17.

Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock.

Webb AB, Lengyel IM, Jörg DJ, Valentin G, Jülicher F, Morelli LG, Oates AC.

Elife. 2016 Feb 13;5. pii: e08438. doi: 10.7554/eLife.08438.

18.

A Population-Based Ultra-Widefield Digital Image Grading Study for Age-Related Macular Degeneration-Like Lesions at the Peripheral Retina.

Lengyel I, Csutak A, Florea D, Leung I, Bird AC, Jonasson F, Peto T.

Ophthalmology. 2015 Jul;122(7):1340-7. doi: 10.1016/j.ophtha.2015.03.005. Epub 2015 Apr 11.

19.

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye.

Thompson RB, Reffatto V, Bundy JG, Kortvely E, Flinn JM, Lanzirotti A, Jones EA, McPhail DS, Fearn S, Boldt K, Ueffing M, Ratu SG, Pauleikhoff L, Bird AC, Lengyel I.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1565-70. doi: 10.1073/pnas.1413347112. Epub 2015 Jan 20. Erratum in: Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3971.

20.

Correlations in distribution and concentration of calcium, copper and iron with zinc in isolated extracellular deposits associated with age-related macular degeneration.

Flinn JM, Kakalec P, Tappero R, Jones B, Lengyel I.

Metallomics. 2014 Jul;6(7):1223-8. doi: 10.1039/c4mt00058g.

PMID:
24740686
21.

Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration.

Nan R, Tetchner S, Rodriguez E, Pao PJ, Gor J, Lengyel I, Perkins SJ.

J Biol Chem. 2013 Jun 28;288(26):19197-210. doi: 10.1074/jbc.M113.476143. Epub 2013 May 9.

22.

Synthesis, resolution and anticonvulsant activity of chiral N-1'-ethyl,N-3'-(1-phenylethyl)-(R,S)-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-trione diastereomers.

Sadarangani IR, Bhatia S, Amarante D, Lengyel I, Stephani RA.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2507-9. doi: 10.1016/j.bmcl.2012.02.005. Epub 2012 Feb 11.

PMID:
22401865
23.

Zinc binding to the Tyr402 and His402 allotypes of complement factor H: possible implications for age-related macular degeneration.

Nan R, Farabella I, Schumacher FF, Miller A, Gor J, Martin AC, Jones DT, Lengyel I, Perkins SJ.

J Mol Biol. 2011 May 13;408(4):714-35. doi: 10.1016/j.jmb.2011.03.006. Epub 2011 Mar 17.

24.

Synthesis and pharmacological activity of 1,3,6-trisubstituted-4-oxo-1,4-dihydroquinoline-2-carboxylic acids as selective ET(A) antagonists.

Patel HJ, Olgun N, Lengyel I, Reznik S, Stephani RA.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6840-4. doi: 10.1016/j.bmcl.2010.08.074.

PMID:
20932745
25.

Blockade of endothelin-1 with a novel series of 1,3,6-trisubstituted-2-carboxy-quinol-4-ones controls infection-associated preterm birth.

Olgun NS, Patel HJ, Stephani R, Lengyel I, Reznik SE.

Am J Pathol. 2010 Oct;177(4):1929-35. doi: 10.2353/ajpath.2010.100281. Epub 2010 Aug 27.

26.

Agreement between image grading of conventional (45°) and ultra wide-angle (200°) digital images in the macula in the Reykjavik eye study.

Csutak A, Lengyel I, Jonasson F, Leung I, Geirsdottir A, Xing W, Peto T.

Eye (Lond). 2010 Oct;24(10):1568-75. doi: 10.1038/eye.2010.85. Epub 2010 Jun 4.

PMID:
20523357
27.

Bruch's membrane changes in transgenic mice overexpressing the human biglycan and apolipoprotein b-100 genes.

Sallo FB, Bereczki E, Csont T, Luthert PJ, Munro P, Ferdinandy P, Sántha M, Lengyel I.

Exp Eye Res. 2009 Aug;89(2):178-86. doi: 10.1016/j.exer.2009.03.006. Epub 2009 Mar 24.

PMID:
19324038
28.

Uncontrolled zinc- and copper-induced oligomerisation of the human complement regulator factor H and its possible implications for function and disease.

Nan R, Gor J, Lengyel I, Perkins SJ.

J Mol Biol. 2008 Dec 31;384(5):1341-52. doi: 10.1016/j.jmb.2008.10.030. Epub 2008 Oct 19.

PMID:
18976665
29.

The resolution of five racemic alpha-lactams by HPLC.

Yu H, Hur K, Lengyel I, Cesare V.

Chirality. 2008 Feb;20(2):69-74.

PMID:
18058862
30.

High concentration of zinc in sub-retinal pigment epithelial deposits.

Lengyel I, Flinn JM, Peto T, Linkous DH, Cano K, Bird AC, Lanzirotti A, Frederickson CJ, van Kuijk FJ.

Exp Eye Res. 2007 Apr;84(4):772-80. Epub 2007 Jan 9.

PMID:
17313944
31.

Partial and full agonism in endomorphin derivatives: comparison by null and operational model.

Rónai AZ, Al-Khrasani M, Benyhe S, Lengyel I, Kocsis L, Orosz G, Tóth G, Kató E, Tóthfalusi L.

Peptides. 2006 Jun;27(6):1507-13. Epub 2006 Jan 18.

PMID:
16413634
32.

Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus.

Lengyel I, Voss K, Cammarota M, Bradshaw K, Brent V, Murphy KP, Giese KP, Rostas JA, Bliss TV.

Eur J Neurosci. 2004 Dec;20(11):3063-72.

PMID:
15579161
33.

Association of drusen deposition with choroidal intercapillary pillars in the aging human eye.

Lengyel I, Tufail A, Hosaini HA, Luthert P, Bird AC, Jeffery G.

Invest Ophthalmol Vis Sci. 2004 Sep;45(9):2886-92.

PMID:
15326099
34.

Enhancement of NMDA responses by beta-amyloid peptides in the hippocampus in vivo.

Molnár Z, Soós K, Lengyel I, Penke B, Szegedi V, Budai D.

Neuroreport. 2004 Jul 19;15(10):1649-52.

PMID:
15232300
35.

Enhanced G-protein activation by a mixture of Abeta(25-35), Abeta(1-40/42) and zinc.

Molnár Z, Kovács P, Laczkó I, Soós K, Fülöp L, Penke B, Lengyel I.

J Neurochem. 2004 Jun;89(5):1215-23.

36.

S100B-mediated inhibition of the phosphorylation of GFAP is prevented by TRTK-12.

Frizzo JK, Tramontina F, Bortoli E, Gottfried C, Leal RB, Lengyel I, Donato R, Dunkley PR, Gonçalves CA.

Neurochem Res. 2004 Apr;29(4):735-40.

PMID:
15098935
37.

Side chain modifications change the binding and agonist properties of endomorphin 2.

Lengyel I, Orosz G, Biyashev D, Kocsis L, Al-Khrasani M, Rónai A, Tömböly C, Fürst Z, Tóth G, Borsodi A.

Biochem Biophys Res Commun. 2002 Jan 11;290(1):153-61.

PMID:
11779147
38.

Receptor constants for endomorphin-1 and endomorphin-1-ol indicate differences in efficacy and receptor occupancy.

Al-Khrasani M, Orosz G, Kocsis L, Farkas V, Magyar A, Lengyel I, Benyhe S, Borsodi A, Rónai AZ.

Eur J Pharmacol. 2001 Jun 1;421(1):61-7.

PMID:
11408050
39.

Influence of degradation on binding properties and biological activity of endomorphin 1.

Szatmári I, Biyashev D, Tömböly C, Tóth G, Mácsai M, Szabó G, Borsodi A, Lengyel I.

Biochem Biophys Res Commun. 2001 Jun 15;284(3):771-6.

PMID:
11396969
40.

Simultaneous measurement of tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells.

Cheah TB, Bobrovskaya L, Gonçalves CA, Hall A, Elliot R, Lengyel I, Bunn SJ, Marley PD, Dunkley PR.

J Neurosci Methods. 1999 Mar 1;87(2):167-74.

PMID:
11230813
41.

Auto-inhibition of Ca(2+)/calmodulin-dependent protein kinase II by its ATP-binding domain.

Lengyel I, Nairn A, McCluskey A, Tóth G, Penke B, Rostas J.

J Neurochem. 2001 Feb;76(4):1066-72.

42.

Autonomous activity and autophosphorylation of CAMPK-II in rat hippocampal slices: effects of tissue preparation.

Lengyel I, Cammarota M, Brent VA, Rostas JA.

J Neurochem. 2001 Jan;76(1):149-54.

43.

Modulation of the phosphorylation and activity of calcium/calmodulin-dependent protein kinase II by zinc.

Lengyel I, Fieuw-Makaroff S, Hall AL, Sim AT, Rostas JA, Dunkley PR.

J Neurochem. 2000 Aug;75(2):594-605.

44.

Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase.

Xue J, Wang X, Malladi CS, Kinoshita M, Milburn PJ, Lengyel I, Rostas JA, Robinson PJ.

J Biol Chem. 2000 Apr 7;275(14):10047-56.

45.

Phosphorylation of proteins in chick ciliary ganglion under conditions that induce long-lasting changes in synaptic transmission: phosphoprotein targets for nitric oxide action.

Lengyel I, Olesen LE, Nichol KA, Brain KL, Wang X, Robinson PJ, Bennett MR, Rostas JA.

Neuroscience. 1999 May;90(2):607-19.

PMID:
10215163
46.

Alpha and beta subunits of CaM-kinase II are localized in different neurons in chick ciliary ganglion.

Lengyel I, Nichol KA, Bennett MR, Heath JW, Little GJ, Rostas JA.

Neuroreport. 1998 Aug 24;9(12):2753-5.

PMID:
9760115
47.

Characterization of protein kinase and phosphatase systems in chick ciliary ganglion.

Lengyel I, Nichol KA, Sim AT, Bennett MR, Dunkley PR, Rostas JA.

Neuroscience. 1996 Jan;70(2):577-88.

PMID:
8848161
48.

Calcium/calmodulin-stimulated protein kinase II is present in primary cultures of cerebral endothelial cells.

Deli MA, Joó F, Krizbai I, Lengyel I, Nunzi MG, Wolff JR.

J Neurochem. 1993 May;60(5):1960-3.

PMID:
8386228
49.

Transient turing structures in a gradient-free closed system.

Lengyel I, Kádár S, Epstein IR.

Science. 1993 Jan 22;259(5094):493-5.

PMID:
17734167
50.

In situ hybridization with digoxigenin labeled oligonucleotide probes: detection of CAMK-II gene expression in primary cultures of cerebral endothelial cells.

Krizbai I, Deli M, Lengyel I, Maderspach K, Pákáski M, Joó F, Wolff JR.

Neurobiology (Bp). 1993;1(3):235-40.

PMID:
8111357

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