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Items: 1 to 50 of 71

1.

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.

Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Roedel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML.

Sci Transl Med. 2019 Nov 27;11(520). pii: eaaw3521. doi: 10.1126/scitranslmed.aaw3521.

PMID:
31776290
2.

In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease.

Park H, Oh J, Shim G, Cho B, Chang Y, Kim S, Baek S, Kim H, Shin J, Choi H, Yoo J, Kim J, Jun W, Lee M, Lengner CJ, Oh YK, Kim J.

Nat Neurosci. 2019 Apr;22(4):524-528. doi: 10.1038/s41593-019-0352-0. Epub 2019 Mar 11.

PMID:
30858603
3.

Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids.

Kim H, Park HJ, Choi H, Chang Y, Park H, Shin J, Kim J, Lengner CJ, Lee YK, Kim J.

Stem Cell Reports. 2019 Mar 5;12(3):518-531. doi: 10.1016/j.stemcr.2019.01.020. Epub 2019 Feb 21.

4.

MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice.

Tian Y, Xu J, Li Y, Zhao R, Du S, Lv C, Wu W, Liu R, Sheng X, Song Y, Bi X, Li G, Li M, Wu X, Lou P, You H, Cui W, Sun J, Shuai J, Ren F, Zhang B, Guo M, Hou X, Wu K, Xue L, Zhang H, Plikus MV, Cong Y, Lengner CJ, Liu Z, Yu Z.

Gastroenterology. 2019 Jun;156(8):2281-2296.e6. doi: 10.1053/j.gastro.2019.02.023. Epub 2019 Feb 16.

PMID:
30779922
5.

Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis.

Palzer L, Bader JJ, Angel F, Witzel M, Blaser S, McNeil A, Wandersee MK, Leu NA, Lengner CJ, Cho CE, Welch KD, Kirkland JB, Meyer RG, Meyer-Ficca ML.

Cell Rep. 2018 Oct 30;25(5):1359-1370.e4. doi: 10.1016/j.celrep.2018.09.091.

6.

The microRNA-23a cluster regulates the developmental HoxA cluster function during osteoblast differentiation.

Godfrey TC, Wildman BJ, Beloti MM, Kemper AG, Ferraz EP, Roy B, Rehan M, Afreen LH, Kim E, Lengner CJ, Hassan Q.

J Biol Chem. 2018 Nov 9;293(45):17646-17660. doi: 10.1074/jbc.RA118.003052. Epub 2018 Sep 21.

7.

The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine.

Chatterji P, Hamilton KE, Liang S, Andres SF, Wijeratne HRS, Mizuno R, Simon LA, Hicks PD, Foley SW, Pitarresi JR, Klein-Szanto AJ, Mah AT, Van Landeghem L, Gregory BD, Lengner CJ, Madison BB, Shah P, Rustgi AK.

Genes Dev. 2018 Aug 1;32(15-16):1020-1034. doi: 10.1101/gad.314369.118.

8.

Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating.

Giroux V, Stephan J, Chatterji P, Rhoades B, Wileyto EP, Klein-Szanto AJ, Lengner CJ, Hamilton KE, Rustgi AK.

Stem Cell Reports. 2018 Jun 5;10(6):1947-1958. doi: 10.1016/j.stemcr.2018.04.022. Epub 2018 May 24.

9.

Epigenetic remodeling and modification to preserve skeletogenesis in vivo.

Godfrey TC, Wildman BJ, Javed A, Lengner CJ, Hassan MQ.

Connect Tissue Res. 2018 Dec;59(sup1):52-54. doi: 10.1080/03008207.2017.1408599.

10.

Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells.

Yousefi M, Nakauka-Ddamba A, Berry CT, Li N, Schoenberger J, Simeonov KP, Cedeno RJ, Yu Z, Lengner CJ.

Stem Cell Reports. 2018 Mar 13;10(3):703-711. doi: 10.1016/j.stemcr.2018.01.026. Epub 2018 Mar 1.

11.

Gut with the Program: Direct Reprogramming toward Intestinal Epithelium Realized.

Nakauka-Ddamba A, Lengner CJ.

Cell Stem Cell. 2017 Oct 5;21(4):417-418. doi: 10.1016/j.stem.2017.09.011.

12.

The histone variant macroH2A confers functional robustness to the intestinal stem cell compartment.

Cedeno RJ, Nakauka-Ddamba A, Yousefi M, Sterling S, Leu NA, Li N, Pehrson JR, Lengner CJ.

PLoS One. 2017 Sep 21;12(9):e0185196. doi: 10.1371/journal.pone.0185196. eCollection 2017.

13.

Modelling APOE ɛ3/4 allele-associated sporadic Alzheimer's disease in an induced neuron.

Kim H, Yoo J, Shin J, Chang Y, Jung J, Jo DG, Kim J, Jang W, Lengner CJ, Kim BS, Kim J.

Brain. 2017 Aug 1;140(8):2193-2209. doi: 10.1093/brain/awx144.

PMID:
28899010
14.

Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis.

Tian Y, Ma X, Lv C, Sheng X, Li X, Zhao R, Song Y, Andl T, Plikus MV, Sun J, Ren F, Shuai J, Lengner CJ, Cui W, Yu Z.

Elife. 2017 Sep 5;6. pii: e29538. doi: 10.7554/eLife.29538.

15.

Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson's disease therapy.

Yoo J, Lee E, Kim HY, Youn DH, Jung J, Kim H, Chang Y, Lee W, Shin J, Baek S, Jang W, Jun W, Kim S, Hong J, Park HJ, Lengner CJ, Moh SH, Kwon Y, Kim J.

Nat Nanotechnol. 2017 Oct;12(10):1006-1014. doi: 10.1038/nnano.2017.133. Epub 2017 Jul 17.

PMID:
28737745
16.

Hierarchy and Plasticity in the Intestinal Stem Cell Compartment.

Yousefi M, Li L, Lengner CJ.

Trends Cell Biol. 2017 Oct;27(10):753-764. doi: 10.1016/j.tcb.2017.06.006. Epub 2017 Jul 18. Review.

17.

Stem Cells, Cancer, and MUSASHI in Blood and Guts.

Kharas MG, Lengner CJ.

Trends Cancer. 2017 May;3(5):347-356. doi: 10.1016/j.trecan.2017.03.007. Epub 2017 Apr 8. Review.

18.

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration.

Giroux V, Lento AA, Islam M, Pitarresi JR, Kharbanda A, Hamilton KE, Whelan KA, Long A, Rhoades B, Tang Q, Nakagawa H, Lengner CJ, Bass AJ, Wileyto EP, Klein-Szanto AJ, Wang TC, Rustgi AK.

J Clin Invest. 2017 Jun 1;127(6):2378-2391. doi: 10.1172/JCI88941. Epub 2017 May 8.

19.

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.

Vu LP, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, Chou T, Chow A, Minuesa G, Park SM, Barlowe TS, Taggart J, Tivnan P, Deering RP, Chu LP, Kwon JA, Meydan C, Perales-Paton J, Arshi A, Gönen M, Famulare C, Patel M, Paietta E, Tallman MS, Lu Y, Glass J, Garret-Bakelman FE, Melnick A, Levine R, Al-Shahrour F, Järås M, Hacohen N, Hwang A, Garippa R, Lengner CJ, Armstrong SA, Cerchietti L, Cowley GS, Root D, Doench J, Leslie C, Ebert BL, Kharas MG.

Nat Genet. 2017 Jun;49(6):866-875. doi: 10.1038/ng.3854. Epub 2017 Apr 24.

20.

Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche.

Yang TB, Chen Q, Deng JT, Jagannathan G, Tobias JW, Schultz DC, Wang S, Lengner CJ, Rustgi AK, Lynch JP, Johnson FB.

Nat Commun. 2017 Mar 17;8:14766. doi: 10.1038/ncomms14766.

21.

Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hh Signaling Pathway.

Ma X, Tian Y, Song Y, Shi J, Xu J, Xiong K, Li J, Xu W, Zhao Y, Shuai J, Chen L, Plikus MV, Lengner CJ, Ren F, Xue L, Yu Z.

J Invest Dermatol. 2017 May;137(5):1015-1024. doi: 10.1016/j.jid.2017.01.012. Epub 2017 Jan 29.

22.

Msi RNA-binding proteins control reserve intestinal stem cell quiescence.

Yousefi M, Li N, Nakauka-Ddamba A, Wang S, Davidow K, Schoenberger J, Yu Z, Jensen ST, Kharas MG, Lengner CJ.

J Cell Biol. 2016 Nov 7;215(3):401-413. Epub 2016 Oct 31.

23.

Enhancing a Wnt-Telomere Feedback Loop Restores Intestinal Stem Cell Function in a Human Organotypic Model of Dyskeratosis Congenita.

Woo DH, Chen Q, Yang TL, Glineburg MR, Hoge C, Leu NA, Johnson FB, Lengner CJ.

Cell Stem Cell. 2016 Sep 1;19(3):397-405. doi: 10.1016/j.stem.2016.05.024. Epub 2016 Aug 18.

24.

Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis.

Zhang Y, Li F, Song Y, Sheng X, Ren F, Xiong K, Chen L, Zhang H, Liu D, Lengner CJ, Xue L, Yu Z.

FASEB J. 2016 Oct;30(10):3474-3488. Epub 2016 Jul 6.

25.

Heterogeneity in readouts of canonical wnt pathway activity within intestinal crypts.

Li N, Yousefi M, Nakauka-Ddamba A, Tobias JW, Jensen ST, Morrisey EE, Lengner CJ.

Dev Dyn. 2016 Aug;245(8):822-33. doi: 10.1002/dvdy.24423. Epub 2016 Jul 5.

26.

Mouse Label-Retaining Cells Are Molecularly and Functionally Distinct From Reserve Intestinal Stem Cells.

Li N, Nakauka-Ddamba A, Tobias J, Jensen ST, Lengner CJ.

Gastroenterology. 2016 Aug;151(2):298-310.e7. doi: 10.1053/j.gastro.2016.04.049. Epub 2016 May 27.

27.

Multiphasic and Dynamic Changes in Alternative Splicing during Induction of Pluripotency Are Coordinated by Numerous RNA-Binding Proteins.

Cieply B, Park JW, Nakauka-Ddamba A, Bebee TW, Guo Y, Shang X, Lengner CJ, Xing Y, Carstens RP.

Cell Rep. 2016 Apr 12;15(2):247-55. doi: 10.1016/j.celrep.2016.03.025. Epub 2016 Mar 31.

28.

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.

Taggart J, Ho TC, Amin E, Xu H, Barlowe TS, Perez AR, Durham BH, Tivnan P, Okabe R, Chow A, Vu L, Park SM, Prieto C, Famulare C, Patel M, Lengner CJ, Verma A, Roboz G, Guzman M, Klimek VM, Abdel-Wahab O, Leslie C, Nimer SD, Kharas MG.

Nat Commun. 2016 Feb 22;7:10739. doi: 10.1038/ncomms10739.

29.

Type I Interferons Control Proliferation and Function of the Intestinal Epithelium.

Katlinskaya YV, Katlinski KV, Lasri A, Li N, Beiting DP, Durham AC, Yang T, Pikarsky E, Lengner CJ, Johnson FB, Ben-Neriah Y, Fuchs SY.

Mol Cell Biol. 2016 Jan 25;36(7):1124-35. doi: 10.1128/MCB.00988-15.

30.

The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.

Li N, Yousefi M, Nakauka-Ddamba A, Li F, Vandivier L, Parada K, Woo DH, Wang S, Naqvi AS, Rao S, Tobias J, Cedeno RJ, Minuesa G, Y K, Barlowe TS, Valvezan A, Shankar S, Deering RP, Klein PS, Jensen ST, Kharas MG, Gregory BD, Yu Z, Lengner CJ.

Cell Rep. 2015 Dec 22;13(11):2440-2455. doi: 10.1016/j.celrep.2015.11.022. Epub 2015 Dec 8.

31.

Homogeneous generation of iDA neurons with high similarity to bona fide DA neurons using a drug inducible system.

Park H, Kim H, Yoo J, Lee J, Choi H, Baek S, Lee CJ, Kim J, Lengner CJ, Sung JS, Kim J.

Biomaterials. 2015 Dec;72:152-62. doi: 10.1016/j.biomaterials.2015.09.002. Epub 2015 Sep 6.

PMID:
26370928
32.

DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.

Yu Q, Katlinskaya YV, Carbone CJ, Zhao B, Katlinski KV, Zheng H, Guha M, Li N, Chen Q, Yang T, Lengner CJ, Greenberg RA, Johnson FB, Fuchs SY.

Cell Rep. 2015 May 5;11(5):785-797. doi: 10.1016/j.celrep.2015.03.069. Epub 2015 Apr 23.

33.

Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.

Wang S, Li N, Yousefi M, Nakauka-Ddamba A, Li F, Parada K, Rao S, Minuesa G, Katz Y, Gregory BD, Kharas MG, Yu Z, Lengner CJ.

Nat Commun. 2015 Mar 16;6:6517. doi: 10.1038/ncomms7517.

34.

Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.

Park SM, Gönen M, Vu L, Minuesa G, Tivnan P, Barlowe TS, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa ME, Paietta E, Fernandez HF, Tallman MS, Melnick A, Levine R, Leslie C, Lengner CJ, Kharas MG.

J Clin Invest. 2015 Mar 2;125(3):1286-98. doi: 10.1172/JCI78440. Epub 2015 Feb 9.

35.

Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy.

Li N, Yousefi M, Nakauka-Ddamba A, Jain R, Tobias J, Epstein JA, Jensen ST, Lengner CJ.

Stem Cell Reports. 2014 Nov 11;3(5):876-91. doi: 10.1016/j.stemcr.2014.09.011. Epub 2014 Oct 23.

36.

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state.

Katz Y, Li F, Lambert NJ, Sokol ES, Tam WL, Cheng AW, Airoldi EM, Lengner CJ, Gupta PB, Yu Z, Jaenisch R, Burge CB.

Elife. 2014 Nov 7;3:e03915. doi: 10.7554/eLife.03915.

37.

A system for genome-wide histone variant dynamics in ES cells reveals dynamic MacroH2A2 replacement at promoters.

Yildirim O, Hung JH, Cedeno RJ, Weng Z, Lengner CJ, Rando OJ.

PLoS Genet. 2014 Aug 7;10(8):e1004515. doi: 10.1371/journal.pgen.1004515. eCollection 2014 Aug.

38.

Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs.

Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG.

J Exp Med. 2014 Jan 13;211(1):71-87. doi: 10.1084/jem.20130736. Epub 2014 Jan 6.

39.

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish.

Valvezan AJ, Huang J, Lengner CJ, Pack M, Klein PS.

Dis Model Mech. 2014 Jan;7(1):63-71. doi: 10.1242/dmm.012625. Epub 2013 Oct 2.

40.

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.

Kim J, Su SC, Wang H, Cheng AW, Cassady JP, Lodato MA, Lengner CJ, Chung CY, Dawlaty MM, Tsai LH, Jaenisch R.

Cell Stem Cell. 2011 Nov 4;9(5):413-9. doi: 10.1016/j.stem.2011.09.011. Epub 2011 Oct 20.

41.

Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation.

Liu JC, Lengner CJ, Gaur T, Lou Y, Hussain S, Jones MD, Borodic B, Colby JL, Steinman HA, van Wijnen AJ, Stein JL, Jones SN, Stein GS, Lian JB.

J Biol Chem. 2011 Aug 26;286(34):30057-70. doi: 10.1074/jbc.M111.241505. Epub 2011 Jun 15.

42.

Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors.

Kim J, Lengner CJ, Kirak O, Hanna J, Cassady JP, Lodato MA, Wu S, Faddah DA, Steine EJ, Gao Q, Fu D, Dawlaty M, Jaenisch R.

Stem Cells. 2011 Jun;29(6):992-1000. doi: 10.1002/stem.641.

43.

Reprogramming the pluripotent cell cycle: restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells.

Ghule PN, Medina R, Lengner CJ, Mandeville M, Qiao M, Dominski Z, Lian JB, Stein JL, van Wijnen AJ, Stein GS.

J Cell Physiol. 2011 May;226(5):1149-56. doi: 10.1002/jcp.22440.

44.

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, Morgan K, Tam W, Paktinat M, Okabe R, Gozo M, Einhorn W, Lane SW, Scholl C, Fröhling S, Fleming M, Ebert BL, Gilliland DG, Jaenisch R, Daley GQ.

Nat Med. 2010 Aug;16(8):903-8. doi: 10.1038/nm.2187. Epub 2010 Jul 8.

45.

Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.

Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalipova M.

Cell. 2010 May 28;141(5):872-83. doi: 10.1016/j.cell.2010.04.010. Epub 2010 May 13.

46.

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs.

Hanna J, Cheng AW, Saha K, Kim J, Lengner CJ, Soldner F, Cassady JP, Muffat J, Carey BW, Jaenisch R.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9222-7. doi: 10.1073/pnas.1004584107. Epub 2010 May 4.

47.

iPS cell technology in regenerative medicine.

Lengner CJ.

Ann N Y Acad Sci. 2010 Mar;1192:38-44. doi: 10.1111/j.1749-6632.2009.05213.x. Review.

PMID:
20392216
48.

Direct cell reprogramming is a stochastic process amenable to acceleration.

Hanna J, Saha K, Pando B, van Zon J, Lengner CJ, Creyghton MP, van Oudenaarden A, Jaenisch R.

Nature. 2009 Dec 3;462(7273):595-601. doi: 10.1038/nature08592. Epub 2009 Nov 8.

49.

Metastable pluripotent states in NOD-mouse-derived ESCs.

Hanna J, Markoulaki S, Mitalipova M, Cheng AW, Cassady JP, Staerk J, Carey BW, Lengner CJ, Foreman R, Love J, Gao Q, Kim J, Jaenisch R.

Cell Stem Cell. 2009 Jun 5;4(6):513-24. doi: 10.1016/j.stem.2009.04.015. Epub 2009 May 7. Erratum in: Cell Stem Cell. 2009 Jul 2;5(1):124. Cell Stem Cell. 2015 May 7;16(5):566-7.

50.

Transgenic mice with defined combinations of drug-inducible reprogramming factors.

Markoulaki S, Hanna J, Beard C, Carey BW, Cheng AW, Lengner CJ, Dausman JA, Fu D, Gao Q, Wu S, Cassady JP, Jaenisch R.

Nat Biotechnol. 2009 Feb;27(2):169-71. doi: 10.1038/nbt.1520. Epub 2009 Jan 18.

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