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Items: 19


Precision Lasso: Accounting for Correlations and Linear Dependencies in High-Dimensional Genomic Data.

Wang H, Lengerich BJ, Aragam B, Xing EP.

Bioinformatics. 2018 Sep 1. doi: 10.1093/bioinformatics/bty750. [Epub ahead of print]


Personalized regression enables sample-specific pan-cancer analysis.

Lengerich BJ, Aragam B, Xing EP.

Bioinformatics. 2018 Jul 1;34(13):i178-i186. doi: 10.1093/bioinformatics/bty250.


Opportunities and obstacles for deep learning in biology and medicine.

Ching T, Himmelstein DS, Beaulieu-Jones BK, Kalinin AA, Do BT, Way GP, Ferrero E, Agapow PM, Zietz M, Hoffman MM, Xie W, Rosen GL, Lengerich BJ, Israeli J, Lanchantin J, Woloszynek S, Carpenter AE, Shrikumar A, Xu J, Cofer EM, Lavender CA, Turaga SC, Alexandari AM, Lu Z, Harris DJ, DeCaprio D, Qi Y, Kundaje A, Peng Y, Wiley LK, Segler MHS, Boca SM, Swamidass SJ, Huang A, Gitter A, Greene CS.

J R Soc Interface. 2018 Apr;15(141). pii: 20170387. doi: 10.1098/rsif.2017.0387. Review.


Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras.

Liang SI, van Lengerich B, Eichel K, Cha M, Patterson DM, Yoon TY, von Zastrow M, Jura N, Gartner ZJ.

Cell Rep. 2018 Mar 6;22(10):2593-2600. doi: 10.1016/j.celrep.2018.02.031.


EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms.

van Lengerich B, Agnew C, Puchner EM, Huang B, Jura N.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2836-E2845. doi: 10.1073/pnas.1617994114. Epub 2017 Mar 20.


Control of cell morphology of probiotic Lactobacillus acidophilus for enhanced cell stability during industrial processing.

Senz M, van Lengerich B, Bader J, Stahl U.

Int J Food Microbiol. 2015 Jan 2;192:34-42. doi: 10.1016/j.ijfoodmicro.2014.09.015. Epub 2014 Sep 22.


Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP.

Johnson MG, Liu JJ, Li AR, van Lengerich B, Wang S, Medina JC, Collins TL, Danao J, Seitz L, Willee A, D'Souza W, Budelsky AL, Fan PW, Wong SG.

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2877-80. doi: 10.1016/j.bmcl.2014.04.092. Epub 2014 May 4.


Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site.

Schwans JP, Hanoian P, Lengerich BJ, Sunden F, Gonzalez A, Tsai Y, Hammes-Schiffer S, Herschlag D.

Biochemistry. 2014 Apr 22;53(15):2541-55. doi: 10.1021/bi401671t. Epub 2014 Apr 9.


Individual vesicle fusion events mediated by lipid-anchored DNA.

van Lengerich B, Rawle RJ, Bendix PM, Boxer SG.

Biophys J. 2013 Jul 16;105(2):409-19. doi: 10.1016/j.bpj.2013.05.056.


Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists.

Liu JJ, Wang Y, Johnson MG, Li AR, Shen W, Wang X, Su Y, Brown M, Van Lengerich B, Rickel E, Martin T, Budelsky A, Seitz L, Danao J, Tang HL, Collins T, Medina JC.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1686-9. doi: 10.1016/j.bmcl.2011.12.107. Epub 2011 Dec 30.


A salty-congruent odor enhances saltiness: functional magnetic resonance imaging study.

Seo HS, Iannilli E, Hummel C, Okazaki Y, Buschhüter D, Gerber J, Krammer GE, van Lengerich B, Hummel T.

Hum Brain Mapp. 2013 Jan;34(1):62-76. doi: 10.1002/hbm.21414. Epub 2011 Oct 22.


Vesicle fusion observed by content transfer across a tethered lipid bilayer.

Rawle RJ, van Lengerich B, Chung M, Bendix PM, Boxer SG.

Biophys J. 2011 Oct 19;101(8):L37-9. doi: 10.1016/j.bpj.2011.09.023.


Discovery of AMG 853, a CRTH2 and DP Dual Antagonist.

Liu J, Li AR, Wang Y, Johnson MG, Su Y, Shen W, Wang X, Lively S, Brown M, Lai S, Gonzalez Lopez De Turiso F, Xu Q, Van Lengerich B, Schmitt M, Fu Z, Sun Y, Lawlis S, Seitz L, Danao J, Wait J, Ye Q, Tang HL, Grillo M, Collins TL, Sullivan TJ, Medina JC.

ACS Med Chem Lett. 2011 Mar 2;2(5):326-30. doi: 10.1021/ml1002234. eCollection 2011 May 12.


Recommendations for optimization of fortified and blended food aid products from the United States.

Fleige LE, Moore WR, Garlick PJ, Murphy SP, Turner EH, Dunn ML, van Lengerich B, Orthoefer FT, Schaefer SE.

Nutr Rev. 2010 May;68(5):290-315. doi: 10.1111/j.1753-4887.2010.00288.x. Review.


Covalent attachment of lipid vesicles to a fluid-supported bilayer allows observation of DNA-mediated vesicle interactions.

van Lengerich B, Rawle RJ, Boxer SG.

Langmuir. 2010 Jun 1;26(11):8666-72. doi: 10.1021/la904822f.


Effects of linker sequences on vesicle fusion mediated by lipid-anchored DNA oligonucleotides.

Chan YH, van Lengerich B, Boxer SG.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):979-84. doi: 10.1073/pnas.0812356106. Epub 2009 Jan 21.


An inhibitory metabolite leads to dose- and time-dependent pharmacokinetics of (R)-N-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in human subjects after multiple dosing.

Tonn GR, Wong SG, Wong SC, Johnson MG, Ma J, Cho R, Floren LC, Kersey K, Berry K, Marcus AP, Wang X, Van Lengerich B, Medina JC, Pearson PG, Wong BK.

Drug Metab Dispos. 2009 Mar;37(3):502-13. doi: 10.1124/dmd.108.021931. Epub 2008 Dec 16.


Lipid-anchored DNA mediates vesicle fusion as observed by lipid and content mixing.

Chan YH, van Lengerich B, Boxer SG.

Biointerphases. 2008 Jun;3(2):FA17. doi: 10.1116/1.2889062.


Facile synthesis of @-tide beta-strand peptidomimetics: improved assembly in solution and on solid phase.

Phillips ST, Piersanti G, Rüth M, Gubernator N, van Lengerich B, Bartlett PA.

Org Lett. 2004 Nov 25;6(24):4483-5.


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