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Items: 1 to 50 of 195

1.

Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling.

Papadakos KS, Bartoschek M, Rodriguez C, Gialeli C, Jin SB, Lendahl U, Pietras K, Blom AM.

Matrix Biol. 2018 Nov 28. pii: S0945-053X(18)30391-3. doi: 10.1016/j.matbio.2018.11.007. [Epub ahead of print]

PMID:
30502484
2.

Notch and Wnt Dysregulation and Its Relevance for Breast Cancer and Tumor Initiation.

Braune EB, Seshire A, Lendahl U.

Biomedicines. 2018 Nov 1;6(4). pii: E101. doi: 10.3390/biomedicines6040101. Review.

3.

Role of NOTCH3 Mutations in the Cerebral Small Vessel Disease Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.

Coupland K, Lendahl U, Karlström H.

Stroke. 2018 Nov;49(11):2793-2800. doi: 10.1161/STROKEAHA.118.021560. No abstract available.

PMID:
30355220
4.

Corrigendum to "Cholangiopathies - Towards a molecular understanding" [EBioMedicine 35 (2018) 381-393].

Tam PKH, Yiu RS, Lendahl U, Andersson ER.

EBioMedicine. 2018 Oct;36:564. doi: 10.1016/j.ebiom.2018.09.044. Epub 2018 Oct 9. No abstract available.

5.

Cholangiopathies - Towards a molecular understanding.

Tam PKH, Yiu RS, Lendahl U, Andersson ER.

EBioMedicine. 2018 Sep;35:381-393. doi: 10.1016/j.ebiom.2018.08.024. Epub 2018 Sep 17. Review. Erratum in: EBioMedicine. 2018 Oct;36:564.

6.

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types.

He L, Vanlandewijck M, Mäe MA, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T, Laviña B, Gouveia L, Sun Y, Raschperger E, Segerstolpe Å, Liu J, Gustafsson S, Räsänen M, Zarb Y, Mochizuki N, Keller A, Lendahl U, Betsholtz C.

Sci Data. 2018 Aug 21;5:180160. doi: 10.1038/sdata.2018.160.

7.

Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types.

Mutvei AP, Landor SK, Fox R, Braune EB, Tsoi YL, Phoon YP, Sahlgren C, Hartman J, Bergh J, Jin S, Lendahl U.

Oncogene. 2018 Jul 11. doi: 10.1038/s41388-018-0400-3. [Epub ahead of print]

8.

Changing master regulator without reprogramming.

Lendahl U, Simon A.

Exp Cell Res. 2018 Sep 15;370(2):189. doi: 10.1016/j.yexcr.2018.06.021. Epub 2018 Jun 20. No abstract available.

PMID:
29935142
9.

Author Correction: A molecular atlas of cell types and zonation in the brain vasculature.

Vanlandewijck M, He L, Mäe MA, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T, Laviña B, Gouveia L, Sun Y, Raschperger E, Räsänen M, Zarb Y, Mochizuki N, Keller A, Lendahl U, Betsholtz C.

Nature. 2018 Aug;560(7716):E3. doi: 10.1038/s41586-018-0232-x.

PMID:
29925939
10.

Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR.

Mol Ther. 2018 Jul 5;26(7):1644-1659. doi: 10.1016/j.ymthe.2018.02.012. Epub 2018 Feb 17.

11.

A molecular atlas of cell types and zonation in the brain vasculature.

Vanlandewijck M, He L, Mäe MA, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T, Laviña B, Gouveia L, Sun Y, Raschperger E, Räsänen M, Zarb Y, Mochizuki N, Keller A, Lendahl U, Betsholtz C.

Nature. 2018 Feb 22;554(7693):475-480. doi: 10.1038/nature25739. Epub 2018 Feb 14. Erratum in: Nature. 2018 Aug;560(7716):E3.

PMID:
29443965
12.

Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis.

Duarte S, Woll PS, Buza-Vidas N, Chin DWL, Boukarabila H, Luís TC, Stenson L, Bouriez-Jones T, Ferry H, Mead AJ, Atkinson D, Jin S, Clark SA, Wu B, Repapi E, Gray N, Taylor S, Mutvei AP, Tsoi YL, Nerlov C, Lendahl U, Jacobsen SEW.

Blood. 2018 Apr 12;131(15):1712-1719. doi: 10.1182/blood-2017-06-788505. Epub 2018 Jan 16.

13.

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.

Andersson ER, Chivukula IV, Hankeova S, Sjöqvist M, Tsoi YL, Ramsköld D, Masek J, Elmansuri A, Hoogendoorn A, Vazquez E, Storvall H, Netušilová J, Huch M, Fischler B, Ellis E, Contreras A, Nemeth A, Chien KC, Clevers H, Sandberg R, Bryja V, Lendahl U.

Gastroenterology. 2018 Mar;154(4):1080-1095. doi: 10.1053/j.gastro.2017.11.002. Epub 2017 Nov 21.

14.

An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.

Zhang H, Wang L, Wong EYM, Tsang SL, Xu PX, Lendahl U, Sham MH.

Elife. 2017 Nov 15;6. pii: e30126. doi: 10.7554/eLife.30126.

15.

Introduction.

Lendahl U.

Exp Cell Res. 2017 Nov 1;360(1):1. doi: 10.1016/j.yexcr.2017.10.001. No abstract available.

PMID:
29056258
16.

Notch Signaling in Development, Tissue Homeostasis, and Disease.

Siebel C, Lendahl U.

Physiol Rev. 2017 Oct 1;97(4):1235-1294. doi: 10.1152/physrev.00005.2017. Review.

17.

The interplay between the cellular hypoxic response and Notch signaling.

Landor SK, Lendahl U.

Exp Cell Res. 2017 Jul 15;356(2):146-151. doi: 10.1016/j.yexcr.2017.04.030. Epub 2017 Apr 26. Review.

PMID:
28456549
18.

MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff.

Yu R, Liu T, Jin SB, Ning C, Lendahl U, Nistér M, Zhao J.

Sci Rep. 2017 Apr 13;7(1):880. doi: 10.1038/s41598-017-00853-x.

19.

Lorenz Poellinger MD, PhD (1957-2016).

Lendahl U.

Cell Death Differ. 2017 Apr;24(4):571. doi: 10.1038/cdd.2017.13. No abstract available.

20.

At the interface of stem cell research and new technologies.

Lendahl U.

J Intern Med. 2016 Sep;280(3):232-5. doi: 10.1111/joim.12513. No abstract available.

21.

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.

Santio NM, Landor SK, Vahtera L, Ylä-Pelto J, Paloniemi E, Imanishi SY, Corthals G, Varjosalo M, Manoharan GB, Uri A, Lendahl U, Sahlgren C, Koskinen PJ.

Oncotarget. 2016 Jul 12;7(28):43220-43238. doi: 10.18632/oncotarget.9215.

22.

Notch -- a goldilocks signaling pathway in disease and cancer therapy.

Braune EB, Lendahl U.

Discov Med. 2016 Mar;21(115):189-96. Review.

23.

Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells.

Braune EB, Tsoi YL, Phoon YP, Landor S, Silva Cascales H, Ramsköld D, Deng Q, Lindqvist A, Lian X, Sahlgren C, Jin SB, Lendahl U.

Stem Cell Reports. 2016 May 10;6(5):643-651. doi: 10.1016/j.stemcr.2016.03.004. Epub 2016 Apr 7.

24.

Endogenous APP accumulates in synapses after BACE1 inhibition.

Nigam SM, Xu S, Ackermann F, Gregory JA, Lundkvist J, Lendahl U, Brodin L.

Neurosci Res. 2016 Aug;109:9-15. doi: 10.1016/j.neures.2016.02.002. Epub 2016 Feb 22.

PMID:
26907521
25.

[2015 Nobel Prize in Physiology or Medicine. Better health for millions of people thanks to drugs against parasites].

Andersson J, Lendahl U, Forssberg H.

Lakartidningen. 2015 Oct 6;112. pii: DRCD. Swedish. No abstract available.

26.

Decoding breast cancer tissue-stroma interactions using species-specific sequencing.

Chivukula IV, Ramsköld D, Storvall H, Anderberg C, Jin S, Mamaeva V, Sahlgren C, Pietras K, Sandberg R, Lendahl U.

Breast Cancer Res. 2015 Aug 13;17:109. doi: 10.1186/s13058-015-0616-x.

27.

Frequency and distribution of Notch mutations in tumor cell lines.

Mutvei AP, Fredlund E, Lendahl U.

BMC Cancer. 2015 Apr 25;15:311. doi: 10.1186/s12885-015-1278-x.

28.

Notch3 is necessary for blood vessel integrity in the central nervous system.

Henshall TL, Keller A, He L, Johansson BR, Wallgard E, Raschperger E, Mäe MA, Jin S, Betsholtz C, Lendahl U.

Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):409-20. doi: 10.1161/ATVBAHA.114.304849. Epub 2014 Dec 4.

PMID:
25477343
29.

Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.

Georgievska B, Gustavsson S, Lundkvist J, Neelissen J, Eketjäll S, Ramberg V, Bueters T, Agerman K, Juréus A, Svensson S, Berg S, Fälting J, Lendahl U.

J Neurochem. 2015 Feb;132(4):477-86. doi: 10.1111/jnc.12937. Epub 2014 Sep 18.

30.

Therapeutic modulation of Notch signalling--are we there yet?

Andersson ER, Lendahl U.

Nat Rev Drug Discov. 2014 May;13(5):357-78. doi: 10.1038/nrd4252. Review.

PMID:
24781550
31.

PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner.

Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, Mutvei A, Imanishi SY, Holmberg J, Jin S, Eriksson JE, Lendahl U, Sahlgren C.

Cell Res. 2014 Apr;24(4):433-50. doi: 10.1038/cr.2014.34. Epub 2014 Mar 25.

32.

Cell surface antigen profiling using a novel type of antibody array immobilised to plasma ion-implanted polycarbonate.

Main H, Radenkovic J, Kosobrodova E, McKenzie D, Bilek M, Lendahl U.

Cell Mol Life Sci. 2014 Oct;71(19):3841-57. doi: 10.1007/s00018-014-1595-2. Epub 2014 Mar 13.

PMID:
24623559
33.

Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions.

Olsson F, Schmidt S, Althoff V, Munter LM, Jin S, Rosqvist S, Lendahl U, Multhaup G, Lundkvist J.

J Biol Chem. 2014 Jan 17;289(3):1540-50. doi: 10.1074/jbc.M113.498246. Epub 2013 Nov 13.

34.

The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics.

Liu T, Yu R, Jin SB, Han L, Lendahl U, Zhao J, Nistér M.

Exp Cell Res. 2013 Nov 1;319(18):2893-904. doi: 10.1016/j.yexcr.2013.07.010. Epub 2013 Jul 20.

PMID:
23880462
35.

Notch signaling maintains neural rosette polarity.

Main H, Radenkovic J, Jin SB, Lendahl U, Andersson ER.

PLoS One. 2013 May 10;8(5):e62959. doi: 10.1371/journal.pone.0062959. Print 2013.

36.

Hypoxia-induced arterial differentiation requires adrenomedullin and notch signaling.

Lanner F, Lee KL, Ortega GC, Sohl M, Li X, Jin S, Hansson EM, Claesson-Welsh L, Poellinger L, Lendahl U, Farnebo F.

Stem Cells Dev. 2013 May 1;22(9):1360-9. doi: 10.1089/scd.2012.0259. Epub 2013 Feb 12.

PMID:
23379656
37.

Regenerative medicine for the treatment of heart disease.

Hansson EM, Lendahl U.

J Intern Med. 2013 Mar;273(3):235-45. doi: 10.1111/joim.12033. Epub 2013 Feb 10. Review.

38.

A critical role for Sox9 in notch-induced astrogliogenesis and stem cell maintenance.

Martini S, Bernoth K, Main H, Ortega GD, Lendahl U, Just U, Schwanbeck R.

Stem Cells. 2013 Apr;31(4):741-51. doi: 10.1002/stem.1320.

39.

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.

Borgegård T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J, Jureus A, Ridderstad-Wollberg A, Wollberg P, Stockling K, Karlström H, Malmberg A, Lund J, Arvidsson PI, De Strooper B, Lendahl U, Lundkvist J.

J Neurosci. 2012 Nov 28;32(48):17297-305. doi: 10.1523/JNEUROSCI.1451-12.2012.

40.

Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ.

Jin S, Mutvei AP, Chivukula IV, Andersson ER, Ramsköld D, Sandberg R, Lee KL, Kronqvist P, Mamaeva V, Ostling P, Mpindi JP, Kallioniemi O, Screpanti I, Poellinger L, Sahlgren C, Lendahl U.

Oncogene. 2013 Oct 10;32(41):4892-902. doi: 10.1038/onc.2012.517. Epub 2012 Nov 26.

41.

Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates.

Zhao J, Lendahl U, Nistér M.

Cell Mol Life Sci. 2013 Mar;70(6):951-76. doi: 10.1007/s00018-012-1066-6. Epub 2012 Jul 18. Review.

42.

Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms.

Landor SK, Mutvei AP, Mamaeva V, Jin S, Busk M, Borra R, Grönroos TJ, Kronqvist P, Lendahl U, Sahlgren CM.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18814-9. doi: 10.1073/pnas.1104943108. Epub 2011 Nov 7.

43.

Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling.

Liu L, Lanner F, Lendahl U, Das D.

Biochem Biophys Res Commun. 2011 Sep 30;413(3):426-31. doi: 10.1016/j.bbrc.2011.08.108. Epub 2011 Aug 27.

PMID:
21893032
44.

Notch signaling: simplicity in design, versatility in function.

Andersson ER, Sandberg R, Lendahl U.

Development. 2011 Sep;138(17):3593-612. doi: 10.1242/dev.063610. Review.

45.

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission.

Zhao J, Liu T, Jin S, Wang X, Qu M, Uhlén P, Tomilin N, Shupliakov O, Lendahl U, Nistér M.

EMBO J. 2011 Jun 24;30(14):2762-78. doi: 10.1038/emboj.2011.198.

46.

Modelling cell lineage using a meta-Boolean tree model with a relation to gene regulatory networks.

Larsson JK, Wadströmer N, Hermanson O, Lendahl U, Forchheimer R.

J Theor Biol. 2011 Jan 7;268(1):62-76. doi: 10.1016/j.jtbi.2010.10.003. Epub 2010 Oct 12.

PMID:
20946901
47.

Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells.

Das D, Lanner F, Main H, Andersson ER, Bergmann O, Sahlgren C, Heldring N, Hermanson O, Hansson EM, Lendahl U.

Dev Biol. 2010 Dec 15;348(2):153-66. doi: 10.1016/j.ydbio.2010.09.018. Epub 2010 Sep 29.

48.

Control of Notch-ligand endocytosis by ligand-receptor interaction.

Hansson EM, Lanner F, Das D, Mutvei A, Marklund U, Ericson J, Farnebo F, Stumm G, Stenmark H, Andersson ER, Lendahl U.

J Cell Sci. 2010 Sep 1;123(Pt 17):2931-42. doi: 10.1242/jcs.073239.

49.

Evidence for dimeric BACE-mediated APP processing.

Jin S, Agerman K, Kolmodin K, Gustafsson E, Dahlqvist C, Jureus A, Liu G, Fälting J, Berg S, Lundkvist J, Lendahl U.

Biochem Biophys Res Commun. 2010 Feb 26;393(1):21-7. doi: 10.1016/j.bbrc.2010.01.064. Epub 2010 Jan 25.

PMID:
20097169
50.

Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression.

Marklund U, Hansson EM, Sundström E, de Angelis MH, Przemeck GK, Lendahl U, Muhr J, Ericson J.

Development. 2010 Feb;137(3):437-45. doi: 10.1242/dev.036806.

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