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Items: 1 to 50 of 143

1.

Transcytosis Assay for Transport of Glycosphingolipids across MDCK-II Cells.

Garcia-Castillo MD, Lencer WI, Chinnapen DJ.

Bio Protoc. 2018 Oct 20;8(20). pii: e3049. doi: 10.21769/BioProtoc.3049.

2.

INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.

Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI.

Elife. 2018 Oct 25;7. pii: e38539. doi: 10.7554/eLife.38539.

3.

CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection.

Pacheco AR, Lazarus JE, Sit B, Schmieder S, Lencer WI, Blondel CJ, Doench JG, Davis BM, Waldor MK.

MBio. 2018 Jun 19;9(3). pii: e01003-18. doi: 10.1128/mBio.01003-18.

4.

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids.

Garcia-Castillo MD, Chinnapen DJ, Te Welscher YM, Gonzalez RJ, Softic S, Pacheco M, Mrsny RJ, Kahn CR, von Andrian UH, Lau J, Pentelute BL, Lencer WI.

Elife. 2018 May 31;7. pii: e34469. doi: 10.7554/eLife.34469.

5.

Advances in Evaluation of Chronic Diarrhea in Infants.

Thiagarajah JR, Kamin DS, Acra S, Goldsmith JD, Roland JT, Lencer WI, Muise AM, Goldenring JR, Avitzur Y, Martín MG; PediCODE Consortium.

Gastroenterology. 2018 Jun;154(8):2045-2059.e6. doi: 10.1053/j.gastro.2018.03.067. Epub 2018 Apr 12. Review.

6.

Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.

Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI.

Cell Host Microbe. 2018 Apr 11;23(4):571. doi: 10.1016/j.chom.2018.03.005. No abstract available.

7.

Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.

Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2862-E2871. doi: 10.1073/pnas.1618291114. Epub 2017 Mar 22.

8.

Membrane Transport across Polarized Epithelia.

Garcia-Castillo MD, Chinnapen DJ, Lencer WI.

Cold Spring Harb Perspect Biol. 2017 Sep 1;9(9). pii: a027912. doi: 10.1101/cshperspect.a027912. Review.

9.

Opening CFTR in the Intestine: Flushing on Demand.

Lencer WI.

Cell Mol Gastroenterol Hepatol. 2016 Mar 19;2(3):256. doi: 10.1016/j.jcmgh.2016.02.005. eCollection 2016 May. No abstract available.

10.

Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia.

Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):568-573. doi: 10.1073/pnas.1612921114. Epub 2017 Jan 3.

11.

Glycolipid Crosslinking Is Required for Cholera Toxin to Partition Into and Stabilize Ordered Domains.

Raghunathan K, Wong TH, Chinnapen DJ, Lencer WI, Jobling MG, Kenworthy AK.

Biophys J. 2016 Dec 20;111(12):2547-2550. doi: 10.1016/j.bpj.2016.11.008. Epub 2016 Nov 30.

12.

CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types.

Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI.

Genome Biol. 2016 Sep 29;17(1):201.

13.

Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion.

Saslowsky DE, Thiagarajah JR, McCormick BA, Lee JC, Lencer WI.

Mol Biol Cell. 2016 Apr 1;27(7):1120-30. doi: 10.1091/mbc.E15-05-0293. Epub 2016 Feb 10.

14.

Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy.

Lexmond WS, Rufo PA, Fiebiger E, Lencer WI.

PLoS Negl Trop Dis. 2015 Sep 25;9(9):e0004098. doi: 10.1371/journal.pntd.0004098. eCollection 2015 Sep.

15.

Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W.

Reimold FR, Balasubramanian S, Doroquez DB, Shmukler BE, Zsengeller ZK, Saslowsky D, Thiagarajah JR, Stillman IE, Lencer WI, Wu BL, Villalpando-Carrion S, Alper SL.

Front Physiol. 2015 Jun 23;6:179. doi: 10.3389/fphys.2015.00179. eCollection 2015.

16.

Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway.

Lencer WI, DeLuca H, Grey MJ, Cho JA.

Trends Immunol. 2015 Jul;36(7):401-9. doi: 10.1016/j.it.2015.05.006. Epub 2015 Jun 17. Review.

17.

FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.

Pyzik M, Rath T, Lencer WI, Baker K, Blumberg RS.

J Immunol. 2015 May 15;194(10):4595-603. doi: 10.4049/jimmunol.1403014. Review.

18.

Microtubule motors power plasma membrane tubulation in clathrin-independent endocytosis.

Day CA, Baetz NW, Copeland CA, Kraft LJ, Han B, Tiwari A, Drake KR, De Luca H, Chinnapen DJ, Davidson MW, Holmes RK, Jobling MG, Schroer TA, Lencer WI, Kenworthy AK.

Traffic. 2015 Jun;16(6):572-90. doi: 10.1111/tra.12269. Epub 2015 Apr 27.

19.

4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.

Cho JA, Zhang X, Miller GM, Lencer WI, Nery FC.

PLoS One. 2014 Nov 7;9(11):e110086. doi: 10.1371/journal.pone.0110086. eCollection 2014.

20.

Remodeling of the intestinal brush border underlies adhesion and virulence of an enteric pathogen.

Zhou X, Massol RH, Nakamura F, Chen X, Gewurz BE, Davis BM, Lencer WI, Waldor MK.

MBio. 2014 Aug 19;5(4). pii: e01639-14. doi: 10.1128/mBio.01639-14.

21.

Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation.

Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Araç D, Piao X.

PLoS One. 2014 Jun 20;9(6):e100043. doi: 10.1371/journal.pone.0100043. eCollection 2014.

22.

Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1.

te Welscher YM, Chinnapen DJ, Kaoutzani L, Mrsny RJ, Lencer WI.

J Control Release. 2014 Feb 10;175:72-8. doi: 10.1016/j.jconrel.2013.12.013. Epub 2013 Dec 23.

23.

Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer.

Baker K, Rath T, Flak MB, Arthur JC, Chen Z, Glickman JN, Zlobec I, Karamitopoulou E, Stachler MD, Odze RD, Lencer WI, Jobin C, Blumberg RS.

Immunity. 2013 Dec 12;39(6):1095-107. doi: 10.1016/j.immuni.2013.11.003. Epub 2013 Nov 27.

24.

Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics.

Rath T, Baker K, Dumont JA, Peters RT, Jiang H, Qiao SW, Lencer WI, Pierce GF, Blumberg RS.

Crit Rev Biotechnol. 2015 Jun;35(2):235-54. doi: 10.3109/07388551.2013.834293. Epub 2013 Oct 24. Review.

25.

Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain.

Saslowsky DE, te Welscher YM, Chinnapen DJ, Wagner JS, Wan J, Kern E, Lencer WI.

J Biol Chem. 2013 Sep 6;288(36):25804-9. doi: 10.1074/jbc.M113.474957. Epub 2013 Jul 24.

26.

Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules.

Weflen AW, Baier N, Tang QJ, Van den Hof M, Blumberg RS, Lencer WI, Massol RH.

Mol Biol Cell. 2013 Aug;24(15):2398-405. doi: 10.1091/mbc.E13-04-0174. Epub 2013 Jun 5.

27.

The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling.

Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI.

Cell Host Microbe. 2013 May 15;13(5):558-569. doi: 10.1016/j.chom.2013.03.011. Retraction in: Cell Host Microbe. 2018 Apr 11;23 (4):571.

28.

A single native ganglioside GM1-binding site is sufficient for cholera toxin to bind to cells and complete the intoxication pathway.

Jobling MG, Yang Z, Kam WR, Lencer WI, Holmes RK.

MBio. 2012 Oct 30;3(6). pii: e00401-12. doi: 10.1128/mBio.00401-12.

29.

Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1.

Chinnapen DJ, Hsieh WT, te Welscher YM, Saslowsky DE, Kaoutzani L, Brandsma E, D'Auria L, Park H, Wagner JS, Drake KR, Kang M, Benjamin T, Ullman MD, Costello CE, Kenworthy AK, Baumgart T, Massol RH, Lencer WI.

Dev Cell. 2012 Sep 11;23(3):573-86. doi: 10.1016/j.devcel.2012.08.002.

30.

The immunologic functions of the neonatal Fc receptor for IgG.

Rath T, Kuo TT, Baker K, Qiao SW, Kobayashi K, Yoshida M, Roopenian D, Fiebiger E, Lencer WI, Blumberg RS.

J Clin Immunol. 2013 Jan;33 Suppl 1:S9-17. doi: 10.1007/s10875-012-9768-y. Epub 2012 Sep 5. Review.

31.

Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins.

Cho JA, Chinnapen DJ, Aamar E, te Welscher YM, Lencer WI, Massol R.

Front Cell Infect Microbiol. 2012 Apr 11;2:51. doi: 10.3389/fcimb.2012.00051. eCollection 2012. Review.

32.

Cross-presentation of IgG-containing immune complexes.

Baker K, Rath T, Lencer WI, Fiebiger E, Blumberg RS.

Cell Mol Life Sci. 2013 Apr;70(8):1319-34. doi: 10.1007/s00018-012-1100-8. Epub 2012 Jul 31. Review.

33.

Eliciting mucosal immunity.

Lencer WI, von Andrian UH.

N Engl J Med. 2011 Sep 22;365(12):1151-3. doi: 10.1056/NEJMcibr1107816. No abstract available.

34.

To translocate or not: that is the problem.

Lencer WI, Tweten RK.

Cell Host Microbe. 2011 Sep 15;10(3):179-80. doi: 10.1016/j.chom.2011.08.009.

35.

Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.

Uchida Y, Hasegawa J, Chinnapen D, Inoue T, Okazaki S, Kato R, Wakatsuki S, Misaki R, Koike M, Uchiyama Y, Iemura S, Natsume T, Kuwahara R, Nakagawa T, Nishikawa K, Mukai K, Miyoshi E, Taniguchi N, Sheff D, Lencer WI, Taguchi T, Arai H.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15846-51. doi: 10.1073/pnas.1109101108. Epub 2011 Sep 12.

36.

TorsinA participates in endoplasmic reticulum-associated degradation.

Nery FC, Armata IA, Farley JE, Cho JA, Yaqub U, Chen P, da Hora CC, Wang Q, Tagaya M, Klein C, Tannous B, Caldwell KA, Caldwell GA, Lencer WI, Ye Y, Breakefield XO.

Nat Commun. 2011 Jul 12;2:393. doi: 10.1038/ncomms1383.

37.

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.

Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9927-32. doi: 10.1073/pnas.1019037108. Epub 2011 May 31.

38.

The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies.

Gupta V, Kawahara G, Gundry SR, Chen AT, Lencer WI, Zhou Y, Zon LI, Kunkel LM, Beggs AH.

Hum Mol Genet. 2011 May 1;20(9):1712-25. doi: 10.1093/hmg/ddr047. Epub 2011 Feb 4.

39.

Functional analysis of VopF activity required for colonization in Vibrio cholerae.

Tam VC, Suzuki M, Coughlin M, Saslowsky D, Biswas K, Lencer WI, Faruque SM, Mekalanos JJ.

MBio. 2010 Dec 7;1(5). pii: e00289-10. doi: 10.1128/mBio.00289-10.

40.

Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2.

Saslowsky DE, Cho JA, Chinnapen H, Massol RH, Chinnapen DJ, Wagner JS, De Luca HE, Kam W, Paw BH, Lencer WI.

J Clin Invest. 2010 Dec;120(12):4399-4409. doi: 10.1172/JCI42958.

41.

Neonatal Fc receptor: from immunity to therapeutics.

Kuo TT, Baker K, Yoshida M, Qiao SW, Aveson VG, Lencer WI, Blumberg RS.

J Clin Immunol. 2010 Nov;30(6):777-89. doi: 10.1007/s10875-010-9468-4. Epub 2010 Oct 1. Review.

42.

Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum.

Wernick NL, Chinnapen DJ, Cho JA, Lencer WI.

Toxins (Basel). 2010 Mar;2(3):310-25. doi: 10.3390/toxins2030310. Epub 2010 Mar 5. Review.

43.

Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.

Eby JC, Ciesla WP, Hamman W, Donato GM, Pickles RJ, Hewlett EL, Lencer WI.

J Biol Chem. 2010 Apr 2;285(14):10662-70. doi: 10.1074/jbc.M109.089219. Epub 2010 Feb 5.

44.

N-terminal extension of the cholera toxin A1-chain causes rapid degradation after retrotranslocation from endoplasmic reticulum to cytosol.

Wernick NL, De Luca H, Kam WR, Lencer WI.

J Biol Chem. 2010 Feb 26;285(9):6145-52. doi: 10.1074/jbc.M109.062067. Epub 2010 Jan 7.

45.

An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.

Kobayashi K, Qiao SW, Yoshida M, Baker K, Lencer WI, Blumberg RS.

Gastroenterology. 2009 Nov;137(5):1746-56.e1. doi: 10.1053/j.gastro.2009.07.059. Epub 2009 Aug 4.

46.

Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn.

Baker K, Qiao SW, Kuo T, Kobayashi K, Yoshida M, Lencer WI, Blumberg RS.

Semin Immunopathol. 2009 Jul;31(2):223-36. doi: 10.1007/s00281-009-0160-9. Epub 2009 Jun 3. Review.

47.

The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.

Tzaban S, Massol RH, Yen E, Hamman W, Frank SR, Lapierre LA, Hansen SH, Goldenring JR, Blumberg RS, Lencer WI.

J Cell Biol. 2009 May 18;185(4):673-84. doi: 10.1083/jcb.200809122.

48.

N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.

Kuo TT, de Muinck EJ, Claypool SM, Yoshida M, Nagaishi T, Aveson VG, Lencer WI, Blumberg RS.

J Biol Chem. 2009 Mar 27;284(13):8292-300. doi: 10.1074/jbc.M805877200. Epub 2009 Jan 21.

49.

Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia.

Saslowsky DE, Tanaka N, Reddy KP, Lencer WI.

FASEB J. 2009 Jan;23(1):259-70. doi: 10.1096/fj.08-116467. Epub 2008 Sep 26.

50.

Patching a leaky intestine.

Lencer WI.

N Engl J Med. 2008 Jul 31;359(5):526-8. doi: 10.1056/NEJMcibr0803745. No abstract available.

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