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Items: 1 to 50 of 214

1.

Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes.

Matsuda-Lennikov M, Biancalana M, Zou J, Ravell JC, Zheng L, Kanellopoulou C, Jiang P, Notarangelo G, Jing H, Masutani E, Oler AJ, Olano LR, Schulz BL, Lenardo MJ.

J Biol Chem. 2019 Sep 13;294(37):13638-13656. doi: 10.1074/jbc.RA119.008903. Epub 2019 Jul 23.

PMID:
31337704
2.

Mg2+ regulation of kinase signaling and immune function.

Kanellopoulou C, George AB, Masutani E, Cannons JL, Ravell JC, Yamamoto TN, Smelkinson MG, Jiang PD, Matsuda-Lennikov M, Reilley J, Handon R, Lee PH, Miller JR, Restifo NP, Zheng L, Schwartzberg PL, Young M, Lenardo MJ.

J Exp Med. 2019 Aug 5;216(8):1828-1842. doi: 10.1084/jem.20181970. Epub 2019 Jun 13.

PMID:
31196981
3.

Development of immune checkpoint therapy for cancer.

Fritz JM, Lenardo MJ.

J Exp Med. 2019 Jun 3;216(6):1244-1254. doi: 10.1084/jem.20182395. Epub 2019 May 8. Review.

PMID:
31068379
4.

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.

Zhang Z, Gothe F, Pennamen P, James JR, McDonald D, Mata CP, Modis Y, Alazami AM, Acres M, Haller W, Bowen C, Döffinger R, Sinclair J, Brothers S, Zhang Y, Matthews HF, Naudion S, Pelluard F, Alajlan H, Yamazaki Y, Notarangelo LD, Thaventhiran JE, Engelhardt KR, Al-Mousa H, Hambleton S, Rooryck C, Smith KGC, Lenardo MJ.

J Exp Med. 2019 Jun 3;216(6):1311-1327. doi: 10.1084/jem.20182304. Epub 2019 Apr 30.

PMID:
31040185
5.

Introduction: Continuing insights into the healthy and diseased immune system through human genetic investigation.

Lenardo MJ, Holland SM.

Immunol Rev. 2019 Jan;287(1):5-8. doi: 10.1111/imr.12730. No abstract available.

PMID:
30565248
6.

Erratum to "Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda" [Cancer Epidemiol. 52 (2018) 70-74].

Ravell J, Otim I, Nabalende H, Legason ID, Reynolds SJ, Ogwang MD, Ndugwa CM, Marshall V, Whitby D, Goedert JJ, Engels EA, Bhatia K, Lenardo MJ, Mbulaiteye SM.

Cancer Epidemiol. 2018 Aug;55:192. doi: 10.1016/j.canep.2018.05.010. Epub 2018 Jun 1. No abstract available.

PMID:
29861403
7.

Molecular Classification of Primary Immunodeficiencies of T Lymphocytes.

Comrie WA, Lenardo MJ.

Adv Immunol. 2018;138:99-193. doi: 10.1016/bs.ai.2018.02.003. Epub 2018 Mar 29. Review.

PMID:
29731008
8.

RELA haploinsufficiency in CD4 lymphoproliferative disease with autoimmune cytopenias.

Comrie WA, Faruqi AJ, Price S, Zhang Y, Rao VK, Su HC, Lenardo MJ.

J Allergy Clin Immunol. 2018 Apr;141(4):1507-1510.e8. doi: 10.1016/j.jaci.2017.11.036. Epub 2018 Jan 2. No abstract available.

9.

Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda.

Ravell J, Otim I, Nabalende H, Legason ID, Reynolds SJ, Ogwang MD, Ndugwa CM, Marshall V, Whitby D, Goedert JJ, Engels EA, Bhatia K, Lenardo MJ, Mbulaiteye SM.

Cancer Epidemiol. 2018 Feb;52:70-74. doi: 10.1016/j.canep.2017.12.004. Epub 2017 Dec 14. Erratum in: Cancer Epidemiol. 2018 Aug;55:192.

10.

STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells.

Majri SS, Fritz JM, Villarino AV, Zheng L, Kanellopoulou C, Chaigne-Delalande B, Grönholm J, Niemela JE, Afzali B, Biancalana M, Pittaluga S, Sun A, Cohen JL, Holland SM, O'Shea JJ, Uzel G, Lenardo MJ.

J Immunol. 2018 Jan 1;200(1):110-118. doi: 10.4049/jimmunol.1701133. Epub 2017 Nov 29.

11.

Editorial overview: Autoimmunity: New genomics approaches are improving our understanding of autoimmunity.

Lo B, Lenardo MJ.

Curr Opin Immunol. 2017 Dec;49:iv-vi. doi: 10.1016/j.coi.2017.11.001. No abstract available.

PMID:
29173328
12.

CD55 Deficiency and Protein-Losing Enteropathy.

Ozen A, Comrie WA, Lenardo MJ.

N Engl J Med. 2017 Oct 12;377(15):1499-1500. doi: 10.1056/NEJMc1710011. No abstract available.

PMID:
29020581
13.

Effective "activated PI3Kδ syndrome"-targeted therapy with the PI3Kδ inhibitor leniolisib.

Rao VK, Webster S, Dalm VASH, Šedivá A, van Hagen PM, Holland S, Rosenzweig SD, Christ AD, Sloth B, Cabanski M, Joshi AD, de Buck S, Doucet J, Guerini D, Kalis C, Pylvaenaeinen I, Soldermann N, Kashyap A, Uzel G, Lenardo MJ, Patel DD, Lucas CL, Burkhart C.

Blood. 2017 Nov 23;130(21):2307-2316. doi: 10.1182/blood-2017-08-801191. Epub 2017 Sep 29.

14.

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis.

Ozen A, Comrie WA, Ardy RC, Domínguez Conde C, Dalgic B, Beser ÖF, Morawski AR, Karakoc-Aydiner E, Tutar E, Baris S, Ozcay F, Serwas NK, Zhang Y, Matthews HF, Pittaluga S, Folio LR, Unlusoy Aksu A, McElwee JJ, Krolo A, Kiykim A, Baris Z, Gulsan M, Ogulur I, Snapper SB, Houwen RHJ, Leavis HL, Ertem D, Kain R, Sari S, Erkan T, Su HC, Boztug K, Lenardo MJ.

N Engl J Med. 2017 Jul 6;377(1):52-61. doi: 10.1056/NEJMoa1615887. Epub 2017 Jun 28.

15.

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali B, Grönholm J, Vandrovcova J, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ.

Nat Immunol. 2017 Jul;18(7):813-823. doi: 10.1038/ni.3753. Epub 2017 May 22.

16.

Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice.

Grönholm J, Pagni PP, Pham MN, Gibson CB, Macomber PF, Vela JL, von Herrath M, Lenardo MJ.

Diabetologia. 2017 Aug;60(8):1475-1482. doi: 10.1007/s00125-017-4276-5. Epub 2017 Apr 28.

17.

30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology.

Zhang Q, Lenardo MJ, Baltimore D.

Cell. 2017 Jan 12;168(1-2):37-57. doi: 10.1016/j.cell.2016.12.012. Epub 2017 Jan 12. Review.

18.

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.

Abolhassani H, Edwards ES, Ikinciogullari A, Jing H, Borte S, Buggert M, Du L, Matsuda-Lennikov M, Romano R, Caridha R, Bade S, Zhang Y, Frederiksen J, Fang M, Bal SK, Haskologlu S, Dogu F, Tacyildiz N, Matthews HF, McElwee JJ, Gostick E, Price DA, Palendira U, Aghamohammadi A, Boisson B, Rezaei N, Karlsson AC, Lenardo MJ, Casanova JL, Hammarström L, Tangye SG, Su HC, Pan-Hammarström Q.

J Exp Med. 2017 Jan;214(1):91-106. doi: 10.1084/jem.20160849. Epub 2016 Dec 23.

19.

Clinical Genomics - Molecular Pathogenesis Revealed.

Lenardo MJ.

N Engl J Med. 2016 Dec 1;375(22):2117-2119. No abstract available.

PMID:
27959769
20.

CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency.

Lo B, Fritz JM, Su HC, Uzel G, Jordan MB, Lenardo MJ.

Blood. 2016 Aug 25;128(8):1037-42. doi: 10.1182/blood-2016-04-712612. Epub 2016 Jul 14. Review.

21.

Life with a Primary Immune Deficiency: a Systematic Synthesis of the Literature and Proposed Research Agenda.

Similuk MN, Wang A, Lenardo MJ, Erby LH.

J Clin Immunol. 2016 Feb;36(2):123-33. doi: 10.1007/s10875-016-0241-1. Epub 2016 Feb 12. Review.

PMID:
26873708
22.

Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis.

Lu W, Sun J, Yoon JS, Zhang Y, Zheng L, Murphy E, Mattson MP, Lenardo MJ.

PLoS One. 2016 Jan 25;11(1):e0147792. doi: 10.1371/journal.pone.0147792. eCollection 2016.

23.

Characterization of a genetically engineered mouse model of hemophilia A with complete deletion of the F8 gene.

Chao BN, Baldwin WH, Healey JF, Parker ET, Shafer-Weaver K, Cox C, Jiang P, Kanellopoulou C, Lollar P, Meeks SL, Lenardo MJ.

J Thromb Haemost. 2016 Feb;14(2):346-55. doi: 10.1111/jth.13202. Epub 2016 Jan 8.

24.

Bill Paul: The heart of immunology.

Lenardo MJ, Staudt LM.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14117-8. doi: 10.1073/pnas.1519815112. Epub 2015 Nov 2. No abstract available.

25.

Reprogramming of Polycomb-Mediated Gene Silencing in Embryonic Stem Cells by the miR-290 Family and the Methyltransferase Ash1l.

Kanellopoulou C, Gilpatrick T, Kilaru G, Burr P, Nguyen CK, Morawski A, Lenardo MJ, Muljo SA.

Stem Cell Reports. 2015 Dec 8;5(6):971-978. doi: 10.1016/j.stemcr.2015.10.001. Epub 2015 Nov 5.

26.

Identifying genetic determinants of autoimmunity and immune dysregulation.

Lucas CL, Lenardo MJ.

Curr Opin Immunol. 2015 Dec;37:28-33. doi: 10.1016/j.coi.2015.09.001. Epub 2015 Oct 2. Review.

27.

Genomics is rapidly advancing precision medicine for immunological disorders.

Zhang Y, Su HC, Lenardo MJ.

Nat Immunol. 2015 Oct;16(10):1001-4. doi: 10.1038/ni.3275. No abstract available.

PMID:
26382860
28.

AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.

Lo B, Zhang K, Lu W, Zheng L, Zhang Q, Kanellopoulou C, Zhang Y, Liu Z, Fritz JM, Marsh R, Husami A, Kissell D, Nortman S, Chaturvedi V, Haines H, Young LR, Mo J, Filipovich AH, Bleesing JJ, Mustillo P, Stephens M, Rueda CM, Chougnet CA, Hoebe K, McElwee J, Hughes JD, Karakoc-Aydiner E, Matthews HF, Price S, Su HC, Rao VK, Lenardo MJ, Jordan MB.

Science. 2015 Jul 24;349(6246):436-40. doi: 10.1126/science.aaa1663.

29.

Dual proteolytic pathways govern glycolysis and immune competence.

Lu W, Zhang Y, McDonald DO, Jing H, Carroll B, Robertson N, Zhang Q, Griffin H, Sanderson S, Lakey JH, Morgan NV, Reynard LN, Zheng L, Murdock HM, Turvey SE, Hackett SJ, Prestidge T, Hall JM, Cant AJ, Matthews HF, Koref MF, Simon AK, Korolchuk VI, Lenardo MJ, Hambleton S, Su HC.

Cell. 2014 Dec 18;159(7):1578-90. doi: 10.1016/j.cell.2014.12.001.

30.

Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K.

Lucas CL, Zhang Y, Venida A, Wang Y, Hughes J, McElwee J, Butrick M, Matthews H, Price S, Biancalana M, Wang X, Richards M, Pozos T, Barlan I, Ozen A, Rao VK, Su HC, Lenardo MJ.

J Exp Med. 2014 Dec 15;211(13):2537-47. doi: 10.1084/jem.20141759. Epub 2014 Dec 8.

31.

Novel diagnostic and therapeutic approaches for autoimmune diabetes--a prime time to treat insulitis as a disease.

Grönholm J, Lenardo MJ.

Clin Immunol. 2015 Feb;156(2):109-18. doi: 10.1016/j.clim.2014.11.007. Epub 2014 Dec 5. Review.

32.

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.

Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, Schickel JN, Tran DQ, Stoddard J, Zhang Y, Frucht DM, Dumitriu B, Scheinberg P, Folio LR, Frein CA, Price S, Koh C, Heller T, Seroogy CM, Huttenlocher A, Rao VK, Su HC, Kleiner D, Notarangelo LD, Rampertaap Y, Olivier KN, McElwee J, Hughes J, Pittaluga S, Oliveira JB, Meffre E, Fleisher TA, Holland SM, Lenardo MJ, Tangye SG, Uzel G.

Science. 2014 Sep 26;345(6204):1623-1627. doi: 10.1126/science.1255904. Epub 2014 Sep 11.

33.

Clinical utility gene card for: X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia (XMEN).

Li FY, Chaigne-Delalande B, Rao VK, Zhang Y, Matthews H, Kuijpers TT, Su H, Uzel G, Lenardo MJ.

Eur J Hum Genet. 2015 Jun;23(6). doi: 10.1038/ejhg.2014.179. Epub 2014 Sep 10. No abstract available.

34.

Divalent cation signaling in immune cells.

Chaigne-Delalande B, Lenardo MJ.

Trends Immunol. 2014 Jul;35(7):332-44. doi: 10.1016/j.it.2014.05.001. Epub 2014 Jun 2. Review.

35.

XMEN disease: a new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus.

Li FY, Chaigne-Delalande B, Su H, Uzel G, Matthews H, Lenardo MJ.

Blood. 2014 Apr 3;123(14):2148-52. doi: 10.1182/blood-2013-11-538686. Epub 2014 Feb 18. Review.

36.

Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations.

Price S, Shaw PA, Seitz A, Joshi G, Davis J, Niemela JE, Perkins K, Hornung RL, Folio L, Rosenberg PS, Puck JM, Hsu AP, Lo B, Pittaluga S, Jaffe ES, Fleisher TA, Rao VK, Lenardo MJ.

Blood. 2014 Mar 27;123(13):1989-99. doi: 10.1182/blood-2013-10-535393. Epub 2014 Jan 7.

37.

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.

Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G.

Nat Immunol. 2014 Jan;15(1):88-97. doi: 10.1038/ni.2771. Epub 2013 Oct 28.

38.

Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D.

Chaigne-Delalande B, Li FY, O'Connor GM, Lukacs MJ, Jiang P, Zheng L, Shatzer A, Biancalana M, Pittaluga S, Matthews HF, Jancel TJ, Bleesing JJ, Marsh RA, Kuijpers TW, Nichols KE, Lucas CL, Nagpal S, Mehmet H, Su HC, Cohen JI, Uzel G, Lenardo MJ.

Science. 2013 Jul 12;341(6142):186-91. doi: 10.1126/science.1240094.

39.

Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.

Snow AL, Xiao W, Stinson JR, Lu W, Chaigne-Delalande B, Zheng L, Pittaluga S, Matthews HF, Schmitz R, Jhavar S, Kuchen S, Kardava L, Wang W, Lamborn IT, Jing H, Raffeld M, Moir S, Fleisher TA, Staudt LM, Su HC, Lenardo MJ.

J Exp Med. 2012 Nov 19;209(12):2247-61. doi: 10.1084/jem.20120831. Epub 2012 Nov 5.

40.

A rapid ex vivo clinical diagnostic assay for fas receptor-induced T lymphocyte apoptosis.

Lo B, Ramaswamy M, Davis J, Price S, Rao VK, Siegel RM, Lenardo MJ.

J Clin Immunol. 2013 Feb;33(2):479-88. doi: 10.1007/s10875-012-9811-z. Epub 2012 Oct 11.

41.

The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes.

Pandiyan P, Yang XP, Saravanamuthu SS, Zheng L, Ishihara S, O'Shea JJ, Lenardo MJ.

J Immunol. 2012 Nov 1;189(9):4237-46. doi: 10.4049/jimmunol.1201476. Epub 2012 Sep 19.

42.

The role of LRRK2 in inflammatory bowel disease.

Liu Z, Lenardo MJ.

Cell Res. 2012 Jul;22(7):1092-4. doi: 10.1038/cr.2012.42. Epub 2012 Mar 20. No abstract available.

43.

Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status.

Lo B, Swafford AD, Shafer-Weaver KA, Jerome LF, Rakhlin L, Mathern DR, Callahan CA, Jiang P, Davison LJ, Stevens HE, Lucas CL, White J, von Borstel R, Todd JA, Lenardo MJ.

J Transl Med. 2011 Nov 28;9:203. doi: 10.1186/1479-5876-9-203.

44.

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.

Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ.

Nat Immunol. 2011 Oct 9;12(11):1063-70. doi: 10.1038/ni.2113.

45.

Loss of MAGT1 abrogates the Mg2+ flux required for T cell signaling and leads to a novel human primary immunodeficiency.

Li FY, Lenardo MJ, Chaigne-Delalande B.

Magnes Res. 2011 Sep;24(3):S109-14. doi: 10.1684/mrh.2011.0286. Review.

46.

Exposed hydrophobic residues in human immunodeficiency virus type 1 Vpr helix-1 are important for cell cycle arrest and cell death.

Barnitz RA, Chaigne-Delalande B, Bolton DL, Lenardo MJ.

PLoS One. 2011;6(9):e24924. doi: 10.1371/journal.pone.0024924. Epub 2011 Sep 16.

47.

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency.

Li FY, Chaigne-Delalande B, Kanellopoulou C, Davis JC, Matthews HF, Douek DC, Cohen JI, Uzel G, Su HC, Lenardo MJ.

Nature. 2011 Jul 27;475(7357):471-6. doi: 10.1038/nature10246.

48.

Human immunodeficiency virus type 1 Vif causes dysfunction of Cdk1 and CyclinB1: implications for cell cycle arrest.

Sakai K, Barnitz RA, Chaigne-Delalande B, Bidère N, Lenardo MJ.

Virol J. 2011 May 11;8:219. doi: 10.1186/1743-422X-8-219.

49.

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation.

Rong Y, McPhee CK, Deng S, Huang L, Chen L, Liu M, Tracy K, Baehrecke EH, Yu L, Lenardo MJ.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7826-31. doi: 10.1073/pnas.1013800108. Epub 2011 Apr 25. Erratum in: Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11297. McPhee, Christina [corrected to McPhee, Christina K]; Baehreck, Eric H [corrected to Baehrecke, Eric H].

50.

CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model.

Pandiyan P, Conti HR, Zheng L, Peterson AC, Mathern DR, Hernández-Santos N, Edgerton M, Gaffen SL, Lenardo MJ.

Immunity. 2011 Mar 25;34(3):422-34. doi: 10.1016/j.immuni.2011.03.002.

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