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Items: 1 to 50 of 324

1.

TIM1 (HAVCR1): an Essential "Receptor" or an "Accessory Attachment Factor" for Hepatitis A Virus?

Das A, Maury W, Lemon SM.

J Virol. 2019 May 15;93(11). pii: e01793-18. doi: 10.1128/JVI.01793-18. Print 2019 Jun 1. No abstract available.

PMID:
31092684
2.

TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.

Li Y, Wang L, Rivera-Serrano EE, Chen X, Lemon SM.

Nucleic Acids Res. 2019 Jul 9;47(12):6411-6424. doi: 10.1093/nar/gkz278.

3.

Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses.

Yamane D, Feng H, Rivera-Serrano EE, Selitsky SR, Hirai-Yuki A, Das A, McKnight KL, Misumi I, Hensley L, Lovell W, González-López O, Suzuki R, Matsuda M, Nakanishi H, Ohto-Nakanishi T, Hishiki T, Wauthier E, Oikawa T, Morita K, Reid LM, Sethupathy P, Kohara M, Whitmire JK, Lemon SM.

Nat Microbiol. 2019 Jul;4(7):1096-1104. doi: 10.1038/s41564-019-0425-6. Epub 2019 Apr 15.

PMID:
30988429
4.

Hepatovirus 3ABC proteases and evolution of mitochondrial antiviral signaling protein (MAVS).

Feng H, Sander AL, Moreira-Soto A, Yamane D, Drexler JF, Lemon SM.

J Hepatol. 2019 Jul;71(1):25-34. doi: 10.1016/j.jhep.2019.02.020. Epub 2019 Mar 13.

PMID:
30876947
5.

Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses.

Rivera-Serrano EE, González-López O, Das A, Lemon SM.

Elife. 2019 Feb 25;8. pii: e43983. doi: 10.7554/eLife.43983.

6.

Redundant Late Domain Functions of Tandem VP2 YPX3L Motifs in Nonlytic Cellular Egress of Quasi-enveloped Hepatitis A Virus.

González-López O, Rivera-Serrano EE, Hu F, Hensley L, McKnight KL, Ren J, Stuart DI, Fry EE, Lemon SM.

J Virol. 2018 Nov 12;92(23). pii: e01308-18. doi: 10.1128/JVI.01308-18. Print 2018 Dec 1.

7.

Evolutionary pathways to NS5A inhibitor resistance in genotype 1 hepatitis C virus.

Zhou S, Williford SE, McGivern DR, Burch CL, Hu F, Benzine T, Ingravallo P, Asante-Appiah E, Howe AYM, Swanstrom R, Lemon SM.

Antiviral Res. 2018 Oct;158:45-51. doi: 10.1016/j.antiviral.2018.07.024. Epub 2018 Aug 3.

8.

Hepatitis A Virus and Hepatitis E Virus: Emerging and Re-Emerging Enterically Transmitted Hepatitis Viruses.

Lemon SM, Walker CM.

Cold Spring Harb Perspect Med. 2019 Jun 3;9(6). pii: a031823. doi: 10.1101/cshperspect.a031823. Review.

9.

Enterically Transmitted Non-A, Non-B Hepatitis and the Discovery of Hepatitis E Virus.

Lemon SM, Walker CM.

Cold Spring Harb Perspect Med. 2019 Aug 1;9(8). pii: a033449. doi: 10.1101/cshperspect.a033449. Review.

10.

Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection.

Cullen JM, Lemon SM.

Cold Spring Harb Perspect Med. 2019 Apr 1;9(4). pii: a033456. doi: 10.1101/cshperspect.a033456. Review.

PMID:
29712683
11.

Nonhuman Primate Models of Hepatitis A Virus and Hepatitis E Virus Infections.

Lanford RE, Walker CM, Lemon SM.

Cold Spring Harb Perspect Med. 2019 Feb 1;9(2). pii: a031815. doi: 10.1101/cshperspect.a031815. Review.

12.

Innate Immunity to Enteric Hepatitis Viruses.

Feng Z, Lemon SM.

Cold Spring Harb Perspect Med. 2019 Mar 1;9(3). pii: a033464. doi: 10.1101/cshperspect.a033464. Review.

PMID:
29686040
13.

Murine Models of Hepatitis A Virus Infection.

Hirai-Yuki A, Whitmire JK, Joyce M, Tyrrell DL, Lemon SM.

Cold Spring Harb Perspect Med. 2019 Jan 2;9(1). pii: a031674. doi: 10.1101/cshperspect.a031674. Review.

PMID:
29661811
14.

Hepatitis A Virus Genome Organization and Replication Strategy.

McKnight KL, Lemon SM.

Cold Spring Harb Perspect Med. 2018 Dec 3;8(12). pii: a033480. doi: 10.1101/cshperspect.a033480. Review.

PMID:
29610147
15.

Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies.

Bartenschlager R, Baumert TF, Bukh J, Houghton M, Lemon SM, Lindenbach BD, Lohmann V, Moradpour D, Pietschmann T, Rice CM, Thimme R, Wakita T.

Virus Res. 2018 Mar 15;248:53-62. doi: 10.1016/j.virusres.2018.02.016. Epub 2018 Mar 2. Review.

16.

An Efficient, Large-Scale Survey of Hepatitis C Viremia in the Democratic Republic of the Congo Using Dried Blood Spots.

Parr JB, Lodge EK, Holzmayer V, Pepin J, Frost EH, Fried MW, McGivern DR, Lemon SM, Keeler C, Emch M, Mwandagalirwa K, Tshefu A, Fwamba F, Muwonga J, Meshnick SR, Cloherty G.

Clin Infect Dis. 2018 Jan 6;66(2):254-260. doi: 10.1093/cid/cix771.

17.

The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis.

Lanford RE, Walker CM, Lemon SM.

ILAR J. 2017 Dec 1;58(2):172-189. doi: 10.1093/ilar/ilx028. Review.

18.

NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.

Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM.

Nat Immunol. 2017 Dec;18(12):1299-1309. doi: 10.1038/ni.3853. Epub 2017 Oct 2.

19.

Type A viral hepatitis: A summary and update on the molecular virology, epidemiology, pathogenesis and prevention.

Lemon SM, Ott JJ, Van Damme P, Shouval D.

J Hepatol. 2017 Sep 5. pii: S0168-8278(17)32278-X. doi: 10.1016/j.jhep.2017.08.034. [Epub ahead of print] Review.

PMID:
28887164
20.

TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions.

Das A, Hirai-Yuki A, González-López O, Rhein B, Moller-Tank S, Brouillette R, Hensley L, Misumi I, Lovell W, Cullen JM, Whitmire JK, Maury W, Lemon SM.

MBio. 2017 Sep 5;8(5). pii: e00969-17. doi: 10.1128/mBio.00969-17.

21.

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.

Benzine T, Brandt R, Lovell WC, Yamane D, Neddermann P, De Francesco R, Lemon SM, Perelson AS, Ke R, McGivern DR.

PLoS Pathog. 2017 Jun 8;13(6):e1006343. doi: 10.1371/journal.ppat.1006343. eCollection 2017 Jun.

22.

Protein composition of the hepatitis A virus quasi-envelope.

McKnight KL, Xie L, González-López O, Rivera-Serrano EE, Chen X, Lemon SM.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6587-6592. doi: 10.1073/pnas.1619519114. Epub 2017 May 10.

23.

Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R.

Mitchell JK, Midkiff BR, Israelow B, Evans MJ, Lanford RE, Walker CM, Lemon SM, McGivern DR.

MBio. 2017 Apr 25;8(2). pii: e00121-17. doi: 10.1128/mBio.00121-17.

24.

Virology: Ins and outs of picornaviruses.

McKnight KL, Lemon SM.

Nature. 2017 Jan 19;541(7637):299-300. doi: 10.1038/nature21116. Epub 2017 Jan 11. No abstract available.

PMID:
28102264
25.

Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3΄ variants.

Yamane D, Selitsky SR, Shimakami T, Li Y, Zhou M, Honda M, Sethupathy P, Lemon SM.

Nucleic Acids Res. 2017 May 5;45(8):4743-4755. doi: 10.1093/nar/gkw1332.

26.

Chronic hepatitis C infection-induced liver fibrogenesis is associated with M2 macrophage activation.

Bility MT, Nio K, Li F, McGivern DR, Lemon SM, Feeney ER, Chung RT, Su L.

Sci Rep. 2016 Dec 21;6:39520. doi: 10.1038/srep39520.

27.

Biliary Secretion of Quasi-Enveloped Human Hepatitis A Virus.

Hirai-Yuki A, Hensley L, Whitmire JK, Lemon SM.

MBio. 2016 Dec 6;7(6). pii: e01998-16. doi: 10.1128/mBio.01998-16.

28.

MAVS-dependent host species range and pathogenicity of human hepatitis A virus.

Hirai-Yuki A, Hensley L, McGivern DR, González-López O, Das A, Feng H, Sun L, Wilson JE, Hu F, Feng Z, Lovell W, Misumi I, Ting JP, Montgomery S, Cullen J, Whitmire JK, Lemon SM.

Science. 2016 Sep 30;353(6307):1541-1545. Epub 2016 Sep 15.

29.

Primer ID ultra-deep sequencing reveals dynamics of drug resistance-associated variants in breakthrough hepatitis C viruses: relevance to treatment outcome and resistance screening.

Barnard R, Chopra A, James I, Blinco J, Watson MW, Jabara CB, Hazuda D, Lemon SM, Mallal S, Gaudieri S.

Antivir Ther. 2016;21(7):567-577. doi: 10.3851/IMP3056. Epub 2016 May 24.

PMID:
27219495
30.

Getting the Skinny on CD4(+) T Cell Survival in Fatty Livers.

Walker CM, Lemon SM.

Immunity. 2016 Apr 19;44(4):725-7. doi: 10.1016/j.immuni.2016.04.001.

31.

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.

Guo H, König R, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefoot B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM, Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK, Ting JP.

Cell Host Microbe. 2016 Apr 13;19(4):515-528. doi: 10.1016/j.chom.2016.03.001.

32.

Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs.

Selitsky SR, Dinh TA, Toth CL, Kurtz CL, Honda M, Struck BR, Kaneko S, Vickers KC, Lemon SM, Sethupathy P.

MBio. 2015 Dec 8;6(6):e01500-15. doi: 10.1128/mBio.01500-15.

33.

Evolutionary origins of hepatitis A virus in small mammals.

Drexler JF, Corman VM, Lukashev AN, van den Brand JM, Gmyl AP, Brünink S, Rasche A, Seggewiβ N, Feng H, Leijten LM, Vallo P, Kuiken T, Dotzauer A, Ulrich RG, Lemon SM, Drosten C; Hepatovirus Ecology Consortium.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15190-5. doi: 10.1073/pnas.1516992112. Epub 2015 Nov 2.

34.

How do persistent infections with hepatitis C virus cause liver cancer?

Mitchell JK, Lemon SM, McGivern DR.

Curr Opin Virol. 2015 Oct;14:101-8. doi: 10.1016/j.coviro.2015.09.003. Epub 2015 Sep 29. Review.

35.

Genotypic distribution and hepatic fibrosis among HIV/HCV co-infected individuals in Southern China: a retrospective cross-sectional study.

Zhou K, Hu F, Wang C, Xu M, Lan Y, Morano JP, Lemon SM, Tucker JD, Cai W.

BMC Infect Dis. 2015 Sep 30;15:401. doi: 10.1186/s12879-015-1135-1.

36.

Ribavirin Contributes to Hepatitis C Virus Suppression by Augmenting pDC Activation and Type 1 IFN Production.

Wang Y, McGivern DR, Cheng L, Li G, Lemon SM, Niu J, Su L, Reszka-Blanco NJ.

PLoS One. 2015 Aug 14;10(8):e0135232. doi: 10.1371/journal.pone.0135232. eCollection 2015.

37.

The yin and yang of hepatitis C: synthesis and decay of hepatitis C virus RNA.

Li Y, Yamane D, Masaki T, Lemon SM.

Nat Rev Microbiol. 2015 Sep;13(9):544-58. doi: 10.1038/nrmicro3506. Epub 2015 Aug 10. Review.

38.

Functionally conserved architecture of hepatitis C virus RNA genomes.

Mauger DM, Golden M, Yamane D, Williford S, Lemon SM, Martin DP, Weeks KM.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3692-7. doi: 10.1073/pnas.1416266112. Epub 2015 Mar 9.

39.

Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication.

Li Y, Yamane D, Lemon SM.

J Virol. 2015 May;89(9):4857-65. doi: 10.1128/JVI.03692-14. Epub 2015 Feb 11.

40.

miR-122 stimulates hepatitis C virus RNA synthesis by altering the balance of viral RNAs engaged in replication versus translation.

Masaki T, Arend KC, Li Y, Yamane D, McGivern DR, Kato T, Wakita T, Moorman NJ, Lemon SM.

Cell Host Microbe. 2015 Feb 11;17(2):217-28. doi: 10.1016/j.chom.2014.12.014. Epub 2015 Feb 5.

41.

Reassessing immune control of hepatitis A virus.

Walker CM, Feng Z, Lemon SM.

Curr Opin Virol. 2015 Apr;11:7-13. doi: 10.1016/j.coviro.2015.01.003. Epub 2015 Jan 21. Review.

42.

Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C.

Selitsky SR, Baran-Gale J, Honda M, Yamane D, Masaki T, Fannin EE, Guerra B, Shirasaki T, Shimakami T, Kaneko S, Lanford RE, Lemon SM, Sethupathy P.

Sci Rep. 2015 Jan 8;5:7675. doi: 10.1038/srep07675.

43.

Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication.

Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M Jr, Shah VH, Rosen HR.

Gastroenterology. 2015 Feb;148(2):392-402.e13. doi: 10.1053/j.gastro.2014.10.040. Epub 2014 Nov 4.

44.

Human pDCs preferentially sense enveloped hepatitis A virions.

Feng Z, Li Y, McKnight KL, Hensley L, Lanford RE, Walker CM, Lemon SM.

J Clin Invest. 2015 Jan;125(1):169-76. doi: 10.1172/JCI77527. Epub 2014 Nov 21.

45.

Naked Viruses That Aren't Always Naked: Quasi-Enveloped Agents of Acute Hepatitis.

Feng Z, Hirai-Yuki A, McKnight KL, Lemon SM.

Annu Rev Virol. 2014 Nov;1(1):539-60. doi: 10.1146/annurev-virology-031413-085359. Epub 2014 Jul 3.

PMID:
26958733
46.

Hepatitis C Virus (HCV) NS3 sequence diversity and antiviral resistance-associated variant frequency in HCV/HIV coinfection.

Jabara CB, Hu F, Mollan KR, Williford SE, Menezes P, Yang Y, Eron JJ, Fried MW, Hudgens MG, Jones CD, Swanstrom R, Lemon SM.

Antimicrob Agents Chemother. 2014 Oct;58(10):6079-92. doi: 10.1128/AAC.03466-14. Epub 2014 Aug 4.

47.

Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.

Yamane D, McGivern DR, Wauthier E, Yi M, Madden VJ, Welsch C, Antes I, Wen Y, Chugh PE, McGee CE, Widman DG, Misumi I, Bandyopadhyay S, Kim S, Shimakami T, Oikawa T, Whitmire JK, Heise MT, Dittmer DP, Kao CC, Pitson SM, Merrill AH Jr, Reid LM, Lemon SM.

Nat Med. 2014 Aug;20(8):927-35. doi: 10.1038/nm.3610. Epub 2014 Jul 27.

48.

Impaired interferon signaling in chronic hepatitis C patients with advanced fibrosis via the transforming growth factor beta signaling pathway.

Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Okada H, Takabatake R, Tokumaru A, Sakai Y, Yamashita T, Lemon SM, Murakami S, Kaneko S.

Hepatology. 2014 Nov;60(5):1519-30. doi: 10.1002/hep.27277. Epub 2014 Oct 2.

PMID:
24962339
49.

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.

McGivern DR, Masaki T, Williford S, Ingravallo P, Feng Z, Lahser F, Asante-Appiah E, Neddermann P, De Francesco R, Howe AY, Lemon SM.

Gastroenterology. 2014 Aug;147(2):453-62.e7. doi: 10.1053/j.gastro.2014.04.021. Epub 2014 Apr 22.

50.

Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-α in infectious virus production.

Masaki T, Matsunaga S, Takahashi H, Nakashima K, Kimura Y, Ito M, Matsuda M, Murayama A, Kato T, Hirano H, Endo Y, Lemon SM, Wakita T, Sawasaki T, Suzuki T.

J Virol. 2014 Jul;88(13):7541-55. doi: 10.1128/JVI.03170-13. Epub 2014 Apr 23.

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