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Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland Tanzania.

Kakolwa MA, Mahende MK, Ishengoma DS, Mandara CI, Ngasala B, Kamugisha E, Kataraihya JB, Mandike R, Mkude S, Chacky F, Njau R, Premji Z, Lemnge MM, Warsame M, Menard D, Kabanywanyi AM.

Malar J. 2018 Oct 17;17(1):369. doi: 10.1186/s12936-018-2524-x.


High efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Muheza and Kigoma Districts, Tanzania.

Mandara CI, Kavishe RA, Gesase S, Mghamba J, Ngadaya E, Mmbuji P, Mkude S, Mandike R, Njau R, Mohamed A, Lemnge MM, Warsame M, Ishengoma DS.

Malar J. 2018 Jul 11;17(1):261. doi: 10.1186/s12936-018-2409-z.


Trends of Plasmodium falciparum prevalence in two communities of Muheza district North-eastern Tanzania: correlation between parasite prevalence, malaria interventions and rainfall in the context of re-emergence of malaria after two decades of progressively declining transmission.

Ishengoma DS, Mmbando BP, Mandara CI, Chiduo MG, Francis F, Timiza W, Msemo H, Kijazi A, Lemnge MM, Malecela MN, Snow RW, Alifrangis M, Bygbjerg IC.

Malar J. 2018 Jul 6;17(1):252. doi: 10.1186/s12936-018-2395-1.


Pattern of all-causes and cause-specific mortality in an area with progressively declining malaria burden in Korogwe district, north-eastern Tanzania.

Challe DP, Kamugisha ML, Mmbando BP, Francis F, Chiduo MG, Mandara CI, Gesase S, Abdul O, Lemnge MM, Ishengoma DS.

Malar J. 2018 Feb 27;17(1):97. doi: 10.1186/s12936-018-2240-6.


Deployment and use of mobile phone technology for real-time reporting of fever cases and malaria treatment failure in areas of declining malaria transmission in Muheza district north-eastern Tanzania.

Francis F, Ishengoma DS, Mmbando BP, Rutta ASM, Malecela MN, Mayala B, Lemnge MM, Michael E.

Malar J. 2017 Aug 1;16(1):308. doi: 10.1186/s12936-017-1956-z.


Performance of health laboratories in provision of HIV diagnostic and supportive services in selected districts of Tanzania.

Ishengoma DS, Kamugisha ML, Rutta AS, Kagaruki GB, Kilale AM, Kahwa A, Kamugisha E, Baraka V, Mandara CI, Materu GS, Massaga JJ, Magesa SM, Lemnge MM, Mboera LE.

BMC Health Serv Res. 2017 Jan 23;17(1):70. doi: 10.1186/s12913-017-2030-9.


Therapeutic efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in North-Eastern Tanzania.

Shayo A, Mandara CI, Shahada F, Buza J, Lemnge MM, Ishengoma DS.

Malar J. 2014 Sep 20;13:376. doi: 10.1186/1475-2875-13-376.


Independent origin of plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia.

Alifrangis M, Nag S, Schousboe ML, Ishengoma D, Lusingu J, Pota H, Kavishe RA, Pearce R, Ord R, Lynch C, Dejene S, Cox J, Rwakimari J, Minja DT, Lemnge MM, Roper C.

Emerg Infect Dis. 2014 Aug;20(8):1280-6. doi: 10.3201/eid2008.131897.


Declining burden of malaria over two decades in a rural community of Muheza district, north-eastern Tanzania.

Ishengoma DS, Mmbando BP, Segeja MD, Alifrangis M, Lemnge MM, Bygbjerg IC.

Malar J. 2013 Sep 22;12:338. doi: 10.1186/1475-2875-12-338.


'… in the project they really care for us': meaning and experiences of participating in a clinical study of first-line treatment for malaria and HIV in Tanzanian adults.

Reynolds J, Mangesho P, Lemnge MM, Vestergaard LS, Chandler CI.

Glob Public Health. 2013 Jul;8(6):670-84. doi: 10.1080/17441692.2013.810297. Epub 2013 Jul 4.


Population pharmacokinetics of intramuscular artesunate in African children with severe malaria: implications for a practical dosing regimen.

Hendriksen IC, Mtove G, Kent A, Gesase S, Reyburn H, Lemnge MM, Lindegardh N, Day NP, von Seidlein L, White NJ, Dondorp AM, Tarning J.

Clin Pharmacol Ther. 2013 May;93(5):443-50. doi: 10.1038/clpt.2013.26. Epub 2013 Feb 8.


Population pharmacokinetic and pharmacodynamic properties of intramuscular quinine in Tanzanian children with severe Falciparum malaria.

Hendriksen IC, Maiga D, Lemnge MM, Mtove G, Gesase S, Reyburn H, Lindegardh N, Day NP, von Seidlein L, Dondorp AM, Tarning J, White NJ.

Antimicrob Agents Chemother. 2013 Feb;57(2):775-83. doi: 10.1128/AAC.01349-12. Epub 2012 Nov 26.


Using community-owned resource persons to provide early diagnosis and treatment and estimate malaria burden at community level in north-eastern Tanzania.

Rutta AS, Francis F, Mmbando BP, Ishengoma DS, Sembuche SH, Malecela EK, Sadi JY, Kamugisha ML, Lemnge MM.

Malar J. 2012 May 3;11:152. doi: 10.1186/1475-2875-11-152.


Prevalence of single nucleotide polymorphisms in the Plasmodium falciparum multidrug resistance gene (Pfmdr-1) in Korogwe District in Tanzania before and after introduction of artemisinin-based combination therapy.

Thomsen TT, Ishengoma DS, Mmbando BP, Lusingu JP, Vestergaard LS, Theander TG, Lemnge MM, Bygbjerg IC, Alifrangis M.

Am J Trop Med Hyg. 2011 Dec;85(6):979-83. doi: 10.4269/ajtmh.2011.11-0071.


Prospective study on severe malaria among in-patients at Bombo regional hospital, Tanga, north-eastern Tanzania.

Msangeni HA, Kamugisha ML, Sembuche SH, Malecela EK, Akida JA, Temba FF, Mmbando BP, Lemnge MM.

BMC Infect Dis. 2011 Sep 29;11:256. doi: 10.1186/1471-2334-11-256.


Establishing and implementing Demographic Surveillance System as a tool for monitoring health interventions in Korogwe District, northastern Tanzania.

Kamugisha ML, Mmbando BP, Francis F, Ishengoma DS, Challe DP, Lemnge MM.

Tanzan J Health Res. 2011 Oct;13(4):57-67.


Saleability of anti-malarials in private drug shops in Muheza, Tanzania: a baseline study in an era of assumed artemisinin combination therapy (ACT).

Ringsted FM, Massawe IS, Lemnge MM, Bygbjerg IC.

Malar J. 2011 Aug 15;10:238. doi: 10.1186/1475-2875-10-238.


Addressing the fear and consequences of stigmatization - a necessary step towards making HAART accessible to women in Tanzania: a qualitative study.

Theilgaard ZP, Katzenstein TL, Chiduo MG, Pahl C, Bygbjerg IC, Gerstoft J, Lemnge MM, Tersbøl BP.

AIDS Res Ther. 2011 Aug 2;8:28. doi: 10.1186/1742-6405-8-28.


Accuracy of malaria rapid diagnostic tests in community studies and their impact on treatment of malaria in an area with declining malaria burden in north-eastern Tanzania.

Ishengoma DS, Francis F, Mmbando BP, Lusingu JP, Magistrado P, Alifrangis M, Theander TG, Bygbjerg IC, Lemnge MM.

Malar J. 2011 Jun 26;10:176. doi: 10.1186/1475-2875-10-176.


Effect of the pre-erythrocytic candidate malaria vaccine RTS,S/AS01E on blood stage immunity in young children.

Bejon P, Cook J, Bergmann-Leitner E, Olotu A, Lusingu J, Mwacharo J, Vekemans J, Njuguna P, Leach A, Lievens M, Dutta S, von Seidlein L, Savarese B, Villafana T, Lemnge MM, Cohen J, Marsh K, Corran PH, Angov E, Riley EM, Drakeley CJ.

J Infect Dis. 2011 Jul 1;204(1):9-18. doi: 10.1093/infdis/jir222.


Spatial variation and socio-economic determinants of Plasmodium falciparum infection in northeastern Tanzania.

Mmbando BP, Kamugisha ML, Lusingu JP, Francis F, Ishengoma DS, Theander TG, Lemnge MM, Scheike TH.

Malar J. 2011 May 25;10:145. doi: 10.1186/1475-2875-10-145.


Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial.

Olotu A, Lusingu J, Leach A, Lievens M, Vekemans J, Msham S, Lang T, Gould J, Dubois MC, Jongert E, Vansadia P, Carter T, Njuguna P, Awuondo KO, Malabeja A, Abdul O, Gesase S, Mturi N, Drakeley CJ, Savarese B, Villafana T, Lapierre D, Ballou WR, Cohen J, Lemnge MM, Peshu N, Marsh K, Riley EM, von Seidlein L, Bejon P.

Lancet Infect Dis. 2011 Feb;11(2):102-9. doi: 10.1016/S1473-3099(10)70262-0. Epub 2011 Jan 13. Erratum in: Lancet Infect Dis. 2011 Mar;11(3):159.


Using rapid diagnostic tests as source of malaria parasite DNA for molecular analyses in the era of declining malaria prevalence.

Ishengoma DS, Lwitiho S, Madebe RA, Nyagonde N, Persson O, Vestergaard LS, Bygbjerg IC, Lemnge MM, Alifrangis M.

Malar J. 2011 Jan 12;10:6. doi: 10.1186/1475-2875-10-6.


Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children.

Lusingu J, Olotu A, Leach A, Lievens M, Vekemans J, Olivier A, Benns S, Olomi R, Msham S, Lang T, Gould J, Hallez K, Guerra Y, Njuguna P, Awuondo KO, Malabeja A, Abdul O, Gesase S, Dekker D, Malle L, Ismael S, Mturi N, Drakeley CJ, Savarese B, Villafana T, Ballou WR, Cohen J, Riley EM, Lemnge MM, Marsh K, Bejon P, von Seidlein L.

PLoS One. 2010 Nov 29;5(11):e14090. doi: 10.1371/journal.pone.0014090. Erratum in: PLoS One. 2010; 5(12) doi: 10.1371/annotation/3b62fdef-4cdd-40cc-b69d-69afd2000c4f. PLoS One. 2010;5(12) doi: 10.1371/annotation/0543a689-83a6-4528-92a1-a0f978b47fcb.


Measurement of lumefantrine and its metabolite in plasma by high performance liquid chromatography with ultraviolet detection.

Khalil IF, Abildrup U, Alifrangis LH, Maiga D, Alifrangis M, Hoegberg L, Vestergaard LS, Persson OP, Nyagonde N, Lemnge MM, Theander TG, Bygbjerg IC.

J Pharm Biomed Anal. 2011 Jan 5;54(1):168-72. doi: 10.1016/j.jpba.2010.08.009. Epub 2010 Aug 17.


A progressive declining in the burden of malaria in north-eastern Tanzania.

Mmbando BP, Vestergaard LS, Kitua AY, Lemnge MM, Theander TG, Lusingu JP.

Malar J. 2010 Jul 23;9:216. doi: 10.1186/1475-2875-9-216.


Acquisition of antibodies to merozoite surface protein 3 among residents of Korogwe, north eastern Tanzania.

Segeja MD, Mmbando BP, Seth MD, Lusingu JP, Lemnge MM.

BMC Infect Dis. 2010 Mar 8;10:55. doi: 10.1186/1471-2334-10-55.


Parasite threshold associated with clinical malaria in areas of different transmission intensities in north eastern Tanzania.

Mmbando BP, Lusingu JP, Vestergaard LS, Lemnge MM, Theander TG, Scheike TH.

BMC Med Res Methodol. 2009 Nov 12;9:75. doi: 10.1186/1471-2288-9-75.


Plasma cytokine levels in Tanzanian HIV-1-infected adults and the effect of antiretroviral treatment.

Haissman JM, Vestergaard LS, Sembuche S, Erikstrup C, Mmbando B, Mtullu S, Lemnge MM, Gerstoft J, Ullum H.

J Acquir Immune Defic Syndr. 2009 Dec 1;52(4):493-7. doi: 10.1097/QAI.0b013e3181b627dc.


Epidemiology of malaria in an area prepared for clinical trials in Korogwe, north-eastern Tanzania.

Mmbando BP, Segeja MD, Msangeni HA, Sembuche SH, Ishengoma DS, Seth MD, Francis F, Rutta AS, Kamugisha ML, Lemnge MM.

Malar J. 2009 Jul 18;8:165. doi: 10.1186/1475-2875-8-165.


Five-year surveillance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe District, Tanzania: accumulation of the 581G mutation in the P. falciparum dihydropteroate synthase gene.

Alifrangis M, Lusingu JP, Mmbando B, Dalgaard MB, Vestergaard LS, Ishengoma D, Khalil IF, Theander TG, Lemnge MM, Bygbjerg IC.

Am J Trop Med Hyg. 2009 Apr;80(4):523-7.


Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age.

Bejon P, Lusingu J, Olotu A, Leach A, Lievens M, Vekemans J, Mshamu S, Lang T, Gould J, Dubois MC, Demoitié MA, Stallaert JF, Vansadia P, Carter T, Njuguna P, Awuondo KO, Malabeja A, Abdul O, Gesase S, Mturi N, Drakeley CJ, Savarese B, Villafana T, Ballou WR, Cohen J, Riley EM, Lemnge MM, Marsh K, von Seidlein L.

N Engl J Med. 2008 Dec 11;359(24):2521-32. doi: 10.1056/NEJMoa0807381. Epub 2008 Dec 8.


Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania.

Massaga JJ, Lusingu JP, Makunde R, Malebo HM, Chile MM, Akida JA, Lemnge MM, Rønn AM, Theander TG, Bygbjerg IC, Kitua AY.

Tanzan J Health Res. 2008 Jul;10(3):144-50.


Risk factors for low birth-weight in areas with varying malaria transmission in Korogwe, Tanzania: implications for malaria control.

Mmbando BP, Cole-Lewis H, Sembuche S, Kamugisha ML, Theander T, Lusingu JP, Lemnge MM.

Tanzan J Health Res. 2008 Jul;10(3):137-43.


Paracheck Pf compared with microscopy for diagnosis of Plasmodium falciparum malaria among children in Tanga City, north-eastern Tanzania.

Kamugisha ML, Msangeni H, Beale E, Malecela EK, Akida J, Ishengoma DR, Lemnge MM.

Tanzan J Health Res. 2008 Jan;10(1):14-9.


Prevalence of glucose-6-phosphate dehydrogenase deficiency and haemoglobin S in high and moderate malaria transmission areas of Muheza, north-eastern Tanzania.

Segeja MD, Mmbando BP, Kamugisha ML, Akida JA, Savaeli ZX, Minja DT, Msangeni HA, Lemnge MM.

Tanzan J Health Res. 2008 Jan;10(1):9-13.


Reduced risk of uncomplicated malaria episodes in children with alpha+-thalassemia in northeastern Tanzania.

Enevold A, Lusingu JP, Mmbando B, Alifrangis M, Lemnge MM, Bygbjerg IC, Theander TG, Vestergaard LS.

Am J Trop Med Hyg. 2008 May;78(5):714-20.


A simple technique for the detection of anti-malarial drug formulations and their presence in human urine.

Lugimbana L, Malebo HM, Segeja MD, Akida JA, Malle LN, Lemnge MM.

Tanzan Health Res Bull. 2006 Sep;8(3):149-54.


Differences in human antibody reactivity to Plasmodium falciparum variant surface antigens are dependent on age and malaria transmission intensity in northeastern Tanzania.

Vestergaard LS, Lusingu JP, Nielsen MA, Mmbando BP, Dodoo D, Akanmori BD, Alifrangis M, Bygbjerg IC, Lemnge MM, Staalsoe T, Hviid L, Theander TG.

Infect Immun. 2008 Jun;76(6):2706-14. doi: 10.1128/IAI.01401-06. Epub 2008 Feb 4.


Associations between alpha+-thalassemia and Plasmodium falciparum malarial infection in northeastern Tanzania.

Enevold A, Alifrangis M, Sanchez JJ, Carneiro I, Roper C, Børsting C, Lusingu J, Vestergaard LS, Lemnge MM, Morling N, Riley E, Drakeley CJ.

J Infect Dis. 2007 Aug 1;196(3):451-9. Epub 2007 Jun 20.


Malaria specific mortality in lowlands and highlands of Muheza district, north-eastern Tanzania.

Kamugisha ML, Gesase S, Mlwilo TD, Mmbando BP, Segeja MD, Minja DT, Massaga JJ, Msangeni HA, Ishengoma DR, Lemnge MM.

Tanzan Health Res Bull. 2007 Jan;9(1):32-7.


Pattern and spatial distribution of plague in Lushoto, north-eastern Tanzania.

Kamugisha ML, Gesase S, Minja D, Mgema S, Mlwilo TD, Mayala BK, Msingwa S, Massaga JJ, Lemnge MM.

Tanzan Health Res Bull. 2007 Jan;9(1):12-8.


Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania.

Alifrangis M, Dalgaard MB, Lusingu JP, Vestergaard LS, Staalsoe T, Jensen AT, Enevold A, Rønn AM, Khalil IF, Warhurst DC, Lemnge MM, Theander TG, Bygbjerg IC.

J Infect Dis. 2006 Jun 15;193(12):1738-41. Epub 2006 May 4.


Levels of plasma immunoglobulin G with specificity against the cysteine-rich interdomain regions of a semiconserved Plasmodium falciparum erythrocyte membrane protein 1, VAR4, predict protection against malarial anemia and febrile episodes.

Lusingu JP, Jensen AT, Vestergaard LS, Minja DT, Dalgaard MB, Gesase S, Mmbando BP, Kitua AY, Lemnge MM, Cavanagh D, Hviid L, Theander TG.

Infect Immun. 2006 May;74(5):2867-75.


Target antigen, age, and duration of antigen exposure independently regulate immunoglobulin G subclass switching in malaria.

Tongren JE, Drakeley CJ, McDonald SL, Reyburn HG, Manjurano A, Nkya WM, Lemnge MM, Gowda CD, Todd JE, Corran PH, Riley EM.

Infect Immun. 2006 Jan;74(1):257-64.


Rapid screening for glucose-6-phosphate dehydrogenase deficiency and haemoglobin polymorphisms in Africa by a simple high-throughput SSOP-ELISA method.

Enevold A, Vestergaard LS, Lusingu J, Drakeley CJ, Lemnge MM, Theander TG, Bygbjerg IC, Alifrangis M.

Malar J. 2005 Dec 15;4:61.


Therapeutic efficacy of sulfadoxine-pyrimethamine and amodiaquine among children with uncomplicated Plasmodium falciparum malaria in Zanzibar, Tanzania.

Lemnge MM, Ali AS, Malecela EK, Sambu E, Abdulla R, Juma MS, Fakih K, Abdulla KH, Njau RJ.

Am J Trop Med Hyg. 2005 Oct;73(4):681-5.


Cytophilic antibodies to Plasmodium falciparum glutamate rich protein are associated with malaria protection in an area of holoendemic transmission.

Lusingu JP, Vestergaard LS, Alifrangis M, Mmbando BP, Theisen M, Kitua AY, Lemnge MM, Theander TG.

Malar J. 2005 Sep 29;4:48.


Altitude-dependent and -independent variations in Plasmodium falciparum prevalence in northeastern Tanzania.

Drakeley CJ, Carneiro I, Reyburn H, Malima R, Lusingu JP, Cox J, Theander TG, Nkya WM, Lemnge MM, Riley EM.

J Infect Dis. 2005 May 15;191(10):1589-98. Epub 2005 Apr 7.


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