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Items: 1 to 50 of 161

1.

Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency.

Al-Ali H, Debevec G, Santos RG, Houghten RA, Davis JC, Nefzi A, Lemmon VP, Bixby JL, Giulianotti MA.

ACS Med Chem Lett. 2018 Sep 24;9(10):1057-1062. doi: 10.1021/acsmedchemlett.8b00425. eCollection 2018 Oct 11.

PMID:
30344917
2.

The effect of Jun dimerization on neurite outgrowth and motif binding.

Danzi MC, Mehta ST, Dulla K, Zunino G, Cooper DJ, Bixby JL, Lemmon VP.

Mol Cell Neurosci. 2018 Oct;92:114-127. doi: 10.1016/j.mcn.2018.08.001. Epub 2018 Aug 3.

PMID:
30077771
3.

Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes.

Hackett AR, Yahn SL, Lyapichev K, Dajnoki A, Lee DH, Rodriguez M, Cammer N, Pak J, Mehta ST, Bodamer O, Lemmon VP, Lee JK.

Exp Neurol. 2018 Oct;308:72-79. doi: 10.1016/j.expneurol.2018.07.001. Epub 2018 Jul 3.

PMID:
30008424
4.

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP.

Clin Transl Sci. 2018 Sep;11(5):461-470. doi: 10.1111/cts.12570. Epub 2018 Jul 24.

5.

Can Chromatin Accessibility be Exploited for Axon Regeneration?

Danzi MC, O'Neill N, Bixby JL, Lemmon VP.

Dev Neurobiol. 2018 Oct;78(10):991-997. doi: 10.1002/dneu.22598. Epub 2018 Aug 27. Review.

PMID:
29664188
6.

Publisher Correction: Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons.

Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, Hutson T, Danzi MC, Perry RB, Santos CXC, Kapustin AN, Fleck RA, Del Río JA, Carroll T, Lemmon V, Bixby JL, Shah AM, Fainzilber M, Di Giovanni S.

Nat Cell Biol. 2018 Sep;20(9):1098. doi: 10.1038/s41556-018-0063-x.

PMID:
29520084
7.

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons.

Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, Hutson T, Danzi MC, Perry RB, Santos CXC, Kapustin AN, Fleck RA, Del Río JA, Carroll T, Lemmon V, Bixby JL, Shah AM, Fainzilber M, Di Giovanni S.

Nat Cell Biol. 2018 Mar;20(3):307-319. doi: 10.1038/s41556-018-0039-x. Epub 2018 Feb 12. Erratum in: Nat Cell Biol. 2018 Mar 8;:.

PMID:
29434374
8.

Region specific knock-out reveals distinct roles of chromatin modifiers in adult neurogenic niches.

Rhodes CT, Zunino G, Huang SA, Cardona SM, Cardona AE, Berger MS, Lemmon VP, Lin CA.

Cell Cycle. 2018;17(3):377-389. doi: 10.1080/15384101.2018.1426417. Epub 2018 Feb 19.

9.

High Content Screening of Mammalian Primary Cortical Neurons.

Motti D, Blackmore M, Bixby JL, Lemmon VP.

Methods Mol Biol. 2018;1683:293-304. doi: 10.1007/978-1-4939-7357-6_17.

PMID:
29082499
10.

Identification of genome-wide targets of Olig2 in the adult mouse spinal cord using ChIP-Seq.

Darr AJ, Danzi MC, Brady L, Emig-Agius D, Hackett A, Golshani R, Warner N, Lee J, Lemmon VP, Tsoulfas P.

PLoS One. 2017 Oct 19;12(10):e0186091. doi: 10.1371/journal.pone.0186091. eCollection 2017.

11.

3D Visualization of Individual Regenerating Retinal Ganglion Cell Axons Reveals Surprisingly Complex Growth Paths.

Bray ER, Noga M, Thakor K, Wang Y, Lemmon VP, Park KK, Tsoulfas P.

eNeuro. 2017 Aug 29;4(4). pii: ENEURO.0093-17.2017. doi: 10.1523/ENEURO.0093-17.2017. eCollection 2017 Jul-Aug.

12.

Stress Increases Peripheral Axon Growth and Regeneration through Glucocorticoid Receptor-Dependent Transcriptional Programs.

Lerch JK, Alexander JK, Madalena KM, Motti D, Quach T, Dhamija A, Zha A, Gensel JC, Webster Marketon J, Lemmon VP, Bixby JL, Popovich PG.

eNeuro. 2017 Aug 21;4(4). pii: ENEURO.0246-17.2017. doi: 10.1523/ENEURO.0246-17.2017. eCollection 2017 Jul-Aug.

13.

Optic nerve regeneration in mammals: Regenerated or spared axons?

Fischer D, Harvey AR, Pernet V, Lemmon VP, Park KK.

Exp Neurol. 2017 Oct;296:83-88. doi: 10.1016/j.expneurol.2017.07.008. Epub 2017 Jul 14. Review.

14.

Identification of miRNAs involved in DRG neurite outgrowth and their putative targets.

Motti D, Lerch JK, Danzi MC, Gans JH, Kuo F, Slepak TI, Bixby JL, Lemmon VP.

FEBS Lett. 2017 Jul;591(14):2091-2105. doi: 10.1002/1873-3468.12718. Epub 2017 Jul 2.

15.

The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.

Al-Ali H, Ding Y, Slepak T, Wu W, Sun Y, Martinez Y, Xu XM, Lemmon VP, Bixby JL.

J Neurosci. 2017 Jul 26;37(30):7079-7095. doi: 10.1523/JNEUROSCI.0931-17.2017. Epub 2017 Jun 16.

16.

Genetically modifying transcription factors to promote CNS axon regeneration.

Mehta ST, Bixby JL, Lemmon VP.

Neural Regen Res. 2017 May;12(5):737-738. doi: 10.4103/1673-5374.206637. No abstract available.

17.

Developing a data sharing community for spinal cord injury research.

Callahan A, Anderson KD, Beattie MS, Bixby JL, Ferguson AR, Fouad K, Jakeman LB, Nielson JL, Popovich PG, Schwab JM, Lemmon VP; FAIR Share Workshop Participants.

Exp Neurol. 2017 Sep;295:135-143. doi: 10.1016/j.expneurol.2017.05.012. Epub 2017 May 30. Review.

PMID:
28576567
18.

Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury.

Zhu Y, Lyapichev K, Lee DH, Motti D, Ferraro NM, Zhang Y, Yahn S, Soderblom C, Zha J, Bethea JR, Spiller KL, Lemmon VP, Lee JK.

J Neurosci. 2017 Mar 1;37(9):2362-2376. doi: 10.1523/JNEUROSCI.2751-16.2017. Epub 2017 Jan 27.

19.

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis.

Gao H, Danzi MC, Choi CS, Taherian M, Dalby-Hansen C, Ellman DG, Madsen PM, Bixby JL, Lemmon VP, Lambertsen KL, Brambilla R.

Cell Rep. 2017 Jan 3;18(1):198-212. doi: 10.1016/j.celrep.2016.11.083.

20.

Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury.

Al-Ali H, Lemmon VP, Bixby JL.

Methods Mol Biol. 2016;1462:677-88. doi: 10.1007/978-1-4939-3816-2_37.

PMID:
27604745
21.

Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration.

Cooper DJ, Zunino G, Bixby JL, Lemmon VP.

Mol Cell Neurosci. 2017 Apr;80:161-169. doi: 10.1016/j.mcn.2016.07.001. Epub 2016 Jul 18. Review.

22.

Messages from forgotten friends: classic cell adhesion molecules inhibit regeneration too.

Danzi MC, Lemmon VP.

EMBO J. 2016 Aug 15;35(16):1721-3. doi: 10.15252/embj.201694938. Epub 2016 Jul 12. No abstract available.

23.

Casein kinase signaling in axon regeneration.

Ayad NG, Lee JK, Lemmon VP.

Neural Regen Res. 2016 Feb;11(2):210-1. doi: 10.4103/1673-5374.177713. No abstract available.

24.

Hyperactivated Stat3 boosts axon regeneration in the CNS.

Mehta ST, Luo X, Park KK, Bixby JL, Lemmon VP.

Exp Neurol. 2016 Jun;280:115-20. doi: 10.1016/j.expneurol.2016.03.004. Epub 2016 Apr 6.

25.

RegenBase: a knowledge base of spinal cord injury biology for translational research.

Callahan A, Abeyruwan SW, Al-Ali H, Sakurai K, Ferguson AR, Popovich PG, Shah NH, Visser U, Bixby JL, Lemmon VP.

Database (Oxford). 2016 Apr 7;2016. pii: baw040. doi: 10.1093/database/baw040. Print 2016.

26.

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System.

Luo X, Ribeiro M, Bray ER, Lee DH, Yungher BJ, Mehta ST, Thakor KA, Diaz F, Lee JK, Moraes CT, Bixby JL, Lemmon VP, Park KK.

Cell Rep. 2016 Apr 12;15(2):398-410. doi: 10.1016/j.celrep.2016.03.029. Epub 2016 Mar 31.

27.

Treatment with analgesics after mouse sciatic nerve injury does not alter expression of wound healing-associated genes.

Danzi MC, Motti D, Avison DL, Bixby JL, Lemmon VP.

Neural Regen Res. 2016 Jan;11(1):144-9. doi: 10.4103/1673-5374.169637.

28.

Exploiting kinase polypharmacology for nerve regeneration.

Al-Ali H, Bixby JL, Lemmon VP.

Neural Regen Res. 2016 Jan;11(1):71-2. doi: 10.4103/1673-5374.169614. No abstract available.

29.

In vitro models of axon regeneration.

Al-Ali H, Beckerman SR, Bixby JL, Lemmon VP.

Exp Neurol. 2017 Jan;287(Pt 3):423-434. doi: 10.1016/j.expneurol.2016.01.020. Epub 2016 Jan 27. Review.

30.

Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells.

Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, Magistri M, Bixby JL, Lemmon VP, Silva JP, Wahlestedt C.

Front Genet. 2015 Aug 10;6:263. doi: 10.3389/fgene.2015.00263. eCollection 2015.

31.

Phenotypic assays to identify agents that induce reactive gliosis: a counter-screen to prioritize compounds for preclinical animal studies.

Beckerman SR, Jimenez JE, Shi Y, Al-Ali H, Bixby JL, Lemmon VP.

Assay Drug Dev Technol. 2015 Sep;13(7):377-88. doi: 10.1089/adt.2015.654. Epub 2015 Jul 31.

32.

Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth.

Al-Ali H, Lee DH, Danzi MC, Nassif H, Gautam P, Wennerberg K, Zuercher B, Drewry DH, Lee JK, Lemmon VP, Bixby JL.

ACS Chem Biol. 2015 Aug 21;10(8):1939-51. doi: 10.1021/acschembio.5b00289. Epub 2015 Jun 24.

33.

3D Imaging of Axons in Transparent Spinal Cords from Rodents and Nonhuman Primates

Soderblom C, Lee DH, Dawood A, Carballosa M, Jimena Santamaria A, Benavides FD, Jergova S, Grumbles RM, Thomas CK, Park KK, Guest JD, Lemmon VP, Lee JK, Tsoulfas P.

eNeuro. 2015 Mar-Apr;2(2). doi: 10.1523/ENEURO.0001-15.2015.

34.

High Content Screening with Primary Neurons.

Al-Ali H, Blackmore M, Bixby JL, Lemmon VP.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2013 Oct 15 [updated 2014 Oct 1].

35.

Assay Development Guidelines for Image-Based High Content Screening, High Content Analysis and High Content Imaging.

Buchser W, Collins M, Garyantes T, Guha R, Haney S, Lemmon V, Li Z, Trask OJ.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 Oct 1 [updated 2014 Sep 22].

36.

Facilitating transparency in spinal cord injury studies using data standards and ontologies.

Lemmon VP, Abeyruwan S, Visser U, Bixby JL.

Neural Regen Res. 2014 Jan 1;9(1):6-7. doi: 10.4103/1673-5374.125322. No abstract available.

37.

Evolving BioAssay Ontology (BAO): modularization, integration and applications.

Abeyruwan S, Vempati UD, Küçük-McGinty H, Visser U, Koleti A, Mir A, Sakurai K, Chung C, Bittker JA, Clemons PA, Brudz S, Siripala A, Morales AJ, Romacker M, Twomey D, Bureeva S, Lemmon V, Schürer SC.

J Biomed Semantics. 2014 Jun 3;5(Suppl 1 Proceedings of the Bio-Ontologies Spec Interest G):S5. doi: 10.1186/2041-1480-5-S1-S5. eCollection 2014.

38.

Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments.

Lemmon VP, Ferguson AR, Popovich PG, Xu XM, Snow DM, Igarashi M, Beattie CE, Bixby JL; MIASCI Consortium.

J Neurotrauma. 2014 Aug 1;31(15):1354-61. doi: 10.1089/neu.2014.3400. Epub 2014 Jul 11.

39.

cJun promotes CNS axon growth.

Lerch JK, Martínez-Ondaro YR, Bixby JL, Lemmon VP.

Mol Cell Neurosci. 2014 Mar;59:97-105. doi: 10.1016/j.mcn.2014.02.002. Epub 2014 Feb 9.

40.

Gene-based vaccination and screening methods to develop monoclonal antibodies.

Daftarian MP, Vosoughi A, Lemmon V.

Methods Mol Biol. 2014;1121:337-46. doi: 10.1007/978-1-4614-9632-8_30.

PMID:
24510837
41.

Astrocytes modulate the polarization of CD4+ T cells to Th1 cells.

Beurel E, Harrington LE, Buchser W, Lemmon V, Jope RS.

PLoS One. 2014 Jan 28;9(1):e86257. doi: 10.1371/journal.pone.0086257. eCollection 2014.

42.

L1cam is crucial for cell locomotion and terminal translocation of the Soma in radial migration during murine corticogenesis.

Tonosaki M, Itoh K, Umekage M, Kishimoto T, Yaoi T, Lemmon VP, Fushiki S.

PLoS One. 2014 Jan 28;9(1):e86186. doi: 10.1371/journal.pone.0086186. eCollection 2014.

43.

A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis.

Daftarian PM, Stone GW, Kovalski L, Kumar M, Vosoughi A, Urbieta M, Blackwelder P, Dikici E, Serafini P, Duffort S, Boodoo R, Rodríguez-Cortés A, Lemmon V, Deo S, Alberola J, Perez VL, Daunert S, Ager AL.

J Infect Dis. 2013 Dec 1;208(11):1914-22. doi: 10.1093/infdis/jit378. Epub 2013 Jul 29.

44.

Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration.

Kuboyama T, Luo X, Park K, Blackmore MG, Tojima T, Tohda C, Bixby JL, Lemmon VP, Kamiguchi H.

Exp Neurol. 2013 Oct;248:157-69. doi: 10.1016/j.expneurol.2013.06.011. Epub 2013 Jun 21.

45.

Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury.

Luo X, Salgueiro Y, Beckerman SR, Lemmon VP, Tsoulfas P, Park KK.

Exp Neurol. 2013 Sep;247:653-62. doi: 10.1016/j.expneurol.2013.03.001. Epub 2013 Mar 16.

46.

Chemical interrogation of the neuronal kinome using a primary cell-based screening assay.

Al-Ali H, Schürer SC, Lemmon VP, Bixby JL.

ACS Chem Biol. 2013 May 17;8(5):1027-36. doi: 10.1021/cb300584e. Epub 2013 Mar 19.

47.

Formalization, annotation and analysis of diverse drug and probe screening assay datasets using the BioAssay Ontology (BAO).

Vempati UD, Przydzial MJ, Chung C, Abeyruwan S, Mir A, Sakurai K, Visser U, Lemmon VP, Schürer SC.

PLoS One. 2012;7(11):e49198. doi: 10.1371/journal.pone.0049198. Epub 2012 Nov 14.

48.

Downregulation of L1 perturbs neuronal migration and alters the expression of transcription factors in murine neocortex.

Kishimoto T, Itoh K, Umekage M, Tonosaki M, Yaoi T, Fukui K, Lemmon VP, Fushiki S.

J Neurosci Res. 2013 Jan;91(1):42-50. doi: 10.1002/jnr.23141. Epub 2012 Oct 17.

49.

MicroRNAs and neuronal development.

Motti D, Bixby JL, Lemmon VP.

Semin Fetal Neonatal Med. 2012 Dec;17(6):347-52. doi: 10.1016/j.siny.2012.07.008. Epub 2012 Aug 18. Review.

50.

Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.

Jo S, Kalló I, Bardóczi Z, Arrojo e Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Gereben B, Bianco AC.

J Neurosci. 2012 Jun 20;32(25):8491-500. doi: 10.1523/JNEUROSCI.6514-11.2012.

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