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Items: 42

1.

The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection.

Stempel M, Chan B, Juranić Lisnić V, Krmpotić A, Hartung J, Paludan SR, Füllbrunn N, Lemmermann NA, Brinkmann MM.

EMBO J. 2019 Jan 29. pii: e100983. doi: 10.15252/embj.2018100983. [Epub ahead of print]

2.
3.

Efficient Delivery of Human Cytomegalovirus T Cell Antigens by Attenuated Sendai Virus Vectors.

Kiener R, Fleischmann M, Wiegand MA, Lemmermann NAW, Schwegler C, Kaufmann C, Renzaho A, Thomas S, Felder E, Niller HH, Asbach B, Wagner R.

J Virol. 2018 Jul 17;92(15). pii: e00569-18. doi: 10.1128/JVI.00569-18. Print 2018 Aug 1.

4.

Recent advances in CMV tropism, latency, and diagnosis during aging.

Leng SX, Kamil J, Purdy JG, Lemmermann NA, Reddehase MJ, Goodrum FD.

Geroscience. 2017 Jun;39(3):251-259. doi: 10.1007/s11357-017-9985-7. Epub 2017 Jul 5.

5.

Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cells.

Tršan T, Vuković K, Filipović P, Brizić AL, Lemmermann NAW, Schober K, Busch DH, Britt WJ, Messerle M, Krmpotić A, Jonjić S.

Eur J Immunol. 2017 Aug;47(8):1354-1367. doi: 10.1002/eji.201746964. Epub 2017 Jul 4.

6.

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.

Chan B, Gonçalves Magalhães V, Lemmermann NAW, Juranić Lisnić V, Stempel M, Bussey KA, Reimer E, Podlech J, Lienenklaus S, Reddehase MJ, Jonjić S, Brinkmann MM.

PLoS Pathog. 2017 May 25;13(5):e1006382. doi: 10.1371/journal.ppat.1006382. eCollection 2017 May.

7.

TLR3-independent activation of mast cells by cytomegalovirus contributes to control of pulmonary infection.

Lemmermann NAW, Reddehase MJ.

Cell Mol Immunol. 2017 Jun;14(6):479-481. doi: 10.1038/cmi.2017.23. Epub 2017 May 8. No abstract available.

8.

NKG2D stimulation of CD8+ T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice.

Kavazović I, Lenartić M, Jelenčić V, Jurković S, Lemmermann NAW, Jonjić S, Polić B, Wensveen FM.

Eur J Immunol. 2017 Jul;47(7):1123-1135. doi: 10.1002/eji.201646805. Epub 2017 May 2.

9.

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors.

Dekhtiarenko I, Ratts RB, Blatnik R, Lee LN, Fischer S, Borkner L, Oduro JD, Marandu TF, Hoppe S, Ruzsics Z, Sonnemann JK, Mansouri M, Meyer C, Lemmermann NA, Holtappels R, Arens R, Klenerman P, Früh K, Reddehase MJ, Riemer AB, Cicin-Sain L.

PLoS Pathog. 2016 Dec 15;12(12):e1006072. doi: 10.1371/journal.ppat.1006072. eCollection 2016 Dec.

10.

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages.

Thiel N, Keyser KA, Lemmermann NA, Oduro JD, Wagner K, Elsner C, Halenius A, Lenac Roviš T, Brinkmann MM, Jonjić S, Cicin-Sain L, Messerle M.

PLoS Pathog. 2016 Dec 7;12(12):e1006057. doi: 10.1371/journal.ppat.1006057. eCollection 2016 Dec.

11.

Refining human T-cell immunotherapy of cytomegalovirus disease: a mouse model with 'humanized' antigen presentation as a new preclinical study tool.

Lemmermann NA, Reddehase MJ.

Med Microbiol Immunol. 2016 Dec;205(6):549-561. Epub 2016 Aug 18. Review.

PMID:
27539576
12.

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance.

Holtappels R, Lemmermann NA, Podlech J, Ebert S, Reddehase MJ.

Front Immunol. 2016 Jun 14;7:232. doi: 10.3389/fimmu.2016.00232. eCollection 2016.

13.

Non-cognate bystander cytolysis by clonal epitope-specific CTL lines through CD28-CD80 interaction inhibits antibody production: A potential caveat to CD8 T-cell immunotherapy.

Holtappels R, Podlech J, Lemmermann NA, Schmitt E, Reddehase MJ.

Cell Immunol. 2016 Oct;308:44-56. doi: 10.1016/j.cellimm.2015.12.004. Epub 2015 Dec 17.

PMID:
26717854
14.

Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection.

Oduro JD, Redeker A, Lemmermann NA, Ebermann L, Marandu TF, Dekhtiarenko I, Holzki JK, Busch DH, Arens R, Čičin-Šain L.

J Gen Virol. 2016 Jan;97(1):185-95. doi: 10.1099/jgv.0.000339. Epub 2015 Nov 10.

PMID:
26555192
15.

Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice.

Thomas S, Klobuch S, Podlech J, Plachter B, Hoffmann P, Renzaho A, Theobald M, Reddehase MJ, Herr W, Lemmermann NA.

PLoS Pathog. 2015 Jul 16;11(7):e1005049. doi: 10.1371/journal.ppat.1005049. eCollection 2015 Jul.

16.

An endocytic YXXΦ (YRRF) cargo sorting motif in the cytoplasmic tail of murine cytomegalovirus AP2 'adapter adapter' protein m04/gp34 antagonizes virus evasion of natural killer cells.

Fink A, Blaum F, Babic Cac M, Ebert S, Lemmermann NA, Reddehase MJ.

Med Microbiol Immunol. 2015 Jun;204(3):383-94. doi: 10.1007/s00430-015-0414-1. Epub 2015 Apr 8.

PMID:
25850989
17.

Identification of an atypical CD8 T cell epitope encoded by murine cytomegalovirus ORF-M54 gaining dominance after deletion of the immunodominant antiviral CD8 T cell specificities.

Holtappels R, Lemmermann NA, Thomas D, Renzaho A, Reddehase MJ.

Med Microbiol Immunol. 2015 Jun;204(3):317-26. doi: 10.1007/s00430-015-0404-3. Epub 2015 Mar 25.

PMID:
25805564
18.

Principles for studying in vivo attenuation of virus mutants: defining the role of the cytomegalovirus gH/gL/gO complex as a paradigm.

Podlech J, Reddehase MJ, Adler B, Lemmermann NA.

Med Microbiol Immunol. 2015 Jun;204(3):295-305. doi: 10.1007/s00430-015-0405-2. Epub 2015 Mar 18. Review.

PMID:
25782576
19.

Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.

Lemmermann NA, Krmpotic A, Podlech J, Brizic I, Prager A, Adler H, Karbach A, Wu Y, Jonjic S, Reddehase MJ, Adler B.

PLoS Pathog. 2015 Feb 6;11(2):e1004640. doi: 10.1371/journal.ppat.1004640. eCollection 2015 Feb.

20.

Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection.

Podlech J, Ebert S, Becker M, Reddehase MJ, Stassen M, Lemmermann NA.

Med Microbiol Immunol. 2015 Jun;204(3):327-34. doi: 10.1007/s00430-015-0386-1. Epub 2015 Feb 4. Review.

PMID:
25648117
21.

Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms.

Becker M, Lemmermann NA, Ebert S, Baars P, Renzaho A, Podlech J, Stassen M, Reddehase MJ.

Cell Mol Immunol. 2015 Mar;12(2):192-201. doi: 10.1038/cmi.2014.73. Epub 2014 Aug 25.

22.

Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs.

Ebert S, Becker M, Lemmermann NA, Büttner JK, Michel A, Taube C, Podlech J, Böhm V, Freitag K, Thomas D, Holtappels R, Reddehase MJ, Stassen M.

PLoS Pathog. 2014 Apr 24;10(4):e1004100. doi: 10.1371/journal.ppat.1004100. eCollection 2014 Apr.

23.

Noncanonical expression of a murine cytomegalovirus early protein CD8 T-cell epitope as an immediate early epitope based on transcription from an upstream gene.

Fink A, Büttner JK, Thomas D, Holtappels R, Reddehase MJ, Lemmermann NA.

Viruses. 2014 Feb 14;6(2):808-31. doi: 10.3390/v6020808.

24.

Spatial distribution and structural arrangement of a murine cytomegalovirus glycoprotein detected by SPDM localization microscopy.

Müller P, Lemmermann NA, Kaufmann R, Gunkel M, Paech D, Hildenbrand G, Holtappels R, Cremer C, Hausmann M.

Histochem Cell Biol. 2014 Jul;142(1):61-7. doi: 10.1007/s00418-014-1185-2. Epub 2014 Feb 7.

PMID:
24504601
25.

The p36 isoform of murine cytomegalovirus m152 protein suffices for mediating innate and adaptive immune evasion.

Fink A, Renzaho A, Reddehase MJ, Lemmermann NA.

Viruses. 2013 Dec 16;5(12):3171-91. doi: 10.3390/v5123171.

26.

Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ.

Trsan T, Busche A, Abram M, Wensveen FM, Lemmermann NA, Arapovic M, Babic M, Tomic A, Golemac M, Brinkmann MM, Jäger W, Oxenius A, Polic B, Krmpotic A, Messerle M, Jonjic S.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16550-5. doi: 10.1073/pnas.1310215110. Epub 2013 Sep 19.

27.

The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex.

Wagner FM, Brizic I, Prager A, Trsan T, Arapovic M, Lemmermann NA, Podlech J, Reddehase MJ, Lemnitzer F, Bosse JB, Gimpfl M, Marcinowski L, MacDonald M, Adler H, Koszinowski UH, Adler B.

PLoS Pathog. 2013;9(7):e1003493. doi: 10.1371/journal.ppat.1003493. Epub 2013 Jul 25.

28.

NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase.

Wensveen FM, Lenartic M, Jelencic V, Lemmermann NA, ten Brinke A, Jonjic S, Polic B.

J Immunol. 2013 Aug 1;191(3):1307-15. doi: 10.4049/jimmunol.1300670. Epub 2013 Jun 26.

29.

Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells.

Ebert S, Lemmermann NA, Thomas D, Renzaho A, Reddehase MJ, Holtappels R.

Med Microbiol Immunol. 2012 Nov;201(4):541-50. doi: 10.1007/s00430-012-0268-8. Epub 2012 Sep 14.

PMID:
22976556
30.

Murine cytomegalovirus immune evasion proteins operative in the MHC class I pathway of antigen processing and presentation: state of knowledge, revisions, and questions.

Lemmermann NA, Fink A, Podlech J, Ebert S, Wilhelmi V, Böhm V, Holtappels R, Reddehase MJ.

Med Microbiol Immunol. 2012 Nov;201(4):497-512. doi: 10.1007/s00430-012-0257-y. Epub 2012 Sep 9. Review.

PMID:
22961127
31.

Antigen presentation under the influence of 'immune evasion' proteins and its modulation by interferon-gamma: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells.

Fink A, Lemmermann NA, Gillert-Marien D, Thomas D, Freitag K, Böhm V, Wilhelmi V, Reifenberg K, Reddehase MJ, Holtappels R.

Med Microbiol Immunol. 2012 Nov;201(4):513-25. doi: 10.1007/s00430-012-0256-z. Epub 2012 Sep 9.

PMID:
22961126
32.

Superresolution imaging of biological nanostructures by spectral precision distance microscopy.

Cremer C, Kaufmann R, Gunkel M, Pres S, Weiland Y, Müller P, Ruckelshausen T, Lemmer P, Geiger F, Degenhard S, Wege C, Lemmermann NA, Holtappels R, Strickfaden H, Hausmann M.

Biotechnol J. 2011 Sep;6(9):1037-51. doi: 10.1002/biot.201100031. Review.

PMID:
21910256
33.

Single cell detection of latent cytomegalovirus reactivation in host tissue.

Marquardt A, Halle S, Seckert CK, Lemmermann NA, Veres TZ, Braun A, Maus UA, Förster R, Reddehase MJ, Messerle M, Busche A.

J Gen Virol. 2011 Jun;92(Pt 6):1279-91. doi: 10.1099/vir.0.029827-0. Epub 2011 Feb 16.

PMID:
21325477
34.

Reverse genetics modification of cytomegalovirus antigenicity and immunogenicity by CD8 T-cell epitope deletion and insertion.

Lemmermann NA, Kropp KA, Seckert CK, Grzimek NK, Reddehase MJ.

J Biomed Biotechnol. 2011;2011:812742. doi: 10.1155/2011/812742. Epub 2010 Dec 26. Review.

35.

In vivo impact of cytomegalovirus evasion of CD8 T-cell immunity: facts and thoughts based on murine models.

Lemmermann NA, Böhm V, Holtappels R, Reddehase MJ.

Virus Res. 2011 May;157(2):161-74. doi: 10.1016/j.virusres.2010.09.022. Epub 2010 Oct 8. Review.

PMID:
20933556
36.

Enhancerless cytomegalovirus is capable of establishing a low-level maintenance infection in severely immunodeficient host tissues but fails in exponential growth.

Podlech J, Pintea R, Kropp KA, Fink A, Lemmermann NA, Erlach KC, Isern E, Angulo A, Ghazal P, Reddehase MJ.

J Virol. 2010 Jun;84(12):6254-61. doi: 10.1128/JVI.00419-10. Epub 2010 Apr 7.

37.

A novel transmembrane domain mediating retention of a highly motile herpesvirus glycoprotein in the endoplasmic reticulum.

Däubner T, Fink A, Seitz A, Tenzer S, Müller J, Strand D, Seckert CK, Janssen C, Renzaho A, Grzimek NK, Simon CO, Ebert S, Reddehase MJ, Oehrlein-Karpi SA, Lemmermann NA.

J Gen Virol. 2010 Jun;91(Pt 6):1524-34. doi: 10.1099/vir.0.018580-0. Epub 2010 Feb 10.

PMID:
20147515
38.

Immune evasion proteins of murine cytomegalovirus preferentially affect cell surface display of recently generated peptide presentation complexes.

Lemmermann NA, Gergely K, Böhm V, Deegen P, Däubner T, Reddehase MJ.

J Virol. 2010 Feb;84(3):1221-36. doi: 10.1128/JVI.02087-09. Epub 2009 Nov 11.

39.

The immune evasion paradox: immunoevasins of murine cytomegalovirus enhance priming of CD8 T cells by preventing negative feedback regulation.

Böhm V, Simon CO, Podlech J, Seckert CK, Gendig D, Deegen P, Gillert-Marien D, Lemmermann NA, Holtappels R, Reddehase MJ.

J Virol. 2008 Dec;82(23):11637-50. doi: 10.1128/JVI.01510-08. Epub 2008 Sep 24.

40.

Transactivation of cellular genes involved in nucleotide metabolism by the regulatory IE1 protein of murine cytomegalovirus is not critical for viral replicative fitness in quiescent cells and host tissues.

Wilhelmi V, Simon CO, Podlech J, Böhm V, Däubner T, Emde S, Strand D, Renzaho A, Lemmermann NA, Seckert CK, Reddehase MJ, Grzimek NK.

J Virol. 2008 Oct;82(20):9900-16. doi: 10.1128/JVI.00928-08. Epub 2008 Aug 6.

41.

Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues.

Wirtz N, Schader SI, Holtappels R, Simon CO, Lemmermann NA, Reddehase MJ, Podlech J.

Med Microbiol Immunol. 2008 Jun;197(2):151-8. doi: 10.1007/s00430-008-0095-0. Epub 2008 Mar 26.

PMID:
18365251
42.

Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy.

Böhm V, Podlech J, Thomas D, Deegen P, Pahl-Seibert MF, Lemmermann NA, Grzimek NK, Oehrlein-Karpi SA, Reddehase MJ, Holtappels R.

Med Microbiol Immunol. 2008 Jun;197(2):135-44. doi: 10.1007/s00430-008-0092-3. Epub 2008 Mar 14.

PMID:
18340461

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