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Items: 1 to 50 of 61

1.

Trimeric structure of the mouse Kupffer cell C-type lectin receptor Clec4f.

Ouyang Z, Felix J, Zhou J, Pei Y, Ma B, Hwang PM, Lemieux MJ, Gutsche I, Zheng F, Wen Y.

FEBS Lett. 2019 Aug 1. doi: 10.1002/1873-3468.13565. [Epub ahead of print]

PMID:
31369681
2.

Reactions at Biomembrane Interfaces.

Bondar AN, Lemieux MJ.

Chem Rev. 2019 May 8;119(9):6162-6183. doi: 10.1021/acs.chemrev.8b00596. Epub 2019 Apr 25.

PMID:
31021080
3.

Regulating the regulator: intramembrane proteolysis of vesicular trafficking proteins and the SERCA regulator phospholamban.

Young HS, Lemieux MJ.

EMBO Rep. 2019 Mar;20(3). pii: e47792. doi: 10.15252/embr.201947792. Epub 2019 Feb 25. No abstract available.

PMID:
30804015
4.

The Phospholamban Pentamer Alters Function of the Sarcoplasmic Reticulum Calcium Pump SERCA.

Glaves JP, Primeau JO, Espinoza-Fonseca LM, Lemieux MJ, Young HS.

Biophys J. 2019 Feb 19;116(4):633-647. doi: 10.1016/j.bpj.2019.01.013. Epub 2019 Jan 22.

PMID:
30712785
5.

Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry.

Lapek JD Jr, Jiang Z, Wozniak JM, Arutyunova E, Wang SC, Lemieux MJ, Gonzalez DJ, O'Donoghue AJ.

Mol Cell Proteomics. 2019 May;18(5):968-981. doi: 10.1074/mcp.TIR118.001099. Epub 2019 Jan 31.

PMID:
30705125
6.

Intrinsic disorder in the regulatory N-terminal domain of diacylglycerol acyltransferase 1 from Brassica napus.

Panigrahi R, Matsui T, Song AH, Caldo KMP, Young HS, Weselake RJ, Lemieux MJ.

Sci Rep. 2018 Nov 12;8(1):16665. doi: 10.1038/s41598-018-34339-1.

7.

The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C.

Li MX, Gelozia S, Danmaliki GI, Wen Y, Liu PB, Lemieux MJ, West FG, Sykes BD, Hwang PM.

Biochem Biophys Rep. 2018 Nov 1;16:145-151. doi: 10.1016/j.bbrep.2018.10.012. eCollection 2018 Dec.

8.

Highlight: Frontiers in Proteolysis.

Lemieux MJ, Denault JB, Overall CM.

Biol Chem. 2018 Nov 27;399(12):1351. doi: 10.1515/hsz-2018-0401. No abstract available.

PMID:
30352023
9.

Understanding Conformational Dynamics of Complex Lipid Mixtures Relevant to Biology.

Friedman R, Khalid S, Aponte-Santamaría C, Arutyunova E, Becker M, Boyd KJ, Christensen M, Coimbra JTS, Concilio S, Daday C, van Eerden FJ, Fernandes PA, Gräter F, Hakobyan D, Heuer A, Karathanou K, Keller F, Lemieux MJ, Marrink SJ, May ER, Mazumdar A, Naftalin R, Pickholz M, Piotto S, Pohl P, Quinn P, Ramos MJ, Schiøtt B, Sengupta D, Sessa L, Vanni S, Zeppelin T, Zoni V, Bondar AN, Domene C.

J Membr Biol. 2018 Dec;251(5-6):609-631. doi: 10.1007/s00232-018-0050-y. Epub 2018 Oct 22. Review.

10.

Properties and Biotechnological Applications of Acyl-CoA:diacylglycerol Acyltransferase and Phospholipid:diacylglycerol Acyltransferase from Terrestrial Plants and Microalgae.

Xu Y, Caldo KMP, Pal-Nath D, Ozga J, Lemieux MJ, Weselake RJ, Chen G.

Lipids. 2018 Jul;53(7):663-688. doi: 10.1002/lipd.12081. Epub 2018 Sep 25. Review.

PMID:
30252128
11.

An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases.

Arutyunova E, Jiang Z, Yang J, Kulepa AN, Young HS, Verhelst S, O'Donoghue AJ, Lemieux MJ.

Biol Chem. 2018 Nov 27;399(12):1389-1397. doi: 10.1515/hsz-2018-0255.

PMID:
30044760
12.

Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1-catalyzed phosphorylation.

Caldo KMP, Shen W, Xu Y, Hanley-Bowdoin L, Chen G, Weselake RJ, Lemieux MJ.

Plant J. 2018 Oct;96(2):287-299. doi: 10.1111/tpj.14029. Epub 2018 Aug 24.

PMID:
30003607
13.

Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis.

Lian J, Bahitham W, Panigrahi R, Nelson R, Li L, Watts R, Thiesen A, Lemieux MJ, Lehner R.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):688-699. doi: 10.1016/j.bbalip.2018.04.002. Epub 2018 Apr 7.

PMID:
29631096
14.

Taking a position on intramembrane proteolysis.

Lemieux MJ.

J Biol Chem. 2018 Mar 30;293(13):4664-4665. doi: 10.1074/jbc.H118.002210. Review.

15.

Conformational memory in the association of the transmembrane protein phospholamban with the sarcoplasmic reticulum calcium pump SERCA.

Smeazzetto S, Armanious GP, Moncelli MR, Bak JJ, Lemieux MJ, Young HS, Tadini-Buoninsegni F.

J Biol Chem. 2017 Dec 29;292(52):21330-21339. doi: 10.1074/jbc.M117.794453. Epub 2017 Oct 29.

16.

Adipose tissue inflammation in insulin resistance: review of mechanisms mediating anti-inflammatory effects of omega-3 polyunsaturated fatty acids.

Pahlavani M, Ramalho T, Koboziev I, LeMieux MJ, Jayarathne S, Ramalingam L, Filgueiras LR, Moustaid-Moussa N.

J Investig Med. 2017 Oct;65(7):1021-1027. doi: 10.1136/jim-2017-000535. Epub 2017 Sep 27. Review.

PMID:
28954844
17.

Multiple mechanisms contribute to increased neutral lipid accumulation in yeast producing recombinant variants of plant diacylglycerol acyltransferase 1.

Xu Y, Chen G, Greer MS, Caldo KMP, Ramakrishnan G, Shah S, Wu L, Lemieux MJ, Ozga J, Weselake RJ.

J Biol Chem. 2017 Oct 27;292(43):17819-17831. doi: 10.1074/jbc.M117.811489. Epub 2017 Sep 12.

18.

Diacylglycerol Acyltransferase 1 Is Regulated by Its N-Terminal Domain in Response to Allosteric Effectors.

Caldo KMP, Acedo JZ, Panigrahi R, Vederas JC, Weselake RJ, Lemieux MJ.

Plant Physiol. 2017 Oct;175(2):667-680. doi: 10.1104/pp.17.00934. Epub 2017 Aug 21.

19.

Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides.

Soueidan OM, Scully TW, Kaur J, Panigrahi R, Belovodskiy A, Do V, Matier CD, Lemieux MJ, Wuest F, Cheeseman C, West FG.

ACS Chem Biol. 2017 Apr 21;12(4):1087-1094. doi: 10.1021/acschembio.6b01101. Epub 2017 Mar 2.

PMID:
28205432
20.

Identification of Key Residues for Urate Specific Transport in Human Glucose Transporter 9 (hSLC2A9).

Long W, Panigrahi R, Panwar P, Wong K, O Neill D, Chen XZ, Lemieux MJ, Cheeseman CI.

Sci Rep. 2017 Jan 24;7:41167. doi: 10.1038/srep41167.

21.

Activity Assays for Rhomboid Proteases.

Arutyunova E, Strisovsky K, Lemieux MJ.

Methods Enzymol. 2017;584:395-437. doi: 10.1016/bs.mie.2016.11.002. Epub 2016 Dec 8.

PMID:
28065272
22.

Production of Recombinant Rhomboid Proteases.

Arutyunova E, Panigrahi R, Strisovsky K, Lemieux MJ.

Methods Enzymol. 2017;584:255-278. doi: 10.1016/bs.mie.2016.10.031. Epub 2016 Dec 13.

PMID:
28065266
23.

Probing catalytic rate enhancement during intramembrane proteolysis.

Arutyunova E, Smithers CC, Corradi V, Espiritu AC, Young HS, Tieleman DP, Lemieux MJ.

Biol Chem. 2016 Sep 1;397(9):907-19. doi: 10.1515/hsz-2016-0124.

PMID:
27071148
24.

Reversible Unfolding of Rhomboid Intramembrane Proteases.

Panigrahi R, Arutyunova E, Panwar P, Gimpl K, Keller S, Lemieux MJ.

Biophys J. 2016 Mar 29;110(6):1379-90. doi: 10.1016/j.bpj.2016.01.032.

25.

Inactivation of adipose angiotensinogen reduces adipose tissue macrophages and increases metabolic activity.

LeMieux MJ, Ramalingam L, Mynatt RL, Kalupahana NS, Kim JH, Moustaïd-Moussa N.

Obesity (Silver Spring). 2016 Feb;24(2):359-67. doi: 10.1002/oby.21352. Epub 2015 Dec 25.

26.

Functional Implications of Domain Organization Within Prokaryotic Rhomboid Proteases.

Panigrahi R, Lemieux MJ.

Adv Exp Med Biol. 2015;883:107-17. doi: 10.1007/978-3-319-23603-2_6. Review.

PMID:
26621464
27.

High yield expression and purification of equilibrative nucleoside transporter 7 (ENT7) from Arabidopsis thaliana.

Girke C, Arutyunova E, Syed M, Traub M, Möhlmann T, Lemieux MJ.

Biochim Biophys Acta. 2015 Sep;1850(9):1921-9. doi: 10.1016/j.bbagen.2015.06.003. Epub 2015 Jun 12.

PMID:
26080001
28.

Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory.

Cournia Z, Allen TW, Andricioaei I, Antonny B, Baum D, Brannigan G, Buchete NV, Deckman JT, Delemotte L, Del Val C, Friedman R, Gkeka P, Hege HC, Hénin J, Kasimova MA, Kolocouris A, Klein ML, Khalid S, Lemieux MJ, Lindow N, Roy M, Selent J, Tarek M, Tofoleanu F, Vanni S, Urban S, Wales DJ, Smith JC, Bondar AN.

J Membr Biol. 2015 Aug;248(4):611-40. doi: 10.1007/s00232-015-9802-0. Epub 2015 Jun 11. Review.

29.

Critical Roles of Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) in Substrate Selectivity and Urate Transport.

Long W, Panwar P, Witkowska K, Wong K, O'Neill D, Chen XZ, Lemieux MJ, Cheeseman CI.

J Biol Chem. 2015 Jun 12;290(24):15292-303. doi: 10.1074/jbc.M114.611178. Epub 2015 Apr 28.

30.

Eicosapentaenoic acid reduces adipocyte hypertrophy and inflammation in diet-induced obese mice in an adiposity-independent manner.

LeMieux MJ, Kalupahana NS, Scoggin S, Moustaid-Moussa N.

J Nutr. 2015 Mar;145(3):411-7. doi: 10.3945/jn.114.202952. Epub 2014 Dec 31.

PMID:
25733455
31.

Purification and properties of recombinant Brassica napus diacylglycerol acyltransferase 1.

Caldo KM, Greer MS, Chen G, Lemieux MJ, Weselake RJ.

FEBS Lett. 2015 Mar 12;589(6):773-8. doi: 10.1016/j.febslet.2015.02.008. Epub 2015 Feb 14.

32.

Nutrimetabolomics.

LeMieux MJ, Aljawadi A, Moustaid-Moussa N.

Adv Nutr. 2014 Nov 14;5(6):792-4. doi: 10.3945/an.114.006684. Print 2014 Nov.

33.

The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences.

Brooks CL, Arutyunova E, Lemieux MJ.

Acta Crystallogr F Struct Biol Commun. 2014 Oct;70(Pt 10):1312-7. doi: 10.1107/S2053230X14019372. Epub 2014 Sep 25.

34.

Biochemical characterization and structure-function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana.

Niopek-Witz S, Deppe J, Lemieux MJ, Möhlmann T.

Biochim Biophys Acta. 2014 Dec;1838(12):3025-35. doi: 10.1016/j.bbamem.2014.08.013. Epub 2014 Aug 16.

35.

Allosteric regulation of rhomboid intramembrane proteolysis.

Arutyunova E, Panwar P, Skiba PM, Gale N, Mak MW, Lemieux MJ.

EMBO J. 2014 Sep 1;33(17):1869-81. doi: 10.15252/embj.201488149. Epub 2014 Jul 9.

36.

Expression and Purification of Haemophilus influenzae Rhomboid Intramembrane Protease GlpG for Structural Studies.

Panwar P, Lemieux MJ.

Curr Protoc Protein Sci. 2014 Apr 1;76:29.9.1-25. doi: 10.1002/0471140864.ps2909s76. Review.

PMID:
24692018
37.

Structure-function relationship of a plant NCS1 member--homology modeling and mutagenesis identified residues critical for substrate specificity of PLUTO, a nucleobase transporter from Arabidopsis.

Witz S, Panwar P, Schober M, Deppe J, Pasha FA, Lemieux MJ, Möhlmann T.

PLoS One. 2014 Mar 12;9(3):e91343. doi: 10.1371/journal.pone.0091343. eCollection 2014.

38.

Untangling structure-function relationships in the rhomboid family of intramembrane proteases.

Brooks CL, Lemieux MJ.

Biochim Biophys Acta. 2013 Dec;1828(12):2862-72. doi: 10.1016/j.bbamem.2013.05.003. Review.

39.

Domain swapping in the cytoplasmic domain of the Escherichia coli rhomboid protease.

Lazareno-Saez C, Arutyunova E, Coquelle N, Lemieux MJ.

J Mol Biol. 2013 Apr 12;425(7):1127-42. doi: 10.1016/j.jmb.2013.01.019. Epub 2013 Jan 23.

PMID:
23353827
40.

Oligomeric state study of prokaryotic rhomboid proteases.

Sampathkumar P, Mak MW, Fischer-Witholt SJ, Guigard E, Kay CM, Lemieux MJ.

Biochim Biophys Acta. 2012 Dec;1818(12):3090-7. doi: 10.1016/j.bbamem.2012.08.004. Epub 2012 Aug 18.

41.

Crystal structure of the N-lobe of lactoferrin binding protein B from Moraxella bovis.

Arutyunova E, Brooks CL, Beddek A, Mak MW, Schryvers AB, Lemieux MJ.

Biochem Cell Biol. 2012 Jun;90(3):351-61. doi: 10.1139/o11-078. Epub 2012 Feb 14.

PMID:
22332934
42.

Structural comparison of substrate entry gate for rhomboid intramembrane peptidases.

Lazareno-Saez C, Brooks CL, Lemieux MJ.

Biochem Cell Biol. 2011 Apr;89(2):216-23. doi: 10.1139/o10-161.

PMID:
21455272
43.

Insights into substrate gating in H. influenzae rhomboid.

Brooks CL, Lazareno-Saez C, Lamoureux JS, Mak MW, Lemieux MJ.

J Mol Biol. 2011 Apr 15;407(5):687-97. doi: 10.1016/j.jmb.2011.01.046. Epub 2011 Feb 3.

PMID:
21295583
44.

A perspective on the structural studies of inner membrane electrochemical potential-driven transporters.

Lemieux MJ.

Biochim Biophys Acta. 2008 Sep;1778(9):1805-13. doi: 10.1016/j.bbamem.2008.01.009. Epub 2008 Jan 16. Review.

45.
46.

The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis.

Lemieux MJ, Fischer SJ, Cherney MM, Bateman KS, James MN.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):750-4. Epub 2007 Jan 8.

47.

Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.

Lemieux MJ, Mark BL, Cherney MM, Withers SG, Mahuran DJ, James MN.

J Mol Biol. 2006 Jun 16;359(4):913-29. Epub 2006 Apr 27.

48.

The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis.

Lemieux MJ, Ference C, Cherney MM, Wang M, Garen C, James MN.

J Struct Funct Genomics. 2005 Dec;6(4):245-57. Epub 2006 Feb 22.

PMID:
16496224
49.

Crystal structure and mechanism of GlpT, the glycerol-3-phosphate transporter from E. coli.

Lemieux MJ, Huang Y, Wang da N.

J Electron Microsc (Tokyo). 2005;54 Suppl 1:i43-6.

PMID:
16157640
50.

Glycerol-3-phosphate transporter of Escherichia coli: structure, function and regulation.

Lemieux MJ, Huang Y, Wang DN.

Res Microbiol. 2004 Oct;155(8):623-9. Review.

PMID:
15380549

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