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Items: 36


Naturally acquired immunity against immature Plasmodium falciparum gametocytes.

Dantzler KW, Ma S, Ngotho P, Stone WJR, Tao D, Rijpma S, De Niz M, Nilsson Bark SK, Jore MM, Raaijmakers TK, Early AM, Ubaida-Mohien C, Lemgruber L, Campo JJ, Teng AA, Le TQ, Walker CL, Hermand P, Deterre P, Davies DH, Felgner P, Morlais I, Wirth DF, Neafsey DE, Dinglasan RR, Laufer M, Huttenhower C, Seydel K, Taylor T, Bousema T, Marti M.

Sci Transl Med. 2019 Jun 5;11(495). pii: eaav3963. doi: 10.1126/scitranslmed.aav3963.


A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii.

Melatti C, Pieperhoff M, Lemgruber L, Pohl E, Sheiner L, Meissner M.

PLoS Pathog. 2019 Apr 4;15(4):e1007512. doi: 10.1371/journal.ppat.1007512. eCollection 2019 Apr.


Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei.

Cerone M, Uliassi E, Prati F, Ebiloma GU, Lemgruber L, Bergamini C, Watson DG, de A M Ferreira T, Roth Cardoso GSH, Soares Romeiro LA, de Koning HP, Bolognesi ML.

ChemMedChem. 2019 Mar 22;14(6):621-635. doi: 10.1002/cmdc.201800790. Epub 2019 Feb 5.


Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs.

Nnadi CO, Ebiloma GU, Black JA, Nwodo NJ, Lemgruber L, Schmidt TJ, de Koning HP.

Molecules. 2019 Jan 12;24(2). pii: E268. doi: 10.3390/molecules24020268.


Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion.

Briggs E, Crouch K, Lemgruber L, Lapsley C, McCulloch R.

PLoS Genet. 2018 Dec 13;14(12):e1007729. doi: 10.1371/journal.pgen.1007729. eCollection 2018 Dec.


Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development.

Das S, Lemgruber L, Tay CL, Baum J, Meissner M.

BMC Biol. 2017 Aug 15;15(1):70. doi: 10.1186/s12915-017-0406-2.


Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei.

Stortz JA, Serafim TD, Alsford S, Wilkes J, Fernandez-Cortes F, Hamilton G, Briggs E, Lemgruber L, Horn D, Mottram JC, McCulloch R.

PLoS Pathog. 2017 Jul 24;13(7):e1006477. doi: 10.1371/journal.ppat.1006477. eCollection 2017 Jul.


Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.

Millan CR, Acosta-Reyes FJ, Lagartera L, Ebiloma GU, Lemgruber L, Nué Martínez JJ, Saperas N, Dardonville C, de Koning HP, Campos JL.

Nucleic Acids Res. 2017 Aug 21;45(14):8378-8391. doi: 10.1093/nar/gkx521.


A Glycosylphosphatidylinositol-Anchored Carbonic Anhydrase-Related Protein of Toxoplasma gondii Is Important for Rhoptry Biogenesis and Virulence.

Chasen NM, Asady B, Lemgruber L, Vommaro RC, Kissinger JC, Coppens I, Moreno SNJ.

mSphere. 2017 May 17;2(3). pii: e00027-17. doi: 10.1128/mSphere.00027-17. eCollection 2017 May-Jun.


Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation.

Periz J, Whitelaw J, Harding C, Gras S, Del Rosario Minina MI, Latorre-Barragan F, Lemgruber L, Reimer MA, Insall R, Heaslip A, Meissner M.

Elife. 2017 Mar 21;6. pii: e24119. doi: 10.7554/eLife.24119.


Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii.

Ovciarikova J, Lemgruber L, Stilger KL, Sullivan WJ, Sheiner L.

Sci Rep. 2017 Feb 16;7:42746. doi: 10.1038/srep42746.


Microstructured Blood Vessel Surrogates Reveal Structural Tropism of Motile Malaria Parasites.

Muthinja MJ, Ripp J, Hellmann JK, Haraszti T, Dahan N, Lemgruber L, Battista A, Schütz L, Fackler OT, Schwarz US, Spatz JP, Frischknecht F.

Adv Healthc Mater. 2017 Mar;6(6). doi: 10.1002/adhm.201601178. Epub 2017 Jan 24.


UAP56 is a conserved crucial component of a divergent mRNA export pathway in Toxoplasma gondii.

Serpeloni M, Jiménez-Ruiz E, Vidal NM, Kroeber C, Andenmatten N, Lemgruber L, Mörking P, Pall GS, Meissner M, Ávila AR.

Mol Microbiol. 2016 Nov;102(4):672-689. doi: 10.1111/mmi.13485. Epub 2016 Sep 14.


A Putative Small Solute Transporter Is Responsible for the Secretion of G377 and TRAP-Containing Secretory Vesicles during Plasmodium Gamete Egress and Sporozoite Motility.

Kehrer J, Singer M, Lemgruber L, Silva PA, Frischknecht F, Mair GR.

PLoS Pathog. 2016 Jul 18;12(7):e1005734. doi: 10.1371/journal.ppat.1005734. eCollection 2016 Jul.


Trojan-Like Internalization of Anatase Titanium Dioxide Nanoparticles by Human Osteoblast Cells.

Ribeiro AR, Gemini-Piperni S, Travassos R, Lemgruber L, Silva RC, Rossi AL, Farina M, Anselme K, Shokuhfar T, Shahbazian-Yassar R, Borojevic R, Rocha LA, Werckmann J, Granjeiro JM.

Sci Rep. 2016 Mar 29;6:23615. doi: 10.1038/srep23615.


Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation.

Marques CA, Tiengwe C, Lemgruber L, Damasceno JD, Scott A, Paape D, Marcello L, McCulloch R.

Nucleic Acids Res. 2016 Jun 2;44(10):4763-84. doi: 10.1093/nar/gkw147. Epub 2016 Mar 6.


PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast.

Grewal JS, McLuskey K, Das D, Myburgh E, Wilkes J, Brown E, Lemgruber L, Gould MK, Burchmore RJ, Coombs GH, Schnaufer A, Mottram JC.

J Biol Chem. 2016 Apr 29;291(18):9492-500. doi: 10.1074/jbc.M116.714972. Epub 2016 Mar 3.


Nanoscopic Localization of Surface-Exposed Antigens of Borrelia burgdorferi.

Lemgruber L, Sant'Anna C, Griffths C, Abud Y, Mhlanga M, Wallich R, Frischknecht F.

Microsc Microanal. 2015 Jun;21(3):680-8. doi: 10.1017/S1431927615000318. Epub 2015 Mar 5.


Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton.

Rug M, Cyrklaff M, Mikkonen A, Lemgruber L, Kuelzer S, Sanchez CP, Thompson J, Hanssen E, O'Neill M, Langer C, Lanzer M, Frischknecht F, Maier AG, Cowman AF.

Blood. 2014 Nov 27;124(23):3459-68. doi: 10.1182/blood-2014-06-583054. Epub 2014 Aug 19.


Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion.

Hanssen E, Dekiwadia C, Riglar DT, Rug M, Lemgruber L, Cowman AF, Cyrklaff M, Kudryashev M, Frischknecht F, Baum J, Ralph SA.

Cell Microbiol. 2013 Sep;15(9):1457-72. doi: 10.1111/cmi.12132. Epub 2013 Mar 22.


Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast.

Lemgruber L, Kudryashev M, Dekiwadia C, Riglar DT, Baum J, Stahlberg H, Ralph SA, Frischknecht F.

Malar J. 2013 Jan 19;12:25. doi: 10.1186/1475-2875-12-25.


Actin-mediated plasma membrane plasticity of the intracellular parasite Theileria annulata.

Kühni-Boghenbor K, Ma M, Lemgruber L, Cyrklaff M, Frischknecht F, Gaschen V, Stoffel M, Baumgartner M.

Cell Microbiol. 2012 Dec;14(12):1867-79. doi: 10.1111/cmi.12006. Epub 2012 Sep 4.


Structural basis for chirality and directional motility of Plasmodium sporozoites.

Kudryashev M, Münter S, Lemgruber L, Montagna G, Stahlberg H, Matuschewski K, Meissner M, Cyrklaff M, Frischknecht F.

Cell Microbiol. 2012 Nov;14(11):1757-68. doi: 10.1111/j.1462-5822.2012.01836.x. Epub 2012 Jul 30.


Crystalloid body, refractile body and virus-like particles in Apicomplexa: what is in there?

Lemgruber L, Lupetti P.

Parasitology. 2012 Mar;139(3):285-93. doi: 10.1017/S0031182011002034. Epub 2012 Jan 5. Review.


The organization of the wall filaments and characterization of the matrix structures of Toxoplasma gondii cyst form.

Lemgruber L, Lupetti P, Martins-Duarte ES, De Souza W, Vommaro RC.

Cell Microbiol. 2011 Dec;13(12):1920-32. doi: 10.1111/j.1462-5822.2011.01681.x. Epub 2011 Sep 22.


New details on the fine structure of the rhoptry of Toxoplasma gondii.

Lemgruber L, Lupetti P, De Souza W, Vommaro RC.

Microsc Res Tech. 2011 Sep;74(9):812-8. doi: 10.1002/jemt.20960. Epub 2010 Nov 17.


Evidence of direct cell-cell fusion in Borrelia by cryogenic electron tomography.

Kudryashev M, Cyrklaff M, Alex B, Lemgruber L, Baumeister W, Wallich R, Frischknecht F.

Cell Microbiol. 2011 May;13(5):731-41. doi: 10.1111/j.1462-5822.2011.01571.x. Epub 2011 Jan 30.


An arrangement of intersecting ideas: the CNC 2010 meeting report.

Singer M, Lemgruber L.

Biotechnol J. 2011 Jan;6(1):12-5. doi: 10.1002/biot.201000389. No abstract available.


Evaluation of three novel azasterols against Toxoplasma gondii.

Martins-Duarte ES, Lemgruber L, Lorente SO, Gros L, Magaraci F, Gilbert IH, de Souza W, Vommaro RC.

Vet Parasitol. 2011 Apr 19;177(1-2):157-61. doi: 10.1016/j.vetpar.2010.11.034. Epub 2010 Dec 1.


The fine structure of the Acanthamoeba polyphaga cyst wall.

Lemgruber L, Lupetti P, De Souza W, Vommaro RC, da Rocha-Azevedo B.

FEMS Microbiol Lett. 2010 Apr;305(2):170-6. doi: 10.1111/j.1574-6968.2010.01925.x. Epub 2010 Feb 6.


Encystation process of Giardia lamblia: morphological and regulatory aspects.

Bittencourt-Silvestre J, Lemgruber L, de Souza W.

Arch Microbiol. 2010 Apr;192(4):259-65. doi: 10.1007/s00203-010-0554-z. Epub 2010 Feb 12.


Toxoplasma gondii: fluconazole and itraconazole activity against toxoplasmosis in a murine model.

Martins-Duarte ES, Lemgruber L, de Souza W, Vommaro RC.

Exp Parasitol. 2010 Apr;124(4):466-9. doi: 10.1016/j.exppara.2009.12.011. Epub 2010 Jan 4.


Toxoplasma gondii: further studies on the subpellicular network.

Lemgruber L, Kloetzel JA, Souza Wd, Vommaro RC.

Mem Inst Oswaldo Cruz. 2009 Aug;104(5):706-9.


New insights into the morphology of Trypanosoma cruzi reservosome.

Sant'Anna C, Pereira MG, Lemgruber L, de Souza W, Cunha e Silva NL.

Microsc Res Tech. 2008 Aug;71(8):599-605. doi: 10.1002/jemt.20592.


Freeze-fracture study of the dynamics of Toxoplasma gondii parasitophorous vacuole development.

Lemgruber L, De Souza W, Vommaro RC.

Micron. 2008;39(2):177-83. Epub 2007 Jan 20.


Intravacuolar network may act as a mechanical support for Toxoplasma gondii inside the parasitophorous vacuole.

Magno RC, Lemgruber L, Vommaro RC, De Souza W, Attias M.

Microsc Res Tech. 2005 May;67(1):45-52.


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