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Brain MRI fiber-tracking reveals white matter alterations in hypertensive patients without damage at conventional neuroimaging.

Carnevale L, D'Angelosante V, Landolfi A, Grillea G, Selvetella G, Storto M, Lembo G, Carnevale D.

Cardiovasc Res. 2018 Jun 12. doi: 10.1093/cvr/cvy104. [Epub ahead of print]


Fatty acids are the best fuel for overloaded hearts.

Maffei A, Lembo G.

Cardiovasc Res. 2018 Apr 27. doi: 10.1093/cvr/cvy106. [Epub ahead of print] No abstract available.


Combined bioaugmentation with anaerobic ruminal fungi and fermentative bacteria to enhance biogas production from wheat straw and mushroom spent straw.

Ferraro A, Dottorini G, Massini G, Mazzurco Miritana V, Signorini A, Lembo G, Fabbricino M.

Bioresour Technol. 2018 Jul;260:364-373. doi: 10.1016/j.biortech.2018.03.128. Epub 2018 Apr 3.


The Interactions of the Immune System and the Brain in Hypertension.

Perrotta M, Lembo G, Carnevale D.

Curr Hypertens Rep. 2018 Feb 24;20(1):7. doi: 10.1007/s11906-018-0808-8. Review.


Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation.

Perrotta M, Lori A, Carnevale L, Fardella S, Cifelli G, Iacobucci R, Mastroiacovo F, Iodice D, Pallante F, Storto M, Lembo G, Carnevale D.

Cardiovasc Res. 2018 Mar 1;114(3):456-467. doi: 10.1093/cvr/cvy001.


From clinical observations to molecular mechanisms and back to patients: the successful circuit of the CANTOS study.

Lembo G.

Cardiovasc Res. 2018 Jan 1;114(1):e3-e5. doi: 10.1093/cvr/cvx219. No abstract available.


Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling.

Da Ros F, Carnevale R, Cifelli G, Bizzotto D, Casaburo M, Perrotta M, Carnevale L, Vinciguerra I, Fardella S, Iacobucci R, Bressan GM, Braghetta P, Lembo G, Carnevale D.

Immunity. 2017 Nov 21;47(5):959-973.e9. doi: 10.1016/j.immuni.2017.10.016. Epub 2017 Nov 14.


The Spleen: A Hub Connecting Nervous and Immune Systems in Cardiovascular and Metabolic Diseases.

Lori A, Perrotta M, Lembo G, Carnevale D.

Int J Mol Sci. 2017 Jun 7;18(6). pii: E1216. doi: 10.3390/ijms18061216. Review.


The Multifaceted Roles of PI3Kγ in Hypertension, Vascular Biology, and Inflammation.

Perrotta M, Lembo G, Carnevale D.

Int J Mol Sci. 2016 Nov 8;17(11). pii: E1858. Review.


A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication.

Carnevale D, Perrotta M, Pallante F, Fardella V, Iacobucci R, Fardella S, Carnevale L, Carnevale R, De Lucia M, Cifelli G, Lembo G.

Nat Commun. 2016 Sep 27;7:13035. doi: 10.1038/ncomms13035.


MiR-153/Kv7.4: a novel molecular axis in the regulation of hypertension.

Maffei A, Di Mauro V, Catalucci D, Lembo G.

Cardiovasc Res. 2016 Sep 15. pii: cvw208. [Epub ahead of print] No abstract available.


PI3Kγ Inhibition Protects Against Diabetic Cardiomyopathy in Mice.

Maffei A, Cifelli G, Carnevale R, Iacobucci R, Pallante F, Fardella V, Fardella S, Hirsch E, Lembo G, Carnevale D.

Rev Esp Cardiol (Engl Ed). 2017 Jan;70(1):16-24. doi: 10.1016/j.rec.2016.04.034. Epub 2016 Jul 13. English, Spanish.


Hemorrhagic transformation of acute ischemic stroke is limited in hypertensive patients with cardiac hypertrophy.

Landolfi A, Selvetella G, Cugino D, Grillea G, Maffei A, Notte A, Lembo G, Carnevale D.

Int J Cardiol. 2016 Sep 15;219:362-6. doi: 10.1016/j.ijcard.2016.06.060. Epub 2016 Jun 23.


Flavanol-rich cocoa at breakfast: the right remedy after a sleepless night to prevent negative effects on blood pressure and cognition?

Lembo G, Grassi G.

J Hypertens. 2016 Jul;34(7):1252-3. doi: 10.1097/HJH.0000000000000959. No abstract available.


Immunological Aspects of Hypertension.

Carnevale D, Lembo G.

High Blood Press Cardiovasc Prev. 2016 Jun;23(2):91-5. doi: 10.1007/s40292-016-0141-8. Epub 2016 Apr 14. Review.


Hypertension and Dementia: Epidemiological and Experimental Evidence Revealing a Detrimental Relationship.

Perrotta M, Lembo G, Carnevale D.

Int J Mol Sci. 2016 Mar 8;17(3):347. doi: 10.3390/ijms17030347. Review.


TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice.

Stöhr R, Kappel BA, Carnevale D, Cavalera M, Mavilio M, Arisi I, Fardella V, Cifelli G, Casagrande V, Rizza S, Cattaneo A, Mauriello A, Menghini R, Lembo G, Federici M.

Mol Metab. 2015 Aug 6;4(10):741-52. doi: 10.1016/j.molmet.2015.07.007. eCollection 2015 Oct.


A Human Deciduous Tooth and New 40Ar/39Ar Dating Results from the Middle Pleistocene Archaeological Site of Isernia La Pineta, Southern Italy.

Peretto C, Arnaud J, Moggi-Cecchi J, Manzi G, Nomade S, Pereira A, Falguères C, Bahain JJ, Grimaud-Hervé D, Berto C, Sala B, Lembo G, Muttillo B, Gallotti R, Thun Hohenstein U, Vaccaro C, Coltorti M, Arzarello M.

PLoS One. 2015 Oct 12;10(10):e0140091. doi: 10.1371/journal.pone.0140091. eCollection 2015.


PlGF, immune system and hypertension.

Carnevale D, Lembo G.

Oncotarget. 2015 Jul 30;6(21):18246-7. No abstract available.


Pathophysiological Links Among Hypertension and Alzheimer's Disease.

Carnevale D, Perrotta M, Lembo G, Trimarco B.

High Blood Press Cardiovasc Prev. 2016 Mar;23(1):3-7. doi: 10.1007/s40292-015-0108-1. Epub 2015 Jun 9. Review.


Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.

D'Andrea I, Fardella V, Fardella S, Pallante F, Ghigo A, Iacobucci R, Maffei A, Hirsch E, Lembo G, Carnevale D.

EMBO Mol Med. 2015 Jul;7(7):904-17. doi: 10.15252/emmm.201404697.


The seascape of demersal fish nursery areas in the North Mediterranean Sea, a first step towards the implementation of spatial planning for trawl fisheries.

Colloca F, Garofalo G, Bitetto I, Facchini MT, Grati F, Martiradonna A, Mastrantonio G, Nikolioudakis N, Ordinas F, Scarcella G, Tserpes G, Tugores MP, Valavanis V, Carlucci R, Fiorentino F, Follesa MC, Iglesias M, Knittweis L, Lefkaditou E, Lembo G, Manfredi C, Massutí E, Pace ML, Papadopoulou N, Sartor P, Smith CJ, Spedicato MT.

PLoS One. 2015 Mar 18;10(3):e0119590. doi: 10.1371/journal.pone.0119590. eCollection 2015.


The angiogenic factor PlGF mediates a neuroimmune interaction in the spleen to allow the onset of hypertension.

Carnevale D, Pallante F, Fardella V, Fardella S, Iacobucci R, Federici M, Cifelli G, De Lucia M, Lembo G.

Immunity. 2014 Nov 20;41(5):737-52. doi: 10.1016/j.immuni.2014.11.002. Epub 2014 Nov 7.


Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive.

Perino A, Beretta M, Kilić A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo D, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E.

Sci Signal. 2014 Nov 18;7(352):ra110. doi: 10.1126/scisignal.2005485.


Evaluation of microvascular structure in humans: a 'state-of-the-art' document of the Working Group on Macrovascular and Microvascular Alterations of the Italian Society of Arterial Hypertension.

Virdis A, Savoia C, Grassi G, Lembo G, Vecchione C, Seravalle G, Taddei S, Volpe M, Rosei EA, Rizzoni D.

J Hypertens. 2014 Nov;32(11):2120-9; discussion 2129. doi: 10.1097/HJH.0000000000000322. Review.


Nitroxyl (HNO) for treatment of acute heart failure.

Arcaro A, Lembo G, Tocchetti CG.

Curr Heart Fail Rep. 2014 Sep;11(3):227-35. doi: 10.1007/s11897-014-0210-z. Review.


G-protein-coupled receptor kinases in hypertension.

Carnevale D, Lembo G.

High Blood Press Cardiovasc Prev. 2013 Mar;20(1):3-4. doi: 10.1007/s40292-013-0004-5. No abstract available.


Successful treatment of Mycobacterium terrae complex infection of the knee.

Lembo G, Goldstein EJ, Troum O, Mandelbaum B.

J Clin Rheumatol. 2012 Oct;18(7):359-62. doi: 10.1097/RHU.0b013e31826d1e11. Review.


Placental growth factor and cardiac inflammation.

Carnevale D, Lembo G.

Trends Cardiovasc Med. 2012 Nov;22(8):209-12. doi: 10.1016/j.tcm.2012.07.022. Epub 2012 Aug 25. Review.


Vascular smooth muscle Emilin-1 is a regulator of arteriolar myogenic response and blood pressure.

Litteri G, Carnevale D, D'Urso A, Cifelli G, Braghetta P, Damato A, Bizzotto D, Landolfi A, Ros FD, Sabatelli P, Facchinello N, Maffei A, Volpin D, Colombatti A, Bressan GM, Lembo G.

Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2178-84. doi: 10.1161/ATVBAHA.112.254664. Epub 2012 Jul 19.


Hypertension induces brain β-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature.

Carnevale D, Mascio G, D'Andrea I, Fardella V, Bell RD, Branchi I, Pallante F, Zlokovic B, Yan SS, Lembo G.

Hypertension. 2012 Jul;60(1):188-97. doi: 10.1161/HYPERTENSIONAHA.112.195511. Epub 2012 May 21.


PI3Kγ in hypertension: a novel therapeutic target controlling vascular myogenic tone and target organ damage.

Carnevale D, Lembo G.

Cardiovasc Res. 2012 Sep 1;95(4):403-8. doi: 10.1093/cvr/cvs166. Epub 2012 May 19. Review.


PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism.

Carnevale D, Vecchione C, Mascio G, Esposito G, Cifelli G, Martinello K, Landolfi A, Selvetella G, Grieco P, Damato A, Franco E, Haase H, Maffei A, Ciraolo E, Fucile S, Frati G, Mazzoni O, Hirsch E, Lembo G.

Cardiovasc Res. 2012 Jan 1;93(1):200-9. doi: 10.1093/cvr/cvr288. Epub 2011 Oct 27.


Ischaemic stroke following tranexamic acid in young patients carrying heterozygosity of MTHFR C677T.

Nardi K, Pelone G, Bartolo M, Di Ruzza MR, Storto M, Notte A, Grillea G, Colonnese C, Lembo G, Vecchione C.

Ann Clin Biochem. 2011 Nov;48(Pt 6):575-8. doi: 10.1258/acb.2011.011101. Epub 2011 Sep 8.


Placental growth factor regulates cardiac inflammation through the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-α-converting enzyme axis: crucial role for adaptive cardiac remodeling during cardiac pressure overload.

Carnevale D, Cifelli G, Mascio G, Madonna M, Sbroggiò M, Perrino C, Persico MG, Frati G, Lembo G.

Circulation. 2011 Sep 20;124(12):1337-50. doi: 10.1161/CIRCULATIONAHA.111.050500. Epub 2011 Sep 6.


'Alzheimer-like' pathology in a murine model of arterial hypertension.

Carnevale D, Lembo G.

Biochem Soc Trans. 2011 Aug;39(4):939-44. doi: 10.1042/BST0390939. Review.


IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

Sbroggiò M, Carnevale D, Bertero A, Cifelli G, De Blasio E, Mascio G, Hirsch E, Bahou WF, Turco E, Silengo L, Brancaccio M, Lembo G, Tarone G.

Cardiovasc Res. 2011 Aug 1;91(3):456-64. doi: 10.1093/cvr/cvr103. Epub 2011 Apr 14.


A lesson from polycystic ovarian syndrome: untangling the role of renal sympathetic nervous system on hypertension and insulin resistance.

Lembo G, Grassi G.

J Hypertens. 2011 May;29(5):836-7. doi: 10.1097/HJH.0b013e3283462d0d. No abstract available.


Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E.

Mol Cell. 2011 Apr 8;42(1):84-95. doi: 10.1016/j.molcel.2011.01.030.


Chronic Type A aortic dissection: could surgical intervention be guided by molecular markers?

Carnevale D, Lembo G, Frati G.

J Cell Mol Med. 2011 Jul;15(7):1615-9. doi: 10.1111/j.1582-4934.2011.01314.x.


Protein kinase Cθ is required for cardiomyocyte survival and cardiac remodeling.

Paoletti R, Maffei A, Madaro L, Notte A, Stanganello E, Cifelli G, Carullo P, Molinaro M, Lembo G, Bouché M.

Cell Death Dis. 2010 May 27;1:e45. doi: 10.1038/cddis.2010.24.


Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.

Damilano F, Franco I, Perrino C, Schaefer K, Azzolino O, Carnevale D, Cifelli G, Carullo P, Ragona R, Ghigo A, Perino A, Lembo G, Hirsch E.

Circulation. 2011 Feb 1;123(4):391-9. doi: 10.1161/CIRCULATIONAHA.110.950543. Epub 2011 Jan 17.


Role of neuroinflammation in hypertension-induced brain amyloid pathology.

Carnevale D, Mascio G, Ajmone-Cat MA, D'Andrea I, Cifelli G, Madonna M, Cocozza G, Frati A, Carullo P, Carnevale L, Alleva E, Branchi I, Lembo G, Minghetti L.

Neurobiol Aging. 2012 Jan;33(1):205.e19-29. doi: 10.1016/j.neurobiolaging.2010.08.013. Epub 2010 Oct 18.


Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients.

Palumbo V, Segat L, Padovan L, Amoroso A, Trimarco B, Izzo R, Lembo G, Regitz-Zagrosek V, Knoll R, Brancaccio M, Tarone G, Crovella S.

BMC Med Genet. 2009 Dec 17;10:140. doi: 10.1186/1471-2350-10-140.


Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-1 pathway.

Vecchione C, Carnevale D, Di Pardo A, Gentile MT, Damato A, Cocozza G, Antenucci G, Mascio G, Bettarini U, Landolfi A, Iorio L, Maffei A, Lembo G.

Hypertension. 2009 Nov;54(5):1028-34. doi: 10.1161/HYPERTENSIONAHA.109.136572. Epub 2009 Sep 21.


Tumor necrosis factor-alpha mediates hemolysis-induced vasoconstriction and the cerebral vasospasm evoked by subarachnoid hemorrhage.

Vecchione C, Frati A, Di Pardo A, Cifelli G, Carnevale D, Gentile MT, Carangi R, Landolfi A, Carullo P, Bettarini U, Antenucci G, Mascio G, Busceti CL, Notte A, Maffei A, Cantore GP, Lembo G.

Hypertension. 2009 Jul;54(1):150-6. doi: 10.1161/HYPERTENSIONAHA.108.128124. Epub 2009 May 26.


Nitric oxide mechanisms of nebivolol.

Maffei A, Lembo G.

Ther Adv Cardiovasc Dis. 2009 Aug;3(4):317-27. doi: 10.1177/1753944709104496. Epub 2009 May 14. Review.


Efficacy of aliskiren/hydrochlorothiazide single-pill combinations in aliskiren non-responders.

Nickenig G, Simanenkov V, Lembo G, Rodriguez P, Salko T, Ritter S, Zhang J.

Blood Press Suppl. 2008 Dec;2:31-40.


Highlights from International Congress : The XI Forum on the Renin-Angiotensin System, Capri, Italy, 11-12 April, 2008.

Azizi M, Borghi C, Coca A, Cosentino F, Crea F, Del Prato S, Lembo G, Mancia G, Modena MG, Rubattu S, Pontremoli R, Ruilope LM, Savoia C, Sciarretta S, Scuteri A, Steckelings UM, Strazzullo P, Trimarco B, Virdis A, Waeber B, Volpe M.

High Blood Press Cardiovasc Prev. 2008 Apr;15(2):91-104. doi: 10.2165/00151642-200815020-00008. No abstract available.


Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs.

Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M.

Circ Res. 2008 Apr 11;102(7):813-22. doi: 10.1161/CIRCRESAHA.107.163188. Epub 2008 Feb 21.

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