Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 120

1.

Kinetic Analysis of Membrane Potential Dye Response to NaV1.7 Channel Activation Identifies Antagonists with Pharmacological Selectivity against NaV1.5.

Finley M, Cassaday J, Kreamer T, Li X, Solly K, O'Donnell G, Clements M, Converso A, Cook S, Daley C, Kraus R, Lai MT, Layton M, Lemaire W, Staas D, Wang J.

J Biomol Screen. 2016 Jun;21(5):480-9. doi: 10.1177/1087057116629669. Epub 2016 Feb 9.

PMID:
26861708
2.

Feminism and the Moral Imperative for Contraception.

LeMaire WJ.

Obstet Gynecol. 2015 Nov;126(5):1108. doi: 10.1097/AOG.0000000000001122. No abstract available.

PMID:
26488505
3.

Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.

Roecker AJ, Mercer SP, Bergman JM, Gilbert KF, Kuduk SD, Harrell CM, Garson SL, Fox SV, Gotter AL, Tannenbaum PL, Prueksaritanont T, Cabalu TD, Cui D, Lemaire W, Winrow CJ, Renger JJ, Coleman PJ.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4992-4999. doi: 10.1016/j.bmcl.2014.12.081. Epub 2015 Jan 6.

PMID:
25613676
4.

Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.

Raheem IT, Breslin MJ, Bruno J, Cabalu TD, Cooke A, Cox CD, Cui D, Garson S, Gotter AL, Fox SV, Harrell CM, Kuduk SD, Lemaire W, Prueksaritanont T, Renger JJ, Stump C, Tannenbaum PL, Williams PD, Winrow CJ, Coleman PJ.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):444-50. doi: 10.1016/j.bmcl.2014.12.056. Epub 2014 Dec 23.

PMID:
25577040
5.

The Catholic medical practitioner, family planning, and the Church.

LeMaire WJ.

J Fam Plann Reprod Health Care. 2015 Jan;41(1):24-6. doi: 10.1136/jfprhc-2014-101013. Epub 2014 Oct 20. No abstract available.

6.

Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.

Roecker AJ, Reger TS, Mattern MC, Mercer SP, Bergman JM, Schreier JD, Cube RV, Cox CD, Li D, Lemaire W, Bruno JG, Harrell CM, Garson SL, Gotter AL, Fox SV, Stevens J, Tannenbaum PL, Prueksaritanont T, Cabalu TD, Cui D, Stellabott J, Hartman GD, Young SD, Winrow CJ, Renger JJ, Coleman PJ.

Bioorg Med Chem Lett. 2014 Oct 15;24(20):4884-90. doi: 10.1016/j.bmcl.2014.08.041. Epub 2014 Aug 26.

PMID:
25248679
7.

Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis.

Roecker AJ, Mercer SP, Harrell CM, Garson SL, Fox SV, Gotter AL, Prueksaritanont T, Cabalu TD, Cui D, Lemaire W, Winrow CJ, Renger JJ, Coleman PJ.

Bioorg Med Chem Lett. 2014 May 1;24(9):2079-85. doi: 10.1016/j.bmcl.2014.03.052. Epub 2014 Mar 26.

PMID:
24704030
8.

Benzimidazole CB2 agonists: design, synthesis and SAR.

Nanda KK, Henze DA, Della Penna K, Desai R, Leitl M, Lemaire W, White RB, Yeh S, Brouillette JN, Hartman GD, Bilodeau MT, Trotter BW.

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1218-21. doi: 10.1016/j.bmcl.2013.12.068. Epub 2013 Dec 25.

PMID:
24461289
9.

Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.

Roecker AJ, Mercer SP, Schreier JD, Cox CD, Fraley ME, Steen JT, Lemaire W, Bruno JG, Harrell CM, Garson SL, Gotter AL, Fox SV, Stevens J, Tannenbaum PL, Prueksaritanont T, Cabalu TD, Cui D, Stellabott J, Hartman GD, Young SD, Winrow CJ, Renger JJ, Coleman PJ.

ChemMedChem. 2014 Feb;9(2):311-22. doi: 10.1002/cmdc.201300447. Epub 2013 Dec 27.

PMID:
24376006
10.

Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).

Mercer SP, Roecker AJ, Garson S, Reiss DR, Meacham Harrell C, Murphy KL, Bruno JG, Bednar RA, Lemaire W, Cui D, Cabalu TD, Tang C, Prueksaritanont T, Hartman GD, Young SD, Winrow CJ, Renger JJ, Coleman PJ.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6620-4. doi: 10.1016/j.bmcl.2013.10.045. Epub 2013 Oct 30.

PMID:
24215892
11.

Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.

Coleman PJ, Schreier JD, Cox CD, Breslin MJ, Whitman DB, Bogusky MJ, McGaughey GB, Bednar RA, Lemaire W, Doran SM, Fox SV, Garson SL, Gotter AL, Harrell CM, Reiss DR, Cabalu TD, Cui D, Prueksaritanont T, Stevens J, Tannenbaum PL, Ball RG, Stellabott J, Young SD, Hartman GD, Winrow CJ, Renger JJ.

ChemMedChem. 2012 Mar 5;7(3):415-24, 337. doi: 10.1002/cmdc.201200025. Epub 2012 Feb 3.

PMID:
22307992
12.

Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.

Trotter BW, Nanda KK, Burgey CS, Potteiger CM, Deng JZ, Green AI, Hartnett JC, Kett NR, Wu Z, Henze DA, Della Penna K, Desai R, Leitl MD, Lemaire W, White RB, Yeh S, Urban MO, Kane SA, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2354-8. doi: 10.1016/j.bmcl.2011.02.082. Epub 2011 Mar 1.

PMID:
21420860
13.

Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia.

Manley PJ, Zartman A, Paone DV, Burgey CS, Henze DA, Della Penna K, Desai R, Leitl MD, Lemaire W, White RB, Yeh S, Urban MO, Kane SA, Hartman GD, Bilodeau MT, Trotter BW.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2359-64. doi: 10.1016/j.bmcl.2011.02.078. Epub 2011 Feb 26.

PMID:
21420857
14.

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.

Cox CD, Breslin MJ, Whitman DB, Schreier JD, McGaughey GB, Bogusky MJ, Roecker AJ, Mercer SP, Bednar RA, Lemaire W, Bruno JG, Reiss DR, Harrell CM, Murphy KL, Garson SL, Doran SM, Prueksaritanont T, Anderson WB, Tang C, Roller S, Cabalu TD, Cui D, Hartman GD, Young SD, Koblan KS, Winrow CJ, Renger JJ, Coleman PJ.

J Med Chem. 2010 Jul 22;53(14):5320-32. doi: 10.1021/jm100541c.

PMID:
20565075
15.

Positive allosteric interaction of structurally diverse T-type calcium channel antagonists.

Uebele VN, Nuss CE, Fox SV, Garson SL, Cristescu R, Doran SM, Kraus RL, Santarelli VP, Li Y, Barrow JC, Yang ZQ, Schlegel KA, Rittle KE, Reger TS, Bednar RA, Lemaire W, Mullen FA, Ballard JE, Tang C, Dai G, McManus OB, Koblan KS, Renger JJ.

Cell Biochem Biophys. 2009;55(2):81-93. doi: 10.1007/s12013-009-9057-4. Epub 2009 Jul 7.

PMID:
19582593
16.

Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.

Whitman DB, Cox CD, Breslin MJ, Brashear KM, Schreier JD, Bogusky MJ, Bednar RA, Lemaire W, Bruno JG, Hartman GD, Reiss DR, Harrell CM, Kraus RL, Li Y, Garson SL, Doran SM, Prueksaritanont T, Li C, Winrow CJ, Koblan KS, Renger JJ, Coleman PJ.

ChemMedChem. 2009 Jul;4(7):1069-74. doi: 10.1002/cmdc.200900069.

PMID:
19418500
17.

Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.

Wolkenberg SE, Zhao Z, Wisnoski DD, Leister WH, O'Brien J, Lemaire W, Williams DL Jr, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Gibson C, Ma BK, Polsky-Fisher SL, Lindsley CW, Hartman GD.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1492-5. doi: 10.1016/j.bmcl.2009.01.015. Epub 2009 Jan 10.

PMID:
19181525
18.

Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.

Zhao Z, Leister WH, O'Brien JA, Lemaire W, Williams DL Jr, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Hartman GD, Lindsley CW, Wolkenberg SE.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1488-91. doi: 10.1016/j.bmcl.2008.12.115. Epub 2009 Jan 9.

PMID:
19179073
19.

A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies.

Zeng Z, O'Brien JA, Lemaire W, O'Malley SS, Miller PJ, Zhao Z, Wallace MA, Raab C, Lindsley CW, Sur C, Williams DL Jr.

Nucl Med Biol. 2008 Apr;35(3):315-25. doi: 10.1016/j.nucmedbio.2007.12.002.

PMID:
18355687
20.

Proline bis-amides as potent dual orexin receptor antagonists.

Bergman JM, Roecker AJ, Mercer SP, Bednar RA, Reiss DR, Ransom RW, Meacham Harrell C, Pettibone DJ, Lemaire W, Murphy KL, Li C, Prueksaritanont T, Winrow CJ, Renger JJ, Koblan KS, Hartman GD, Coleman PJ.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1425-30. doi: 10.1016/j.bmcl.2008.01.001. Epub 2008 Jan 8.

PMID:
18207395
21.

Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists.

Wood MR, Schirripa KM, Kim JJ, Kuduk SD, Chang RK, Di Marco CN, DiPardo RM, Wan BL, Murphy KL, Ransom RW, Chang RS, Holahan MA, Cook JJ, Lemaire W, Mosser SD, Bednar RA, Tang C, Prueksaritanont T, Wallace AA, Mei Q, Yu J, Bohn DL, Clayton FC, Adarayn ED, Sitko GR, Leonard YM, Freidinger RM, Pettibone DJ, Bock MG.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):716-20. Epub 2007 Nov 19.

PMID:
18061443
22.

Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

Zhao Z, Wisnoski DD, O'Brien JA, Lemaire W, Williams DL Jr, Jacobson MA, Wittman M, Ha SN, Schaffhauser H, Sur C, Pettibone DJ, Duggan ME, Conn PJ, Hartman GD, Lindsley CW.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1386-91. Epub 2006 Dec 3.

PMID:
17210250
23.

Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides.

Zhao Z, O'Brien JA, Lemaire W, Williams DL Jr, Jacobson MA, Sur C, Pettibone DJ, Tiller PR, Smith S, Hartman GD, Wolkenberg SE, Lindsley CW.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):5968-72. Epub 2006 Sep 20.

PMID:
16987662
24.

Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides.

Lindsley CW, Zhao Z, Leister WH, O'Brien J, Lemaire W, Williams DL Jr, Chen TB, Chang RS, Burno M, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Tsou NN, Duggan ME, Conn PJ, Hartman GD.

ChemMedChem. 2006 Aug;1(8):807-11. No abstract available.

PMID:
16902933
25.

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.

Kinney GG, O'Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK, Chen TB, Wisnoski DD, Lindsley CW, Tiller PR, Smith S, Jacobson MA, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL Jr.

J Pharmacol Exp Ther. 2005 Apr;313(1):199-206. Epub 2004 Dec 17.

PMID:
15608073
26.

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL Jr, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR.

J Med Chem. 2004 Nov 18;47(24):5825-8.

PMID:
15537338
27.

A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain.

O'Brien JA, Lemaire W, Wittmann M, Jacobson MA, Ha SN, Wisnoski DD, Lindsley CW, Schaffhauser HJ, Rowe B, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL Jr.

J Pharmacol Exp Ther. 2004 May;309(2):568-77. Epub 2004 Jan 27.

PMID:
14747613
28.

Difference in mGluR5 interaction between positive allosteric modulators from two structural classes.

Williams DL Jr, O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Wisnoski DD, Lindsley CW, Sur C, Duggan ME, Pettibone DJ, Conn PJ.

Ann N Y Acad Sci. 2003 Nov;1003:481-4. No abstract available.

PMID:
14684495
29.

Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity.

Williams JB, Mallorga PJ, Lemaire W, Williams DL, Na S, Patel S, Conn PJ, Pettibone DJ, Austin C, Sur C.

Anal Biochem. 2003 Oct 1;321(1):31-7. Erratum in: Anal Biochem. 2012 Oct 1;429(1):18. Conn, Jeffrey P [corrected to Conn, P Jeffrey].

PMID:
12963052
30.
31.

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Lindsley CW, Schaffhauser HJ, Sur C, Pettibone DJ, Conn PJ, Williams DL Jr.

Mol Pharmacol. 2003 Sep;64(3):731-40.

PMID:
12920211
32.

Neurilemmoma: an unusual benign tumor of the cervix.

LeMaire WJ, Kreiss C, Commodore A, Barker EA.

Alaska Med. 2002 Jul-Sep;44(3):63-5.

PMID:
12497666
33.

A nonpeptide oxytocin receptor antagonist radioligand highly selective for human receptors.

Lemaire W, O'Brien JA, Burno M, Chaudhary AG, Dean DC, Williams PD, Freidinger RM, Pettibone DJ, Williams DL Jr.

Eur J Pharmacol. 2002 Aug 16;450(1):19-28.

PMID:
12176104
34.

Placenta percreta with spontaneous rupture of an unscarred uterus in the second trimester.

LeMaire WJ, Louisy C, Dalessandri K, Muschenheim F.

Obstet Gynecol. 2001 Nov;98(5 Pt 2):927-9.

PMID:
11704207
35.

Uterine polypoid hemangioendothelioma: conservative treatment.

Peterson CM, Nadji M, Shapiro A, Hung TT, LeMaire WJ.

Lasers Surg Med. 1996;18(2):206-9.

PMID:
8833291
36.

Angiotensin-converting enzyme inhibitors have no effect on ovulation and ovarian steroidogenesis in the perfused rat ovary.

Peterson CM, Morioka N, Zhu C, Ryan JW, LeMaire WJ.

Reprod Toxicol. 1993;7(2):131-5.

PMID:
8499664
37.

The angiotensin II antagonist saralasin inhibits ovulation in the perfused rat ovary.

Peterson CM, Zhu C, Mukaida T, Butler TA, Woessner JF Jr, LeMaire WJ.

Am J Obstet Gynecol. 1993 Jan;168(1 Pt 1):242-5.

PMID:
8420334
38.

Plasmin activation of collagenase during ovulation in the perfused rat ovary.

Mukaida T, Morioka N, Zhu C, Butler TA, Lemaire WJ, Woessner JF Jr.

Matrix Suppl. 1992;1:402-3. No abstract available.

PMID:
1480073
39.

Inhibition of ovulation in the perfused rat ovary by a synthetic collagenase inhibitor.

Butler TA, Zhu C, Mueller RA, Fuller GC, Lemaire WJ, Woessner JF Jr.

Matrix Suppl. 1992;1:400-1. No abstract available.

PMID:
1480072
40.

Inhibition of ovulation in the perfused rat ovary by the synthetic collagenase inhibitor SC 44463.

Butler TA, Zhu C, Mueller RA, Fuller GC, Lemaire WJ, Woessner JF Jr.

Biol Reprod. 1991 Jun;44(6):1183-8.

PMID:
1714777
41.

Macromastia in a woman treated with penicillamine and oral contraceptives. A case report.

Rose BI, LeMaire WJ, Jeffers LJ.

J Reprod Med. 1990 Jan;35(1):43-5.

PMID:
2299611
42.

Connective tissue breakdown in ovulation.

Woessner JF Jr, Morioka N, Zhu C, Mukaida T, Butler T, LeMaire WJ.

Steroids. 1989 Nov;54(5):491-9.

PMID:
2559498
43.

Mechanism of mammalian ovulation.

LeMaire WJ.

Steroids. 1989 Nov;54(5):455-69. Review.

PMID:
2559497
44.

Mechanism of mammalian ovulation.

Morioka N, Zhu C, Brännström M, Woessner JF, LeMaire WJ.

Prog Clin Biol Res. 1989;294:65-85. Review.

PMID:
2657783
46.

Inhibitors of mammalian tissue collagenase and metalloproteinases suppress ovulation in the perfused rat ovary.

Brännström M, Woessner JF Jr, Koos RD, Sear CH, LeMaire WJ.

Endocrinology. 1988 May;122(5):1715-21.

PMID:
2452070
47.

Ovulation in the perfused ovary in vitro: further evidence that estrogen is not required.

Morioka N, Brännstörm M, Koos RD, LeMaire WJ.

Steroids. 1988 Jan-Feb;51(1-2):173-83.

PMID:
2468193
48.

Inhibition of follicle-stimulating hormone-induced ovulation by indomethacin in the perfused rat ovary.

Sogn JH, Curry TE Jr, Brännström M, Lemaire WJ, Koos RD, Papkoff H, Janson PO.

Biol Reprod. 1987 Apr;36(3):536-42.

PMID:
3109504
49.

The preovulatory increase in ovarian collagenase activity in the rat is independent of prostaglandin production.

Curry TE Jr, Clark MR, Dean DD, Woessner JF Jr, LeMaire WJ.

Endocrinology. 1986 May;118(5):1823-8.

PMID:
3009137
50.

The extraction of a tissue collagenase associated with ovulation in the rat.

Curry TE Jr, Dean DD, Woessner JF Jr, LeMaire WJ.

Biol Reprod. 1985 Nov;33(4):981-91.

PMID:
3002508

Supplemental Content

Loading ...
Support Center