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Genetically engineered animal models of biliary tract cancers.

Pirenne S, Lemaigre FP.

Curr Opin Gastroenterol. 2020 Jan 20. doi: 10.1097/MOG.0000000000000610. [Epub ahead of print]


Development of the Intrahepatic and Extrahepatic Biliary Tract: A Framework for Understanding Congenital Diseases.

Lemaigre FP.

Annu Rev Pathol. 2020 Jan 24;15:1-22. doi: 10.1146/annurev-pathmechdis-012418-013013. Epub 2019 Jul 12.


Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells.

Collet L, Ghurburrun E, Meyers N, Assi M, Pirlot B, Leclercq IA, Couvelard A, Komuta M, Cros J, Demetter P, Lemaigre FP, Borbath I, Jacquemin P.

Gut. 2019 Jun 1. pii: gutjnl-2018-318059. doi: 10.1136/gutjnl-2018-318059. [Epub ahead of print]


Mechanical stimuli control liver homeostasis.

Lemaigre FP.

J Hepatol. 2019 Jul;71(1):12-13. doi: 10.1016/j.jhep.2019.04.002. Epub 2019 Apr 26. No abstract available.


Comparison of the Opn-CreER and Ck19-CreER Drivers in Bile Ducts of Normal and Injured Mouse Livers.

Lesaffer B, Verboven E, Van Huffel L, Moya IM, van Grunsven LA, Leclercq IA, Lemaigre FP, Halder G.

Cells. 2019 Apr 25;8(4). pii: E380. doi: 10.3390/cells8040380.


Dynamics and predicted drug response of a gene network linking dedifferentiation with beta-catenin dysfunction in hepatocellular carcinoma.

Gérard C, Di-Luoffo M, Gonay L, Caruso S, Couchy G, Loriot A, Castven D, Tao J, Konobrocka K, Cordi S, Monga SP, Hanert E, Marquardt JU, Zucman-Rossi J, Lemaigre FP.

J Hepatol. 2019 Aug;71(2):323-332. doi: 10.1016/j.jhep.2019.03.024. Epub 2019 Apr 4.


Liver and Pancreas: Do Similar Embryonic Development and Tissue Organization Lead to Similar Mechanisms of Tumorigenesis?

Ghurburrun E, Borbath I, Lemaigre FP, Jacquemin P.

Gene Expr. 2018 Aug 22;18(3):149-155. doi: 10.3727/105221618X15216414278706. Epub 2018 Mar 26. Review.


Development of the liver: Insights into organ and tissue morphogenesis.

Ober EA, Lemaigre FP.

J Hepatol. 2018 May;68(5):1049-1062. doi: 10.1016/j.jhep.2018.01.005. Epub 2018 Jan 13. Review.


MicroRNA-337-3p controls hepatobiliary gene expression and transcriptional dynamics during hepatic cell differentiation.

Demarez C, Gérard C, Cordi S, Poncy A, Achouri Y, Dauguet N, Rosa DA, Gunning PT, Manfroid I, Lemaigre FP.

Hepatology. 2018 Jan;67(1):313-327. doi: 10.1002/hep.29475. Epub 2017 Nov 16.


Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells.

Augereau C, Collet L, Vargiu P, Guerra C, Ortega S, Lemaigre FP, Jacquemin P.

Hum Mol Genet. 2016 Nov 15;25(22):5017-5026. doi: 10.1093/hmg/ddw332.


Vps33b is crucial for structural and functional hepatocyte polarity.

Hanley J, Dhar DK, Mazzacuva F, Fiadeiro R, Burden JJ, Lyne AM, Smith H, Straatman-Iwanowska A, Banushi B, Virasami A, Mills K, Lemaigre FP, Knisely AS, Howe S, Sebire N, Waddington SN, Paulusma CC, Clayton P, Gissen P.

J Hepatol. 2017 May;66(5):1001-1011. doi: 10.1016/j.jhep.2017.01.001. Epub 2017 Jan 9.


Gene regulatory networks in differentiation and direct reprogramming of hepatic cells.

Gérard C, Tys J, Lemaigre FP.

Semin Cell Dev Biol. 2017 Jun;66:43-50. doi: 10.1016/j.semcdb.2016.12.003. Epub 2016 Dec 12. Review.


Expression of Molecular Differentiation Markers Does Not Correlate with Histological Differentiation Grade in Intrahepatic Cholangiocarcinoma.

Demarez C, Hubert C, Sempoux C, Lemaigre FP.

PLoS One. 2016 Jun 9;11(6):e0157140. doi: 10.1371/journal.pone.0157140. eCollection 2016.


Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.

Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsée J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE.

Development. 2016 Jun 1;143(11):1958-70. doi: 10.1242/dev.134171. Epub 2016 Apr 11.


Extraction of high-quality RNA from pancreatic tissues for gene expression studies.

Augereau C, Lemaigre FP, Jacquemin P.

Anal Biochem. 2016 May 1;500:60-2. doi: 10.1016/j.ab.2016.02.008. Epub 2016 Feb 17.


Role of β-catenin in development of bile ducts.

Cordi S, Godard C, Saandi T, Jacquemin P, Monga SP, Colnot S, Lemaigre FP.

Differentiation. 2016 Jan-Mar;91(1-3):42-9. doi: 10.1016/j.diff.2016.02.001. Epub 2016 Feb 5.


Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.

Mu X, Español-Suñer R, Mederacke I, Affò S, Manco R, Sempoux C, Lemaigre FP, Adili A, Yuan D, Weber A, Unger K, Heikenwälder M, Leclercq IA, Schwabe RF.

J Clin Invest. 2015 Oct 1;125(10):3891-903. doi: 10.1172/JCI77995. Epub 2015 Sep 8.


Proliferation-Independent Initiation of Biliary Cysts in Polycystic Liver Diseases.

Beaudry JB, Cordi S, Demarez C, Lepreux S, Pierreux CE, Lemaigre FP.

PLoS One. 2015 Jun 30;10(6):e0132295. doi: 10.1371/journal.pone.0132295. eCollection 2015.


Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts.

Poncy A, Antoniou A, Cordi S, Pierreux CE, Jacquemin P, Lemaigre FP.

Dev Biol. 2015 Aug 15;404(2):136-48. doi: 10.1016/j.ydbio.2015.05.012. Epub 2015 May 29.


Determining the fate of hepatic cells by lineage tracing: facts and pitfalls.

Lemaigre FP.

Hepatology. 2015 Jun;61(6):2100-3. doi: 10.1002/hep.27659. Epub 2015 Apr 15. Review.


SOX9 regulates ERBB signalling in pancreatic cancer development.

Grimont A, Pinho AV, Cowley MJ, Augereau C, Mawson A, Giry-Laterrière M, Van den Steen G, Waddell N, Pajic M, Sempoux C, Wu J, Grimmond SM, Biankin AV, Lemaigre FP, Rooman I, Jacquemin P.

Gut. 2015 Nov;64(11):1790-9. doi: 10.1136/gutjnl-2014-307075. Epub 2014 Oct 21.


Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.

Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B.

Development. 2014 Feb;141(3):538-47. doi: 10.1242/dev.099481.


Hepatocytes as a source of cholangiocytes in injured liver.

Lemaigre FP.

Hepatology. 2014 Feb;59(2):726-8. doi: 10.1002/hep.26673. Epub 2013 Dec 18. No abstract available.


Reply: To PMID 22922013.

Español-Suñer R, Lemaigre FP, Leclercq IA.

Gastroenterology. 2013 Jul;145(1):255-256. doi: 10.1053/j.gastro.2013.05.037. Epub 2013 May 31. No abstract available.


Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6.

Prévot PP, Augereau C, Simion A, Van den Steen G, Dauguet N, Lemaigre FP, Jacquemin P.

Gastroenterology. 2013 Sep;145(3):668-78.e3. doi: 10.1053/j.gastro.2013.05.016. Epub 2013 May 16.


A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden.

Funnell AP, Wilson MD, Ballester B, Mak KS, Burdach J, Magan N, Pearson RC, Lemaigre FP, Stowell KM, Odom DT, Flicek P, Crossley M.

Am J Hum Genet. 2013 Mar 7;92(3):460-7. doi: 10.1016/j.ajhg.2013.02.003.


Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia.

Prévot PP, Simion A, Grimont A, Colletti M, Khalaileh A, Van den Steen G, Sempoux C, Xu X, Roelants V, Hald J, Bertrand L, Heimberg H, Konieczny SF, Dor Y, Lemaigre FP, Jacquemin P.

Gut. 2012 Dec;61(12):1723-32. doi: 10.1136/gutjnl-2011-300266. Epub 2012 Jan 22.


A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation.

Laudadio I, Manfroid I, Achouri Y, Schmidt D, Wilson MD, Cordi S, Thorrez L, Knoops L, Jacquemin P, Schuit F, Pierreux CE, Odom DT, Peers B, Lemaigre FP.

Gastroenterology. 2012 Jan;142(1):119-29. doi: 10.1053/j.gastro.2011.09.001. Epub 2011 Sep 12.


Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells.

Carpentier R, Suñer RE, van Hul N, Kopp JL, Beaudry JB, Cordi S, Antoniou A, Raynaud P, Lepreux S, Jacquemin P, Leclercq IA, Sander M, Lemaigre FP.

Gastroenterology. 2011 Oct;141(4):1432-8, 1438.e1-4. doi: 10.1053/j.gastro.2011.06.049. Epub 2011 Jun 25.


A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis.

Raynaud P, Tate J, Callens C, Cordi S, Vandersmissen P, Carpentier R, Sempoux C, Devuyst O, Pierreux CE, Courtoy P, Dahan K, Delbecque K, Lepreux S, Pontoglio M, Guay-Woodford LM, Lemaigre FP.

Hepatology. 2011 Jun;53(6):1959-66. doi: 10.1002/hep.24292. Epub 2011 May 2.


Molecular mechanisms of biliary development.

Lemaigre FP.

Prog Mol Biol Transl Sci. 2010;97:103-26. doi: 10.1016/B978-0-12-385233-5.00004-0. Review.


Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas.

Pierreux CE, Cordi S, Hick AC, Achouri Y, Ruiz de Almodovar C, Prévot PP, Courtoy PJ, Carmeliet P, Lemaigre FP.

Dev Biol. 2010 Nov 1;347(1):216-27. doi: 10.1016/j.ydbio.2010.08.024. Epub 2010 Aug 31.


Organogenesis and development of the liver.

Si-Tayeb K, Lemaigre FP, Duncan SA.

Dev Cell. 2010 Feb 16;18(2):175-89. doi: 10.1016/j.devcel.2010.01.011. Review.


Interaction between Hhex and SOX13 modulates Wnt/TCF activity.

Marfil V, Moya M, Pierreux CE, Castell JV, Lemaigre FP, Real FX, Bort R.

J Biol Chem. 2010 Feb 19;285(8):5726-37. doi: 10.1074/jbc.M109.046649. Epub 2009 Dec 22.


Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1.

Hick AC, van Eyll JM, Cordi S, Forez C, Passante L, Kohara H, Nagasawa T, Vanderhaeghen P, Courtoy PJ, Rousseau GG, Lemaigre FP, Pierreux CE.

BMC Dev Biol. 2009 Dec 14;9:66. doi: 10.1186/1471-213X-9-66.


MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2.

Simion A, Laudadio I, Prévot PP, Raynaud P, Lemaigre FP, Jacquemin P.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):293-8. doi: 10.1016/j.bbrc.2009.11.052. Epub 2009 Nov 12.


Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.

Kang HS, Kim YS, ZeRuth G, Beak JY, Gerrish K, Kilic G, Sosa-Pineda B, Jensen J, Pierreux CE, Lemaigre FP, Foley J, Jetten AM.

Mol Cell Biol. 2009 Dec;29(24):6366-79. doi: 10.1128/MCB.01259-09. Epub 2009 Oct 5. Erratum in: Mol Cell Biol. 2010 Apr;30(7):1864. Pierreux, Christophe E [added]; Lemaigre, Frederic P [added].


Biliary differentiation and bile duct morphogenesis in development and disease.

Raynaud P, Carpentier R, Antoniou A, Lemaigre FP.

Int J Biochem Cell Biol. 2011 Feb;43(2):245-56. doi: 10.1016/j.biocel.2009.07.020. Epub 2009 Sep 6. Review.


Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9.

Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger BZ, Jacquemin P, Pierreux CE, Clotman F, Lemaigre FP.

Gastroenterology. 2009 Jun;136(7):2325-33. doi: 10.1053/j.gastro.2009.02.051. Epub 2009 Feb 21.


Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies.

Lemaigre FP.

Gastroenterology. 2009 Jul;137(1):62-79. doi: 10.1053/j.gastro.2009.03.035. Epub 2009 Mar 27. Review.


Notch signaling in bile duct development: new insights raise new questions.

Lemaigre FP.

Hepatology. 2008 Aug;48(2):358-60. doi: 10.1002/hep.22480. No abstract available.


Role of metalloproteinases at the onset of liver development.

Margagliotti S, Clotman F, Pierreux CE, Lemoine P, Rousseau GG, Henriet P, Lemaigre FP.

Dev Growth Differ. 2008 Jun;50(5):331-8. doi: 10.1111/j.1440-169X.2008.01031.x. Epub 2008 Apr 28.


Lack of cilia and differentiation defects in the liver of human foetuses with the Meckel syndrome.

Clotman F, Libbrecht L, Killingsworth MC, Loo CC, Roskams T, Lemaigre FP.

Liver Int. 2008 Mar;28(3):377-84. Epub 2007 Nov 1.


The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration.

Margagliotti S, Clotman F, Pierreux CE, Beaudry JB, Jacquemin P, Rousseau GG, Lemaigre FP.

Dev Biol. 2007 Nov 15;311(2):579-89. Epub 2007 Sep 16.


Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation.

Vanhorenbeeck V, Jenny M, Cornut JF, Gradwohl G, Lemaigre FP, Rousseau GG, Jacquemin P.

Dev Biol. 2007 May 15;305(2):685-94. Epub 2007 Feb 28.


Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development.

Beaudry JB, Pierreux CE, Hayhurst GP, Plumb-Rudewiez N, Weiss MC, Rousseau GG, Lemaigre FP.

Mol Cell Biol. 2006 Aug;26(16):6037-46.


The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.

Pierreux CE, Poll AV, Kemp CR, Clotman F, Maestro MA, Cordi S, Ferrer J, Leyns L, Rousseau GG, Lemaigre FP.

Gastroenterology. 2006 Feb;130(2):532-41.


Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.

van Eyll JM, Passante L, Pierreux CE, Lemaigre FP, Vanderhaeghen P, Rousseau GG.

Gene Expr Patterns. 2006 Apr;6(4):353-9. Epub 2006 Jan 30.


An endothelial-mesenchymal relay pathway regulates early phases of pancreas development.

Jacquemin P, Yoshitomi H, Kashima Y, Rousseau GG, Lemaigre FP, Zaret KS.

Dev Biol. 2006 Feb 1;290(1):189-99. Epub 2006 Jan 4.


A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells.

Poll AV, Pierreux CE, Lokmane L, Haumaitre C, Achouri Y, Jacquemin P, Rousseau GG, Cereghini S, Lemaigre FP.

Diabetes. 2006 Jan;55(1):61-9.

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