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Items: 1 to 50 of 56

1.

Lung Cancer-Related Mortality With Inhaled Insulin or a Comparator: Follow-Up Study of patients previously enrolled in Exubera Controlled Clinical Trials (FUSE) Final Results.

Gatto NM, Koralek DO, Bracken MB, Duggan WT, Lem J, Klioze S, Koch GG, Wise RA, Cohen RB, Jackson NC.

Diabetes Care. 2019 Sep;42(9):1708-1715. doi: 10.2337/dc18-2529. Epub 2019 Jul 22.

PMID:
31331907
2.

Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress.

Dickson DA, Paulus JK, Mensah V, Lem J, Saavedra-Rodriguez L, Gentry A, Pagidas K, Feig LA.

Transl Psychiatry. 2018 May 23;8(1):101. doi: 10.1038/s41398-018-0146-2.

3.

Probing Homogeneous Line Broadening in CdSe Nanocrystals Using Multidimensional Electronic Spectroscopy.

Gellen TA, Lem J, Turner DB.

Nano Lett. 2017 May 10;17(5):2809-2815. doi: 10.1021/acs.nanolett.6b05068. Epub 2017 Apr 20.

PMID:
28422505
4.

Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes.

Cowan CS, Abd-El-Barr M, van der Heijden M, Lo EM, Paul D, Bramblett DE, Lem J, Simons DL, Wu SM.

Vision Res. 2016 Feb;119:99-109. doi: 10.1016/j.visres.2015.11.006. Epub 2016 Feb 5.

5.

CCN5 Expression in mammals. III. Early embryonic mouse development.

Myers RB, Rwayitare K, Richey L, Lem J, Castellot JJ Jr.

J Cell Commun Signal. 2012 Dec;6(4):217-23. doi: 10.1007/s12079-012-0176-0. Epub 2012 Aug 28.

6.

Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics.

Makino CL, Wen XH, Michaud NA, Covington HI, DiBenedetto E, Hamm HE, Lem J, Caruso G.

PLoS One. 2012;7(5):e37832. doi: 10.1371/journal.pone.0037832. Epub 2012 May 25.

7.

Is the large simple trial design used for comparative, post-approval safety research? A review of a clinical trials registry and the published literature.

Reynolds RF, Lem JA, Gatto NM, Eng SM.

Drug Saf. 2011 Oct 1;34(10):799-820. doi: 10.2165/11593820-000000000-00000. Review.

PMID:
21879776
8.

ECG on the road: robust and unobtrusive estimation of heart rate.

Wartzek T, Eilebrecht B, Lem J, Lindner HJ, Leonhardt S, Walter M.

IEEE Trans Biomed Eng. 2011 Nov;58(11):3112-20. doi: 10.1109/TBME.2011.2163715. Epub 2011 Aug 4.

PMID:
21824839
9.

Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo.

Zachar Z, Marecek J, Maturo C, Gupta S, Stuart SD, Howell K, Schauble A, Lem J, Piramzadian A, Karnik S, Lee K, Rodriguez R, Shorr R, Bingham PM.

J Mol Med (Berl). 2011 Nov;89(11):1137-48. doi: 10.1007/s00109-011-0785-8. Epub 2011 Jul 19.

PMID:
21769686
10.

Palmitoylation stabilizes unliganded rod opsin.

Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8428-33. doi: 10.1073/pnas.1000640107. Epub 2010 Apr 19.

11.

Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.

Pang JJ, Gao F, Lem J, Bramblett DE, Paul DL, Wu SM.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):395-400. doi: 10.1073/pnas.0907178107. Epub 2009 Dec 14.

12.

Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.

Abd-El-Barr MM, Pennesi ME, Saszik SM, Barrow AJ, Lem J, Bramblett DE, Paul DL, Frishman LJ, Wu SM.

J Neurophysiol. 2009 Sep;102(3):1945-55. doi: 10.1152/jn.00142.2009. Epub 2009 Jul 8.

13.

Modulation of molecular interactions and function by rhodopsin palmitylation.

Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K.

Biochemistry. 2009 May 26;48(20):4294-304. doi: 10.1021/bi900417b.

14.

Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors.

Wen XH, Shen L, Brush RS, Michaud N, Al-Ubaidi MR, Gurevich VV, Hamm HE, Lem J, Dibenedetto E, Anderson RE, Makino CL.

Biophys J. 2009 Feb;96(3):939-50. doi: 10.1016/j.bpj.2008.10.016.

15.

Rhodopsin-mediated retinitis pigmentosa.

Malanson KM, Lem J.

Prog Mol Biol Transl Sci. 2009;88:1-31. doi: 10.1016/S1877-1173(09)88001-0. Epub 2009 Oct 7. Review.

PMID:
20374723
16.

A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin.

Brill E, Malanson KM, Radu RA, Boukharov NV, Wang Z, Chung HY, Lloyd MB, Bok D, Travis GH, Obin M, Lem J.

Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5445-53.

17.

Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins.

Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ.

J Neurosci. 2007 May 16;27(20):5484-94.

18.

G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor.

Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RV.

J Biol Chem. 2007 Mar 30;282(13):9865-73. Epub 2007 Feb 1.

19.

Lentiviral vectors containing a retinal pigment epithelium specific promoter for leber congenital amaurosis gene therapy. Lentiviral gene therapy for LCA.

Bemelmans AP, Kostic C, Hornfeld D, Jaquet M, Crippa SV, Hauswirth WW, Lem J, Wang Z, Schorderet DE, Munier FL, Wenzel A, Arsenijevic Y.

Adv Exp Med Biol. 2006;572:247-53. No abstract available.

PMID:
17249581
20.

Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography.

Srinivasan VJ, Ko TH, Wojtkowski M, Carvalho M, Clermont A, Bursell SE, Song QH, Lem J, Duker JS, Schuman JS, Fujimoto JG.

Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5522-8.

21.

Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosis.

Bemelmans AP, Kostic C, Crippa SV, Hauswirth WW, Lem J, Munier FL, Seeliger MW, Wenzel A, Arsenijevic Y.

PLoS Med. 2006 Oct;3(10):e347.

22.

Phototransduction in a transgenic mouse model of Nougaret night blindness.

Moussaif M, Rubin WW, Kerov V, Reh R, Chen D, Lem J, Chen CK, Hurley JB, Burns ME, Artemyev NO.

J Neurosci. 2006 Jun 21;26(25):6863-72.

23.

Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.

Nikonov SS, Kholodenko R, Lem J, Pugh EN Jr.

J Gen Physiol. 2006 Apr;127(4):359-74.

24.

A critical role of CaBP4 in the cone synapse.

Maeda T, Lem J, Palczewski K, Haeseleer F.

Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4320-7.

25.

Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin.

Wang Z, Wen XH, Ablonczy Z, Crouch RK, Makino CL, Lem J.

J Biol Chem. 2005 Jul 1;280(26):24293-300. Epub 2005 Apr 25.

26.

Retinal abnormalities associated with the G90D mutation in opsin.

Naash MI, Wu TH, Chakraborty D, Fliesler SJ, Ding XQ, Nour M, Peachey NS, Lem J, Qtaishat N, Al-Ubaidi MR, Ripps H.

J Comp Neurol. 2004 Oct 11;478(2):149-63. Erratum in: J Comp Neurol. 2004 Dec 6;480(2):250.

PMID:
15349976
27.

Umami taste responses are mediated by alpha-transducin and alpha-gustducin.

He W, Yasumatsu K, Varadarajan V, Yamada A, Lem J, Ninomiya Y, Margolskee RF, Damak S.

J Neurosci. 2004 Sep 1;24(35):7674-80.

28.

Bright light induces retinal degeneration by a transducin-independent mechanism.

Brill E, Patnala S, Lem J, Obin M.

Adv Exp Med Biol. 2003;533:213-9. No abstract available.

PMID:
15180267
29.

New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant.

Danciger M, Lyon J, Worrill D, Hoffman S, Lem J, Reme CE, Wenzel A, Grimm C.

Mamm Genome. 2004 Apr;15(4):277-83.

PMID:
15112105
30.

Early receptor current of wild-type and transducin knockout mice: photosensitivity and light-induced Ca2+ release.

Woodruff ML, Lem J, Fain GL.

J Physiol. 2004 Jun 15;557(Pt 3):821-8. Epub 2004 Apr 8.

31.

Constitutive opsin signaling: night blindness or retinal degeneration?

Lem J, Fain GL.

Trends Mol Med. 2004 Apr;10(4):150-7.

PMID:
15059605
32.

The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.

Martemyanov KA, Lishko PV, Calero N, Keresztes G, Sokolov M, Strissel KJ, Leskov IB, Hopp JA, Kolesnikov AV, Chen CK, Lem J, Heller S, Burns ME, Arshavsky VY.

J Neurosci. 2003 Nov 12;23(32):10175-81.

33.

Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis.

Woodruff ML, Wang Z, Chung HY, Redmond TM, Fain GL, Lem J.

Nat Genet. 2003 Oct;35(2):158-64. Epub 2003 Sep 21.

PMID:
14517541
34.

Piecing together the timetable for visual transduction with transgenic animals.

Makino CL, Wen XH, Lem J.

Curr Opin Neurobiol. 2003 Aug;13(4):404-12. Review.

PMID:
12965286
35.

Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice.

Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG, Yau KW.

Nature. 2003 Jul 3;424(6944):76-81. Epub 2003 Jun 15.

36.
37.

Evidence for two apoptotic pathways in light-induced retinal degeneration.

Hao W, Wenzel A, Obin MS, Chen CK, Brill E, Krasnoperova NV, Eversole-Cire P, Kleyner Y, Taylor A, Simon MI, Grimm C, Remé CE, Lem J.

Nat Genet. 2002 Oct;32(2):254-60. Epub 2002 Sep 3.

PMID:
12219089
38.

Measurement of cytoplasmic calcium concentration in the rods of wild-type and transducin knock-out mice.

Woodruff ML, Sampath AP, Matthews HR, Krasnoperova NV, Lem J, Fain GL.

J Physiol. 2002 Aug 1;542(Pt 3):843-54.

39.

Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy.

Lyubarsky AL, Lem J, Chen J, Falsini B, Iannaccone A, Pugh EN Jr.

Vision Res. 2002 Feb;42(4):401-15.

40.

Membrane protein diffusion sets the speed of rod phototransduction.

Calvert PD, Govardovskii VI, Krasnoperova N, Anderson RE, Lem J, Makino CL.

Nature. 2001 May 3;411(6833):90-4.

PMID:
11333983
41.

AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse.

Liang FQ, Dejneka NS, Cohen DR, Krasnoperova NV, Lem J, Maguire AM, Dudus L, Fisher KJ, Bennett J.

Mol Ther. 2001 Feb;3(2):241-8.

42.

Mutant rhodopsin transgene expression on a null background.

Frederick JM, Krasnoperova NV, Hoffmann K, Church-Kopish J, Rüther K, Howes K, Lem J, Baehr W.

Invest Ophthalmol Vis Sci. 2001 Mar;42(3):826-33.

PMID:
11222546
43.

The relationship between opsin overexpression and photoreceptor degeneration.

Tan E, Wang Q, Quiambao AB, Xu X, Qtaishat NM, Peachey NS, Lem J, Fliesler SJ, Pepperberg DR, Naash MI, Al-Ubaidi MR.

Invest Ophthalmol Vis Sci. 2001 Mar;42(3):589-600.

PMID:
11222515
44.

Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit.

Calvert PD, Krasnoperova NV, Lyubarsky AL, Isayama T, Nicoló M, Kosaras B, Wong G, Gannon KS, Margolskee RF, Sidman RL, Pugh EN Jr, Makino CL, Lem J.

Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13913-8. Erratum in: Proc Natl Acad Sci U S A 2001 Aug 28;98(18):10515.

45.

Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites.

Mendez A, Burns ME, Roca A, Lem J, Wu LW, Simon MI, Baylor DA, Chen J.

Neuron. 2000 Oct;28(1):153-64.

46.

Functional study of rhodopsin phosphorylation in vivo.

Mendez A, Krasnoperova NV, Lem J, Chen J.

Methods Enzymol. 2000;316:167-85. No abstract available.

PMID:
10800675
47.

Morphological, physiological, and biochemical changes in rhodopsin knockout mice.

Lem J, Krasnoperova NV, Calvert PD, Kosaras B, Cameron DA, Nicolò M, Makino CL, Sidman RL.

Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):736-41.

48.

Phototransduction in transgenic mice.

Lem J, Makino CL.

Curr Opin Neurobiol. 1996 Aug;6(4):453-8. Review.

PMID:
8794096
49.

Downregulation of cGMP phosphodiesterase induced by expression of GTPase-deficient cone transducin in mouse rod photoreceptors.

Raport CJ, Lem J, Makino C, Chen CK, Fitch CL, Hobson A, Baylor D, Simon MI, Hurley JB.

Invest Ophthalmol Vis Sci. 1994 Jun;35(7):2932-47.

PMID:
8206711
50.

The human blue opsin promoter directs transgene expression in short-wave cones and bipolar cells in the mouse retina.

Chen J, Tucker CL, Woodford B, Szél A, Lem J, Gianella-Borradori A, Simon MI, Bogenmann E.

Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2611-5.

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