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Items: 50

1.

Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex.

Zhang Q, Narayanan V, Mui KL, O'Bryan CS, Anderson RH, Kc B, Cabe JI, Denis KB, Antoku S, Roux KJ, Dickinson RB, Angelini TE, Gundersen GG, Conway DE, Lele TP.

Curr Biol. 2019 Sep 9;29(17):2826-2839.e4. doi: 10.1016/j.cub.2019.07.021. Epub 2019 Aug 8.

PMID:
31402305
2.

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver.

Bennett RL, Bele A, Small EC, Will CM, Nabet B, Oyer JA, Huang X, Ghosh RP, Grzybowski AT, Yu T, Zhang Q, Riva A, Lele TP, Schatz GC, Kelleher NL, Ruthenburg AJ, Liphardt J, Licht JD.

Cancer Discov. 2019 Jul 23. doi: 10.1158/2159-8290.CD-19-0393. [Epub ahead of print]

PMID:
31337617
3.

Mechanics of nuclear membranes.

Agrawal A, Lele TP.

J Cell Sci. 2019 Jul 15;132(14). pii: jcs229245. doi: 10.1242/jcs.229245. Review.

PMID:
31308244
4.

Repair of nuclear ruptures requires barrier-to-autointegration factor.

Halfmann CT, Sears RM, Katiyar A, Busselman BW, Aman LK, Zhang Q, O'Bryan CS, Angelini TE, Lele TP, Roux KJ.

J Cell Biol. 2019 Jul 1;218(7):2136-2149. doi: 10.1083/jcb.201901116. Epub 2019 May 30.

PMID:
31147383
5.

Apical cell protrusions cause vertical deformation of the soft cancer nucleus.

Kent IA, Zhang Q, Katiyar A, Li Y, Pathak S, Dickinson RB, Lele TP.

J Cell Physiol. 2019 Nov;234(11):20675-20684. doi: 10.1002/jcp.28672. Epub 2019 Apr 21.

PMID:
31006858
6.

Local, transient tensile stress on the nuclear membrane causes membrane rupture.

Zhang Q, Tamashunas AC, Agrawal A, Torbati M, Katiyar A, Dickinson RB, Lammerding J, Lele TP.

Mol Biol Cell. 2019 Mar 21;30(7):899-906. doi: 10.1091/mbc.E18-09-0604. Epub 2018 Dec 19.

7.

Periodontal cell mechanotransduction.

Chukkapalli SS, Lele TP.

Open Biol. 2018 Aug 16;8(9). pii: 180053. doi: 10.1098/rsob.180053. Review.

8.

Mechanical principles of nuclear shaping and positioning.

Lele TP, Dickinson RB, Gundersen GG.

J Cell Biol. 2018 Oct 1;217(10):3330-3342. doi: 10.1083/jcb.201804052. Epub 2018 Sep 7. Review.

9.

Direct Force Probe for Nuclear Mechanics.

Tocco VJ, Neelam S, Zhang Q, Dickinson RB, Lele TP.

Methods Mol Biol. 2018;1840:81-90. doi: 10.1007/978-1-4939-8691-0_8.

10.

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton.

Zhang Q, Tamashunas AC, Lele TP.

J Vis Exp. 2018 Jul 29;(137). doi: 10.3791/58038.

11.

The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells.

Tocco VJ, Li Y, Christopher KG, Matthews JH, Aggarwal V, Paschall L, Luesch H, Licht JD, Dickinson RB, Lele TP.

J Cell Physiol. 2018 Feb;233(2):1446-1454. doi: 10.1002/jcp.26031. Epub 2017 Jul 31.

12.

The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity.

Alam SG, Zhang Q, Prasad N, Li Y, Chamala S, Kuchibhotla R, Kc B, Aggarwal V, Shrestha S, Jones AL, Levy SE, Roux KJ, Nickerson JA, Lele TP.

Sci Rep. 2016 Dec 1;6:38063. doi: 10.1038/srep38063.

13.

Ultradonut topology of the nuclear envelope.

Torbati M, Lele TP, Agrawal A.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11094-11099. Epub 2016 Sep 19.

14.

Microtubule-based force generation.

Kent IA, Lele TP.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 May;9(3). doi: 10.1002/wnan.1428. Epub 2016 Aug 25. Review.

15.

An unresolved LINC in the nuclear envelope.

Torbati M, Lele TP, Agrawal A.

Cell Mol Bioeng. 2016 Jun;9(2):252-257. Epub 2016 Feb 18.

16.

Transient Pinning and Pulling: A Mechanism for Bending Microtubules.

Kent IA, Rane PS, Dickinson RB, Ladd AJ, Lele TP.

PLoS One. 2016 Mar 14;11(3):e0151322. doi: 10.1371/journal.pone.0151322. eCollection 2016.

17.

Concentration Sensing by the Moving Nucleus in Cell Fate Determination: A Computational Analysis.

Aggarwal V, Dickinson RB, Lele TP.

PLoS One. 2016 Feb 12;11(2):e0149213. doi: 10.1371/journal.pone.0149213. eCollection 2016.

18.

Vertical uniformity of cells and nuclei in epithelial monolayers.

Neelam S, Hayes PR, Zhang Q, Dickinson RB, Lele TP.

Sci Rep. 2016 Jan 22;6:19689. doi: 10.1038/srep19689.

19.

Coordinated Dynamics of RNA Splicing Speckles in the Nucleus.

Zhang Q, Kota KP, Alam SG, Nickerson JA, Dickinson RB, Lele TP.

J Cell Physiol. 2016 Jun;231(6):1269-75. doi: 10.1002/jcp.25224. Epub 2015 Nov 24.

20.

Dynamic, mechanical integration between nucleus and cell- where physics meets biology.

Dickinson RB, Neelam S, Lele TP.

Nucleus. 2015;6(5):360-5. doi: 10.1080/19491034.2015.1090074. Review.

21.

Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading.

Li Y, Lovett D, Zhang Q, Neelam S, Kuchibhotla RA, Zhu R, Gundersen GG, Lele TP, Dickinson RB.

Biophys J. 2015 Aug 18;109(4):670-86. doi: 10.1016/j.bpj.2015.07.006.

22.

New approaches for understanding the nuclear force balance in living, adherent cells.

Neelam S, Dickinson RB, Lele TP.

Methods. 2016 Feb 1;94:27-32. doi: 10.1016/j.ymeth.2015.06.014. Epub 2015 Jun 24. Review.

23.

The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts.

Alam SG, Lovett D, Kim DI, Roux KJ, Dickinson RB, Lele TP.

J Cell Sci. 2015 May 15;128(10):1901-11. doi: 10.1242/jcs.161703. Epub 2015 Apr 23.

24.

Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell.

Neelam S, Chancellor TJ, Li Y, Nickerson JA, Roux KJ, Dickinson RB, Lele TP.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5720-5. doi: 10.1073/pnas.1502111112. Epub 2015 Apr 21.

25.

Nuclear forces and cell mechanosensing.

Alam S, Lovett DB, Dickinson RB, Roux KJ, Lele TP.

Prog Mol Biol Transl Sci. 2014;126:205-15. doi: 10.1016/B978-0-12-394624-9.00008-7. Review.

26.

Actomyosin pulls to advance the nucleus in a migrating tissue cell.

Wu J, Kent IA, Shekhar N, Chancellor TJ, Mendonca A, Dickinson RB, Lele TP.

Biophys J. 2014 Jan 7;106(1):7-15. doi: 10.1016/j.bpj.2013.11.4489.

27.

FLUCTUATING MOTOR FORCES BEND GROWING MICROTUBULES.

Shekhar N, Neelam S, Wu J, Ladd AJ, Dickinson RB, Lele TP.

Cell Mol Bioeng. 2013 Jun 1;6(2):120-129.

28.

The effect of cyclic mechanical strain on activation of dendritic cells cultured on adhesive substrates.

Lewis JS, Dolgova NV, Chancellor TJ, Acharya AP, Karpiak JV, Lele TP, Keselowsky BG.

Biomaterials. 2013 Dec;34(36):9063-70. doi: 10.1016/j.biomaterials.2013.08.021. Epub 2013 Sep 3.

29.

Modulation of Nuclear Shape by Substrate Rigidity.

Lovett DB, Shekhar N, Nickerson JA, Roux KJ, Lele TP.

Cell Mol Bioeng. 2013 Jun 1;6(2):230-238.

30.

Cytoplasmic dynein: tension generation on microtubules and the nucleus.

Shekhar N, Wu J, Dickinson RB, Lele TP.

Cell Mol Bioeng. 2013 Mar 1;6(1):74-81.

31.

FRAP analysis: accounting for bleaching during image capture.

Wu J, Shekhar N, Lele PP, Lele TP.

PLoS One. 2012;7(8):e42854. doi: 10.1371/journal.pone.0042854. Epub 2012 Aug 9.

32.

Investigation of in vivo microtubule and stress fiber mechanics with laser ablation.

Wu J, Dickinson RB, Lele TP.

Integr Biol (Camb). 2012 May;4(5):471-9. doi: 10.1039/c2ib20015e. Epub 2012 Apr 11. Review.

PMID:
22495508
33.

Effects of dynein on microtubule mechanics and centrosome positioning.

Wu J, Misra G, Russell RJ, Ladd AJ, Lele TP, Dickinson RB.

Mol Biol Cell. 2011 Dec;22(24):4834-41. doi: 10.1091/mbc.E11-07-0611. Epub 2011 Oct 19.

34.

How dynein and microtubules rotate the nucleus.

Wu J, Lee KC, Dickinson RB, Lele TP.

J Cell Physiol. 2011 Oct;226(10):2666-74. doi: 10.1002/jcp.22616.

PMID:
21792925
35.

Sarcomere length fluctuations and flow in capillary endothelial cells.

Russell RJ, Grubbs AY, Mangroo SP, Nakasone SE, Dickinson RB, Lele TP.

Cytoskeleton (Hoboken). 2011 Mar;68(3):150-6. doi: 10.1002/cm.20501. Epub 2011 Feb 3.

PMID:
21225702
36.

Stamp wound assay for studying coupled cell migration and cell debris clearance.

Lee J, Wang YL, Ren F, Lele TP.

Langmuir. 2010 Nov 16;26(22):16672-6. doi: 10.1021/la103542y. Epub 2010 Oct 20.

PMID:
20961056
37.

Modulating malignant epithelial tumor cell adhesion, migration and mechanics with nanorod surfaces.

Lee J, Chu BH, Sen S, Gupte A, Chancellor TJ, Chang CY, Ren F, Kumar S, Lele TP.

Biomed Microdevices. 2011 Feb;13(1):89-95. doi: 10.1007/s10544-010-9473-7.

PMID:
20830527
38.

Contributions of surface topography and cytotoxicity to the macrophage response to zinc oxide nanorods.

Zaveri TD, Dolgova NV, Chu BH, Lee J, Wong J, Lele TP, Ren F, Keselowsky BG.

Biomaterials. 2010 Apr;31(11):2999-3007. doi: 10.1016/j.biomaterials.2009.12.055. Epub 2010 Jan 15.

PMID:
20074795
39.

Sarcomere mechanics in capillary endothelial cells.

Russell RJ, Xia SL, Dickinson RB, Lele TP.

Biophys J. 2009 Sep 16;97(6):1578-85. doi: 10.1016/j.bpj.2009.07.017.

40.

Randomly oriented, upright SiO2 coated nanorods for reduced adhesion of mammalian cells.

Lee J, Chu BH, Chen KH, Ren F, Lele TP.

Biomaterials. 2009 Sep;30(27):4488-93. doi: 10.1016/j.biomaterials.2009.05.028. Epub 2009 Jun 10.

PMID:
19515416
41.

The control of cell adhesion and viability by zinc oxide nanorods.

Lee J, Kang BS, Hicks B, Chancellor TF Jr, Chu BH, Wang HT, Keselowsky BG, Ren F, Lele TP.

Biomaterials. 2008 Sep;29(27):3743-9. doi: 10.1016/j.biomaterials.2008.05.029. Epub 2008 Jun 11.

PMID:
18550161
42.

Investigating complexity of protein-protein interactions in focal adhesions.

Lele TP, Thodeti CK, Pendse J, Ingber DE.

Biochem Biophys Res Commun. 2008 May 9;369(3):929-34. doi: 10.1016/j.bbrc.2008.02.137. Epub 2008 Mar 10.

43.

Toward in situ biochemistry: combining chemical kinetics approaches with biomolecular imaging in living cells.

Chancellor TF Jr, Russell RJ, Dravid V, Lele TP.

Biotechnol Prog. 2008 Jan-Feb;24(1):89-95. Epub 2007 Sep 26.

PMID:
17894467
44.
45.

Tools to study cell mechanics and mechanotransduction.

Lele TP, Sero JE, Matthews BD, Kumar S, Xia S, Montoya-Zavala M, Polte T, Overby D, Wang N, Ingber DE.

Methods Cell Biol. 2007;83:443-72.

PMID:
17613320
46.

Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent.

Sharp ZD, Mancini MG, Hinojos CA, Dai F, Berno V, Szafran AT, Smith KP, Lele TP, Ingber DE, Mancini MA.

J Cell Sci. 2006 Oct 1;119(Pt 19):4101-16. Epub 2006 Sep 12. Erratum in: J Cell Sci. 2006 Oct 15;119(Pt 20):4365. Lele, Tanmay T [corrected to Lele, Tanmay P].

47.

Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics.

Kumar S, Maxwell IZ, Heisterkamp A, Polte TR, Lele TP, Salanga M, Mazur E, Ingber DE.

Biophys J. 2006 May 15;90(10):3762-73. Epub 2006 Feb 24.

48.
49.

Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells.

Lele TP, Pendse J, Kumar S, Salanga M, Karavitis J, Ingber DE.

J Cell Physiol. 2006 Apr;207(1):187-94.

PMID:
16288479

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