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Items: 40

1.

T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma.

Leivonen SK, Pollari M, Brück O, Pellinen T, Autio M, Karjalainen-Lindsberg ML, Mannisto S, Kellokumpu-Lehtinen PL, Kallioniemi O, Mustjoki S, Leppä S.

Haematologica. 2018 Sep 20. pii: haematol.2018.200105. doi: 10.3324/haematol.2018.200105. [Epub ahead of print]

2.

PD-L1+ tumor-associated macrophages and PD-1+ tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma.

Pollari M, Brück O, Pellinen T, Vähämurto P, Karjalainen-Lindsberg ML, Mannisto S, Kallioniemi O, Kellokumpu-Lehtinen PL, Mustjoki S, Leivonen SK, Leppä S.

Haematologica. 2018 Nov;103(11):1908-1914. doi: 10.3324/haematol.2018.197194. Epub 2018 Jul 19.

3.

MicroRNAs regulate key cell survival pathways and mediate chemosensitivity during progression of diffuse large B-cell lymphoma.

Leivonen SK, Icay K, Jäntti K, Siren I, Liu C, Alkodsi A, Cervera A, Ludvigsen M, Hamilton-Dutoit SJ, d'Amore F, Karjalainen-Lindsberg ML, Delabie J, Holte H, Lehtonen R, Hautaniemi S, Leppä S.

Blood Cancer J. 2017 Dec 15;7(12):654. doi: 10.1038/s41408-017-0033-8.

4.

Alternative splicing discriminates molecular subtypes and has prognostic impact in diffuse large B-cell lymphoma.

Leivonen SK, Taskinen M, Cervera A, Karjalainen-Lindsberg ML, Delabie J, Holte H, Lehtonen R, Hautaniemi S, Leppä S.

Blood Cancer J. 2017 Aug 25;7(8):e596. doi: 10.1038/bcj.2017.71.

5.

Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample.

Chudal R, Leivonen S, Rintala H, Hinkka-Yli-Salomäki S, Sourander A.

J Affect Disord. 2017 Dec 1;223:101-105. doi: 10.1016/j.jad.2017.07.033. Epub 2017 Jul 18.

PMID:
28738196
6.

Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response.

Jernström S, Hongisto V, Leivonen SK, Due EU, Tadele DS, Edgren H, Kallioniemi O, Perälä M, Mælandsmo GM, Sahlberg KK.

Breast Cancer (Dove Med Press). 2017 Mar 21;9:185-198. doi: 10.2147/BCTT.S115600. eCollection 2017.

7.

Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome.

Aure MR, Vitelli V, Jernström S, Kumar S, Krohn M, Due EU, Haukaas TH, Leivonen SK, Vollan HK, Lüders T, Rødland E, Vaske CJ, Zhao W, Møller EK, Nord S, Giskeødegård GF, Bathen TF, Caldas C, Tramm T, Alsner J, Overgaard J, Geisler J, Bukholm IR, Naume B, Schlichting E, Sauer T, Mills GB, Kåresen R, Mælandsmo GM, Lingjærde OC, Frigessi A, Kristensen VN, Børresen-Dale AL, Sahlberg KK; OSBREAC.

Breast Cancer Res. 2017 Mar 29;19(1):44. doi: 10.1186/s13058-017-0812-y.

8.

Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study.

Leivonen S, Scharf JM, Mathews CA, Chudal R, Gyllenberg D, Sucksdorff D, Suominen A, Voutilainen A, Brown AS, Sourander A.

J Am Acad Child Adolesc Psychiatry. 2017 Apr;56(4):297-303.e4. doi: 10.1016/j.jaac.2017.01.009. Epub 2017 Feb 2.

PMID:
28335873
9.

Register-based study of the incidence, comorbidities and demographics of obsessive-compulsive disorder in specialist healthcare.

Rintala H, Chudal R, Leppämäki S, Leivonen S, Hinkka-Yli-Salomäki S, Sourander A.

BMC Psychiatry. 2017 Feb 10;17(1):64. doi: 10.1186/s12888-017-1224-3.

10.

Risk of Psychiatric and Neurodevelopmental Disorders Among Siblings of Probands With Autism Spectrum Disorders.

Jokiranta-Olkoniemi E, Cheslack-Postava K, Sucksdorff D, Suominen A, Gyllenberg D, Chudal R, Leivonen S, Gissler M, Brown AS, Sourander A.

JAMA Psychiatry. 2016 Jun 1;73(6):622-9. doi: 10.1001/jamapsychiatry.2016.0495.

PMID:
27145529
11.

Obstetric and Neonatal Adversities, Parity, and Tourette Syndrome: A Nationwide Registry.

Leivonen S, Voutilainen A, Chudal R, Suominen A, Gissler M, Sourander A.

J Pediatr. 2016 Apr;171:213-9. doi: 10.1016/j.jpeds.2015.10.063. Epub 2015 Nov 19.

PMID:
26608088
12.

Systematic Identification of MicroRNAs That Impact on Proliferation of Prostate Cancer Cells and Display Changed Expression in Tumor Tissue.

Aakula A, Kohonen P, Leivonen SK, Mäkelä R, Hintsanen P, Mpindi JP, Martens-Uzunova E, Aittokallio T, Jenster G, Perälä M, Kallioniemi O, Östling P.

Eur Urol. 2016 Jun;69(6):1120-8. doi: 10.1016/j.eururo.2015.09.019. Epub 2015 Oct 20.

PMID:
26489476
13.

Parental and comorbid epilepsy in persons with bipolar disorder.

Sucksdorff D, Brown AS, Chudal R, Jokiranta-Olkoniemi E, Leivonen S, Suominen A, Heinimaa M, Sourander A.

J Affect Disord. 2015 Dec 1;188:107-11. doi: 10.1016/j.jad.2015.08.051. Epub 2015 Sep 2.

14.

[Tourette's syndrome--diverse group of patients, individual need for treatment].

Leivonen S, Sourander A, Voutilainen A, Leppämäki S.

Duodecim. 2015;131(11):1058-64. Review. Finnish.

PMID:
26245067
15.

Parental age and the risk of attention-deficit/hyperactivity disorder: a nationwide, population-based cohort study.

Chudal R, Joelsson P, Gyllenberg D, Lehti V, Leivonen S, Hinkka-Yli-Salomäki S, Gissler M, Sourander A.

J Am Acad Child Adolesc Psychiatry. 2015 Jun;54(6):487-94.e1. doi: 10.1016/j.jaac.2015.03.013. Epub 2015 Mar 27.

PMID:
26004664
16.

MicroRNA-135b regulates ERα, AR and HIF1AN and affects breast and prostate cancer cell growth.

Aakula A, Leivonen SK, Hintsanen P, Aittokallio T, Ceder Y, Børresen-Dale AL, Perälä M, Östling P, Kallioniemi O.

Mol Oncol. 2015 Aug;9(7):1287-300. doi: 10.1016/j.molonc.2015.03.001. Epub 2015 Mar 21.

17.

Prenatal Maternal Smoking and Tourette Syndrome: A Nationwide Register Study.

Leivonen S, Chudal R, Joelsson P, Ekblad M, Suominen A, Brown AS, Gissler M, Voutilainen A, Sourander A.

Child Psychiatry Hum Dev. 2016 Feb;47(1):75-82. doi: 10.1007/s10578-015-0545-z.

PMID:
25796373
18.

Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivo.

Winsel S, Mäki-Jouppila J, Tambe M, Aure MR, Pruikkonen S, Salmela AL, Halonen T, Leivonen SK, Kallio L, Børresen-Dale AL, Kallio MJ.

Br J Cancer. 2014 Nov 25;111(11):2142-51. doi: 10.1038/bjc.2014.524. Epub 2014 Sep 30.

19.

The association between congenital anomalies and autism spectrum disorders in a Finnish national birth cohort.

Timonen-Soivio L, Vanhala R, Malm H, Leivonen S, Jokiranta E, Hinkka-Yli-Salomäki S, Gissler M, Brown AS, Sourander A.

Dev Med Child Neurol. 2015 Jan;57(1):75-80. doi: 10.1111/dmcn.12581. Epub 2014 Sep 8.

20.

A nationwide register study of the characteristics, incidence and validity of diagnosed Tourette syndrome and other tic disorders.

Leivonen S, Voutilainen A, Hinkka-Yli-Salomäki S, Timonen-Soivio L, Chudal R, Gissler M, Huttunen J, Sourander A.

Acta Paediatr. 2014 Sep;103(9):984-90. doi: 10.1111/apa.12708. Epub 2014 Aug 1.

PMID:
24862980
21.

Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c.

Nygren MK, Tekle C, Ingebrigtsen VA, Mäkelä R, Krohn M, Aure MR, Nunes-Xavier CE, Perälä M, Tramm T, Alsner J, Overgaard J, Nesland JM, Borgen E, Børresen-Dale AL, Fodstad Ø, Sahlberg KK, Leivonen SK.

Br J Cancer. 2014 Apr 15;110(8):2072-80. doi: 10.1038/bjc.2014.113. Epub 2014 Feb 27.

22.

Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors.

Aure MR, Leivonen SK, Fleischer T, Zhu Q, Overgaard J, Alsner J, Tramm T, Louhimo R, Alnæs GI, Perälä M, Busato F, Touleimat N, Tost J, Børresen-Dale AL, Hautaniemi S, Troyanskaya OG, Lingjærde OC, Sahlberg KK, Kristensen VN.

Genome Biol. 2013 Nov 20;14(11):R126. doi: 10.1186/gb-2013-14-11-r126.

23.

High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth.

Leivonen SK, Sahlberg KK, Mäkelä R, Due EU, Kallioniemi O, Børresen-Dale AL, Perälä M.

Mol Oncol. 2014 Feb;8(1):93-104. doi: 10.1016/j.molonc.2013.10.001. Epub 2013 Oct 11.

24.

Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors.

Tahiri A, Leivonen SK, Lüders T, Steinfeld I, Ragle Aure M, Geisler J, Mäkelä R, Nord S, Riis ML, Yakhini Z, Kleivi Sahlberg K, Børresen-Dale AL, Perälä M, Bukholm IR, Kristensen VN.

Carcinogenesis. 2014 Jan;35(1):76-85. doi: 10.1093/carcin/bgt333. Epub 2013 Oct 8.

PMID:
24104550
25.

TGF-β-elicited induction of tissue inhibitor of metalloproteinases (TIMP)-3 expression in fibroblasts involves complex interplay between Smad3, p38α, and ERK1/2.

Leivonen SK, Lazaridis K, Decock J, Chantry A, Edwards DR, Kähäri VM.

PLoS One. 2013;8(2):e57474. doi: 10.1371/journal.pone.0057474. Epub 2013 Feb 28.

26.

Identification of microRNAs inhibiting TGF-β-induced IL-11 production in bone metastatic breast cancer cells.

Pollari S, Leivonen SK, Perälä M, Fey V, Käkönen SM, Kallioniemi O.

PLoS One. 2012;7(5):e37361. doi: 10.1371/journal.pone.0037361. Epub 2012 May 21.

27.

Human papillomavirus 16 E5 modulates the expression of host microRNAs.

Greco D, Kivi N, Qian K, Leivonen SK, Auvinen P, Auvinen E.

PLoS One. 2011;6(7):e21646. doi: 10.1371/journal.pone.0021646. Epub 2011 Jul 1.

28.

Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact.

Leivonen SK, Rokka A, Ostling P, Kohonen P, Corthals GL, Kallioniemi O, Perälä M.

Mol Cell Proteomics. 2011 Jul;10(7):M110.005322. doi: 10.1074/mcp.M110.005322. Epub 2011 Apr 21.

29.

miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors.

Enerly E, Steinfeld I, Kleivi K, Leivonen SK, Aure MR, Russnes HG, Rønneberg JA, Johnsen H, Navon R, Rødland E, Mäkelä R, Naume B, Perälä M, Kallioniemi O, Kristensen VN, Yakhini Z, Børresen-Dale AL.

PLoS One. 2011 Feb 22;6(2):e16915. doi: 10.1371/journal.pone.0016915.

30.

Systematic analysis of microRNAs targeting the androgen receptor in prostate cancer cells.

Östling P, Leivonen SK, Aakula A, Kohonen P, Mäkelä R, Hagman Z, Edsjö A, Kangaspeska S, Edgren H, Nicorici D, Bjartell A, Ceder Y, Perälä M, Kallioniemi O.

Cancer Res. 2011 Mar 1;71(5):1956-67. doi: 10.1158/0008-5472.CAN-10-2421. Epub 2011 Feb 22.

31.

Hypoxia-activated Smad3-specific dephosphorylation by PP2A.

Heikkinen PT, Nummela M, Leivonen SK, Westermarck J, Hill CS, Kähäri VM, Jaakkola PM.

J Biol Chem. 2010 Feb 5;285(6):3740-9. doi: 10.1074/jbc.M109.042978. Epub 2009 Dec 1.

32.

Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines.

Leivonen SK, Mäkelä R, Ostling P, Kohonen P, Haapa-Paananen S, Kleivi K, Enerly E, Aakula A, Hellström K, Sahlberg N, Kristensen VN, Børresen-Dale AL, Saviranta P, Perälä M, Kallioniemi O.

Oncogene. 2009 Nov 5;28(44):3926-36. doi: 10.1038/onc.2009.241. Epub 2009 Aug 17.

PMID:
19684618
34.

Transforming growth factor-beta signaling in cancer invasion and metastasis.

Leivonen SK, Kähäri VM.

Int J Cancer. 2007 Nov 15;121(10):2119-24. Review.

35.

EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways.

Kajanne R, Miettinen P, Mehlem A, Leivonen SK, Birrer M, Foschi M, Kähäri VM, Leppä S.

J Cell Physiol. 2007 Aug;212(2):489-97.

PMID:
17348021
36.

Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiation.

Rönty MJ, Leivonen SK, Hinz B, Rachlin A, Otey CA, Kähäri VM, Carpén OM.

J Invest Dermatol. 2006 Nov;126(11):2387-96. Epub 2006 Jun 22.

37.

Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells.

Leivonen SK, Ala-Aho R, Koli K, Grénman R, Peltonen J, Kähäri VM.

Oncogene. 2006 Apr 27;25(18):2588-600.

PMID:
16407850
40.

Identification of essential subelements in the hHSD17B1 enhancer: difference in function of the enhancer and that of the hHSD17BP1 analog is due to -480C and -486G.

Leivonen S, Piao YS, Peltoketo H, Numchaisrika P, Vihko R, Vihko P.

Endocrinology. 1999 Aug;140(8):3478-87.

PMID:
10433203

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