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Items: 30


β-Secretase BACE1 Is Required for Normal Cochlear Function.

Dierich M, Hartmann S, Dietrich N, Moeser P, Brede F, Johnson Chacko L, Tziridis K, Schilling A, Krauss P, Hessler S, Karch S, Schrott-Fischer A, Blumer M, Birchmeier C, Oliver D, Moser T, Schulze H, Alzheimer C, Leitner MG, Huth T.

J Neurosci. 2019 Nov 6;39(45):9013-9027. doi: 10.1523/JNEUROSCI.0028-19.2019. Epub 2019 Sep 16.


Histidine at position 462 determines the low quinine sensitivity of ether-à-go-go channel superfamily member Kv 12.1.

Dierich M, van Ham WB, Stary-Weinzinger A, Leitner MG.

Br J Pharmacol. 2019 Aug;176(15):2708-2723. doi: 10.1111/bph.14693. Epub 2019 Jun 17.


A choreography of intracellular Ca2+ and extracellular ATP to refine auditory nociceptors before hearing.

Leitner MG, Oliver D.

EMBO J. 2019 May 2;38(9). pii: e101980. doi: 10.15252/embj.2019101980. Epub 2019 Apr 11. No abstract available.


The N-terminal homology (ENTH) domain of Epsin 1 is a sensitive reporter of physiological PI(4,5)P2 dynamics.

Leitner MG, Thallmair V, Wilke BU, Neubert V, Kronimus Y, Halaszovich CR, Oliver D.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):433-442. doi: 10.1016/j.bbalip.2018.08.005. Epub 2018 Aug 16.


Kv12.1 channels are not sensitive to GqPCR-triggered activation of phospholipase Cβ.

Dierich M, Leitner MG.

Channels (Austin). 2018;12(1):228-239. doi: 10.1080/19336950.2018.1475783.


A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN.

Leitner MG, Hobiger K, Mavrantoni A, Feuer A, Oberwinkler J, Oliver D, Halaszovich CR.

Cell Mol Life Sci. 2018 Nov;75(22):4235-4250. doi: 10.1007/s00018-018-2867-z. Epub 2018 Jul 9.


Identification of Chloride Channels CLCN3 and CLCN5 Mediating the Excitatory Cl- Currents Activated by Sphingosine-1-Phosphate in Sensory Neurons.

Qi Y, Mair N, Kummer KK, Leitner MG, Camprubí-Robles M, Langeslag M, Kress M.

Front Mol Neurosci. 2018 Feb 9;11:33. doi: 10.3389/fnmol.2018.00033. eCollection 2018.


Inverse Modulation of Neuronal Kv12.1 and Kv11.1 Channels by 4-Aminopyridine and NS1643.

Dierich M, Evers S, Wilke BU, Leitner MG.

Front Mol Neurosci. 2018 Jan 30;11:11. doi: 10.3389/fnmol.2018.00011. eCollection 2018.


The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.

Vogl C, Butola T, Haag N, Hausrat TJ, Leitner MG, Moutschen M, Lefèbvre PP, Speckmann C, Garrett L, Becker L, Fuchs H, Hrabe de Angelis M, Nietzsche S, Kessels MM, Oliver D, Kneussel M, Kilimann MW, Strenzke N.

EMBO Rep. 2017 Nov;18(11):2015-2029. doi: 10.15252/embr.201643689. Epub 2017 Sep 11.


Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels.

Dembla S, Behrendt M, Mohr F, Goecke C, Sondermann J, Schneider FM, Schmidt M, Stab J, Enzeroth R, Leitner MG, Nuñez-Badinez P, Schwenk J, Nürnberg B, Cohen A, Philipp SE, Greffrath W, Bünemann M, Oliver D, Zakharian E, Schmidt M, Oberwinkler J.

Elife. 2017 Aug 15;6. pii: e26280. doi: 10.7554/eLife.26280.


Identification of Cav2-PKCβ and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling.

Constantin CE, Müller CS, Leitner MG, Bildl W, Schulte U, Oliver D, Fakler B.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):5707-5712. doi: 10.1073/pnas.1616394114. Epub 2017 May 15.


Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122.

Leitner MG, Michel N, Behrendt M, Dierich M, Dembla S, Wilke BU, Konrad M, Lindner M, Oberwinkler J, Oliver D.

Br J Pharmacol. 2016 Aug;173(16):2555-69. doi: 10.1111/bph.13538. Epub 2016 Jul 18.


Discovery and functional characterization of a neomorphic PTEN mutation.

Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee MC, De La Vega FM, Ford JM, Krogan NJ, Shokat KM, Oliver D, Halaszovich CR, Bustamante CD.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13976-81. doi: 10.1073/pnas.1422504112. Epub 2015 Oct 26.


Ion channel regulation by phosphoinositides analyzed with VSPs-PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility.

Rjasanow A, Leitner MG, Thallmair V, Halaszovich CR, Oliver D.

Front Pharmacol. 2015 Jun 19;6:127. doi: 10.3389/fphar.2015.00127. eCollection 2015.


Regulation of the transient receptor potential channel TRPM3 by phosphoinositides.

Tóth BI, Konrad M, Ghosh D, Mohr F, Halaszovich CR, Leitner MG, Vriens J, Oberwinkler J, Voets T.

J Gen Physiol. 2015 Jul;146(1):51-63. doi: 10.1085/jgp.201411339.


Phosphoinositide dynamics in the postsynaptic membrane compartment: Mechanisms and experimental approach.

Leitner MG, Halaszovich CR, Ivanova O, Oliver D.

Eur J Cell Biol. 2015 Jul-Sep;94(7-9):401-14. doi: 10.1016/j.ejcb.2015.06.003. Epub 2015 Jun 3. Review.


A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases.

Mavrantoni A, Thallmair V, Leitner MG, Schreiber DN, Oliver D, Halaszovich CR.

Front Pharmacol. 2015 Mar 31;6:68. doi: 10.3389/fphar.2015.00068. eCollection 2015.


Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons.

Langeslag M, Quarta S, Leitner MG, Kress M, Mair N.

Mol Pain. 2014 Nov 28;10:74. doi: 10.1186/1744-8069-10-74.


Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors.

Wilke BU, Lindner M, Greifenberg L, Albus A, Kronimus Y, Bünemann M, Leitner MG, Oliver D.

Nat Commun. 2014 Nov 25;5:5540. doi: 10.1038/ncomms6540.


Zebrafish in auditory research: are fish better than mice?

Leitner MG.

J Physiol. 2014 Nov 1;592(21):4611-2. doi: 10.1113/jphysiol.2014.280438. No abstract available.


A human phospholipid phosphatase activated by a transmembrane control module.

Halaszovich CR, Leitner MG, Mavrantoni A, Le A, Frezza L, Feuer A, Schreiber DN, Villalba-Galea CA, Oliver D.

J Lipid Res. 2012 Nov;53(11):2266-74. doi: 10.1194/jlr.M026021. Epub 2012 Aug 15.


Restoration of ion channel function in deafness-causing KCNQ4 mutants by synthetic channel openers.

Leitner MG, Feuer A, Ebers O, Schreiber DN, Halaszovich CR, Oliver D.

Br J Pharmacol. 2012 Apr;165(7):2244-59. doi: 10.1111/j.1476-5381.2011.01697.x.


Probing the regulation of TASK potassium channels by PI4,5P₂ with switchable phosphoinositide phosphatases.

Lindner M, Leitner MG, Halaszovich CR, Hammond GR, Oliver D.

J Physiol. 2011 Jul 1;589(Pt 13):3149-62. doi: 10.1113/jphysiol.2011.208983. Epub 2011 May 3.


Controlling the activity of a phosphatase and tensin homolog (PTEN) by membrane potential.

Lacroix J, Halaszovich CR, Schreiber DN, Leitner MG, Bezanilla F, Oliver D, Villalba-Galea CA.

J Biol Chem. 2011 May 20;286(20):17945-53. doi: 10.1074/jbc.M110.201749. Epub 2011 Mar 17.


Genetic evidence for involvement of neuronally expressed S1P₁ receptor in nociceptor sensitization and inflammatory pain.

Mair N, Benetti C, Andratsch M, Leitner MG, Constantin CE, Camprubí-Robles M, Quarta S, Biasio W, Kuner R, Gibbins IL, Kress M, Haberberger RV.

PLoS One. 2011 Feb 17;6(2):e17268. doi: 10.1371/journal.pone.0017268.


Aminoglycosides inhibit KCNQ4 channels in cochlear outer hair cells via depletion of phosphatidylinositol(4,5)bisphosphate.

Leitner MG, Halaszovich CR, Oliver D.

Mol Pharmacol. 2011 Jan;79(1):51-60. doi: 10.1124/mol.110.068130. Epub 2010 Oct 8.


Wound healing. Oral and topical activity of Aloe vera.

Davis RH, Leitner MG, Russo JM, Byrne ME.

J Am Podiatr Med Assoc. 1989 Nov;79(11):559-62.


Anti-inflammatory activity of Aloe vera against a spectrum of irritants.

Davis RH, Leitner MG, Russo JM, Byrne ME.

J Am Podiatr Med Assoc. 1989 Jun;79(6):263-76.


Aloe vera. A natural approach for treating wounds, edema, and pain in diabetes.

Davis RH, Leitner MG, Russo JM.

J Am Podiatr Med Assoc. 1988 Feb;78(2):60-8. No abstract available.


Topical anti-inflammatory activity of Aloe vera as measured by ear swelling.

Davis RH, Leitner MG, Russo JM.

J Am Podiatr Med Assoc. 1987 Nov;77(11):610-2. No abstract available.


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