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Items: 1 to 50 of 182


Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.

Ramrath DJF, Niemann M, Leibundgut M, Bieri P, Prange C, Horn EK, Leitner A, Boehringer D, Schneider A, Ban N.

Science. 2018 Oct 26;362(6413). pii: eaau7735. doi: 10.1126/science.aau7735. Epub 2018 Sep 13.


Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2.

Schütz S, Michel E, Damberger FF, Oplová M, Peña C, Leitner A, Aebersold R, Allain FH, Panse VG.

Nat Commun. 2018 Sep 10;9(1):3669. doi: 10.1038/s41467-018-06160-x.


Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex.

Chowdhury S, Otomo C, Leitner A, Ohashi K, Aebersold R, Lander GC, Otomo T.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9792-E9801. doi: 10.1073/pnas.1811874115. Epub 2018 Sep 5.


An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor.

Martinez-Martin N, Marcandalli J, Huang CS, Arthur CP, Perotti M, Foglierini M, Ho H, Dosey AM, Shriver S, Payandeh J, Leitner A, Lanzavecchia A, Perez L, Ciferri C.

Cell. 2018 Aug 23;174(5):1158-1171.e19. doi: 10.1016/j.cell.2018.06.028. Epub 2018 Jul 26.


Conformational control and DNA-binding mechanism of the metazoan origin recognition complex.

Bleichert F, Leitner A, Aebersold R, Botchan MR, Berger JM.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5906-E5915. doi: 10.1073/pnas.1806315115. Epub 2018 Jun 13.


High Temperature Flow Behavior of Ultra-Strong Nanoporous Au assessed by Spherical Nanoindentation.

Leitner A, Maier-Kiener V, Kiener D.

Nanomaterials (Basel). 2018 May 24;8(6). pii: E366. doi: 10.3390/nano8060366.


Comparison of tear proteome in allergic rhinoconjunctivitis patients and controls with respect to pollen season.

Tomazic PV, Liesinger L, Pucher B, Thallinger GG, Leitner A, Spoerk S, Gerstenberger C, Lang-Loidolt D, Birner-Gruenberger R.

Allergy. 2018 Jul;73(7):1541-1543. doi: 10.1111/all.13444. Epub 2018 Apr 15. No abstract available.


Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding.

Yoon J, Kim SJ, An S, Cho S, Leitner A, Jung T, Aebersold R, Hebert H, Cho US, Song JJ.

J Mol Biol. 2018 Mar 16;430(6):822-841. doi: 10.1016/j.jmb.2018.01.015. Epub 2018 Jan 31.


Structure of a human cap-dependent 48S translation pre-initiation complex.

Eliseev B, Yeramala L, Leitner A, Karuppasamy M, Raimondeau E, Huard K, Alkalaeva E, Aebersold R, Schaffitzel C.

Nucleic Acids Res. 2018 Mar 16;46(5):2678-2689. doi: 10.1093/nar/gky054.


A review of the role of chemical modification methods in contemporary mass spectrometry-based proteomics research.

Leitner A.

Anal Chim Acta. 2018 Feb 13;1000:2-19. doi: 10.1016/j.aca.2017.08.026. Epub 2017 Aug 26. Review.


Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.

Lehmann LC, Hewitt G, Aibara S, Leitner A, Marklund E, Maslen SL, Maturi V, Chen Y, van der Spoel D, Skehel JM, Moustakas A, Boulton SJ, Deindl S.

Mol Cell. 2017 Dec 7;68(5):847-859.e7. doi: 10.1016/j.molcel.2017.10.017.


Dynamic nanoindentation testing: is there an influence on a material's hardness?

Leitner A, Maier-Kiener V, Kiener D.

Mater Res Lett. 2017 Nov 3;5(7):486-493. doi: 10.1080/21663831.2017.1331384. eCollection 2017 Nov.


Megafauna of the UKSRL exploration contract area and eastern Clarion-Clipperton Zone in the Pacific Ocean: Annelida, Arthropoda, Bryozoa, Chordata, Ctenophora, Mollusca.

Amon DJ, Ziegler AF, Drazen JC, Grischenko AV, Leitner AB, Lindsay DJ, Voight JR, Wicksten MK, Young CM, Smith CR.

Biodivers Data J. 2017 Aug 14;(5):e14598. doi: 10.3897/BDJ.5.e14598. eCollection 2017.


The mzIdentML Data Standard Version 1.2, Supporting Advances in Proteome Informatics.

Vizcaíno JA, Mayer G, Perkins S, Barsnes H, Vaudel M, Perez-Riverol Y, Ternent T, Uszkoreit J, Eisenacher M, Fischer L, Rappsilber J, Netz E, Walzer M, Kohlbacher O, Leitner A, Chalkley RJ, Ghali F, Martínez-Bartolomé S, Deutsch EW, Jones AR.

Mol Cell Proteomics. 2017 Jul;16(7):1275-1285. doi: 10.1074/mcp.M117.068429. Epub 2017 May 17.


Structural modeling of protein-RNA complexes using crosslinking of segmentally isotope-labeled RNA and MS/MS.

Dorn G, Leitner A, Boudet J, Campagne S, von Schroetter C, Moursy A, Aebersold R, Allain FH.

Nat Methods. 2017 May;14(5):487-490. doi: 10.1038/nmeth.4235. Epub 2017 Mar 27.


A TiO2/FeMnP Core/Shell Nanorod Array Photoanode for Efficient Photoelectrochemical Oxygen Evolution.

Schipper DE, Zhao Z, Leitner AP, Xie L, Qin F, Alam MK, Chen S, Wang D, Ren Z, Wang Z, Bao J, Whitmire KH.

ACS Nano. 2017 Apr 25;11(4):4051-4059. doi: 10.1021/acsnano.7b00704. Epub 2017 Mar 27.


Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.

Wang X, Cimermancic P, Yu C, Schweitzer A, Chopra N, Engel JL, Greenberg C, Huszagh AS, Beck F, Sakata E, Yang Y, Novitsky EJ, Leitner A, Nanni P, Kahraman A, Guo X, Dixon JE, Rychnovsky SD, Aebersold R, Baumeister W, Sali A, Huang L.

Mol Cell Proteomics. 2017 May;16(5):840-854. doi: 10.1074/mcp.M116.065326. Epub 2017 Mar 14.


Synthesis of Hexagonal FeMnP Thin Films from a Single-Source Molecular Precursor.

Leitner AP, Schipper DE, Chen JH, Colson AC, Rusakova I, Rai BK, Morosan E, Whitmire KH.

Chemistry. 2017 Apr 24;23(23):5565-5572. doi: 10.1002/chem.201700203. Epub 2017 Apr 3.


A meta-analytic review of brief guided self-help education for chronic pain.

Liegl G, Boeckle M, Leitner A, Pieh C.

Eur J Pain. 2016 Nov;20(10):1551-1562. doi: 10.1002/ejp.881. Epub 2016 May 10. Review.


Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling.

Ciuffa R, Caron E, Leitner A, Uliana F, Gstaiger M, Aebersold R.

J Proteome Res. 2017 Jan 6;16(1):14-33. doi: 10.1021/acs.jproteome.6b00728. Epub 2016 Oct 20. Review.


Cross-linking and other structural proteomics techniques: how chemistry is enabling mass spectrometry applications in structural biology.

Leitner A.

Chem Sci. 2016 Aug 1;7(8):4792-4803. doi: 10.1039/c5sc04196a. Epub 2016 Apr 26. Review.


Molecular Architecture of  Yeast Chromatin Assembly Factor 1.

Kim D, Setiaputra D, Jung T, Chung J, Leitner A, Yoon J, Aebersold R, Hebert H, Yip CK, Song JJ.

Sci Rep. 2016 May 25;6:26702. doi: 10.1038/srep26702.


Mass Spectrometry Applied to Bottom-Up Proteomics: Entering the High-Throughput Era for Hypothesis Testing.

Gillet LC, Leitner A, Aebersold R.

Annu Rev Anal Chem (Palo Alto Calif). 2016 Jun 12;9(1):449-72. doi: 10.1146/annurev-anchem-071015-041535. Epub 2016 Mar 30. Review.


Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle.

Mosadeghi R, Reichermeier KM, Winkler M, Schreiber A, Reitsma JM, Zhang Y, Stengel F, Cao J, Kim M, Sweredoski MJ, Hess S, Leitner A, Aebersold R, Peter M, Deshaies RJ, Enchev RI.

Elife. 2016 Mar 31;5. pii: e12102. doi: 10.7554/eLife.12102.


Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function.

Vijayvargia R, Epand R, Leitner A, Jung TY, Shin B, Jung R, Lloret A, Singh Atwal R, Lee H, Lee JM, Aebersold R, Hebert H, Song JJ, Seong IS.

Elife. 2016 Mar 22;5:e11184. doi: 10.7554/eLife.11184.


Three dimensional sensitivity characterization of plasmonic nanorods for refractometric biosensors.

Leitgeb V, Trügler A, Köstler S, Krug MK, Hohenester U, Hohenau A, Leitner A, Krenn JR.

Nanoscale. 2016 Feb 7;8(5):2974-81. doi: 10.1039/c5nr06401e.


Seasonal proteome changes of nasal mucus reflect perennial inflammatory response and reduced defence mechanisms and plasticity in allergic rhinitis.

Tomazic PV, Birner-Gruenberger R, Leitner A, Spoerk S, Lang-Loidolt D.

J Proteomics. 2016 Feb 5;133:153-160. doi: 10.1016/j.jprot.2015.12.021. Epub 2015 Dec 28.


Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation.

Greber BJ, Gerhardy S, Leitner A, Leibundgut M, Salem M, Boehringer D, Leulliot N, Aebersold R, Panse VG, Ban N.

Cell. 2016 Jan 14;164(1-2):91-102. doi: 10.1016/j.cell.2015.11.027. Epub 2015 Dec 17.


Crosslinking and Mass Spectrometry: An Integrated Technology to Understand the Structure and Function of Molecular Machines.

Leitner A, Faini M, Stengel F, Aebersold R.

Trends Biochem Sci. 2016 Jan;41(1):20-32. doi: 10.1016/j.tibs.2015.10.008. Epub 2015 Dec 1. Review.


[Austrian expenditures on psychopharmaceutical drugs between 2006 and 2013].

Boeckle M, Chetouani Y, Schrimpf M, Liegl G, Leitner A, Pieh C.

Z Psychosom Med Psychother. 2015;61(4):359-69. doi: 10.13109/zptm.2015.61.4.359. German.


Enrichment Strategies in Phosphoproteomics.

Leitner A.

Methods Mol Biol. 2016;1355:105-21. doi: 10.1007/978-1-4939-3049-4_7. Review.


xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry.

Walzthoeni T, Joachimiak LA, Rosenberger G, Röst HL, Malmström L, Leitner A, Frydman J, Aebersold R.

Nat Methods. 2015 Dec;12(12):1185-90. doi: 10.1038/nmeth.3631. Epub 2015 Oct 26.


The effect of sleep deprivation on pain perception in healthy subjects: a meta-analysis.

Schrimpf M, Liegl G, Boeckle M, Leitner A, Geisler P, Pieh C.

Sleep Med. 2015 Nov;16(11):1313-1320. doi: 10.1016/j.sleep.2015.07.022. Epub 2015 Aug 20.


Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies.

Ciferri C, Chandramouli S, Leitner A, Donnarumma D, Cianfrocco MA, Gerrein R, Friedrich K, Aggarwal Y, Palladino G, Aebersold R, Norais N, Settembre EC, Carfi A.

PLoS Pathog. 2015 Oct 20;11(10):e1005230. doi: 10.1371/journal.ppat.1005230. eCollection 2015 Oct.


Guided self-help interventions for irritable bowel syndrome: a systematic review and meta-analysis.

Liegl G, Plessen CY, Leitner A, Boeckle M, Pieh C.

Eur J Gastroenterol Hepatol. 2015 Oct;27(10):1209-21. doi: 10.1097/MEG.0000000000000428. Review.


Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

Gaubitz C, Oliveira TM, Prouteau M, Leitner A, Karuppasamy M, Konstantinidou G, Rispal D, Eltschinger S, Robinson GC, Thore S, Aebersold R, Schaffitzel C, Loewith R.

Mol Cell. 2015 Jun 18;58(6):977-88. doi: 10.1016/j.molcel.2015.04.031. Epub 2015 May 28.


Local refractive index sensitivity of gold nanodisks.

Häfele V, Trügler A, Hohenester U, Hohenau A, Leitner A, Krenn JR.

Opt Express. 2015 Apr 20;23(8):10293-300. doi: 10.1364/OE.23.010293.


Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome.

Greber BJ, Bieri P, Leibundgut M, Leitner A, Aebersold R, Boehringer D, Ban N.

Science. 2015 Apr 17;348(6232):303-8. doi: 10.1126/science.aaa3872. Epub 2015 Apr 2.


[How burdensome is the treatment of patients with somatoform disorders?].

Böckle M, Liegl G, Leitner A, Pieh C.

Z Psychosom Med Psychother. 2014;60(4):383-91. doi: 10.13109/zptm.2014.60.4.383. German.


Architecture and conformational switch mechanism of the ryanodine receptor.

Efremov RG, Leitner A, Aebersold R, Raunser S.

Nature. 2015 Jan 1;517(7532):39-43. doi: 10.1038/nature13916. Epub 2014 Dec 1.


Apolipoproteins have a potential role in nasal mucus of allergic rhinitis patients: a proteomic study.

Tomazic PV, Birner-Gruenberger R, Leitner A, Darnhofer B, Spoerk S, Lang-Loidolt D.

Laryngoscope. 2015 Mar;125(3):E91-6. doi: 10.1002/lary.25003. Epub 2014 Nov 1.


Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.

Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, Kashofer K, Nojima S, Leitner A, Zebisch A, Wölfler A, Hofer S, Gerger A, Lax S, Beham-Schmid C, Steinke V, Heitzer E, Geigl JB, Windpassinger C, Hoefler G, Speicher MR, Boland CR, Kumanogoh A, Sill H.

Nat Commun. 2014 Oct 13;5:5191. doi: 10.1038/ncomms6191.


The complete structure of the large subunit of the mammalian mitochondrial ribosome.

Greber BJ, Boehringer D, Leibundgut M, Bieri P, Leitner A, Schmitz N, Aebersold R, Ban N.

Nature. 2014 Nov 13;515(7526):283-6. doi: 10.1038/nature13895. Epub 2014 Sep 1.


Framework complexes of group 2 metals organized by homochiral rods and π···π stacking forces: a breathing supramolecular MOF.

Reger DL, Leitner A, Pellechia PJ, Smith MD.

Inorg Chem. 2014 Sep 15;53(18):9932-45. doi: 10.1021/ic501581c. Epub 2014 Aug 26.


Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes.

Leitner A, Joachimiak LA, Unverdorben P, Walzthoeni T, Frydman J, Förster F, Aebersold R.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9455-60. doi: 10.1073/pnas.1320298111. Epub 2014 Jun 17.


Interaction of 2-oxoglutarate dehydrogenase OdhA with its inhibitor OdhI in Corynebacterium glutamicum: Mutants and a model.

Raasch K, Bocola M, Labahn J, Leitner A, Eggeling L, Bott M.

J Biotechnol. 2014 Dec 10;191:99-105. doi: 10.1016/j.jbiotec.2014.05.023. Epub 2014 Jun 4.


Conserved peptide fragmentation as a benchmarking tool for mass spectrometers and a discriminating feature for targeted proteomics.

Toprak UH, Gillet LC, Maiolica A, Navarro P, Leitner A, Aebersold R.

Mol Cell Proteomics. 2014 Aug;13(8):2056-71. doi: 10.1074/mcp.O113.036475. Epub 2014 Mar 12.

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