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Items: 36

1.

Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications.

Totland MZ, Rasmussen NL, Knudsen LM, Leithe E.

Cell Mol Life Sci. 2019 Sep 9. doi: 10.1007/s00018-019-03285-0. [Epub ahead of print] Review.

PMID:
31501970
2.

Connexins in cancer: bridging the gap to the clinic.

Aasen T, Leithe E, Graham SV, Kameritsch P, Mayán MD, Mesnil M, Pogoda K, Tabernero A.

Oncogene. 2019 Jun;38(23):4429-4451. doi: 10.1038/s41388-019-0741-6. Epub 2019 Feb 27.

3.

The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions.

Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E.

J Cell Sci. 2017 Sep 1;130(17):2867-2882. doi: 10.1242/jcs.202408. Epub 2017 Jul 21.

4.

An update on minding the gap in cancer.

Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC.

Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):237-243. doi: 10.1016/j.bbamem.2017.06.015. Epub 2017 Jun 24. Review.

5.

Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1.

Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA.

Genome Med. 2017 May 24;9(1):46. doi: 10.1186/s13073-017-0434-0.

6.

The connexin 43 C-terminus: A tail of many tales.

Leithe E, Mesnil M, Aasen T.

Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):48-64. doi: 10.1016/j.bbamem.2017.05.008. Epub 2017 May 16. Review.

7.

A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells.

Dukic AR, Haugen LH, Pidoux G, Leithe E, Bakke O, Taskén K.

Cell Signal. 2017 Apr;32:1-11. doi: 10.1016/j.cellsig.2017.01.008. Epub 2017 Jan 8.

PMID:
28077322
8.

Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding.

Fykerud TA, Knudsen LM, Totland MZ, Sørensen V, Dahal-Koirala S, Lothe RA, Brech A, Leithe E.

Cell Cycle. 2016 Nov;15(21):2943-2957. Epub 2016 Sep 13.

9.

Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer.

Leithe E.

Biochim Biophys Acta. 2016 Apr;1865(2):133-46. doi: 10.1016/j.bbcan.2016.02.001. Epub 2016 Feb 12. Review.

PMID:
26855059
10.

Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.

Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA.

Clin Cancer Res. 2015 Aug 15;21(16):3759-70. doi: 10.1158/1078-0432.CCR-14-3294. Epub 2015 Apr 24.

11.

Portrait of the PI3K/AKT pathway in colorectal cancer.

Danielsen SA, Eide PW, Nesbakken A, Guren T, Leithe E, Lothe RA.

Biochim Biophys Acta. 2015 Jan;1855(1):104-21. doi: 10.1016/j.bbcan.2014.09.008. Epub 2014 Nov 22. Review.

PMID:
25450577
12.

Connexins in colorectal cancer pathogenesis.

Sirnes S, Lind GE, Bruun J, Fykerud TA, Mesnil M, Lothe RA, Rivedal E, Kolberg M, Leithe E.

Int J Cancer. 2015 Jul 1;137(1):1-11. doi: 10.1002/ijc.28911. Epub 2014 May 5. Review.

13.

NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.

Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, Ågesen TH, Bruun J, Rivedal E, Lothe RA, Leithe E.

Cell Signal. 2013 Jan;25(1):12-8. doi: 10.1016/j.cellsig.2012.08.012. Epub 2012 Sep 5.

PMID:
22974840
14.

Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43.

Fykerud TA, Kjenseth A, Schink KO, Sirnes S, Bruun J, Omori Y, Brech A, Rivedal E, Leithe E.

J Cell Sci. 2012 Sep 1;125(Pt 17):3966-76. doi: 10.1242/jcs.093500. Epub 2012 May 23.

15.

The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation.

Kjenseth A, Fykerud TA, Sirnes S, Bruun J, Yohannes Z, Kolberg M, Omori Y, Rivedal E, Leithe E.

J Biol Chem. 2012 May 4;287(19):15851-61. doi: 10.1074/jbc.M111.281832. Epub 2012 Mar 12.

16.

Endocytosis and post-endocytic sorting of connexins.

Leithe E, Sirnes S, Fykerud T, Kjenseth A, Rivedal E.

Biochim Biophys Acta. 2012 Aug;1818(8):1870-9. doi: 10.1016/j.bbamem.2011.09.029. Epub 2011 Oct 4. Review.

17.

Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions.

Mollerup S, Hofgaard JP, Braunstein TH, Kjenseth A, Leithe E, Rivedal E, Holstein-Rathlou NH, Nielsen MS.

Cell Commun Adhes. 2011 Aug;18(4):57-65. doi: 10.3109/15419061.2011.611920. Epub 2011 Sep 21.

PMID:
21936631
18.

Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome.

Sirnes S, Bruun J, Kolberg M, Kjenseth A, Lind GE, Svindland A, Brech A, Nesbakken A, Lothe RA, Leithe E, Rivedal E.

Int J Cancer. 2012 Aug 1;131(3):570-81. doi: 10.1002/ijc.26392. Epub 2011 Oct 20.

19.

Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting.

Malerød L, Pedersen NM, Sem Wegner CE, Lobert VH, Leithe E, Brech A, Rivedal E, Liestøl K, Stenmark H.

Traffic. 2011 Sep;12(9):1211-26. doi: 10.1111/j.1600-0854.2011.01220.x. Epub 2011 Jun 13.

20.

DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer.

Sirnes S, Honne H, Ahmed D, Danielsen SA, Rognum TO, Meling GI, Leithe E, Rivedal E, Lothe RA, Lind GE.

Epigenetics. 2011 May;6(5):602-9. Epub 2011 May 1.

PMID:
21406965
21.

Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil.

Leithe E, Kjenseth A, Bruun J, Sirnes S, Rivedal E.

Toxicol Appl Pharmacol. 2010 Aug 15;247(1):10-7. doi: 10.1016/j.taap.2010.05.006. Epub 2010 May 25.

PMID:
20510257
22.

Regulation of gap junction intercellular communication by the ubiquitin system.

Kjenseth A, Fykerud T, Rivedal E, Leithe E.

Cell Signal. 2010 Sep;22(9):1267-73. doi: 10.1016/j.cellsig.2010.03.005. Epub 2010 Mar 4. Review.

PMID:
20206687
23.

Gap junction intercellular communication and benzene toxicity.

Rivedal E, Witz G, Leithe E.

Chem Biol Interact. 2010 Mar 19;184(1-2):229-32. doi: 10.1016/j.cbi.2009.11.013. Epub 2009 Nov 22.

PMID:
19932693
24.

Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.

Leithe E, Kjenseth A, Sirnes S, Stenmark H, Brech A, Rivedal E.

J Cell Sci. 2009 Nov 1;122(Pt 21):3883-93. doi: 10.1242/jcs.053801. Epub 2009 Oct 6.

25.

Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication.

Sirnes S, Kjenseth A, Leithe E, Rivedal E.

Biochem Biophys Res Commun. 2009 Apr 24;382(1):41-5. doi: 10.1016/j.bbrc.2009.02.141. Epub 2009 Mar 1.

PMID:
19258009
26.

The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43.

Rivedal E, Leithe E.

Toxicol Appl Pharmacol. 2008 Nov 1;232(3):463-8. doi: 10.1016/j.taap.2008.07.022. Epub 2008 Aug 6.

PMID:
18723040
27.

The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis.

Sirnes S, Leithe E, Rivedal E.

Biochem Biophys Res Commun. 2008 Sep 5;373(4):597-601. doi: 10.1016/j.bbrc.2008.06.095. Epub 2008 Jul 2.

PMID:
18601906
28.

Ubiquitination of gap junction proteins.

Leithe E, Rivedal E.

J Membr Biol. 2007 Jun;217(1-3):43-51. Epub 2007 Jul 28. Review.

PMID:
17657522
29.

Downregulation of gap junctions in cancer cells.

Leithe E, Sirnes S, Omori Y, Rivedal E.

Crit Rev Oncog. 2006 Dec;12(3-4):225-56. Review.

PMID:
17425504
30.

Endocytic processing of connexin43 gap junctions: a morphological study.

Leithe E, Brech A, Rivedal E.

Biochem J. 2006 Jan 1;393(Pt 1):59-67.

32.
33.

Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43.

Leithe E, Rivedal E.

J Cell Sci. 2004 Mar 1;117(Pt 7):1211-20. Epub 2004 Feb 17. Erratum in: J Cell Sci. 2004 Mar 15;117(8):1613.

34.

Recovery of gap junctional intercellular communication after phorbol ester treatment requires proteasomal degradation of protein kinase C.

Leithe E, Cruciani V, Sanner T, Mikalsen SO, Rivedal E.

Carcinogenesis. 2003 Jul;24(7):1239-45. Epub 2003 May 9.

PMID:
12807762
35.

Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport.

Cruciani V, Leithe E, Mikalsen SO.

Exp Cell Res. 2003 Jul 1;287(1):130-42.

PMID:
12799189
36.

Relationship between vaccinia virus intracellular cores, early mRNAs, and DNA replication sites.

Mallardo M, Leithe E, Schleich S, Roos N, Doglio L, Krijnse Locker J.

J Virol. 2002 May;76(10):5167-83.

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