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Items: 19

1.

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).

Qiao JX, Wang TC, Adam LP, Chen AY, Taylor DS, Yang RZ, Zhuang S, Sleph PG, Li JP, Li D, Yin X, Chang M, Chen XQ, Shen H, Li J, Smith D, Wu DR, Leith L, Harikrishnan LS, Kamau MG, Miller MM, Bilder D, Rampulla R, Li YX, Xu C, Lawrence RM, Poss MA, Levesque P, Gordon DA, Huang CS, Finlay HJ, Wexler RR, Salvati ME.

J Med Chem. 2015 Nov 25;58(22):9010-26. doi: 10.1021/acs.jmedchem.5b01363. Epub 2015 Nov 17.

PMID:
26524347
2.

Improving surgical access: the Vancouver experience.

Williams DH, Iker C, Leith L, Masri BA.

Can J Surg. 2011 Aug;54(4):277-1. doi: 10.1503/cjs.020110. Review.

3.

Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker.

Roberge JY, Harikrishnan LS, Kamau MG, Ruan Z, Van Kirk K, Liu Y, Cooper CB, Poss MA, Dickson JK Jr, Gavai AV, Chao ST, Leith LW, Bednarz MS, Mathur A, Kakarla R, Schnur DM, Vaz R, Lawrence RM.

J Comb Chem. 2009 Jan-Feb;11(1):72-82. doi: 10.1021/cc800051u.

PMID:
19086798
4.

Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.

Potin D, Launay M, Monatlik F, Malabre P, Fabreguettes M, Fouquet A, Maillet M, Nicolai E, Dorgeret L, Chevallier F, Besse D, Dufort M, Caussade F, Ahmad SZ, Stetsko DK, Skala S, Davis PM, Balimane P, Patel K, Yang Z, Marathe P, Postelneck J, Townsend RM, Goldfarb V, Sheriff S, Einspahr H, Kish K, Malley MF, DiMarco JD, Gougoutas JZ, Kadiyala P, Cheney DL, Tejwani RW, Murphy DK, Mcintyre KW, Yang X, Chao S, Leith L, Xiao Z, Mathur A, Chen BC, Wu DR, Traeger SC, McKinnon M, Barrish JC, Robl JA, Iwanowicz EJ, Suchard SJ, Dhar TG.

J Med Chem. 2006 Nov 30;49(24):6946-9.

PMID:
17125246
5.

Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.

Bhide RS, Cai ZW, Zhang YZ, Qian L, Wei D, Barbosa S, Lombardo LJ, Borzilleri RM, Zheng X, Wu LI, Barrish JC, Kim SH, Leavitt K, Mathur A, Leith L, Chao S, Wautlet B, Mortillo S, Jeyaseelan R Sr, Kukral D, Hunt JT, Kamath A, Fura A, Vyas V, Marathe P, D'Arienzo C, Derbin G, Fargnoli J.

J Med Chem. 2006 Apr 6;49(7):2143-6.

PMID:
16570908
6.

The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists.

Balog A, Salvati ME, Shan W, Mathur A, Leith LW, Wei DD, Attar RM, Geng J, Rizzo CA, Wang C, Krystek SR, Tokarski JS, Hunt JT, Gottardis M, Weinmann R.

Bioorg Med Chem Lett. 2004 Dec 20;14(24):6107-11.

PMID:
15546739
7.

Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors.

Chen P, Norris D, Das J, Spergel SH, Wityak J, Leith L, Zhao R, Chen BC, Pitt S, Pang S, Shen DR, Zhang R, De Fex HF, Doweyko AM, McIntyre KW, Shuster DJ, Behnia K, Schieven GL, Barrish JC.

Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6.

PMID:
15546730
8.

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.

Murugesan N, Gu Z, Spergel S, Young M, Chen P, Mathur A, Leith L, Hermsmeier M, Liu EC, Zhang R, Bird E, Waldron T, Marino A, Koplowitz B, Humphreys WG, Chong S, Morrison RA, Webb ML, Moreland S, Trippodo N, Barrish JC.

J Med Chem. 2003 Jan 2;46(1):125-37.

PMID:
12502366
9.

Different types of asynchronous music and effects on performance of basketball foul shot.

Geisler G, Leith LM.

Percept Mot Skills. 2001 Dec;93(3):734.

PMID:
11806595
10.

Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.

Kim KS, Sack JS, Tokarski JS, Qian L, Chao ST, Leith L, Kelly YF, Misra RN, Hunt JT, Kimball SD, Humphreys WG, Wautlet BS, Mulheron JG, Webster KR.

J Med Chem. 2000 Nov 2;43(22):4126-34.

PMID:
11063609
11.

Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.

Murugesan N, Gu Z, Stein PD, Spergel S, Mathur A, Leith L, Liu EC, Zhang R, Bird E, Waldron T, Marino A, Morrison RA, Webb ML, Moreland S, Barrish JC.

J Med Chem. 2000 Aug 10;43(16):3111-7.

PMID:
10956219
12.

Do coaches encourage aggressive behaviour in sport?

Leith LM.

Can J Sport Sci. 1991 Jun;16(2):85-6. No abstract available.

PMID:
1647864
13.

Managing national sport organizations.

Leith LM.

Can J Sport Sci. 1991 Jun;16(2):83-4. No abstract available.

PMID:
1647861
14.

How physical education students see themselves.

Leith LM.

Can J Sport Sci. 1990 Dec;15(4):228. No abstract available.

PMID:
2272003
15.

The national coaching certification program: objectives and reality.

Leith L.

Can J Sport Sci. 1990 Sep;15(3):163. No abstract available.

PMID:
2257527
16.

Discovery learning or knowledge of results?

Leith LM.

Can J Sport Sci. 1990 Jun;15(2):83-4. No abstract available.

PMID:
2383821
17.

Motivation and exercise adherence.

Leith LM.

Can J Sport Sci. 1990 Mar;15(1):7-8. No abstract available.

PMID:
2331644
18.

Central fatigue and lactate levels.

Leith LM.

Can J Sport Sci. 1990 Mar;15(1):6-7. No abstract available.

PMID:
2331642
19.

Verbal and non-verbal feedback from coaches.

Leith LM.

Can J Sport Sci. 1990 Mar;15(1):3-4. No abstract available.

PMID:
2331635

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