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Items: 1 to 50 of 77

1.

Block of NF-kB signaling accelerates MYC-driven hepatocellular carcinogenesis and modifies the tumor phenotype towards combined hepatocellular cholangiocarcinoma.

He J, Gerstenlauer M, Chan LK, Leithäuser F, Yeh MM, Wirth T, Maier HJ.

Cancer Lett. 2019 Aug 28;458:113-122. doi: 10.1016/j.canlet.2019.05.023. Epub 2019 May 22.

2.

CK1α overexpression correlates with poor survival in colorectal cancer.

Richter J, Kretz AL, Lemke J, Fauler M, Werner JU, Paschke S, Leithäuser F, Henne-Bruns D, Hillenbrand A, Knippschild U.

BMC Cancer. 2018 Feb 6;18(1):140. doi: 10.1186/s12885-018-4019-0.

3.

Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.

Hartmann K, Illing A, Leithäuser F, Baisantry A, Quintanilla-Martinez L, Rudolph KL.

Leukemia. 2017 Dec;31(12):2853. doi: 10.1038/leu.2017.224. Epub 2017 Nov 10.

4.

CDK9 is a prognostic marker and therapeutic target in pancreatic cancer.

Kretz AL, Schaum M, Richter J, Kitzig EF, Engler CC, Leithäuser F, Henne-Bruns D, Knippschild U, Lemke J.

Tumour Biol. 2017 Feb;39(2):1010428317694304. doi: 10.1177/1010428317694304.

PMID:
28231737
5.

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

Sunami Y, Ringelhan M, Kokai E, Lu M, O'Connor T, Lorentzen A, Weber A, Rodewald AK, Müllhaupt B, Terracciano L, Gul S, Wissel S, Leithäuser F, Krappmann D, Riedl P, Hartmann D, Schirmbeck R, Strnad P, Hüser N, Kleeff J, Friess H, Schmid RM, Geisler F, Wirth T, Heikenwalder M.

Hepatology. 2016 May;63(5):1592-607. doi: 10.1002/hep.28435. Epub 2016 Mar 4.

6.

Decreased CK1δ expression predicts prolonged survival in colorectal cancer patients.

Richter J, Rudeck S, Kretz AL, Kramer K, Just S, Henne-Bruns D, Hillenbrand A, Leithäuser F, Lemke J, Knippschild U.

Tumour Biol. 2016 Jul;37(7):8731-9. doi: 10.1007/s13277-015-4745-8. Epub 2016 Jan 7.

PMID:
26738869
7.

In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity.

Messmann JJ, Reisser T, Leithäuser F, Lutz MB, Debatin KM, Strauss G.

Blood. 2015 Aug 27;126(9):1138-48. doi: 10.1182/blood-2015-01-624163. Epub 2015 Jul 16.

8.

Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice.

Hartmann K, Illing A, Leithäuser F, Baisantry A, Quintanilla-Martinez L, Rudolph KL.

Leukemia. 2016 Mar;30(3):749-53. doi: 10.1038/leu.2015.173. Epub 2015 Jul 2. No abstract available. Erratum in: Leukemia. 2017 Nov 10;:.

9.

Nck adaptor proteins modulate differentiation and effector function of T cells.

Lu KH, Keppler S, Leithäuser F, Mattfeldt T, Castello A, Kostezka U, Küblbeck G, Schmitt S, Klevenz A, Prokosch S, Pougialis G, Pawson T, Batista F, Tafuri A, Arnold B.

J Leukoc Biol. 2015 Sep;98(3):301-11. doi: 10.1189/jlb.1HI1114-565R. Epub 2015 May 20.

PMID:
25995205
10.

CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application.

Winkler BS, Oltmer F, Richter J, Bischof J, Xu P, Burster T, Leithäuser F, Knippschild U.

Front Cell Dev Biol. 2015 Feb 20;3:9. doi: 10.3389/fcell.2015.00009. eCollection 2015.

11.

Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.

Richter J, Ullah K, Xu P, Alscher V, Blatz A, Peifer C, Halekotte J, Leban J, Vitt D, Holzmann K, Bakulev V, Pinna LA, Henne-Bruns D, Hillenbrand A, Kornmann M, Leithäuser F, Bischof J, Knippschild U.

Int J Cancer. 2015 Jun 15;136(12):2799-810. doi: 10.1002/ijc.29346. Epub 2014 Dec 1. Erratum in: Int J Cancer. 2016 Aug 15;139(4):E5.

12.

FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma.

Xie L, Ritz O, Leithäuser F, Guan H, Färbinger J, Weitzer CD, Gehringer F, Bruederlein S, Holzmann K, Vogel MJ, Möller P, Wirth T, Ushmorov A.

Oncotarget. 2014 Jul 30;5(14):5392-402.

13.

Recombinant CD95-Fc (APG101) prevents graft-versus-host disease in mice without disabling antitumor cytotoxicity and T-cell functions.

Hartmann N, Messmann JJ, Leithäuser F, Weiswange M, Kluge M, Fricke H, Debatin KM, Strauss G.

Blood. 2013 Jan 17;121(3):556-65. doi: 10.1182/blood-2012-04-423392. Epub 2012 Nov 30.

14.

Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation.

Sunami Y, Leithäuser F, Gul S, Fiedler K, Güldiken N, Espenlaub S, Holzmann KH, Hipp N, Sindrilaru A, Luedde T, Baumann B, Wissel S, Kreppel F, Schneider M, Scharffetter-Kochanek K, Kochanek S, Strnad P, Wirth T.

Hepatology. 2012 Sep;56(3):1117-28. doi: 10.1002/hep.25711. Epub 2012 Jul 10.

PMID:
22407857
15.

FOXO1 is a tumor suppressor in classical Hodgkin lymphoma.

Xie L, Ushmorov A, Leithäuser F, Guan H, Steidl C, Färbinger J, Pelzer C, Vogel MJ, Maier HJ, Gascoyne RD, Möller P, Wirth T.

Blood. 2012 Apr 12;119(15):3503-11. doi: 10.1182/blood-2011-09-381905. Epub 2012 Feb 17.

16.

Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo.

Hirner H, Günes C, Bischof J, Wolff S, Grothey A, Kühl M, Oswald F, Wegwitz F, Bösl MR, Trauzold A, Henne-Bruns D, Peifer C, Leithäuser F, Deppert W, Knippschild U.

PLoS One. 2012;7(1):e29709. doi: 10.1371/journal.pone.0029709. Epub 2012 Jan 3.

17.

In vitro-established alloantigen-specific CD8+ CTLs mediate graft-versus-tumor activity in the absence of graft-versus-host disease.

Hartmann N, Leithäuser F, Albers C, Duyster J, Möller P, Debatin KM, Strauss G.

Leukemia. 2011 May;25(5):848-55. doi: 10.1038/leu.2011.16. Epub 2011 Feb 18.

PMID:
21331071
18.

Fine tuning of the threshold of T cell selection by the Nck adapters.

Roy E, Togbe D, Holdorf A, Trubetskoy D, Nabti S, Küblbeck G, Schmitt S, Kopp-Schneider A, Leithäuser F, Möller P, Bladt F, Hämmerling GJ, Arnold B, Pawson T, Tafuri A.

J Immunol. 2010 Dec 15;185(12):7518-26. doi: 10.4049/jimmunol.1000008. Epub 2010 Nov 15.

19.

Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.

Roy E, Togbe D, Holdorf AD, Trubetskoy D, Nabti S, Küblbeck G, Klevenz A, Kopp-Schneider A, Leithäuser F, Möller P, Bladt F, Hämmerling G, Arnold B, Pawson T, Tafuri A.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15529-34. doi: 10.1073/pnas.1009743107. Epub 2010 Aug 13.

20.

KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma.

Guan H, Xie L, Leithäuser F, Flossbach L, Möller P, Wirth T, Ushmorov A.

Blood. 2010 Sep 2;116(9):1469-78. doi: 10.1182/blood-2009-12-256446. Epub 2010 Jun 2.

21.

Safety of probiotic Escherichia coli strain Nissle 1917 depends on intestinal microbiota and adaptive immunity of the host.

Gronbach K, Eberle U, Müller M, Olschläger TA, Dobrindt U, Leithäuser F, Niess JH, Döring G, Reimann J, Autenrieth IB, Frick JS.

Infect Immun. 2010 Jul;78(7):3036-46. doi: 10.1128/IAI.00218-10. Epub 2010 Apr 26.

22.

Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice.

Utz AC, Hirner H, Blatz A, Hillenbrand A, Schmidt B, Deppert W, Henne-Bruns D, Fischer D, Thal DR, Leithäuser F, Knippschild U.

J Histochem Cytochem. 2010 Jan;58(1):1-15. doi: 10.1369/jhc.2009.954628. Epub 2009 Sep 15.

23.

Myc regulates embryonic vascular permeability and remodeling.

Kokai E, Voss F, Fleischer F, Kempe S, Marinkovic D, Wolburg H, Leithäuser F, Schmidt V, Deutsch U, Wirth T.

Circ Res. 2009 May 22;104(10):1151-9. doi: 10.1161/CIRCRESAHA.108.191460. Epub 2009 Apr 30.

PMID:
19407242
24.

IL-22-dependent attenuation of T cell-dependent (ConA) hepatitis in herpes virus entry mediator deficiency.

Wahl C, Wegenka UM, Leithäuser F, Schirmbeck R, Reimann J.

J Immunol. 2009 Apr 15;182(8):4521-8. doi: 10.4049/jimmunol.0802810.

25.

Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.

Löhler J, Hirner H, Schmidt B, Kramer K, Fischer D, Thal DR, Leithäuser F, Knippschild U.

PLoS One. 2009;4(1):e4174. doi: 10.1371/journal.pone.0004174. Epub 2009 Jan 12.

26.

IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses.

Wahl C, Müller W, Leithäuser F, Adler G, Oswald F, Reimann J, Schirmbeck R, Seier A, Weiss JM, Prochnow B, Wegenka UM.

J Immunol. 2009 Jan 15;182(2):802-10.

27.

ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma.

Ushmorov A, Leithäuser F, Ritz O, Barth TF, Möller P, Wirth T.

Leukemia. 2008 Oct;22(10):1942-4. doi: 10.1038/leu.2008.70. Epub 2008 Mar 27. No abstract available.

PMID:
18368067
28.

Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo.

Brockschmidt C, Hirner H, Huber N, Eismann T, Hillenbrand A, Giamas G, Radunsky B, Ammerpohl O, Bohm B, Henne-Bruns D, Kalthoff H, Leithäuser F, Trauzold A, Knippschild U.

Gut. 2008 Jun;57(6):799-806. doi: 10.1136/gut.2007.123695. Epub 2008 Jan 18.

PMID:
18203806
29.
30.

[Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in MedB-1 mediastinal lymphoma line].

Barth TF, Melzner I, Wegener S, Bucur AJ, Brüderlein S, Dorsch K, Hasel C, Leithäuser F, Möller P.

Verh Dtsch Ges Pathol. 2005;89:234-44. German.

PMID:
18035697
31.

Images in cardiovascular medicine. Left ventricular bronchogenic cyst.

Klass O, Hoffmann MH, Ludwig B, Leithäuser F, Hannekum A.

Circulation. 2007 Oct 16;116(16):e385-7. No abstract available.

PMID:
17938294
32.

Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma.

Popov SW, Moldenhauer G, Wotschke B, Brüderlein S, Barth TF, Dorsch K, Ritz O, Möller P, Leithäuser F.

Cancer Res. 2007 Jul 15;67(14):6555-64.

33.

Two cases of primary malignant NK/T-cell lymphoma in the small intestine following an aggressive clinical course: Morphological, immunohistochemical, and molecular analysis.

Moubayed P, Leithäuser F, Binder T, Uppenkamp M, Feller AC.

Leuk Lymphoma. 2007 Jul;48(7):1451-5. No abstract available.

PMID:
17613782
34.

Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.

Leithäuser F, Meinhardt-Krajina T, Fink K, Wotschke B, Möller P, Reimann J.

Am J Pathol. 2006 Jun;168(6):1898-909.

35.

Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma.

Ushmorov A, Leithäuser F, Sakk O, Weinhaüsel A, Popov SW, Möller P, Wirth T.

Blood. 2006 Mar 15;107(6):2493-500. Epub 2005 Nov 22.

36.

Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein.

Melzner I, Weniger MA, Bucur AJ, Brüderlein S, Dorsch K, Hasel C, Leithäuser F, Ritz O, Dyer MJ, Barth TF, Möller P.

Int J Cancer. 2006 Apr 15;118(8):1941-4.

37.

AID expression identifies interfollicular large B cells as putative precursors of mature B-cell malignancies.

Moldenhauer G, Popov SW, Wotschke B, Brüderlein S, Riedl P, Fissolo N, Schirmbeck R, Ritz O, Möller P, Leithäuser F.

Blood. 2006 Mar 15;107(6):2470-3. Epub 2005 Nov 3.

38.

Report: workshop on mediastinal grey zone lymphoma.

Poppema S, Kluiver JL, Atayar C, van den Berg A, Rosenwald A, Hummel M, Lenze D, Lammert H, Stein H, Joos S, Barth T, Dyer M, Lichter P, Klein U, Cattoretti G, Gloghini A, Tu Y, Stolovitzky GA, Califano A, Carbone A, Dalla-Favera R, Melzner I, Bucur AJ, Brüderlein S, Dorsch K, Hasel C, Barth TF, Leithäuser F, Möller P.

Eur J Haematol Suppl. 2005 Jul;(66):45-52.

PMID:
16007868
39.

Downregulation of internal enhancer activity contributes to abnormally low immunoglobulin expression in the MedB-1 mediastinal B-cell lymphoma cell line.

Ritz O, Leithäuser F, Hasel C, Brüderlein S, Ushmorov A, Möller P, Wirth T.

J Pathol. 2005 Feb;205(3):336-48.

PMID:
15682441
40.

Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line.

Melzner I, Bucur AJ, Brüderlein S, Dorsch K, Hasel C, Barth TF, Leithäuser F, Möller P.

Blood. 2005 Mar 15;105(6):2535-42. Epub 2004 Nov 30.

41.

Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression.

Ushmorov A, Ritz O, Hummel M, Leithäuser F, Möller P, Stein H, Wirth T.

Blood. 2004 Nov 15;104(10):3326-34. Epub 2004 Jul 29.

42.

MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitis.

Krajina T, Leithäuser F, Reimann J.

Eur J Immunol. 2004 Mar;34(3):705-714. doi: 10.1002/eji.200324463.

43.

Hepatic dendritic cell subsets in the mouse.

Jomantaite I, Dikopoulos N, Kröger A, Leithäuser F, Hauser H, Schirmbeck R, Reimann J.

Eur J Immunol. 2004 Feb;34(2):355-65.

44.

Breaking tolerance in hepatitis B surface antigen (HBsAg) transgenic mice by vaccination with cross-reactive, natural HBsAg variants.

Schirmbeck R, Dikopoulos N, Kwissa M, Leithäuser F, Lamberth K, Buus S, Melber K, Reimann J.

Eur J Immunol. 2003 Dec;33(12):3342-52.

45.

[18F]5-fluoro-2-deoxyuridine-PET for imaging of malignant tumors and for measuring tissue proliferation.

Buchmann I, Vogg AT, Glatting G, Schultheiss S, Möller P, Leithäuser F, Schulte M, Gfrörer W, Kotzerke J, Reske SN.

Cancer Biother Radiopharm. 2003 Jun;18(3):327-37.

PMID:
12954120
46.

Epidemiology and virulence gene expression of intracellular group A streptococci in tonsils of recurrently infected adults.

Podbielski A, Beckert S, Schattke R, Leithäuser F, Lestin F, Gossler B, Kreikemeyer B.

Int J Med Microbiol. 2003 Jun;293(2-3):179-90.

PMID:
12868654
47.

3'-[18F]fluoro-3'-deoxythymidine ([18F]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-Cell lymphoma model and in the human disease.

Wagner M, Seitz U, Buck A, Neumaier B, Schultheiss S, Bangerter M, Bommer M, Leithäuser F, Wawra E, Munzert G, Reske SN.

Cancer Res. 2003 May 15;63(10):2681-7.

48.

Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis.

Krajina T, Leithäuser F, Möller P, Trobonjaca Z, Reimann J.

Eur J Immunol. 2003 Apr;33(4):1073-83.

49.

Early events in the pathogenesis of a murine transfer colitis.

Leithäuser F, Krajina T, Trobonjaca Z, Reimann J.

Pathobiology. 2002-2003;70(3):156-63. Review.

PMID:
12571420
50.

The hepatic immune system.

Wick MJ, Leithäuser F, Reimann J.

Crit Rev Immunol. 2002;22(1):47-103. Review.

PMID:
12186188

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