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The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.

Mayer AE, Löffler MC, Loza Valdés AE, Schmitz W, El-Merahbi R, Viera JT, Erk M, Zhang T, Braun U, Heikenwalder M, Leitges M, Schulze A, Sumara G.

Sci Signal. 2019 Aug 6;12(593). pii: eaav9150. doi: 10.1126/scisignal.aav9150.


Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.

Yin N, Liu Y, Khoor A, Wang X, Thompson EA, Leitges M, Justilien V, Weems C, Murray NR, Fields AP.

Cancer Cell. 2019 Aug 12;36(2):156-167.e7. doi: 10.1016/j.ccell.2019.07.002. Epub 2019 Aug 1.


Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4+ T lymphocyte activation.

Siegmund K, Thuille N, Posch N, Fresser F, Leitges M, Baier G.

Cell Commun Signal. 2019 May 28;17(1):56. doi: 10.1186/s12964-019-0364-0.


PKCα integrates spatiotemporally distinct Ca2+ and autocrine BDNF signaling to facilitate synaptic plasticity.

Colgan LA, Hu M, Misler JA, Parra-Bueno P, Moran CM, Leitges M, Yasuda R.

Nat Neurosci. 2018 Aug;21(8):1027-1037. doi: 10.1038/s41593-018-0184-3. Epub 2018 Jul 16.


Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis.

Tsui C, Martinez-Martin N, Gaya M, Maldonado P, Llorian M, Legrave NM, Rossi M, MacRae JI, Cameron AJ, Parker PJ, Leitges M, Bruckbauer A, Batista FD.

Immunity. 2018 Jun 19;48(6):1144-1159.e5. doi: 10.1016/j.immuni.2018.04.031. Epub 2018 Jun 5.


Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis.

Vorhagen S, Kleefisch D, Persa OD, Graband A, Schwickert A, Saynisch M, Leitges M, Niessen CM, Iden S.

Oncogene. 2018 Sep;37(37):5136-5146. doi: 10.1038/s41388-018-0313-1. Epub 2018 May 23.


Retraction: Protein kinase C is a calcium sensor for presynaptic short-term plasticity.

Fioravante D, Chu Y, de Jong AP, Leitges M, Kaeser PS, Regehr WG.

Elife. 2018 Mar 7;7. pii: e35974. doi: 10.7554/eLife.35974. No abstract available.


Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.

Parihar SP, Ozturk M, Marakalala MJ, Loots DT, Hurdayal R, Beukes D, Van Reenen M, Zak DE, Mbandi SK, Darboe F, Penn-Nicholson A, Hanekom WA, Leitges M, Scriba TJ, Guler R, Brombacher F.

Mucosal Immunol. 2018 Mar;11(2):579-580. doi: 10.1038/mi.2017.108. Epub 2017 Dec 20.


Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.

Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV.

Neurobiol Aging. 2018 Jan;61:225-237. doi: 10.1016/j.neurobiolaging.2017.09.001. Epub 2017 Sep 15.


Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.

Parihar SP, Ozturk M, Marakalala MJ, Loots DT, Hurdayal R, Maasdorp DB, Van Reenen M, Zak DE, Darboe F, Penn-Nicholson A, Hanekom WA, Leitges M, Scriba TJ, Guler R, Brombacher F.

Mucosal Immunol. 2018 Mar;11(2):496-511. doi: 10.1038/mi.2017.68. Epub 2017 Aug 9. Erratum in: Mucosal Immunol. 2017 Dec 20;:.


Protein kinase Cι/λ is dispensable for platelet function in thrombosis and hemostasis in mice.

Beck S, Leitges M, Stegner D.

Cell Signal. 2017 Oct;38:223-229. doi: 10.1016/j.cellsig.2017.07.015. Epub 2017 Jul 21.


Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.

Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP.

Diabetes. 2017 Apr;66(4):920-934. doi: 10.2337/db16-0482. Epub 2017 Jan 10.


High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

van der Vorst EPC, Theodorou K, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LFA, Tas SW, Wolfs IMJ, Kuijpers MJE, Gijbels MJ, Schalkwijk CG, Koonen DPY, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, de Winther MPJ, Biessen EAL, Donners MMPC.

Cell Metab. 2017 Jan 10;25(1):197-207. doi: 10.1016/j.cmet.2016.10.013. Epub 2016 Nov 17.


Role of Integrins α1β1 and α2β1 in Wound and Tumor Angiogenesis in Mice.

Ghatak S, Niland S, Schulz JN, Wang F, Eble JA, Leitges M, Mauch C, Krieg T, Zigrino P, Eckes B.

Am J Pathol. 2016 Nov;186(11):3011-3027. doi: 10.1016/j.ajpath.2016.06.021. Epub 2016 Sep 14.


Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ.

Kim YK, Yadava RS, Mandal M, Mahadevan K, Yu Q, Leitges M, Mahadevan MS.

PLoS One. 2016 Sep 22;11(9):e0163325. doi: 10.1371/journal.pone.0163325. eCollection 2016.


Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι.

Nakanishi Y, Reina-Campos M, Nakanishi N, Llado V, Elmen L, Peterson S, Campos A, De SK, Leitges M, Ikeuchi H, Pellecchia M, Blumberg RS, Diaz-Meco MT, Moscat J.

Cell Rep. 2016 Sep 20;16(12):3297-3310. doi: 10.1016/j.celrep.2016.08.054.


Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc.

Haller M, Khalid S, Kremser L, Fresser F, Furlan T, Hermann M, Guenther J, Drasche A, Leitges M, Giorgio M, Baier G, Lindner H, Troppmair J.

J Biol Chem. 2016 Nov 4;291(45):23557-23568. Epub 2016 Sep 13.


PKD1 protein is involved in reactive oxygen species-mediated mitochondrial depolarization in cooperation with protein kinase Cδ (PKCδ).

Zhang T, Sell P, Braun U, Leitges M.

J Biol Chem. 2016 Aug 5;291(32):16877. doi: 10.1074/jbc.A114.619148. No abstract available.


A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer.

Liou GY, Storz P, Leitges M.

Mol Cell Oncol. 2015 Dec 10;3(1):e1035477. doi: 10.1080/23723556.2015.1035477. eCollection 2016 Jan.


PKD3 deficiency causes alterations in microtubule dynamics during the cell cycle.

Zhang T, Braun U, Leitges M.

Cell Cycle. 2016 Jul 17;15(14):1844-54. doi: 10.1080/15384101.2016.1188237. Epub 2016 May 31.


Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.

Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R.

Sci Signal. 2016 May 10;9(427):ra47. doi: 10.1126/scisignal.aaf6209.


Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.

Liou GY, Döppler H, DelGiorno KE, Zhang L, Leitges M, Crawford HC, Murphy MP, Storz P.

Cell Rep. 2016 Mar 15;14(10):2325-36. doi: 10.1016/j.celrep.2016.02.029. Epub 2016 Mar 3.


Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.

Sajan M, Hansen B, Ivey R 3rd, Sajan J, Ari C, Song S, Braun U, Leitges M, Farese-Higgs M, Farese RV.

Diabetes. 2016 Jul;65(7):1892-903. doi: 10.2337/db15-1428. Epub 2016 Feb 19.


Retinol as a cofactor for PKCδ-mediated impairment of insulin sensitivity in a mouse model of diet-induced obesity.

Shabrova E, Hoyos B, Vinogradov V, Kim YK, Wassef L, Leitges M, Quadro L, Hammerling U.

FASEB J. 2016 Mar;30(3):1339-55. doi: 10.1096/fj.15-281543. Epub 2015 Dec 15.


Contraction stimulates muscle glucose uptake independent of atypical PKC.

Yu H, Fujii NL, Toyoda T, An D, Farese RV, Leitges M, Hirshman MF, Mul JD, Goodyear LJ.

Physiol Rep. 2015 Nov;3(11). pii: e12565. doi: 10.14814/phy2.12565.


The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62.

Bell KS, Al-Riyami L, Lumb FE, Britton GJ, Poole AW, Williams CM, Braun U, Leitges M, Harnett MM, Harnett W.

Immunol Lett. 2015 Nov;168(1):31-40. doi: 10.1016/j.imlet.2015.09.001. Epub 2015 Sep 3.


Pancreatic oncogenic signaling cascades converge at Protein Kinase D1.

Liou GY, Leitges M, Storz P.

Cell Cycle. 2015;14(10):1489-90. doi: 10.1080/15384101.2015.1032646. No abstract available.


PKD1 protein is involved in reactive oxygen species-mediated mitochondrial depolarization in cooperation with protein kinase Cδ (PKCδ).

Zhang T, Sell P, Braun U, Leitges M.

J Biol Chem. 2015 Apr 17;290(16):10472-85. doi: 10.1074/jbc.M114.619148. Epub 2015 Mar 10. Erratum in: J Biol Chem. 2016 Aug 5;291(32):16877.


Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.

Liou GY, Döppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P.

Nat Commun. 2015 Feb 20;6:6200. doi: 10.1038/ncomms7200.


Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ.

Llado V, Nakanishi Y, Duran A, Reina-Campos M, Shelton PM, Linares JF, Yajima T, Campos A, Aza-Blanc P, Leitges M, Diaz-Meco MT, Moscat J.

Cell Rep. 2015 Feb 10;10(5):740-754. doi: 10.1016/j.celrep.2015.01.007. Epub 2015 Feb 5.


Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors.

Valtcheva MV, Davidson S, Zhao C, Leitges M, Gereau RW 4th.

Mol Pain. 2015 Jan 6;11:1. doi: 10.1186/1744-8069-11-1.


Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.

Baumann U, Fernández-Sáiz V, Rudelius M, Lemeer S, Rad R, Knorn AM, Slawska J, Engel K, Jeremias I, Li Z, Tomiatti V, Illert AL, Targosz BS, Braun M, Perner S, Leitges M, Klapper W, Dreyling M, Miething C, Lenz G, Rosenwald A, Peschel C, Keller U, Kuster B, Bassermann F.

Nat Med. 2014 Dec;20(12):1401-9. doi: 10.1038/nm.3740. Epub 2014 Nov 24.


Multiple endothelial cells constitute the tip of developing blood vessels and polarize to promote lumen formation.

Pelton JC, Wright CE, Leitges M, Bautch VL.

Development. 2014 Nov;141(21):4121-6. doi: 10.1242/dev.110296.


PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages.

Szilagyi K, Meijer AB, Neele AE, Verkuijlen P, Leitges M, Dabernat S, Förster-Waldl E, Boztug K, Belot A, Kuijpers TW, Kraal G, de Winther MP, van den Berg TK.

Cardiovasc Res. 2014 Dec 1;104(3):467-76. doi: 10.1093/cvr/cvu213. Epub 2014 Sep 24.


Protein kinase C is a calcium sensor for presynaptic short-term plasticity.

Fioravante D, Chu Y, de Jong AP, Leitges M, Kaeser PS, Regehr WG.

Elife. 2014 Aug 5;3:e03011. doi: 10.7554/eLife.03011. Retraction in: Elife. 2018 Mar 07;7:null.


Redundant role of protein kinase C delta and epsilon during mouse embryonic development.

Carracedo S, Sacher F, Brandes G, Braun U, Leitges M.

PLoS One. 2014 Aug 1;9(8):e103686. doi: 10.1371/journal.pone.0103686. eCollection 2014.


Renal PKC-ε deficiency attenuates acute kidney injury and ischemic allograft injury via TNF-α-dependent inhibition of apoptosis and inflammation.

Rong S, Hueper K, Kirsch T, Greite R, Klemann C, Mengel M, Meier M, Menne J, Leitges M, Susnik N, Meier M, Haller H, Shushakova N, Gueler F.

Am J Physiol Renal Physiol. 2014 Sep 15;307(6):F718-26. doi: 10.1152/ajprenal.00372.2013. Epub 2014 Jul 23.


Corrigendum to "PKC∝ and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription" [Immunol. Lett. 151 (1-2) (2013) 31-38)].

Lutz-Nicoladoni C, Thuille N, Wachowicz K, Gruber T, Leitges M, Baier G.

Immunol Lett. 2014 Jul;160(1):104. doi: 10.1016/j.imlet.2013.11.020. Epub 2013 Dec 7. No abstract available.


PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.

Sajan MP, Ivey RA 3rd, Lee M, Mastorides S, Jurczak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV.

Mol Endocrinol. 2014 Jul;28(7):1097-107. doi: 10.1210/me.2014-1025. Epub 2014 May 30.


Calcium-dependent PKC isoforms have specialized roles in short-term synaptic plasticity.

Chu Y, Fioravante D, Leitges M, Regehr WG.

Neuron. 2014 May 21;82(4):859-71. doi: 10.1016/j.neuron.2014.04.003. Epub 2014 May 1.


Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.

Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP.

Mol Cell Biol. 2014 Apr;34(8):1474-85. doi: 10.1128/MCB.01699-13. Epub 2014 Feb 10.


Wnt6 is expressed in granulomatous lesions of Mycobacterium tuberculosis-infected mice and is involved in macrophage differentiation and proliferation.

Schaale K, Brandenburg J, Kispert A, Leitges M, Ehlers S, Reiling N.

J Immunol. 2013 Nov 15;191(10):5182-95. doi: 10.4049/jimmunol.1201819. Epub 2013 Oct 11.


Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) λ/ι.

Worthmann K, Leitges M, Teng B, Sestu M, Tossidou I, Samson T, Haller H, Huber TB, Schiffer M.

Am J Pathol. 2013 Dec;183(6):1945-1959. doi: 10.1016/j.ajpath.2013.08.026. Epub 2013 Oct 3.


aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation.

Niessen MT, Scott J, Zielinski JG, Vorhagen S, Sotiropoulou PA, Blanpain C, Leitges M, Niessen CM.

J Cell Biol. 2013 Sep 16;202(6):887-900. doi: 10.1083/jcb.201307001. Epub 2013 Sep 9.


PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.

Walser R, Burke JE, Gogvadze E, Bohnacker T, Zhang X, Hess D, Küenzi P, Leitges M, Hirsch E, Williams RL, Laffargue M, Wymann MP.

PLoS Biol. 2013;11(6):e1001587. doi: 10.1371/journal.pbio.1001587. Epub 2013 Jun 25.


PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice.

Kong L, Shen X, Lin L, Leitges M, Rosario R, Zou YS, Yan SF.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1779-87. doi: 10.1161/ATVBAHA.112.301113. Epub 2013 Jun 13.


Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance.

Habegger KM, Matzke D, Ottaway N, Hembree J, Holland J, Raver C, Mansfeld J, Müller TD, Perez-Tilve D, Pfluger PT, Lee SJ, Diaz-Meco M, Moscat J, Leitges M, Tschöp MH, Hofmann SM.

Adipocyte. 2012 Oct 1;1(4):203-214.


Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5.

Seidl S, Braun U, Roos N, Li S, Lüdtke TH, Kispert A, Leitges M.

PLoS One. 2013 May 14;8(5):e62756. doi: 10.1371/journal.pone.0062756. Print 2013.


Expression pattern of protein kinase C ϵ during mouse embryogenesis.

Carracedo S, Braun U, Leitges M.

BMC Dev Biol. 2013 May 2;13:16. doi: 10.1186/1471-213X-13-16.

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