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Items: 1 to 50 of 107

1.

Convergent Synthesis of the NS5B Inhibitor GSK8175 Enabled by Transition Metal Catalysis.

Arrington K, Barcan GA, Calandra NA, Erickson GA, Li L, Liu L, Nilson MG, Strambeanu II, VanGelder KF, Woodard JL, Xie S, Allen CL, Kowalski JA, Leitch DC.

J Org Chem. 2019 Apr 19;84(8):4680-4694. doi: 10.1021/acs.joc.8b02269. Epub 2018 Oct 29.

PMID:
30339385
2.

Molecular tuning of electroreception in sharks and skates.

Bellono NW, Leitch DB, Julius D.

Nature. 2018 Jun;558(7708):122-126. doi: 10.1038/s41586-018-0160-9. Epub 2018 May 30.

3.

Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.

Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D.

Cell. 2017 Jun 29;170(1):185-198.e16. doi: 10.1016/j.cell.2017.05.034. Epub 2017 Jun 22.

4.

Molecular basis of ancestral vertebrate electroreception.

Bellono NW, Leitch DB, Julius D.

Nature. 2017 Mar 16;543(7645):391-396. doi: 10.1038/nature21401. Epub 2017 Mar 6.

5.

Development and Cycloaddition Reactivity of a New Class of Pyridine-Based Mesoionic 1,3-Dipole.

Erguven H, Leitch DC, Keyzer EN, Arndtsen BA.

Angew Chem Int Ed Engl. 2017 May 22;56(22):6078-6082. doi: 10.1002/anie.201609726. Epub 2016 Dec 22.

PMID:
28004875
6.

A palladium-catalysed multicomponent coupling approach to conjugated poly(1,3-dipoles) and polyheterocycles.

Leitch DC, Kayser LV, Han ZY, Siamaki AR, Keyzer EN, Gefen A, Arndtsen BA.

Nat Commun. 2015 Jun 16;6:7411. doi: 10.1038/ncomms8411.

7.

Brain mass and cranial nerve size in shrews and moles.

Leitch DB, Sarko DK, Catania KC.

Sci Rep. 2014 Sep 1;4:6241. doi: 10.1038/srep06241.

8.

The health implications of low hemoglobin deferral in infrequent blood donors.

Annen K, Delaney M, Leitch D, Mast AE.

Transfusion. 2015 Jan;55(1):86-90. doi: 10.1111/trf.12801. Epub 2014 Aug 1.

9.

Organization of the spinal trigeminal nucleus in star-nosed moles.

Sawyer EK, Leitch DB, Catania KC.

J Comp Neurol. 2014 Oct 1;522(14):3335-50. doi: 10.1002/cne.23605. Epub 2014 Apr 29.

10.

Bis(amidate)bis(amido) titanium complex: a regioselective intermolecular alkyne hydroamination catalyst.

Yim JC, Bexrud JA, Ayinla RO, Leitch DC, Schafer LL.

J Org Chem. 2014 Mar 7;79(5):2015-28. doi: 10.1021/jo402668q. Epub 2014 Feb 21.

PMID:
24506303
11.

Cutaneous and periodontal inputs to the cerebellum of the naked mole-rat (Heterocephalus glaber).

Sarko DK, Leitch DB, Catania KC.

Front Neuroanat. 2013 Nov 18;7:39. doi: 10.3389/fnana.2013.00039. eCollection 2013.

12.

Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: potent inhibitors of R5 HIV-1 replication.

Skerlj R, Bridger G, Zhou Y, Bourque E, McEachern E, Metz M, Harwig C, Li TS, Yang W, Bogucki D, Zhu Y, Langille J, Veale D, Ba T, Bey M, Baird I, Kaller A, Krumpak M, Leitch D, Satori M, Vocadlo K, Guay D, Nan S, Yee H, Crawford J, Chen G, Wilson T, Carpenter B, Gauthier D, Macfarland R, Mosi R, Bodart V, Wong R, Fricker S, Schols D.

J Med Chem. 2013 Oct 24;56(20):8049-65. doi: 10.1021/jm401101p. Epub 2013 Oct 3.

PMID:
24090135
13.

Upgrading light hydrocarbons via tandem catalysis: a dual homogeneous Ta/Ir system for alkane/alkene coupling.

Leitch DC, Lam YC, Labinger JA, Bercaw JE.

J Am Chem Soc. 2013 Jul 17;135(28):10302-5. doi: 10.1021/ja405191a. Epub 2013 Jul 2.

PMID:
23799786
14.

Barrelettes without barrels in the American water shrew.

Catania KC, Catania EH, Sawyer EK, Leitch DB.

PLoS One. 2013 Jun 3;8(6):e65975. doi: 10.1371/journal.pone.0065975. Print 2013.

15.

The star-nosed mole reveals clues to the molecular basis of mammalian touch.

Gerhold KA, Pellegrino M, Tsunozaki M, Morita T, Leitch DB, Tsuruda PR, Brem RB, Catania KC, Bautista DM.

PLoS One. 2013;8(1):e55001. doi: 10.1371/journal.pone.0055001. Epub 2013 Jan 30.

16.

Structure, innervation and response properties of integumentary sensory organs in crocodilians.

Leitch DB, Catania KC.

J Exp Biol. 2012 Dec 1;215(Pt 23):4217-30. doi: 10.1242/jeb.076836.

17.

Faster scaling of visual neurons in cortical areas relative to subcortical structures in non-human primate brains.

Collins CE, Leitch DB, Wong P, Kaas JH, Herculano-Houzel S.

Brain Struct Funct. 2013 May;218(3):805-16. doi: 10.1007/s00429-012-0430-5. Epub 2012 Jun 9.

18.

Chemoarchitecture of layer 4 isocortex in the American water shrew (Sorex palustris).

Leitch DB, Gauthier D, Sarko DK, Catania KC.

Brain Behav Evol. 2011;78(4):261-71. doi: 10.1159/000330832. Epub 2011 Oct 7.

PMID:
21985842
19.

Mechanistic elucidation of intramolecular aminoalkene hydroamination catalyzed by a tethered bis(ureate) complex: evidence for proton-assisted C-N bond formation at zirconium.

Leitch DC, Platel RH, Schafer LL.

J Am Chem Soc. 2011 Oct 5;133(39):15453-63. doi: 10.1021/ja202448b. Epub 2011 Sep 7.

PMID:
21851117
20.

A star in the brainstem reveals the first step of cortical magnification.

Catania KC, Leitch DB, Gauthier D.

PLoS One. 2011;6(7):e22406. doi: 10.1371/journal.pone.0022406. Epub 2011 Jul 19.

21.

Cavitating mesenteric lymph node syndrome in association with coeliac disease and enteropathy associated T-cell lymphoma: a case report and review of the literature.

McBride OM, Skipworth RJ, Leitch D, Yalamarthi S.

Case Rep Med. 2010;2010:478269. doi: 10.1155/2010/478269. Epub 2011 Jan 2.

22.

Organization of somatosensory cortex in the Northern grasshopper mouse (Onychomys leucogaster), a predatory rodent.

Sarko DK, Leitch DB, Girard I, Sikes RS, Catania KC.

J Comp Neurol. 2011 Jan 1;519(1):64-74. doi: 10.1002/cne.22504.

23.

Neuron densities vary across and within cortical areas in primates.

Collins CE, Airey DC, Young NA, Leitch DB, Kaas JH.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15927-32. doi: 10.1073/pnas.1010356107. Epub 2010 Aug 23.

24.

Isolation of catalytic intermediates in hydroamination reactions: insertion of internal alkynes into a zirconium-amido bond.

Leitch DC, Turner CS, Schafer LL.

Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6382-6. doi: 10.1002/anie.201001927. No abstract available.

PMID:
20665612
25.

Function of the appendages in tentacled snakes (Erpeton tentaculatus).

Catania KC, Leitch DB, Gauthier D.

J Exp Biol. 2010 Feb 1;213(3):359-67. doi: 10.1242/jeb.039685.

26.

Broadening the scope of group 4 hydroamination catalysis using a tethered ureate ligand.

Leitch DC, Payne PR, Dunbar CR, Schafer LL.

J Am Chem Soc. 2009 Dec 30;131(51):18246-7. doi: 10.1021/ja906955b.

PMID:
19994887
27.

Minimal-change nephrotic syndrome due to occupational mercury vapor inhalation.

Campbell G, Leitch D, Lewington A, Dargan PI, Baker RJ.

Clin Nephrol. 2009 Sep;72(3):216-9.

PMID:
19761728
28.

Cellular scaling rules of insectivore brains.

Sarko DK, Catania KC, Leitch DB, Kaas JH, Herculano-Houzel S.

Front Neuroanat. 2009 Jun 29;3:8. doi: 10.3389/neuro.05.008.2009. eCollection 2009.

29.

Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia.

Stanwood GD, Leitch DB, Savchenko V, Wu J, Fitsanakis VA, Anderson DJ, Stankowski JN, Aschner M, McLaughlin B.

J Neurochem. 2009 Jul;110(1):378-89. doi: 10.1111/j.1471-4159.2009.06145.x. Epub 2009 May 5.

30.

Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme.

Diggle CP, Shires M, Leitch D, Brooke D, Carr IM, Markham AF, Hayward BE, Asipu A, Bonthron DT.

J Histochem Cytochem. 2009 Aug;57(8):763-74. doi: 10.1369/jhc.2009.953190. Epub 2009 Apr 13.

31.

Selective C-H activation alpha to primary amines. Bridging metallaaziridines for catalytic, intramolecular alpha-alkylation.

Bexrud JA, Eisenberger P, Leitch DC, Payne PR, Schafer LL.

J Am Chem Soc. 2009 Feb 18;131(6):2116-8. doi: 10.1021/ja808862w.

PMID:
19173650
32.

Incomplete cellular depopulation may explain the high failure rate of bovine ureteric grafts.

Spark JI, Yeluri S, Derham C, Wong YT, Leitch D.

Br J Surg. 2008 May;95(5):582-5. doi: 10.1002/bjs.6052.

PMID:
18344206
33.

Acute renal failure secondary to HIVAN despite HAART: a possible pathogenic role for cytomegalovirus.

Tan J, Semple D, Armstrong N, Leitch D, Wright M.

Nephrology (Carlton). 2007 Feb;12(1):108-9. No abstract available.

PMID:
17295671
34.

The delivery of mercury to the Beaufort Sea of the Arctic Ocean by the Mackenzie River.

Leitch DR, Carrie J, Lean D, Macdonald RW, Stern GA, Wang F.

Sci Total Environ. 2007 Feb 1;373(1):178-95. Epub 2006 Dec 12.

PMID:
17169406
36.

Chiral neutral zirconium amidate complexes for the asymmetric hydroamination of alkenes.

Wood MC, Leitch DC, Yeung CS, Kozak JA, Schafer LL.

Angew Chem Int Ed Engl. 2007;46(3):354-8. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2009;48(38):6937. Angew Chem Int Ed Engl. 2010 Sep 3;49(37):6475.

PMID:
17029322
37.

Redefining the R1 resection in pancreatic cancer.

Verbeke CS, Leitch D, Menon KV, McMahon MJ, Guillou PJ, Anthoney A.

Br J Surg. 2006 Oct;93(10):1232-7.

PMID:
16804874
38.

Lung cancer in Teesside (UK) and Varese (Italy): a comparison of management and survival.

Imperatori A, Harrison RN, Leitch DN, Rovera F, Lepore G, Dionigi G, Sutton P, Dominioni L.

Thorax. 2006 Mar;61(3):232-9. Epub 2005 Nov 11.

39.

Ileitis in ulcerative colitis: is it a backwash?

Abdelrazeq AS, Wilson TR, Leitch DL, Lund JN, Leveson SH.

Dis Colon Rectum. 2005 Nov;48(11):2038-46.

PMID:
16175321
40.

Intramolecular hydroamination of unactived olefins with Ti(NMe2)4 as a precatalyst.

Bexrud JA, Beard JD, Leitch DC, Schafer LL.

Org Lett. 2005 May 12;7(10):1959-62.

PMID:
15876029
41.

Survey of flexible working amongst specialist registrars and consultants in respiratory medicine in the UK.

Leitch DN, Brown JL, Campbell IA, Elston C, Hardinge M, Macklinlay C, Moon J, Patel I, Ryan PJ, Stevenson N, Restrick L, Macfarlane J.

Clin Med (Lond). 2005 Mar-Apr;5(2):187-8. No abstract available.

42.

Interactive textiles for warrior systems applications.

Leitch DP.

Stud Health Technol Inform. 2004;108:88-94.

PMID:
15718634
43.

Relation of expired carbon monoxide to smoking history, lapsed time, TLCO measurement and passive smoking.

Leitch DN, Harkawat R, Askew J, Masel P, Hendrick DJ.

Respir Med. 2005 Jan;99(1):32-8.

44.

Dysregulation of apoptosis in Waldenstrom's macroglobulinemia does not involve nuclear factor kappa B activation.

Leitch D, Barrans SL, Jack AS, Owen RG.

Semin Oncol. 2003 Apr;30(2):161-4.

PMID:
12720128
45.

Liver abscesses due to Fusobacterium spp that mimick malignant metastatic liver disease.

Athavale NV, Leitch DG, Cowling P.

Eur J Clin Microbiol Infect Dis. 2002 Dec;21(12):884-6. Epub 2002 Dec 10.

PMID:
12525925
46.

Effect of inhaled fluticasone propionate on airway responsiveness in treatment-naive individuals--a lesser benefit in females.

Convery RP, Leitch DN, Bromly C, Ward RJ, Bartlett G, Hendrick DJ.

Eur Respir J. 2000 Jan;15(1):19-24.

47.

The administrative support team: specialized support.

Leitch DB.

J Nurs Adm. 1999 Sep;29(9):9-11.

PMID:
10491663
48.

Osteoporosis in patients attending a fracture clinic.

Leitch DN, Khurana PS, Fordham JN.

Br J Gen Pract. 1998 Nov;48(436):1790-1. No abstract available.

49.

Mother-infant interaction: achieving synchrony.

Leitch DB.

Nurs Res. 1999 Jan-Feb;48(1):55-8.

PMID:
10029403
50.

Intestinal perforation in a patient with severe ankylosing spondylitis.

Leitch DN, Fordham JN.

Ann Rheum Dis. 1997 Aug;56(8):458-60. No abstract available.

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