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Items: 18


Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.

Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, Cihlar T, Jordan R, Denison MR, Baric RS.

Nat Commun. 2020 Jan 10;11(1):222. doi: 10.1038/s41467-019-13940-6.


Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome.

Leist SR, Cockrell AS.

Methods Mol Biol. 2020;2099:137-159. doi: 10.1007/978-1-0716-0211-9_12.


Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis.

Leist SR, Jensen KL, Baric RS, Sheahan TP.

PLoS One. 2019 Jul 24;14(7):e0220126. doi: 10.1371/journal.pone.0220126. eCollection 2019.


Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis.

Lambertz RLO, Gerhauser I, Nehlmeier I, Leist SR, Kollmus H, Pöhlmann S, Schughart K.

J Gen Virol. 2019 Jul;100(7):1073-1078. doi: 10.1099/jgv.0.001274. Epub 2019 May 17.


Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.

Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS.

mBio. 2018 Oct 9;9(5). pii: e01753-18. doi: 10.1128/mBio.01753-18.


Giving the Genes a Shuffle: Using Natural Variation to Understand Host Genetic Contributions to Viral Infections.

Leist SR, Baric RS.

Trends Genet. 2018 Oct;34(10):777-789. doi: 10.1016/j.tig.2018.07.005. Epub 2018 Aug 18. Review.


Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice.

Cockrell AS, Leist SR, Douglas MG, Baric RS.

Mamm Genome. 2018 Aug;29(7-8):367-383. doi: 10.1007/s00335-018-9760-9. Epub 2018 Jul 24. Review.


Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, McAnarney ET, Graham RL, Waters KM, Baric RS.

J Virol. 2018 Aug 16;92(17). pii: e00710-18. doi: 10.1128/JVI.00710-18. Print 2018 Sep 1.


Of mice and men: the host response to influenza virus infection.

Kollmus H, Pilzner C, Leist SR, Heise M, Geffers R, Schughart K.

Mamm Genome. 2018 Aug;29(7-8):446-470. doi: 10.1007/s00335-018-9750-y. Epub 2018 Jun 15.


Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, Graham RL, McAnarney ET, Stratton KG, Cockrell AS, Debbink K, Sims AC, Waters KM, Baric RS.

mSphere. 2017 Nov 15;2(6). pii: e00346-17. doi: 10.1128/mSphere.00346-17. eCollection 2017 Nov-Dec.


Increased virulence of a PB2/HA mutant of an avian H9N2 influenza strain after three passages in porcine differentiated airway epithelial cells.

Yang W, Lambertz RLO, Punyadarsaniya D, Leist SR, Stech J, Schughart K, Herrler G, Wu NH, Meng F.

Vet Microbiol. 2017 Nov;211:129-134. doi: 10.1016/j.vetmic.2017.10.015. Epub 2017 Oct 16.


Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653.


Mutations during the Adaptation of H9N2 Avian Influenza Virus to the Respiratory Epithelium of Pigs Enhance Sialic Acid Binding Activity and Virulence in Mice.

Yang W, Punyadarsaniya D, Lambertz RLO, Lee DCC, Liang CH, Höper D, Leist SR, Hernández-Cáceres A, Stech J, Beer M, Wu CY, Wong CH, Schughart K, Meng F, Herrler G.

J Virol. 2017 Mar 29;91(8). pii: e02125-16. doi: 10.1128/JVI.02125-16. Print 2017 Apr 15.


Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.

Leist SR, Pilzner C, van den Brand JM, Dengler L, Geffers R, Kuiken T, Balling R, Kollmus H, Schughart K.

BMC Genomics. 2016 Feb 27;17:143. doi: 10.1186/s12864-016-2483-y.


Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice.

Leist SR, Kollmus H, Hatesuer B, Lambertz RL, Schughart K.

Virol J. 2016 Jan 27;13:17. doi: 10.1186/s12985-016-0471-0.


RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection.

Wilk E, Pandey AK, Leist SR, Hatesuer B, Preusse M, Pommerenke C, Wang J, Schughart K.

BMC Genomics. 2015 Sep 2;16:655. doi: 10.1186/s12864-015-1867-8.


In vivo knockdown of Piccolino disrupts presynaptic ribbon morphology in mouse photoreceptor synapses.

Regus-Leidig H, Fuchs M, Löhner M, Leist SR, Leal-Ortiz S, Chiodo VA, Hauswirth WW, Garner CC, Brandstätter JH.

Front Cell Neurosci. 2014 Sep 3;8:259. doi: 10.3389/fncel.2014.00259. eCollection 2014.


27th International Mammalian Genome Conference meeting report.

Gamache B, Leist SR, Bard AD, Logan DW, Carpanini SM.

Mamm Genome. 2014 Jun;25(5-6):195-201. doi: 10.1007/s00335-014-9513-3. Epub 2014 Apr 22. No abstract available.


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