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Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli.

Gerding HR, Karreman C, Daiber A, Delp J, Hammler D, Mex M, Schildknecht S, Leist M.

Redox Biol. 2019 Jun 10;26:101251. doi: 10.1016/j.redox.2019.101251. [Epub ahead of print]


Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants.

Delp J, Funke M, Rudolf F, Cediel A, Bennekou SH, van der Stel W, Carta G, Jennings P, Toma C, Gardner I, van de Water B, Forsby A, Leist M.

Arch Toxicol. 2019 Jun 12. doi: 10.1007/s00204-019-02473-y. [Epub ahead of print]


Prevalence and incidence of disability based on the Unique Certificate of Disability at a teaching hospital in the Metropolitan Area of Buenos Aires.

Puga C, Pagotto V, Giunta D, Vicens J, Leist M, Vaucheret Paz E, Hornstein L, Garfi L, Agosta G.

Arch Argent Pediatr. 2019 Jun 1;117(3):183-187. doi: 10.5546/aap.2019.eng.183. English, Spanish.


Corrigendum to Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity Toxicol Appl Pharmacol, 354 (2018) 64-80.

Delp J, Gutbier S, Cerff M, Zasada C, Niedenführ S, Zhao L, Smirnova L, Hartung T, Borlinghaus H, Schreiber F, Bergemann J, Gätgens J, Beyss M, Azzouzi S, Waldmann T, Kempa S, Nöh K, Leist M.

Toxicol Appl Pharmacol. 2019 Jun 1;372:70. doi: 10.1016/j.taap.2019.04.010. Epub 2019 Apr 16. No abstract available.


Functionalized DNA Hydrogels Produced by Polymerase-Catalyzed Incorporation of Non-Natural Nucleotides as a Surface Coating for Cell Culture Applications.

Finke A, Schneider AK, Spreng AS, Leist M, Niemeyer CM, Marx A.

Adv Healthc Mater. 2019 May;8(9):e1900080. doi: 10.1002/adhm.201900080. Epub 2019 Mar 12.


Chemical concentrations in cell culture compartments (C5) - concentration definitions.

Kisitu J, Hougaard Bennekou S, Leist M.

ALTEX. 2019;36(1):154-160. doi: 10.14573/altex.1901031.


Toward Good In Vitro Reporting Standards.

Hartung T, De Vries R, Hoffmann S, Hogberg HT, Smirnova L, Tsaioun K, Whaley P, Leist M.

ALTEX. 2019;36(1):3-17. doi: 10.14573/altex.1812191.


Optimizing drug discovery by Investigative Toxicology: Current and future trends.

Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T, Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T.

ALTEX. 2018 Dec 20. doi: 10.14573/altex.1808181. [Epub ahead of print]


Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.

Grinberg M, Stöber RM, Albrecht W, Edlund K, Schug M, Godoy P, Cadenas C, Marchan R, Lampen A, Braeuning A, Buhrke T, Leist M, Oberemm A, Hellwig B, Kamp H, Gardner I, Escher S, Taboureau O, Aguayo-Orozco A, Sachinidis A, Ellinger-Ziegelbauer H, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3. Epub 2018 Dec 3.


The synthetic peptide LyeTxI-b derived from Lycosa erythrognatha spider venom is cytotoxic to U-87 MG glioblastoma cells.

Abdel-Salam MAL, Carvalho-Tavares J, Gomes KS, Teixeira-Carvalho A, Kitten GT, Nyffeler J, Dias FF, Dos Reis PVM, Pimenta AMC, Leist M, de Lima ME, de Souza-Fagundes EM.

Amino Acids. 2019 Mar;51(3):433-449. doi: 10.1007/s00726-018-2678-4. Epub 2018 Nov 17.


Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress.

Gutbier S, Spreng AS, Delp J, Schildknecht S, Karreman C, Suciu I, Brunner T, Groettrup M, Leist M.

Cell Death Differ. 2018 Dec;25(12):2101-2117. doi: 10.1038/s41418-018-0229-x. Epub 2018 Nov 2.


HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.

Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L.

Nat Commun. 2018 Oct 19;9(1):4345. doi: 10.1038/s41467-018-06486-6.


Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.

Gu X, Albrecht W, Edlund K, Kappenberg F, Rahnenführer J, Leist M, Moritz W, Godoy P, Cadenas C, Marchan R, Brecklinghaus T, Pardo LT, Castell JV, Gardner I, Han B, Hengstler JG, Stoeber R.

Arch Toxicol. 2018 Dec;92(12):3505-3515. doi: 10.1007/s00204-018-2302-0. Epub 2018 Oct 13.


Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift.

Gutbier S, May P, Berthelot S, Krishna A, Trefzer T, Behbehani M, Efremova L, Delp J, Gstraunthaler G, Waldmann T, Leist M.

Arch Toxicol. 2018 Dec;92(12):3487-3503. doi: 10.1007/s00204-018-2326-5. Epub 2018 Oct 8.


Carbamylated Erythropoietin Decreased Proliferation and Neurogenesis in the Subventricular Zone, but Not the Dentate Gyrus, After Irradiation to the Developing Rat Brain.

Osato K, Sato Y, Osato A, Sato M, Zhu C, Leist M, Kuhn HG, Blomgren K.

Front Neurol. 2018 Sep 12;9:738. doi: 10.3389/fneur.2018.00738. eCollection 2018.


Essential components of methods papers.

Leist M, Hengstler JG.

ALTEX. 2018;35(3):429-432. doi: 10.14573/altex.1807031.


Animal testing and its alternatives - the most important omics is economics.

Meigs L, Smirnova L, Rovida C, Leist M, Hartung T.

ALTEX. 2018;35(3):275-305. doi: 10.14573/altex.1807041.


Normalization of data for viability and relative cell function curves.

Krebs A, Nyffeler J, Rahnenführer J, Leist M.

ALTEX. 2018;35(2):268-271. doi: 10.14573/1803231.


Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone.

Harris G, Eschment M, Orozco SP, McCaffery JM, Maclennan R, Severin D, Leist M, Kleensang A, Pamies D, Maertens A, Hogberg HT, Freeman D, Kirkwood A, Hartung T, Smirnova L.

Arch Toxicol. 2018 Aug;92(8):2587-2606. doi: 10.1007/s00204-018-2250-8. Epub 2018 Jun 28.


Increasing the Resistance of Living Cells against Oxidative Stress by Nonnatural Surfactants as Membrane Guards.

Kunkel M, Schildknecht S, Boldt K, Zeyffert L, Schleheck D, Leist M, Polarz S.

ACS Appl Mater Interfaces. 2018 Jul 18;10(28):23638-23646. doi: 10.1021/acsami.8b07032. Epub 2018 Jul 5.


Correlation of structural features of novel 1,2,3-triazoles with their neurotoxic and tumoricidal properties.

de Souza-Fagundes EM, Delp J, Prazeres PDM, Marques LB, Carmo AML, Stroppa PHF, Glanzmann N, Kisitu J, Szamosvàri D, Böttcher T, Leist M, da Silva AD.

Chem Biol Interact. 2018 Aug 1;291:253-263. doi: 10.1016/j.cbi.2018.06.029. Epub 2018 Jun 23.


Reduced Aβ secretion by human neurons under conditions of strongly increased BACE activity.

Scholz D, Chernyshova Y, Ückert AK, Leist M.

J Neurochem. 2018 Oct;147(2):256-274. doi: 10.1111/jnc.14467. Epub 2018 Sep 26.


Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems.

Pamies D, Bal-Price A, Chesné C, Coecke S, Dinnyes A, Eskes C, Grillari R, Gstraunthaler G, Hartung T, Jennings P, Leist M, Martin U, Passier R, Schwamborn JC, Stacey GN, Ellinger-Ziegelbauer H, Daneshian M.

ALTEX. 2018;35(3):353-378. doi: 10.14573/altex.1710081. Epub 2018 Apr 13.


Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity.

Bal-Price A, Hogberg HT, Crofton KM, Daneshian M, FitzGerald RE, Fritsche E, Heinonen T, Hougaard Bennekou S, Klima S, Piersma AH, Sachana M, Shafer TJ, Terron A, Monnet-Tschudi F, Viviani B, Waldmann T, Westerink RHS, Wilks MF, Witters H, Zurich MG, Leist M.

ALTEX. 2018;35(3):306-352. doi: 10.14573/altex.1712081. Epub 2018 Feb 23.


Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.

Fritsche E, Grandjean P, Crofton KM, Aschner M, Goldberg A, Heinonen T, Hessel EVS, Hogberg HT, Bennekou SH, Lein PJ, Leist M, Mundy WR, Paparella M, Piersma AH, Sachana M, Schmuck G, Solecki R, Terron A, Monnet-Tschudi F, Wilks MF, Witters H, Zurich MG, Bal-Price A.

Toxicol Appl Pharmacol. 2018 Sep 1;354:3-6. doi: 10.1016/j.taap.2018.02.004. Epub 2018 Feb 12.


Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect.

Secker PF, Beneke S, Schlichenmaier N, Delp J, Gutbier S, Leist M, Dietrich DR.

Cell Death Dis. 2018 Feb 14;9(2):226. doi: 10.1038/s41419-018-0273-y.


A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays.

Delp J, Gutbier S, Klima S, Hoelting L, Pinto-Gil K, Hsieh JH, Aichem M, Klein K, Schreiber F, Tice RR, Pastor M, Behl M, Leist M.

ALTEX. 2018;35(2):235-253. doi: 10.14573/altex.1712182. Epub 2018 Jan 21.


Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity.

Delp J, Gutbier S, Cerff M, Zasada C, Niedenführ S, Zhao L, Smirnova L, Hartung T, Borlinghaus H, Schreiber F, Bergemann J, Gätgens J, Beyss M, Azzouzi S, Waldmann T, Kempa S, Nöh K, Leist M.

Toxicol Appl Pharmacol. 2018 Sep 1;354:64-80. doi: 10.1016/j.taap.2017.12.013. Epub 2017 Dec 24. Erratum in: Toxicol Appl Pharmacol. 2019 Jun 1;372:70.


An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition.

Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH; EFSA WG EPI1 Members, Leist M, Schildknecht S.

Arch Toxicol. 2018 Jan;92(1):41-82. doi: 10.1007/s00204-017-2133-4. Epub 2017 Dec 5. Review.


A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins.

Nyffeler J, Chovancova P, Dolde X, Holzer AK, Purvanov V, Kindinger I, Kerins A, Higton D, Silvester S, van Vugt-Lussenburg BMA, Glaab E, van der Burg B, Maclennan R, Legler DF, Leist M.

Arch Toxicol. 2018 Mar;92(3):1225-1247. doi: 10.1007/s00204-017-2125-4. Epub 2017 Nov 21.


A direct access to heterobimetallic complexes by roll-over cyclometallation.

Schön F, Leist M, Neuba A, Lang J, Braun C, Sun Y, Niedner-Schatteburg G, Bräse S, Thiel WR.

Chem Commun (Camb). 2017 Nov 2;53(88):12016-12019. doi: 10.1039/c7cc07119a.


Adverse outcome pathways: opportunities, limitations and open questions.

Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG.

Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19. Review.


Simultaneous IR-Spectroscopic Observation of α-Synuclein, Lipids, and Solvent Reveals an Alternative Membrane-Induced Oligomerization Pathway.

Fallah MA, Gerding HR, Scheibe C, Drescher M, Karreman C, Schildknecht S, Leist M, Hauser K.

Chembiochem. 2017 Dec 5;18(23):2312-2316. doi: 10.1002/cbic.201700355. Epub 2017 Nov 2.


Mast cells are critical for the limitation of thrombin-induced skin inflammation.

Suender CA, Leist M, Åbrink M, Valentin P, Geldmacher A, Steinhoff M, Metz M, Maurer M.

Exp Dermatol. 2018 Jan;27(1):50-57. doi: 10.1111/exd.13407. Epub 2017 Oct 19.


Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.

Leist M, Rinné S, Datunashvili M, Aissaoui A, Pape HC, Decher N, Meuth SG, Budde T.

J Physiol. 2017 Sep 1;595(17):5875-5893. doi: 10.1113/JP274527. Epub 2017 Aug 3.


Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library.

Nyffeler J, Dolde X, Krebs A, Pinto-Gil K, Pastor M, Behl M, Waldmann T, Leist M.

Arch Toxicol. 2017 Nov;91(11):3613-3632. doi: 10.1007/s00204-017-1977-y. Epub 2017 May 5.


Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP.

Schildknecht S, Di Monte DA, Pape R, Tieu K, Leist M.

Trends Pharmacol Sci. 2017 Jun;38(6):541-555. doi: 10.1016/ Epub 2017 Apr 23. Review.


OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes.

Fritsche E, Crofton KM, Hernandez AF, Hougaard Bennekou S, Leist M, Bal-Price A, Reaves E, Wilks MF, Terron A, Solecki R, Sachana M, Gourmelon A.

ALTEX. 2017;34(2):311-315. doi: 10.14573/altex.1701171. No abstract available.


Impairment of human neural crest cell migration by prolonged exposure to interferon-beta.

Pallocca G, Nyffeler J, Dolde X, Grinberg M, Gstraunthaler G, Waldmann T, Rahnenführer J, Sachinidis A, Leist M.

Arch Toxicol. 2017 Oct;91(10):3385-3402. doi: 10.1007/s00204-017-1966-1. Epub 2017 Apr 1.


Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells.

Shinde V, Perumal Srinivasan S, Henry M, Rotshteyn T, Hescheler J, Rahnenführer J, Grinberg M, Meisig J, Blüthgen N, Waldmann T, Leist M, Hengstler JG, Sachinidis A.

Stem Cell Res Ther. 2016 Dec 30;7(1):190. doi: 10.1186/s13287-016-0449-2.


Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity.

Waldmann T, Grinberg M, König A, Rempel E, Schildknecht S, Henry M, Holzer AK, Dreser N, Shinde V, Sachinidis A, Rahnenführer J, Hengstler JG, Leist M.

Chem Res Toxicol. 2017 Apr 17;30(4):905-922. doi: 10.1021/acs.chemrestox.6b00259. Epub 2016 Dec 21.


Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research.

Chandrasekaran A, Avci HX, Leist M, Kobolák J, Dinnyés A.

Front Cell Neurosci. 2016 Sep 26;10:215. eCollection 2016. Review.


Membrane-bound stem cell factor is the major but not only driver of fibroblast-induced murine skin mast cell differentiation.

Leist M, Sünder CA, Drube S, Zimmermann C, Geldmacher A, Metz M, Dudeck A, Maurer M.

Exp Dermatol. 2017 Mar;26(3):255-262. doi: 10.1111/exd.13206. Epub 2017 Feb 9.


Conversion of Nonproliferating Astrocytes into Neurogenic Neural Stem Cells: Control by FGF2 and Interferon-γ.

Kleiderman S, Gutbier S, Ugur Tufekci K, Ortega F, Sá JV, Teixeira AP, Brito C, Glaab E, Berninger B, Alves PM, Leist M.

Stem Cells. 2016 Dec;34(12):2861-2874. doi: 10.1002/stem.2483. Epub 2016 Sep 23.


Good Cell Culture Practice for stem cells and stem-cell-derived models.

Pamies D, Bal-Price A, Simeonov A, Tagle D, Allen D, Gerhold D, Yin D, Pistollato F, Inutsuka T, Sullivan K, Stacey G, Salem H, Leist M, Daneshian M, Vemuri MC, McFarland R, Coecke S, Fitzpatrick SC, Lakshmipathy U, Mack A, Wang WB, Yamazaki D, Sekino Y, Kanda Y, Smirnova L, Hartung T.

ALTEX. 2017;34(1):95-132. doi: 10.14573/altex.1607121. Epub 2016 Aug 23.


In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities.

Schmidt BZ, Lehmann M, Gutbier S, Nembo E, Noel S, Smirnova L, Forsby A, Hescheler J, Avci HX, Hartung T, Leist M, Kobolák J, Dinnyés A.

Arch Toxicol. 2017 Jan;91(1):1-33. doi: 10.1007/s00204-016-1805-9. Epub 2016 Aug 4. Review.


Design of a high-throughput human neural crest cell migration assay to indicate potential developmental toxicants.

Nyffeler J, Karreman C, Leisner H, Kim YJ, Lee G, Waldmann T, Leist M.

ALTEX. 2017;34(1):75-94. doi: 10.14573/altex.1605031. Epub 2016 Jul 27.


Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.

Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg HT, Leist M, Li A, Mundi WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink RH, Zimmer B, Lein PJ.

ALTEX. 2017;34(1):49-74. doi: 10.14573/altex.1604201. Epub 2016 Jul 25.


Major Histocompatibility Complex class I proteins are critical for maintaining neuronal structural complexity in the aging brain.

Lazarczyk MJ, Kemmler JE, Eyford BA, Short JA, Varghese M, Sowa A, Dickstein DR, Yuk FJ, Puri R, Biron KE, Leist M, Jefferies WA, Dickstein DL.

Sci Rep. 2016 May 27;6:26199. doi: 10.1038/srep26199.

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