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Items: 7


Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR+ and Heterogeneous Tumor Models.

Burke PJ, Hamilton JZ, Pires TA, Lai HWH, Leiske CI, Emmerton KK, Waight AB, Senter PD, Lyon RP, Jeffrey SC.

Mol Cancer Ther. 2018 Aug;17(8):1752-1760. doi: 10.1158/1535-7163.MCT-18-0073. Epub 2018 Jun 4.


Engineered cysteine antibodies: an improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability.

Sussman D, Westendorf L, Meyer DW, Leiske CI, Anderson M, Okeley NM, Alley SC, Lyon R, Sanderson RJ, Carter PJ, Benjamin DR.

Protein Eng Des Sel. 2018 Feb 1;31(2):47-54. doi: 10.1093/protein/gzx067.


Temperature-Induced Transitions in the Structure and Interfacial Rheology of Human Meibum.

Leiske DL, Leiske CI, Leiske DR, Toney MF, Senchyna M, Ketelson HA, Meadows DL, Fuller GG.

Biophys J. 2017 Dec 5;113(11):2575. doi: 10.1016/j.bpj.2017.11.001. No abstract available.


The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates.

Kolakowski RV, Haelsig KT, Emmerton KK, Leiske CI, Miyamoto JB, Cochran JH, Lyon RP, Senter PD, Jeffrey SC.

Angew Chem Int Ed Engl. 2016 Jul 4;55(28):7948-51. doi: 10.1002/anie.201601506. Epub 2016 May 20.


Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates.

Lyon RP, Setter JR, Bovee TD, Doronina SO, Hunter JH, Anderson ME, Balasubramanian CL, Duniho SM, Leiske CI, Li F, Senter PD.

Nat Biotechnol. 2014 Oct;32(10):1059-62. doi: 10.1038/nbt.2968. Epub 2014 Sep 7.


A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology.

Jeffrey SC, Burke PJ, Lyon RP, Meyer DW, Sussman D, Anderson M, Hunter JH, Leiske CI, Miyamoto JB, Nicholas ND, Okeley NM, Sanderson RJ, Stone IJ, Zeng W, Gregson SJ, Masterson L, Tiberghien AC, Howard PW, Thurston DE, Law CL, Senter PD.

Bioconjug Chem. 2013 Jul 17;24(7):1256-63. doi: 10.1021/bc400217g. Epub 2013 Jun 28.


Temperature-induced transitions in the structure and interfacial rheology of human meibum.

Leiske D, Leiske C, Leiske D, Toney M, Senchyna M, Ketelson H, Meadows D, Fuller GG.

Biophys J. 2012 Jan 18;102(2):369-76. doi: 10.1016/j.bpj.2011.12.017. Erratum in: Biophys J. 2012 Feb 8;102(3):719. Leiske, Danielle L [corrected to Leiske, Danielle]; Leiske, Christopher I [corrected to Leiske, Christopher]; Leiske, Daniel R [corrected to Leiske, Daniel]; Toney, Michael F [corrected to Toney, Michael]; Ketelson, Howard A [corrected to Ketelson, Howard]. Biophys J. 2017 Dec 5;113(11):2575.

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