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Items: 46


Bioactive Lipids in Cancer, Inflammation and Related Diseases : Acute and Chronic Mild Traumatic Brain Injury Differentially Changes Levels of Bioactive Lipids in the CNS Associated with Headache.

Leishman E, Kunkler PE, Hurley JH, Miller S, Bradshaw HB.

Adv Exp Med Biol. 2019;1161:193-217. doi: 10.1007/978-3-030-21735-8_16.


Chemotherapy-induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol.

Brierley DI, Harman JR, Giallourou N, Leishman E, Roashan AE, Mellows BAD, Bradshaw HB, Swann JR, Patel K, Whalley BJ, Williams CM.

J Cachexia Sarcopenia Muscle. 2019 Aug;10(4):844-859. doi: 10.1002/jcsm.12426. Epub 2019 Apr 29.


Dissecting the Components of Sindbis Virus from Arthropod and Vertebrate Hosts: Implications for Infectivity Differences.

Dunbar CA, Rayaprolu V, Wang JC, Brown CJ, Leishman E, Jones-Burrage S, Trinidad JC, Bradshaw HB, Clemmer DE, Mukhopadhyay S, Jarrold MF.

ACS Infect Dis. 2019 Jun 14;5(6):892-902. doi: 10.1021/acsinfecdis.8b00356. Epub 2019 Apr 15.


Changes in laboratory markers of thrombotic risk early in the first trimester of pregnancy may be linked to an increase in estradiol and progesterone.

Bagot CN, Leishman E, Onyiaodike CC, Jordan F, Gibson VB, Freeman DJ.

Thromb Res. 2019 Jun;178:47-53. doi: 10.1016/j.thromres.2019.03.015. Epub 2019 Mar 25.


Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing.

Murataeva N, Miller S, Dhopeshwarkar A, Leishman E, Daily L, Taylor X, Morton B, Lashmet M, Bradshaw H, Hillard CJ, Romero J, Straiker A.

Exp Eye Res. 2019 May;182:74-84. doi: 10.1016/j.exer.2019.03.011. Epub 2019 Mar 21.


Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure.

Miller S, Daily L, Leishman E, Bradshaw H, Straiker A.

Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5904-5911. doi: 10.1167/iovs.18-24838.


Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains.

Leishman E, Murphy MN, Murphy MI, Mackie K, Bradshaw HB.

Front Mol Neurosci. 2018 Nov 27;11:436. doi: 10.3389/fnmol.2018.00436. eCollection 2018.


Cannabidiol's Upregulation of N-acyl Ethanolamines in the Central Nervous System Requires N-acyl Phosphatidyl Ethanolamine-Specific Phospholipase D.

Leishman E, Manchanda M, Thelen R, Miller S, Mackie K, Bradshaw HB.

Cannabis Cannabinoid Res. 2018 Nov 30;3(1):228-241. doi: 10.1089/can.2018.0031. eCollection 2018.


Inflammation and CB2 signaling drive novel changes in the ocular lipidome and regulate immune cell activity in the eye.

Toguri JT, Leishman E, Szczesniak AM, Laprairie RB, Oehler O, Straiker AJ, Kelly MEM, Bradshaw HB.

Prostaglandins Other Lipid Mediat. 2018 Nov;139:54-62. doi: 10.1016/j.prostaglandins.2018.09.004. Epub 2018 Sep 16.


Revisiting cannabinoid receptor 2 expression and function in murine retina.

Borowska-Fielding J, Murataeva N, Smith B, Szczesniak AM, Leishman E, Daily L, Toguri JT, Hillard CJ, Romero J, Bradshaw H, Kelly MEM, Straiker A.

Neuropharmacology. 2018 Oct;141:21-31. doi: 10.1016/j.neuropharm.2018.08.007. Epub 2018 Aug 16.


Corticotropin-releasing factor regulates caspase-3 and may protect developing zebrafish from stress-induced apoptosis.

Alderman SL, Leishman EM, Fuzzen MLM, Bernier NJ.

Gen Comp Endocrinol. 2018 Sep 1;265:207-213. doi: 10.1016/j.ygcen.2018.05.025. Epub 2018 May 25.


Environmental Toxin Acrolein Alters Levels of Endogenous Lipids, Including TRP Agonists: A Potential Mechanism for Headache Driven by TRPA1 Activation.

Leishman E, Kunkler PE, Manchanda M, Sangani K, Stuart JM, Oxford GS, Hurley JH, Bradshaw HB.

Neurobiol Pain. 2017 Jan-Jul;1:28-36. doi: 10.1016/j.ynpai.2017.03.001. Epub 2017 May 17.


Δ9-Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adult.

Leishman E, Murphy M, Mackie K, Bradshaw HB.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 May;1863(5):479-492. doi: 10.1016/j.bbalip.2018.02.001. Epub 2018 Feb 8.


Impact of Pharmacist Previsit Input to Providers on Chronic Opioid Prescribing Safety.

Cox N, Tak CR, Cochella SE, Leishman E, Gunning K.

J Am Board Fam Med. 2018 Jan-Feb;31(1):105-112. doi: 10.3122/jabfm.2018.01.170210.


Metformin attenuates susceptibility to inflammation-induced preterm birth in mice with higher endocannabinoid levels.

Sun X, Tavenier A, Deng W, Leishman E, Bradshaw HB, Dey SK.

Biol Reprod. 2018 Feb 1;98(2):208-217. doi: 10.1093/biolre/iox164.


Chronic Adolescent Δ9-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment.

Murphy M, Mills S, Winstone J, Leishman E, Wager-Miller J, Bradshaw H, Mackie K.

Cannabis Cannabinoid Res. 2017 Sep 1;2(1):235-246. doi: 10.1089/can.2017.0034. eCollection 2017.


Acute Phencyclidine Alters Neural Oscillations Evoked by Tones in the Auditory Cortex of Rats.

Schnakenberg Martin AM, OʼDonnell BF, Millward JB, Vohs JL, Leishman E, Bolbecker AR, Rass O, Morzorati SL.

Neuropsychobiology. 2017;75(2):53-62. doi: 10.1159/000480511. Epub 2017 Oct 24.


The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.

Crowe MS, Wilson CD, Leishman E, Prather PL, Bradshaw HB, Banks ML, Kinsey SG.

Br J Pharmacol. 2017 Dec;174(23):4523-4539. doi: 10.1111/bph.14055. Epub 2017 Nov 20.


Resveratrol protects from lipopolysaccharide-induced inflammation in the uterus and prevents experimental preterm birth.

Bariani MV, Correa F, Leishman E, Domínguez Rubio AP, Arias A, Stern A, Bradshaw HB, Franchi AM.

Mol Hum Reprod. 2017 Aug 1;23(8):571-581. doi: 10.1093/molehr/gax036.


Lipidomics: A Corrective Lens for Enzyme Myopia.

Bradshaw HB, Leishman E.

Methods Enzymol. 2017;593:123-141. doi: 10.1016/bs.mie.2017.06.024. Epub 2017 Jul 13.


Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester.

Bagot CN, Leishman E, Onyiaodike CC, Jordan F, Freeman DJ.

Thromb Res. 2017 Sep;157:49-54. doi: 10.1016/j.thromres.2017.06.027. Epub 2017 Jun 29.


A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner.

Miller S, Hu SS, Leishman E, Morgan D, Wager-Miller J, Mackie K, Bradshaw HB, Straiker A.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2930-2938. doi: 10.1167/iovs.16-21330.


Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure.

Miller S, Leishman E, Oehler O, Daily L, Murataeva N, Wager-Miller J, Bradshaw H, Straiker A.

Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6419-6426. doi: 10.1167/iovs.16-19437.


Prostaglandin levels, vaginal innervation, and cyst innervation as peripheral contributors to endometriosis-associated vaginal hyperalgesia in rodents.

McAllister SL, Giourgas BK, Faircloth EK, Leishman E, Bradshaw HB, Gross ER.

Mol Cell Endocrinol. 2016 Dec 5;437:120-129. doi: 10.1016/j.mce.2016.08.017. Epub 2016 Aug 11.


p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing.

Deng W, Cha J, Yuan J, Haraguchi H, Bartos A, Leishman E, Viollet B, Bradshaw HB, Hirota Y, Dey SK.

J Clin Invest. 2016 Aug 1;126(8):2941-54. doi: 10.1172/JCI87715. Epub 2016 Jul 25.


Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons.

Tung LW, Lu GL, Lee YH, Yu L, Lee HJ, Leishman E, Bradshaw H, Hwang LL, Hung MS, Mackie K, Zimmer A, Chiou LC.

Nat Commun. 2016 Jul 22;7:12199. doi: 10.1038/ncomms12199.


Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model.

Miller S, Leishman E, Hu SS, Elghouche A, Daily L, Murataeva N, Bradshaw H, Straiker A.

Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3287-96. doi: 10.1167/iovs.16-19356.


A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.

Carey LM, Slivicki RA, Leishman E, Cornett B, Mackie K, Bradshaw H, Hohmann AG.

Mol Pain. 2016 May 13;12. pii: 1744806916649192. doi: 10.1177/1744806916649192. Print 2016.


Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain.

Leishman E, Cornett B, Spork K, Straiker A, Mackie K, Bradshaw HB.

Pharmacol Res. 2016 Aug;110:159-172. doi: 10.1016/j.phrs.2016.04.020. Epub 2016 Apr 22.


Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain.

Leishman E, Mackie K, Luquet S, Bradshaw HB.

Biochim Biophys Acta. 2016 Jun;1861(6):491-500. doi: 10.1016/j.bbalip.2016.03.003. Epub 2016 Mar 5.


Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth.

Sun X, Deng W, Li Y, Tang S, Leishman E, Bradshaw HB, Dey SK.

J Biol Chem. 2016 Apr 8;291(15):8231-40. doi: 10.1074/jbc.M115.707836. Epub 2016 Feb 21.


Levels of bioactive lipids in cooking oils: olive oil is the richest source of oleoyl serine.

Bradshaw HB, Leishman E.

J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):247-52. doi: 10.1515/jbcpp-2015-0104.


Phencyclidine Disrupts the Auditory Steady State Response in Rats.

Leishman E, O'Donnell BF, Millward JB, Vohs JL, Rass O, Krishnan GP, Bolbecker AR, Morzorati SL.

PLoS One. 2015 Aug 10;10(8):e0134979. doi: 10.1371/journal.pone.0134979. eCollection 2015.


Lipopolysaccharide-induced murine embryonic resorption involves changes in endocannabinoid profiling and alters progesterone secretion and inflammatory response by a CB1-mediated fashion.

Wolfson ML, Correa F, Leishman E, Vercelli C, Cymeryng C, Blanco J, Bradshaw HB, Franchi AM.

Mol Cell Endocrinol. 2015 Aug 15;411:214-22. doi: 10.1016/j.mce.2015.04.032. Epub 2015 May 6.


Establishing a reference range for thrombin generation using a standard plasma significantly improves assay precision.

Bagot CN, Leishman E.

Thromb Res. 2015 Jul;136(1):139-43. doi: 10.1016/j.thromres.2015.04.020. Epub 2015 Apr 22.


Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice.

Crowe MS, Leishman E, Banks ML, Gujjar R, Mahadevan A, Bradshaw HB, Kinsey SG.

Br J Pharmacol. 2015 Apr;172(7):1700-12. doi: 10.1111/bph.13012. Epub 2015 Jan 20.


Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation.

Raboune S, Stuart JM, Leishman E, Takacs SM, Rhodes B, Basnet A, Jameyfield E, McHugh D, Widlanski T, Bradshaw HB.

Front Cell Neurosci. 2014 Aug 1;8:195. doi: 10.3389/fncel.2014.00195. eCollection 2014.


TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.

Balakrishna S, Song W, Achanta S, Doran SF, Liu B, Kaelberer MM, Yu Z, Sui A, Cheung M, Leishman E, Eidam HS, Ye G, Willette RN, Thorneloe KS, Bradshaw HB, Matalon S, Jordt SE.

Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15;307(2):L158-72. doi: 10.1152/ajplung.00065.2014. Epub 2014 May 16.


Long-term consequences of perinatal fatty acid amino hydrolase inhibition.

Wu CS, Morgan D, Jew CP, Haskins C, Andrews MJ, Leishman E, Spencer CM, Czyzyk T, Bradshaw H, Mackie K, Lu HC.

Br J Pharmacol. 2014 Mar;171(6):1420-34. doi: 10.1111/bph.12500.


Mutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in mice.

Morgan DJ, Davis BJ, Kearn CS, Marcus D, Cook AJ, Wager-Miller J, Straiker A, Myoga MH, Karduck J, Leishman E, Sim-Selley LJ, Czyzyk TA, Bradshaw HB, Selley DE, Mackie K.

J Neurosci. 2014 Apr 9;34(15):5152-63. doi: 10.1523/JNEUROSCI.3445-12.2014.


Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH).

Sałaga M, Mokrowiecka A, Zakrzewski PK, Cygankiewicz A, Leishman E, Sobczak M, Zatorski H, Małecka-Panas E, Kordek R, Storr M, Krajewska WM, Bradshaw HB, Fichna J.

J Crohns Colitis. 2014 Sep;8(9):998-1009. doi: 10.1016/j.crohns.2014.01.025. Epub 2014 Feb 14.


Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death.

Rimmerman N, Ben-Hail D, Porat Z, Juknat A, Kozela E, Daniels MP, Connelly PS, Leishman E, Bradshaw HB, Shoshan-Barmatz V, Vogel Z.

Cell Death Dis. 2013 Dec 5;4:e949. doi: 10.1038/cddis.2013.471.


Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions.

Cha J, Bartos A, Egashira M, Haraguchi H, Saito-Fujita T, Leishman E, Bradshaw H, Dey SK, Hirota Y.

J Clin Invest. 2013 Sep;123(9):4063-75. doi: 10.1172/JCI70098. Epub 2013 Aug 27.


Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18.

Leishman E, Howard JM, Garcia GE, Miao Q, Ku AT, Dekker JD, Tucker H, Nguyen H.

Development. 2013 Sep;140(18):3809-18. doi: 10.1242/dev.097477. Epub 2013 Aug 14.


Lipids and addiction: how sex steroids, prostaglandins, and cannabinoids interact with drugs of abuse.

Leishman E, Kokesh KJ, Bradshaw HB.

Ann N Y Acad Sci. 2013 Apr;1282:25-38. doi: 10.1111/nyas.12081. Epub 2013 Mar 19. Review.


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