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Items: 1 to 50 of 53

1.

Improving prediction of torsadogenic risk in the CiPA in silico model by appropriately accounting for clinical exposure.

Leishman DJ.

J Pharmacol Toxicol Methods. 2019 Nov 12:106654. doi: 10.1016/j.vascn.2019.106654. [Epub ahead of print]

PMID:
31730936
2.

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.

Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG.

Clin Pharmacol Ther. 2019 Nov 10. doi: 10.1002/cpt.1647. [Epub ahead of print]

PMID:
31709525
3.

Relationship of clinical adverse event reports to models of arrhythmia risk.

Ether N, Leishman D, Bailie M, Lauver A.

J Pharmacol Toxicol Methods. 2019 Nov - Dec;100:106622. doi: 10.1016/j.vascn.2019.106622. Epub 2019 Aug 6.

PMID:
31398384
4.

Suture Tape With Broad Full-Width Core Versus Traditional Round Suture With Round Core: A Mechanical Comparison.

Leishman DJ, Chudik SC.

Arthroscopy. 2019 Aug;35(8):2461-2466. doi: 10.1016/j.arthro.2019.03.053.

PMID:
31395187
5.

Real estate diagrams: A tool to quickly assess the utility of a new predictive technology.

Felli JC, Leishman DJ.

J Pharmacol Toxicol Methods. 2018 Sep - Oct;99:106603. doi: 10.1016/j.vascn.2019.106603. Epub 2019 Jun 24.

PMID:
31247306
6.

Corrigendum to An overview of the safety pharmacology society strategic plan [Journal of Pharmacological and Toxicological Methods 93 (2018) 35-45].

Pugsley MK, Authier S, Koerner JE, Redfern WS, Markgraf CG, Brabham T, Correll K, Soloviev MV, Botchway A, Engwall M, Traebert M, Valentin JP, Mow TJ, Greiter-Wilke A, Leishman DJ, Vargas HM.

J Pharmacol Toxicol Methods. 2019 Jan - Feb;95:1. doi: 10.1016/j.vascn.2018.09.003. Epub 2018 Nov 3. No abstract available.

PMID:
30399523
7.

An overview of the safety pharmacology society strategic plan.

Pugsley MK, Authier S, Koerner JE, Redfern WS, Markgraf CG, Brabham T, Correll K, Soloviev MV, Botchway A, Engwall M, Traebert M, Valentin JP, Mow TJ, Greiter-Wilke A, Leishman DJ, Vargas HM.

J Pharmacol Toxicol Methods. 2018 Sep - Oct;93:35-45. doi: 10.1016/j.vascn.2018.01.001. Epub 2018 Jan 9. Review. Erratum in: J Pharmacol Toxicol Methods. 2019 Jan - Feb;95:1.

PMID:
29330132
8.

Fowl Aviadenovirus 9 dUTPase Plays a Role in Regulation of the Host Immune Response.

Deng L, Griffin BD, Pei Y, Leishman D, McBey BA, Sharif S, Nagy É.

Viral Immunol. 2017 Nov;30(9):662-670. doi: 10.1089/vim.2017.0068. Epub 2017 Sep 25.

PMID:
28945170
9.

The Safety Pharmacology Society salary survey.

Pugsley MK, Authier S, Brabham T, Soloviev M, Markgraf CG, Correll K, Traebert M, Greiter-Wilke A, Valentin JP, Vargas H, Botchway A, Leishman DJ, Curtis MJ.

J Pharmacol Toxicol Methods. 2017 Nov;88(Pt 1):85-91. doi: 10.1016/j.vascn.2017.08.002. Epub 2017 Aug 7.

PMID:
28797763
10.

Replication and Oncolytic Activity of an Avian Orthoreovirus in Human Hepatocellular Carcinoma Cells.

Kozak RA, Hattin L, Biondi MJ, Corredor JC, Walsh S, Xue-Zhong M, Manuel J, McGilvray ID, Morgenstern J, Lusty E, Cherepanov V, McBey BA, Leishman D, Feld JJ, Bridle B, Nagy É.

Viruses. 2017 Apr 24;9(4). pii: E90. doi: 10.3390/v9040090.

11.

Proarrhythmia liability assessment and the comprehensive in vitro Proarrhythmia Assay (CiPA): An industry survey on current practice.

Authier S, Pugsley MK, Koerner JE, Fermini B, Redfern WS, Valentin JP, Vargas HM, Leishman DJ, Correll K, Curtis MJ.

J Pharmacol Toxicol Methods. 2017 Jul;86:34-43. doi: 10.1016/j.vascn.2017.02.021. Epub 2017 Feb 20.

12.

Minimal ecosystem uptake of selenium from Westland petrels, a forest-breeding seabird.

Hawke DJ, Gamlen-Greene R, Harding JS, Leishman D.

Sci Total Environ. 2017 Jan 1;574:148-154. doi: 10.1016/j.scitotenv.2016.08.203. Epub 2016 Sep 12.

PMID:
27627690
13.

Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium.

Heller S, Darpö B, Mitchell MI, Linnebjerg H, Leishman DJ, Mehrotra N, Zhu H, Koerner J, Fiszman ML, Balakrishnan S, Xiao S, Todaro TG, Hensley I, Guth BD, Michelson EL, Sager P.

Am Heart J. 2015 Jul;170(1):23-35. doi: 10.1016/j.ahj.2015.03.007. Epub 2015 Mar 18. Review.

PMID:
26093861
14.

Gastrointestinal Safety Pharmacology in Drug Discovery and Development.

Al-Saffar A, Nogueira da Costa A, Delaunois A, Leishman DJ, Marks L, Rosseels ML, Valentin JP.

Handb Exp Pharmacol. 2015;229:291-321. doi: 10.1007/978-3-662-46943-9_12. Review.

PMID:
26091645
15.

The Diplomate in Safety Pharmacology (DSP) certification scheme.

Authier S, Curtis MJ, Soloviev M, Redfern WS, Kallman MJ, Hamlin RL, Leishman DJ, Valentin JP, Koerner JE, Vargas HM, Botchway A, Correll K, Pugsley MK.

J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:1-4. doi: 10.1016/j.vascn.2015.04.008. Epub 2015 May 8.

PMID:
25959882
16.

The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative.

Ewart L, Aylott M, Deurinck M, Engwall M, Gallacher DJ, Geys H, Jarvis P, Ju H, Leishman D, Leong L, McMahon N, Mead A, Milliken P, Suter W, Teisman A, Van Ammel K, Vargas HM, Wallis R, Valentin JP.

Toxicol Sci. 2014 Dec;142(2):427-35. doi: 10.1093/toxsci/kfu198. Epub 2014 Sep 21.

PMID:
25246669
17.

The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues.

Alexandrou AJ, Milnes JT, Sun SZ, Fermini B, Kim SC, Jenkinson S, Leishman DJ, Witchel HJ, Hancox JC, Leaney JL.

J Physiol Pharmacol. 2014 Aug;65(4):511-23.

18.

Cardiac Safety Research Consortium: can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies? Scientific update and a research proposal for a path forward.

Darpo B, Garnett C, Benson CT, Keirns J, Leishman D, Malik M, Mehrotra N, Prasad K, Riley S, Rodriguez I, Sager P, Sarapa N, Wallis R.

Am Heart J. 2014 Sep;168(3):262-72. doi: 10.1016/j.ahj.2014.06.003. Epub 2014 Jun 6.

PMID:
25173536
19.

Predicting QTc Prolongation in Man From Only In Vitro Data.

Leishman DJ.

CPT Pharmacometrics Syst Pharmacol. 2014 Aug 20;3:e131. doi: 10.1038/psp.2014.33.

20.

Avian bornavirus in free-ranging waterfowl: prevalence of antibodies and cloacal shedding of viral RNA.

Delnatte P, Nagy É, Ojkic D, Leishman D, Crawshaw G, Elias K, Smith DA.

J Wildl Dis. 2014 Jul;50(3):512-23. doi: 10.7589/2013-08-218. Epub 2014 Apr 29.

PMID:
24779463
21.

How do the top 12 pharmaceutical companies operate safety pharmacology?

Ewart L, Gallacher DJ, Gintant G, Guillon JM, Leishman D, Levesque P, McMahon N, Mylecraine L, Sanders M, Suter W, Wallis R, Valentin JP.

J Pharmacol Toxicol Methods. 2012 Sep;66(2):66-70. doi: 10.1016/j.vascn.2012.03.004. Epub 2012 Apr 1.

PMID:
22510338
22.

Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: current recommendations from the Safety Pharmacology Society.

Leishman DJ, Beck TW, Dybdal N, Gallacher DJ, Guth BD, Holbrook M, Roche B, Wallis RM.

J Pharmacol Toxicol Methods. 2012 May-Jun;65(3):93-101. doi: 10.1016/j.vascn.2011.08.006. Epub 2011 Aug 31.

PMID:
21907296
23.

Utility of positive controls in assessing assay sensitivity in ICH S7B and ICH E14 guidance for evaluation of QT/QTc interval prolongation.

Chiang AY, Mallinckrodt CH, Dmitrienko AA, Leishman DJ.

J Pharmacol Toxicol Methods. 2010 Sep-Oct;62(2):143-7. doi: 10.1016/j.vascn.2010.05.013. Epub 2010 Jun 4.

PMID:
20570744
24.

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.

Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC.

J Pharmacol Toxicol Methods. 2010 Mar-Apr;61(2):178-91. doi: 10.1016/j.vascn.2010.02.007. Epub 2010 Feb 19.

PMID:
20172036
25.

Overcoming hERG affinity in the discovery of maraviroc; a CCR5 antagonist for the treatment of HIV.

Price DA, Armour D, de Groot M, Leishman D, Napier C, Perros M, Stammen BL, Wood A.

Curr Top Med Chem. 2008;8(13):1140-51.

PMID:
18782009
26.

International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes.

Bass AS, Darpo B, Breidenbach A, Bruse K, Feldman HS, Garnes D, Hammond T, Haverkamp W, January C, Koerner J, Lawrence C, Leishman D, Roden D, Valentin JP, Vos MA, Zhou YY, Karluss T, Sager P.

Br J Pharmacol. 2008 Aug;154(7):1491-501. doi: 10.1038/bjp.2008.279.

27.

Heartbeat dynamics in adrenergic blocker treated conscious beagle dogs.

Li D, Chiang AY, Clawson CA, Main BW, Leishman DJ.

J Pharmacol Toxicol Methods. 2008 Sep-Oct;58(2):118-28. doi: 10.1016/j.vascn.2008.05.005. Epub 2008 Jul 10.

PMID:
18619862
28.

Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics.

Vargas HM, Bass AS, Breidenbach A, Feldman HS, Gintant GA, Harmer AR, Heath B, Hoffmann P, Lagrutta A, Leishman D, McMahon N, Mittelstadt S, Polonchuk L, Pugsley MK, Salata JJ, Valentin JP.

J Pharmacol Toxicol Methods. 2008 Sep-Oct;58(2):72-6. doi: 10.1016/j.vascn.2008.04.001. Epub 2008 Apr 18.

PMID:
18508287
29.

Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model.

Steidl-Nichols JV, Hanton G, Leaney J, Liu RC, Leishman D, McHarg A, Wallis R.

J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):9-22. Epub 2007 Jul 3.

PMID:
17707659
30.

Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro.

Lightbown ID, Johnson M, Davis A, Leaney J, Leishman DJ.

J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):194-202. Epub 2007 May 24.

PMID:
17583537
31.

Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.

Duncan RS, McPate MJ, Ridley JM, Gao Z, James AF, Leishman DJ, Leaney JL, Witchel HJ, Hancox JC.

Biochem Pharmacol. 2007 Aug 1;74(3):425-37. Epub 2007 May 3.

32.

hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656.

Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC.

Biochem Biophys Res Commun. 2006 Dec 8;351(1):273-80. Epub 2006 Oct 23.

PMID:
17056009
33.

Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc.

Price DA, Armour D, de Groot M, Leishman D, Napier C, Perros M, Stammen BL, Wood A.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4633-7. Epub 2006 Jun 16.

PMID:
16782336
34.

A one-step approach to the analysis of the QT interval in conscious telemetrized dogs.

Chiang AY, Holdsworth DL, Leishman DJ.

J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):183-8. Epub 2006 Mar 6.

PMID:
16567113
35.

Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin.

Alexandrou AJ, Duncan RS, Sullivan A, Hancox JC, Leishman DJ, Witchel HJ, Leaney JL.

Br J Pharmacol. 2006 Apr;147(8):905-16.

36.

Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652.

Duncan RS, Ridley JM, Dempsey CE, Leishman DJ, Leaney JL, Hancox JC, Witchel HJ.

Biochem Biophys Res Commun. 2006 Mar 10;341(2):500-6. Epub 2006 Jan 13.

PMID:
16446155
37.

Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs.

Perry M, Stansfeld PJ, Leaney J, Wood C, de Groot MJ, Leishman D, Sutcliffe MJ, Mitcheson JS.

Mol Pharmacol. 2006 Feb;69(2):509-19. Epub 2005 Nov 16.

PMID:
16291873
38.

A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data.

Jonker DM, Kenna LA, Leishman D, Wallis R, Milligan PA, Jonsson EN.

Clin Pharmacol Ther. 2005 Jun;77(6):572-82.

PMID:
15961988
39.

Structural determinants of HERG channel block by clofilium and ibutilide.

Perry M, de Groot MJ, Helliwell R, Leishman D, Tristani-Firouzi M, Sanguinetti MC, Mitcheson J.

Mol Pharmacol. 2004 Aug;66(2):240-9.

PMID:
15266014
40.

Evidence for a role of MCM (mini-chromosome maintenance)5 in transcriptional repression of sub-telomeric and Ty-proximal genes in Saccharomyces cerevisiae.

Dziak R, Leishman D, Radovic M, Tye BK, Yankulov K.

J Biol Chem. 2003 Jul 25;278(30):27372-81. Epub 2003 May 15.

41.

The role of the carboxyterminal domain of RNA polymerase II in regulating origins of DNA replication in Saccharomyces cerevisiae.

Gauthier L, Dziak R, Kramer DJ, Leishman D, Song X, Ho J, Radovic M, Bentley D, Yankulov K.

Genetics. 2002 Nov;162(3):1117-29.

42.

The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment.

Fossa AA, DePasquale MJ, Raunig DL, Avery MJ, Leishman DJ.

J Pharmacol Exp Ther. 2002 Aug;302(2):828-33.

PMID:
12130750
43.

Towards a drug concentration effect relationship for QT prolongation and torsades de pointes.

Webster R, Leishman D, Walker D.

Curr Opin Drug Discov Devel. 2002 Jan;5(1):116-26. Review.

PMID:
11865665
44.

Effects of the class III antiarrhythmic agent dofetilide (UK-68,798) on L-type calcium current from rabbit ventricular myocytes.

Paul AA, Leishman DJ, Witchel HJ, Hancox JC.

J Pharm Pharmacol. 2001 Dec;53(12):1671-8.

PMID:
11804397
45.

Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog.

Webster R, Allan G, Anto-Awuakye K, Harrison A, Kidd T, Leishman D, Phipps J, Walker D.

Xenobiotica. 2001 Aug-Sep;31(8-9):633-50.

PMID:
11569530
47.

Identification of a low molecular mass (14.2 kDa) alpha-tocopherol-binding protein in the cytosol of rat liver and heart.

Dutta-Roy AK, Leishman DJ, Gordon MJ, Campbell FM, Duthie GG.

Biochem Biophys Res Commun. 1993 Nov 15;196(3):1108-12.

PMID:
8250868
48.

A low molecular weight (12-15kDa) protein fraction in rat liver binds alpha-tocopherol.

Leishman DJ, Campbell FM, Gordon MJ, Duthie GG, Dutta-Roy AK.

Biochem Soc Trans. 1993 Nov;21(4):408S. No abstract available.

PMID:
8131982
49.

Purification and partial characterisation of an alpha-tocopherol-binding protein from rabbit heart cytosol.

Dutta-Roy AK, Gordon MJ, Leishman DJ, Paterson BJ, Duthie GG, James WP.

Mol Cell Biochem. 1993 Jun 9-23;123(1-2):139-44.

PMID:
8232255
50.

Identification of a vitamin E-binding protein in rat heart cytosol.

Leishman DJ, Duthie G, Dutta-Roy AK.

Biochem Soc Trans. 1992 Nov;20(4):339S. No abstract available.

PMID:
1487004

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