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Items: 1 to 50 of 59

1.

"Designer cytokines" targeting the tumor vasculature-think global and act local.

Kammertoens T, Kemna J, Leisegang M.

EMBO Mol Med. 2020 Feb 7;12(2):e11801. doi: 10.15252/emmm.201911801. Epub 2020 Jan 9.

2.

Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors.

Schreiber K, Karrison TG, Wolf SP, Kiyotani K, Steiner M, Littmann ER, Pamer EG, Kammertoens T, Schreiber H, Leisegang M.

Cancer Immunol Res. 2020 Feb;8(2):192-202. doi: 10.1158/2326-6066.CIR-19-0567. Epub 2019 Dec 12.

PMID:
31831634
3.

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.

He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Leisegang M, Meredith SC, Kranz DM, Schreiber H.

JCI Insight. 2019 Dec 5;4(23). pii: 135306. doi: 10.1172/jci.insight.135306. No abstract available.

4.

Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation.

Bibli SI, Hu J, Leisegang MS, Wittig J, Zukunft S, Kapasakalidi A, Fisslthaler B, Tsilimigras D, Zografos G, Filis K, Brandes RP, Papapetropoulos A, Sigala F, Fleming I.

Redox Biol. 2020 Jan;28:101379. doi: 10.1016/j.redox.2019.101379. Epub 2019 Nov 13.

5.

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.

He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Leisegang M, Meredith SC, Kranz DM, Schreiber H.

JCI Insight. 2019 Nov 1;4(21). pii: 130416. doi: 10.1172/jci.insight.130416. Erratum in: JCI Insight. 2019 Dec 5;4(23):.

6.

Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS.

Leisegang MS, Bibli SI, Günther S, Pflüger-Müller B, Oo JA, Höper C, Seredinski S, Yekelchyk M, Schmitz-Rixen T, Schürmann C, Hu J, Looso M, Sigala F, Boon RA, Fleming I, Brandes RP.

Eur Heart J. 2019 Aug 7;40(30):2523-2533. doi: 10.1093/eurheartj/ehz393.

PMID:
31222221
7.

TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion.

Raimann FJ, Dröse S, Bonke E, Schneider L, Tybl E, Wittig I, Heidler J, Heide H, Josipovic I, Leisegang M, Brandes RP, Roeper J, Zacharowski K, Mersmann J.

J Cardiovasc Transl Res. 2019 Oct;12(5):478-487. doi: 10.1007/s12265-019-09887-0. Epub 2019 Apr 8.

PMID:
30963423
8.

The polarity protein Scrib limits atherosclerosis development in mice.

Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP.

Cardiovasc Res. 2019 Dec 1;115(14):1963-1974. doi: 10.1093/cvr/cvz093.

PMID:
30949676
9.

Identification of neoantigen-specific T cells and their targets: implications for immunotherapy of head and neck squamous cell carcinoma.

Ren L, Leisegang M, Deng B, Matsuda T, Kiyotani K, Kato T, Harada M, Park JH, Saloura V, Seiwert T, Vokes E, Agrawal N, Nakamura Y.

Oncoimmunology. 2019 Feb 6;8(4):e1568813. doi: 10.1080/2162402X.2019.1568813. eCollection 2019.

10.

The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G.

Leisegang MS, Gu L, Preussner J, Günther S, Hitzel J, Ratiu C, Weigert A, Chen W, Schwarz EC, Looso M, Fork C, Brandes RP.

FEBS Lett. 2019 Mar;593(5):487-498. doi: 10.1002/1873-3468.13337. Epub 2019 Feb 27.

PMID:
30758047
11.

IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors.

Gupta S, Jain A, Syed SN, Snodgrass RG, Pflüger-Müller B, Leisegang MS, Weigert A, Brandes RP, Ebersberger I, Brüne B, Namgaladze D.

Oncoimmunology. 2018 Jul 30;7(10):e1494110. doi: 10.1080/2162402X.2018.1494110. eCollection 2018.

12.

Imprinting Directionality into Proton Transfer Reactions of an Achiral Molecule.

Kügel J, Leisegang M, Bode M.

ACS Nano. 2018 Aug 28;12(8):8733-8738. doi: 10.1021/acsnano.8b04868. Epub 2018 Aug 9.

PMID:
30086226
13.

The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase.

Vasconez AE, Janetzko P, Oo JA, Pflüger-Müller B, Ratiu C, Gu L, Helin K, Geisslinger G, Fleming I, Schröder K, Fork C, Brandes RP, Leisegang MS.

Acta Physiol (Oxf). 2019 Jan;225(1):e13168. doi: 10.1111/apha.13168. Epub 2018 Aug 25.

PMID:
30076673
14.

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.

Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP.

Nat Commun. 2018 Jun 12;9(1):2292. doi: 10.1038/s41467-018-04602-0.

15.

Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor-Engineered T Cells for Ovarian Cancer.

Matsuda T, Leisegang M, Park JH, Ren L, Kato T, Ikeda Y, Harada M, Kiyotani K, Lengyel E, Fleming GF, Nakamura Y.

Clin Cancer Res. 2018 Nov 1;24(21):5357-5367. doi: 10.1158/1078-0432.CCR-18-0142. Epub 2018 May 2.

16.

Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell Polyomavirus.

Gavvovidis I, Leisegang M, Willimsky G, Miller N, Nghiem P, Blankenstein T.

Clin Cancer Res. 2018 Aug 1;24(15):3644-3655. doi: 10.1158/1078-0432.CCR-17-2661. Epub 2018 Apr 18.

17.

Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells.

Kato T, Matsuda T, Ikeda Y, Park JH, Leisegang M, Yoshimura S, Hikichi T, Harada M, Zewde M, Sato S, Hasegawa K, Kiyotani K, Nakamura Y.

Oncotarget. 2018 Jan 13;9(13):11009-11019. doi: 10.18632/oncotarget.24232. eCollection 2018 Feb 16.

18.

Analyzing the Wave Nature of Hot Electrons with a Molecular Nanoprobe.

Leisegang M, Kügel J, Klein L, Bode M.

Nano Lett. 2018 Mar 14;18(3):2165-2171. doi: 10.1021/acs.nanolett.8b00465. Epub 2018 Mar 1.

PMID:
29486560
19.

LET's sponge: How the lncRNA PFL promotes cardiac fibrosis.

Leisegang MS.

Theranostics. 2018 Jan 1;8(4):874-877. doi: 10.7150/thno.23364. eCollection 2018.

20.

Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell function.

Josipovic I, Pflüger B, Fork C, Vasconez AE, Oo JA, Hitzel J, Seredinski S, Gamen E, Heringdorf DMZ, Chen W, Looso M, Pullamsetti SS, Brandes RP, Leisegang MS.

J Mol Cell Cardiol. 2018 Mar;116:57-68. doi: 10.1016/j.yjmcc.2018.01.015. Epub 2018 Feb 3.

PMID:
29408197
21.

A positive feedback loop between IL-1β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages.

Sieve I, Ricke-Hoch M, Kasten M, Battmer K, Stapel B, Falk CS, Leisegang MS, Haverich A, Scherr M, Hilfiker-Kleiner D.

Vascul Pharmacol. 2018 Apr;103-105:16-28. doi: 10.1016/j.vph.2018.01.005. Epub 2018 Jan 31.

PMID:
29371126
22.

Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families.

Moretti AIS, Pavanelli JC, Nolasco P, Leisegang MS, Tanaka LY, Fernandes CG, Wosniak J Jr, Kajihara D, Dias MH, Fernandes DC, Jo H, Tran NV, Ebersberger I, Brandes RP, Bonatto D, Laurindo FRM.

Sci Rep. 2017 Dec 8;7(1):17262. doi: 10.1038/s41598-017-16947-5.

23.

Redox Regulation and Noncoding RNAs.

Leisegang MS, Schröder K, Brandes RP.

Antioxid Redox Signal. 2018 Sep 20;29(9):793-812. doi: 10.1089/ars.2017.7276. Epub 2017 Sep 18. Review.

PMID:
28816061
24.

Remote Single-Molecule Switching: Identification and Nanoengineering of Hot Electron-Induced Tautomerization.

Kügel J, Leisegang M, Böhme M, Krönlein A, Sixta A, Bode M.

Nano Lett. 2017 Aug 9;17(8):5106-5112. doi: 10.1021/acs.nanolett.7b02419. Epub 2017 Jul 26.

PMID:
28732159
25.

Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy.

Schlenker R, Olguín-Contreras LF, Leisegang M, Schnappinger J, Disovic A, Rühland S, Nelson PJ, Leonhardt H, Harz H, Wilde S, Schendel DJ, Uckert W, Willimsky G, Noessner E.

Cancer Res. 2017 Jul 1;77(13):3577-3590. doi: 10.1158/0008-5472.CAN-16-1922. Epub 2017 May 22.

26.

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.

Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, Ivanov A, Szymborska A, Patone G, Kunz S, Sommermeyer D, Engels B, Leisegang M, Textor A, Fehling HJ, Fruttiger M, Lohoff M, Herrmann A, Yu H, Weichselbaum R, Uckert W, Hübner N, Gerhardt H, Beule D, Schreiber H, Blankenstein T.

Nature. 2017 May 4;545(7652):98-102. doi: 10.1038/nature22311. Epub 2017 Apr 26.

27.

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Günther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Künne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP.

Circulation. 2017 Jul 4;136(1):65-79. doi: 10.1161/CIRCULATIONAHA.116.026991. Epub 2017 Mar 28.

28.

Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300.

Fork C, Vasconez AE, Janetzko P, Angioni C, Schreiber Y, Ferreirós N, Geisslinger G, Leisegang MS, Steinhilber D, Brandes RP.

J Lipid Res. 2017 Feb;58(2):386-392. doi: 10.1194/jlr.M072280. Epub 2016 Dec 2.

29.

CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity.

Prior KK, Leisegang MS, Josipovic I, Löwe O, Shah AM, Weissmann N, Schröder K, Brandes RP.

Redox Biol. 2016 Oct;9:287-295. doi: 10.1016/j.redox.2016.08.013. Epub 2016 Aug 24.

30.

The NADPH Oxidase Nox2 Mediates Vitamin D-Induced Vascular Regeneration in Male Mice.

Leisegang MS, Babelova A, Wong MS, Helfinger V, Weißmann N, Brandes RP, Schröder K.

Endocrinology. 2016 Oct;157(10):4032-4040. Epub 2016 Jul 11.

PMID:
27399878
31.

PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells.

Josipovic I, Fork C, Preussner J, Prior KK, Iloska D, Vasconez AE, Labocha S, Angioni C, Thomas D, Ferreirós N, Looso M, Pullamsetti SS, Geisslinger G, Steinhilber D, Brandes RP, Leisegang MS.

Acta Physiol (Oxf). 2016 Sep;218(1):13-27. doi: 10.1111/apha.12700. Epub 2016 May 20.

PMID:
27124368
32.

The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein.

Prior KK, Wittig I, Leisegang MS, Groenendyk J, Weissmann N, Michalak M, Jansen-Dürr P, Shah AM, Brandes RP.

J Biol Chem. 2016 Mar 25;291(13):7045-59. doi: 10.1074/jbc.M115.710772. Epub 2016 Feb 9.

33.

Targeting human melanoma neoantigens by T cell receptor gene therapy.

Leisegang M, Kammertoens T, Uckert W, Blankenstein T.

J Clin Invest. 2016 Mar 1;126(3):854-8. doi: 10.1172/JCI83465. Epub 2016 Jan 25.

34.

The Histone Demethylase PHF8 Is Essential for Endothelial Cell Migration.

Gu L, Hitzel J, Moll F, Kruse C, Malik RA, Preussner J, Looso M, Leisegang MS, Steinhilber D, Brandes RP, Fork C.

PLoS One. 2016 Jan 11;11(1):e0146645. doi: 10.1371/journal.pone.0146645. eCollection 2016.

35.

Eukaryotic Hsp70 chaperones in the intermembrane space of chloroplasts.

Bionda T, Gross LE, Becker T, Papasotiriou DG, Leisegang MS, Karas M, Schleiff E.

Planta. 2016 Mar;243(3):733-47. doi: 10.1007/s00425-015-2440-z. Epub 2015 Dec 15.

PMID:
26669598
36.

Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation.

Leisegang M, Engels B, Schreiber K, Yew PY, Kiyotani K, Idel C, Arina A, Duraiswamy J, Weichselbaum RR, Uckert W, Nakamura Y, Schreiber H.

Clin Cancer Res. 2016 Jun 1;22(11):2734-43. doi: 10.1158/1078-0432.CCR-15-2361. Epub 2015 Dec 14.

37.

Response to letter regarding article, "Vitamin D promotes vascular regeneration".

Ka Wong MS, Leisegang MS, Kruse C, Vogel J, Schürmann C, Dehne N, Weigert A, Herrmann E, Brüne B, Shah AM, Steinhilber D, Offermanns S, Carmeliet G, Badenhoop K, Schröder K, Brandes RP.

Circulation. 2015 Jun 2;131(22):e515-6. doi: 10.1161/CIRCULATIONAHA.114.014781. No abstract available.

PMID:
26034089
38.

Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5.

Fork C, Gu L, Hitzel J, Josipovic I, Hu J, SzeKa Wong M, Ponomareva Y, Albert M, Schmitz SU, Uchida S, Fleming I, Helin K, Steinhilber D, Leisegang MS, Brandes RP.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1645-52. doi: 10.1161/ATVBAHA.115.305561. Epub 2015 May 28.

PMID:
26023081
39.

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice.

Obenaus M, Leitão C, Leisegang M, Chen X, Gavvovidis I, van der Bruggen P, Uckert W, Schendel DJ, Blankenstein T.

Nat Biotechnol. 2015 Apr;33(4):402-7. doi: 10.1038/nbt.3147. Epub 2015 Mar 16.

PMID:
25774714
40.

Targeting cancer-specific mutations by T cell receptor gene therapy.

Blankenstein T, Leisegang M, Uckert W, Schreiber H.

Curr Opin Immunol. 2015 Apr;33:112-9. doi: 10.1016/j.coi.2015.02.005. Epub 2015 Feb 27. Review.

41.

The association of late-acting snoRNPs with human pre-ribosomal complexes requires the RNA helicase DDX21.

Sloan KE, Leisegang MS, Doebele C, Ramírez AS, Simm S, Safferthal C, Kretschmer J, Schorge T, Markoutsa S, Haag S, Karas M, Ebersberger I, Schleiff E, Watkins NJ, Bohnsack MT.

Nucleic Acids Res. 2015 Jan;43(1):553-64. doi: 10.1093/nar/gku1291. Epub 2014 Dec 4.

42.

HEK293-based production platform for γ-retroviral (self-inactivating) vectors: application for safe and efficient transfer of COL7A1 cDNA.

Hennig K, Raasch L, Kolbe C, Weidner S, Leisegang M, Uckert W, Titeux M, Hovnanian A, Kuehlcke K, Loew R.

Hum Gene Ther Clin Dev. 2014 Dec;25(4):218-28. doi: 10.1089/humc.2014.083.

PMID:
25381930
43.

Vitamin D promotes vascular regeneration.

Wong MS, Leisegang MS, Kruse C, Vogel J, Schürmann C, Dehne N, Weigert A, Herrmann E, Brüne B, Shah AM, Steinhilber D, Offermanns S, Carmeliet G, Badenhoop K, Schröder K, Brandes RP.

Circulation. 2014 Sep 16;130(12):976-86. doi: 10.1161/CIRCULATIONAHA.114.010650. Epub 2014 Jul 11.

PMID:
25015343
44.

The evolution of the ribosome biogenesis pathway from a yeast perspective.

Ebersberger I, Simm S, Leisegang MS, Schmitzberger P, Mirus O, von Haeseler A, Bohnsack MT, Schleiff E.

Nucleic Acids Res. 2014 Feb;42(3):1509-23. doi: 10.1093/nar/gkt1137. Epub 2013 Nov 14.

45.

Monoamine oxidases are mediators of endothelial dysfunction in the mouse aorta.

Sturza A, Leisegang MS, Babelova A, Schröder K, Benkhoff S, Loot AE, Fleming I, Schulz R, Muntean DM, Brandes RP.

Hypertension. 2013 Jul;62(1):140-6. doi: 10.1161/HYPERTENSIONAHA.113.01314. Epub 2013 May 13.

PMID:
23670301
46.

Defining the core proteome of the chloroplast envelope membranes.

Simm S, Papasotiriou DG, Ibrahim M, Leisegang MS, Müller B, Schorge T, Karas M, Mirus O, Sommer MS, Schleiff E.

Front Plant Sci. 2013 Feb 6;4:11. doi: 10.3389/fpls.2013.00011. eCollection 2013.

47.

Exportin t and Exportin 5: tRNA and miRNA biogenesis - and beyond.

Leisegang MS, Martin R, Ramírez AS, Bohnsack MT.

Biol Chem. 2012 Jul;393(7):599-604. doi: 10.1515/hsz-2012-0146. Review.

PMID:
22944664
48.

Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo.

Mueller K, von Mässenhausen A, Aichele U, Stärck L, Leisegang M, Uckert W, Pircher H.

J Virol. 2012 Oct;86(19):10866-9. doi: 10.1128/JVI.01472-12. Epub 2012 Jul 11.

49.

Human antitumor CD8+ T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition.

Wilde S, Sommermeyer D, Leisegang M, Frankenberger B, Mosetter B, Uckert W, Schendel DJ.

J Immunol. 2012 Jul 15;189(2):598-605. doi: 10.4049/jimmunol.1102165. Epub 2012 Jun 11.

50.

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

Spranger S, Jeremias I, Wilde S, Leisegang M, Stärck L, Mosetter B, Uckert W, Heemskerk MH, Schendel DJ, Frankenberger B.

Blood. 2012 Apr 12;119(15):3440-9. doi: 10.1182/blood-2011-06-357939. Epub 2012 Feb 27.

PMID:
22371883

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